Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATS6_LEIMU

TriTrypDb:

LmxM.36.4920

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005938	cell cortex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ATS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.295
CLV_C14_Caspase3-7	313	317	PF00656	0.394
CLV_C14_Caspase3-7	550	554	PF00656	0.672
CLV_C14_Caspase3-7	565	569	PF00656	0.540
CLV_C14_Caspase3-7	93	97	PF00656	0.518
CLV_NRD_NRD_1	102	104	PF00675	0.529
CLV_NRD_NRD_1	112	114	PF00675	0.561
CLV_NRD_NRD_1	273	275	PF00675	0.331
CLV_NRD_NRD_1	560	562	PF00675	0.767
CLV_NRD_NRD_1	597	599	PF00675	0.598
CLV_NRD_NRD_1	66	68	PF00675	0.491
CLV_NRD_NRD_1	672	674	PF00675	0.558
CLV_PCSK_KEX2_1	112	114	PF00082	0.610
CLV_PCSK_KEX2_1	253	255	PF00082	0.527
CLV_PCSK_KEX2_1	272	274	PF00082	0.216
CLV_PCSK_KEX2_1	559	561	PF00082	0.762
CLV_PCSK_KEX2_1	66	68	PF00082	0.534
CLV_PCSK_KEX2_1	672	674	PF00082	0.558
CLV_PCSK_KEX2_1	682	684	PF00082	0.384
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.385
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.209
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.439
CLV_PCSK_PC7_1	678	684	PF00082	0.443
CLV_PCSK_SKI1_1	112	116	PF00082	0.498
CLV_PCSK_SKI1_1	14	18	PF00082	0.420
CLV_PCSK_SKI1_1	653	657	PF00082	0.505
CLV_PCSK_SKI1_1	673	677	PF00082	0.343
CLV_PCSK_SKI1_1	682	686	PF00082	0.409
CLV_PCSK_SKI1_1	90	94	PF00082	0.540
CLV_PCSK_SKI1_1	95	99	PF00082	0.466
DEG_APCC_DBOX_1	188	196	PF00400	0.525
DEG_APCC_DBOX_1	335	343	PF00400	0.564
DEG_APCC_DBOX_1	94	102	PF00400	0.505
DEG_SCF_FBW7_1	515	520	PF00400	0.632
DEG_SPOP_SBC_1	373	377	PF00917	0.588
DOC_AGCK_PIF_2	17	22	PF00069	0.439
DOC_CKS1_1	390	395	PF01111	0.571
DOC_CKS1_1	514	519	PF01111	0.636
DOC_MAPK_gen_1	24	34	PF00069	0.495
DOC_MAPK_gen_1	672	679	PF00069	0.461
DOC_MAPK_MEF2A_6	227	236	PF00069	0.385
DOC_MAPK_MEF2A_6	315	322	PF00069	0.491
DOC_MAPK_MEF2A_6	625	634	PF00069	0.516
DOC_MAPK_MEF2A_6	672	679	PF00069	0.461
DOC_PP1_RVXF_1	602	608	PF00149	0.677
DOC_PP1_RVXF_1	670	677	PF00149	0.463
DOC_PP2B_LxvP_1	217	220	PF13499	0.265
DOC_PP2B_LxvP_1	249	252	PF13499	0.385
DOC_PP2B_LxvP_1	488	491	PF13499	0.586
DOC_PP4_FxxP_1	390	393	PF00568	0.577
DOC_PP4_MxPP_1	471	474	PF00568	0.533
DOC_USP7_MATH_1	139	143	PF00917	0.646
DOC_USP7_MATH_1	169	173	PF00917	0.582
