TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATS5_LEIMU

TriTrypDb:

LmxM.36.4910

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.572
CLV_NRD_NRD_1	15	17	PF00675	0.483
CLV_NRD_NRD_1	157	159	PF00675	0.488
CLV_NRD_NRD_1	189	191	PF00675	0.560
CLV_NRD_NRD_1	220	222	PF00675	0.465
CLV_NRD_NRD_1	263	265	PF00675	0.489
CLV_NRD_NRD_1	274	276	PF00675	0.457
CLV_NRD_NRD_1	295	297	PF00675	0.588
CLV_NRD_NRD_1	33	35	PF00675	0.493
CLV_NRD_NRD_1	332	334	PF00675	0.469
CLV_NRD_NRD_1	336	338	PF00675	0.474
CLV_NRD_NRD_1	63	65	PF00675	0.669
CLV_PCSK_FUR_1	261	265	PF00082	0.511
CLV_PCSK_KEX2_1	113	115	PF00082	0.525
CLV_PCSK_KEX2_1	15	17	PF00082	0.483
CLV_PCSK_KEX2_1	183	185	PF00082	0.519
CLV_PCSK_KEX2_1	189	191	PF00082	0.472
CLV_PCSK_KEX2_1	220	222	PF00082	0.447
CLV_PCSK_KEX2_1	263	265	PF00082	0.470
CLV_PCSK_KEX2_1	295	297	PF00082	0.666
CLV_PCSK_KEX2_1	332	334	PF00082	0.511
CLV_PCSK_KEX2_1	52	54	PF00082	0.587
CLV_PCSK_KEX2_1	63	65	PF00082	0.650
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.525
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.512
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.522
CLV_PCSK_PC7_1	48	54	PF00082	0.574
CLV_PCSK_SKI1_1	131	135	PF00082	0.579
CLV_PCSK_SKI1_1	16	20	PF00082	0.468
CLV_PCSK_SKI1_1	223	227	PF00082	0.485
CLV_PCSK_SKI1_1	263	267	PF00082	0.532
CLV_PCSK_SKI1_1	319	323	PF00082	0.563
CLV_PCSK_SKI1_1	43	47	PF00082	0.545
CLV_PCSK_SKI1_1	52	56	PF00082	0.366
DEG_APCC_DBOX_1	15	23	PF00400	0.585
DOC_CKS1_1	29	34	PF01111	0.346
DOC_MAPK_gen_1	220	229	PF00069	0.344
DOC_MAPK_MEF2A_6	220	229	PF00069	0.358
DOC_USP7_MATH_1	314	318	PF00917	0.466
DOC_USP7_MATH_1	5	9	PF00917	0.609
DOC_USP7_MATH_1	66	70	PF00917	0.705
DOC_USP7_UBL2_3	179	183	PF12436	0.620
DOC_WW_Pin1_4	28	33	PF00397	0.342
LIG_14-3-3_CanoR_1	131	136	PF00244	0.548
LIG_14-3-3_CanoR_1	24	32	PF00244	0.578
LIG_FHA_1	224	230	PF00498	0.626
LIG_FHA_1	99	105	PF00498	0.614
LIG_FHA_2	264	270	PF00498	0.528
LIG_FHA_2	351	357	PF00498	0.647
LIG_LIR_Nem_3	317	321	PF02991	0.577
LIG_Pex14_2	280	284	PF04695	0.472
LIG_PTB_Apo_2	230	237	PF02174	0.500
LIG_SH2_CRK	116	120	PF00017	0.573
LIG_SH2_CRK	318	322	PF00017	0.507
LIG_SH2_NCK_1	252	256	PF00017	0.536
LIG_SH2_NCK_1	70	74	PF00017	0.596
LIG_SH2_SRC	252	255	PF00017	0.540
LIG_SH2_SRC	300	303	PF00017	0.510
LIG_SH2_STAP1	120	124	PF00017	0.555
LIG_SH2_STAP1	252	256	PF00017	0.634
LIG_SH2_STAP1	300	304	PF00017	0.543
LIG_SH2_STAT5	30	33	PF00017	0.462
LIG_TRAF2_1	167	170	PF00917	0.573
LIG_TRAF2_1	257	260	PF00917	0.519
LIG_TRAF2_1	266	269	PF00917	0.521
LIG_UBA3_1	340	347	PF00899	0.438
MOD_CDK_SPxK_1	28	34	PF00069	0.343
MOD_CDK_SPxxK_3	28	35	PF00069	0.343
MOD_CK1_1	28	34	PF00069	0.409
MOD_CK2_1	263	269	PF00069	0.528
MOD_GlcNHglycan	7	10	PF01048	0.624
MOD_GlcNHglycan	76	79	PF01048	0.739
MOD_GlcNHglycan	91	94	PF01048	0.591
MOD_GSK3_1	300	307	PF00069	0.395
MOD_GSK3_1	346	353	PF00069	0.605
MOD_GSK3_1	81	88	PF00069	0.757
MOD_N-GLC_1	223	228	PF02516	0.508
MOD_NEK2_1	178	183	PF00069	0.490
MOD_NEK2_1	25	30	PF00069	0.580
MOD_NEK2_1	294	299	PF00069	0.500
MOD_NEK2_1	304	309	PF00069	0.595
MOD_NEK2_1	89	94	PF00069	0.689
MOD_PIKK_1	25	31	PF00454	0.523
MOD_PKA_1	263	269	PF00069	0.625
MOD_PKA_2	25	31	PF00069	0.579
MOD_PKA_2	263	269	PF00069	0.462
MOD_PKA_2	294	300	PF00069	0.596
MOD_PKA_2	350	356	PF00069	0.558
MOD_PKA_2	89	95	PF00069	0.610
MOD_PKB_1	261	269	PF00069	0.656
MOD_Plk_1	223	229	PF00069	0.507
MOD_Plk_1	300	306	PF00069	0.466
MOD_Plk_1	98	104	PF00069	0.676
MOD_Plk_4	223	229	PF00069	0.446
MOD_Plk_4	81	87	PF00069	0.522
MOD_ProDKin_1	28	34	PF00069	0.343
MOD_SUMO_rev_2	154	161	PF00179	0.543
TRG_ENDOCYTIC_2	116	119	PF00928	0.574
TRG_ENDOCYTIC_2	252	255	PF00928	0.540
TRG_ENDOCYTIC_2	318	321	PF00928	0.513
TRG_ER_diArg_1	24	27	PF00400	0.492
TRG_ER_diArg_1	261	264	PF00400	0.589
TRG_ER_diArg_1	294	296	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM7	Leptomonas seymouri	68%	100%
A0A1X0P2Z9	Trypanosomatidae	40%	100%
A0A3Q8ILH7	Leishmania donovani	92%	100%
A0A3R7KX10	Trypanosoma rangeli	38%	100%
A4HQ08	Leishmania braziliensis	80%	100%
A4IDR9	Leishmania infantum	92%	100%
D0A8W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q0S1	Leishmania major	92%	100%
V5B8Z3	Trypanosoma cruzi	41%	100%