DOC_USP7_MATH_1	225	229	PF00917	0.399
DOC_USP7_MATH_1	401	405	PF00917	0.569
DOC_USP7_MATH_1	448	452	PF00917	0.733
DOC_USP7_MATH_1	501	505	PF00917	0.551
DOC_USP7_MATH_1	517	521	PF00917	0.678
DOC_USP7_MATH_1	527	531	PF00917	0.545
DOC_USP7_MATH_1	554	558	PF00917	0.667
DOC_USP7_MATH_1	97	101	PF00917	0.451
DOC_USP7_UBL2_3	437	441	PF12436	0.601
DOC_WW_Pin1_4	121	126	PF00397	0.630
DOC_WW_Pin1_4	238	243	PF00397	0.342
DOC_WW_Pin1_4	375	380	PF00397	0.649
DOC_WW_Pin1_4	38	43	PF00397	0.506
DOC_WW_Pin1_4	389	394	PF00397	0.566
DOC_WW_Pin1_4	395	400	PF00397	0.534
DOC_WW_Pin1_4	410	415	PF00397	0.557
DOC_WW_Pin1_4	457	462	PF00397	0.643
DOC_WW_Pin1_4	513	518	PF00397	0.659
DOC_WW_Pin1_4	536	541	PF00397	0.546
DOC_WW_Pin1_4	584	589	PF00397	0.601
DOC_WW_Pin1_4	609	614	PF00397	0.649
DOC_WW_Pin1_4	645	650	PF00397	0.514
LIG_14-3-3_CanoR_1	103	108	PF00244	0.392
LIG_14-3-3_CanoR_1	119	125	PF00244	0.514
LIG_14-3-3_CanoR_1	295	304	PF00244	0.449
LIG_14-3-3_CanoR_1	423	427	PF00244	0.600
LIG_14-3-3_CanoR_1	463	469	PF00244	0.554
LIG_14-3-3_CanoR_1	651	656	PF00244	0.569
LIG_14-3-3_CanoR_1	85	92	PF00244	0.510
LIG_Actin_WH2_1	672	689	PF00022	0.470
LIG_Actin_WH2_2	212	229	PF00022	0.385
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BIR_III_2	553	557	PF00653	0.670
LIG_BRCT_BRCA1_1	1	5	PF00533	0.600
LIG_BRCT_BRCA1_2	1	7	PF00533	0.417
LIG_EH1_1	282	290	PF00400	0.342
LIG_FHA_1	368	374	PF00498	0.530
LIG_FHA_1	427	433	PF00498	0.623
LIG_FHA_1	474	480	PF00498	0.820
LIG_FHA_2	159	165	PF00498	0.624
LIG_FHA_2	186	192	PF00498	0.507
LIG_FHA_2	282	288	PF00498	0.385
LIG_FHA_2	311	317	PF00498	0.404
LIG_FHA_2	333	339	PF00498	0.568
LIG_FHA_2	39	45	PF00498	0.494
LIG_FHA_2	4	10	PF00498	0.459
LIG_FHA_2	405	411	PF00498	0.649
LIG_FHA_2	423	429	PF00498	0.520
LIG_FHA_2	516	522	PF00498	0.535
LIG_FHA_2	537	543	PF00498	0.719
LIG_FHA_2	585	591	PF00498	0.600
LIG_FHA_2	610	616	PF00498	0.599
LIG_FHA_2	656	662	PF00498	0.523
LIG_FHA_2	74	80	PF00498	0.524
LIG_FHA_2	91	97	PF00498	0.372
LIG_LIR_Apic_2	389	393	PF02991	0.512
LIG_LIR_Gen_1	21	28	PF02991	0.439
LIG_LIR_Gen_1	44	53	PF02991	0.478
LIG_LIR_Nem_3	15	20	PF02991	0.469
LIG_LIR_Nem_3	21	25	PF02991	0.423
LIG_LIR_Nem_3	44	49	PF02991	0.474
LIG_LIR_Nem_3	624	630	PF02991	0.542
LIG_LIR_Nem_3	659	665	PF02991	0.476
LIG_NRBOX	231	237	PF00104	0.385
LIG_PDZ_Class_2	705	710	PF00595	0.526
LIG_REV1ctd_RIR_1	256	265	PF16727	0.385
LIG_RPA_C_Fungi	662	674	PF08784	0.466
LIG_SH2_NCK_1	275	279	PF00017	0.385
LIG_SH2_STAP1	323	327	PF00017	0.519
LIG_SH2_STAT3	105	108	PF00017	0.567
LIG_SH2_STAT5	575	578	PF00017	0.635
LIG_SH2_STAT5	662	665	PF00017	0.456
LIG_SH3_3	360	366	PF00018	0.566
LIG_SH3_3	368	374	PF00018	0.533
LIG_SH3_3	530	536	PF00018	0.672
LIG_TRAF2_1	394	397	PF00917	0.629
LIG_TRAF2_1	588	591	PF00917	0.650
LIG_TYR_ITIM	663	668	PF00017	0.471
LIG_UBA3_1	16	24	PF00899	0.479
LIG_UBA3_1	45	54	PF00899	0.481
LIG_WRC_WIRS_1	264	269	PF05994	0.385
LIG_WW_1	619	622	PF00397	0.554
LIG_WW_3	472	476	PF00397	0.493
LIG_WW_3	618	622	PF00397	0.570
MOD_CDC14_SPxK_1	648	651	PF00782	0.483
MOD_CDK_SPxK_1	457	463	PF00069	0.579
MOD_CDK_SPxK_1	645	651	PF00069	0.511
MOD_CDK_SPxxK_3	121	128	PF00069	0.635
MOD_CDK_SPxxK_3	375	382	PF00069	0.638
MOD_CDK_SPxxK_3	536	543	PF00069	0.548
MOD_CK1_1	152	158	PF00069	0.673
MOD_CK1_1	170	176	PF00069	0.554
MOD_CK1_1	181	187	PF00069	0.530
MOD_CK1_1	310	316	PF00069	0.454
MOD_CK1_1	367	373	PF00069	0.560
MOD_CK1_1	404	410	PF00069	0.682
MOD_CK1_1	451	457	PF00069	0.618
MOD_CK1_1	489	495	PF00069	0.680
MOD_CK1_1	509	515	PF00069	0.576
MOD_CK1_1	609	615	PF00069	0.576
MOD_CK2_1	38	44	PF00069	0.506
MOD_CK2_1	380	386	PF00069	0.638
MOD_CK2_1	404	410	PF00069	0.611
MOD_CK2_1	559	565	PF00069	0.678
MOD_CK2_1	584	590	PF00069	0.644
MOD_CK2_1	609	615	PF00069	0.606
MOD_CK2_1	655	661	PF00069	0.539
MOD_GlcNHglycan	1	4	PF01048	0.585
MOD_GlcNHglycan	161	164	PF01048	0.686
MOD_GlcNHglycan	183	186	PF01048	0.590
MOD_GlcNHglycan	227	230	PF01048	0.399
MOD_GlcNHglycan	309	312	PF01048	0.503
MOD_GlcNHglycan	403	406	PF01048	0.693
MOD_GlcNHglycan	450	453	PF01048	0.806
MOD_GlcNHglycan	464	467	PF01048	0.622
MOD_GlcNHglycan	488	491	PF01048	0.645
MOD_GlcNHglycan	511	514	PF01048	0.663
MOD_GlcNHglycan	561	564	PF01048	0.647
MOD_GlcNHglycan	658	661	PF01048	0.519
MOD_GSK3_1	148	155	PF00069	0.633
MOD_GSK3_1	181	188	PF00069	0.541
MOD_GSK3_1	238	245	PF00069	0.342
MOD_GSK3_1	263	270	PF00069	0.342
MOD_GSK3_1	296	303	PF00069	0.385
MOD_GSK3_1	373	380	PF00069	0.675
MOD_GSK3_1	422	429	PF00069	0.565
MOD_GSK3_1	447	454	PF00069	0.743
MOD_GSK3_1	509	516	PF00069	0.635
MOD_GSK3_1	651	658	PF00069	0.535
MOD_N-GLC_1	120	125	PF02516	0.504
MOD_N-GLC_1	148	153	PF02516	0.577
MOD_N-GLC_1	367	372	PF02516	0.558
MOD_N-GLC_1	501	506	PF02516	0.629
MOD_N-GLC_1	73	78	PF02516	0.545
MOD_NEK2_1	115	120	PF00069	0.666
MOD_NEK2_1	153	158	PF00069	0.639
MOD_NEK2_1	267	272	PF00069	0.342
MOD_NEK2_1	462	467	PF00069	0.693
MOD_NEK2_1	614	619	PF00069	0.629
MOD_NEK2_1	668	673	PF00069	0.576
MOD_NEK2_2	139	144	PF00069	0.678
MOD_OFUCOSY	470	477	PF10250	0.502
MOD_PIKK_1	392	398	PF00454	0.595
MOD_PIKK_1	404	410	PF00454	0.597
MOD_PIKK_1	506	512	PF00454	0.537
MOD_PIKK_1	614	620	PF00454	0.573
MOD_PK_1	103	109	PF00069	0.523
MOD_PKA_1	103	109	PF00069	0.523
MOD_PKA_1	253	259	PF00069	0.385
MOD_PKA_1	559	565	PF00069	0.678
MOD_PKA_1	598	604	PF00069	0.629
MOD_PKA_2	253	259	PF00069	0.385
MOD_PKA_2	332	338	PF00069	0.666
MOD_PKA_2	422	428	PF00069	0.601
MOD_PKA_2	462	468	PF00069	0.640
MOD_PKA_2	546	552	PF00069	0.632
MOD_PKA_2	559	565	PF00069	0.629
MOD_PKA_2	60	66	PF00069	0.524
MOD_PKA_2	84	90	PF00069	0.490
MOD_PKB_1	651	659	PF00069	0.492
MOD_Plk_1	148	154	PF00069	0.670
MOD_Plk_1	170	176	PF00069	0.574
MOD_Plk_1	28	34	PF00069	0.497
MOD_Plk_1	367	373	PF00069	0.532
MOD_Plk_1	501	507	PF00069	0.663
MOD_Plk_4	154	160	PF00069	0.554
MOD_Plk_4	170	176	PF00069	0.655
MOD_Plk_4	263	269	PF00069	0.385
MOD_Plk_4	79	85	PF00069	0.440
MOD_ProDKin_1	121	127	PF00069	0.632
MOD_ProDKin_1	238	244	PF00069	0.342
MOD_ProDKin_1	375	381	PF00069	0.647
MOD_ProDKin_1	38	44	PF00069	0.506
MOD_ProDKin_1	389	395	PF00069	0.569
MOD_ProDKin_1	410	416	PF00069	0.573
MOD_ProDKin_1	457	463	PF00069	0.646
MOD_ProDKin_1	513	519	PF00069	0.661
MOD_ProDKin_1	536	542	PF00069	0.546
MOD_ProDKin_1	584	590	PF00069	0.600
MOD_ProDKin_1	609	615	PF00069	0.650
MOD_ProDKin_1	645	651	PF00069	0.511
MOD_SUMO_rev_2	245	252	PF00179	0.383
MOD_SUMO_rev_2	440	448	PF00179	0.535
MOD_SUMO_rev_2	82	92	PF00179	0.501
MOD_SUMO_rev_2	96	106	PF00179	0.384
TRG_ENDOCYTIC_2	275	278	PF00928	0.385
TRG_ENDOCYTIC_2	50	53	PF00928	0.485
TRG_ENDOCYTIC_2	665	668	PF00928	0.478
TRG_ER_diArg_1	273	275	PF00400	0.331
TRG_ER_diArg_1	559	561	PF00400	0.738
TRG_ER_diArg_1	66	69	PF00400	0.495
TRG_ER_diArg_1	672	674	PF00400	0.551
TRG_NES_CRM1_1	224	240	PF08389	0.385
TRG_NES_CRM1_1	44	56	PF08389	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBQ1	Leishmania donovani	84%	100%
A4HQ09	Leishmania braziliensis	64%	100%
A4IDS0	Leishmania infantum	84%	100%
Q4Q0S0	Leishmania major	84%	100%