LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATS2_LEIMU

TriTrypDb:

LmxM.36.4890

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	12
GO:0110165	cellular anatomical entity	1	13
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ATS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATS2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0036158	outer dynein arm assembly	7	12
GO:0036159	inner dynein arm assembly	7	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070286	axonemal dynein complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0044877	protein-containing complex binding	2	12
GO:0070840	dynein complex binding	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.472
CLV_C14_Caspase3-7	5	9	PF00656	0.578
CLV_C14_Caspase3-7	79	83	PF00656	0.514
CLV_C14_Caspase3-7	92	96	PF00656	0.518
CLV_NRD_NRD_1	192	194	PF00675	0.311
CLV_NRD_NRD_1	26	28	PF00675	0.533
CLV_NRD_NRD_1	264	266	PF00675	0.529
CLV_PCSK_KEX2_1	194	196	PF00082	0.347
CLV_PCSK_KEX2_1	26	28	PF00082	0.523
CLV_PCSK_KEX2_1	263	265	PF00082	0.526
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.440
CLV_PCSK_PC7_1	260	266	PF00082	0.549
CLV_PCSK_SKI1_1	176	180	PF00082	0.388
DEG_APCC_DBOX_1	171	179	PF00400	0.457
DEG_Nend_UBRbox_1	1	4	PF02207	0.524
DOC_CDC14_PxL_1	97	105	PF14671	0.432
DOC_CKS1_1	31	36	PF01111	0.383
DOC_CYCLIN_RxL_1	172	184	PF00134	0.278
DOC_WW_Pin1_4	270	275	PF00397	0.608
DOC_WW_Pin1_4	277	282	PF00397	0.622
DOC_WW_Pin1_4	30	35	PF00397	0.385
LIG_14-3-3_CanoR_1	172	176	PF00244	0.451
LIG_APCC_ABBA_1	60	65	PF00400	0.347
LIG_BRCT_BRCA1_1	18	22	PF00533	0.312
LIG_Clathr_ClatBox_1	148	152	PF01394	0.444
LIG_FHA_1	103	109	PF00498	0.464
LIG_FHA_1	15	21	PF00498	0.388
LIG_FHA_1	175	181	PF00498	0.367
LIG_FHA_1	278	284	PF00498	0.685
LIG_FHA_1	31	37	PF00498	0.217
LIG_FHA_1	55	61	PF00498	0.357
LIG_FHA_2	225	231	PF00498	0.299
LIG_FHA_2	46	52	PF00498	0.273
LIG_FHA_2	77	83	PF00498	0.468
LIG_LIR_Nem_3	207	212	PF02991	0.392
LIG_LIR_Nem_3	247	252	PF02991	0.451
LIG_LRP6_Inhibitor_1	153	159	PF00058	0.194
LIG_NRBOX	125	131	PF00104	0.444
LIG_NRBOX	144	150	PF00104	0.444
LIG_NRBOX	174	180	PF00104	0.444
LIG_Pex14_1	196	200	PF04695	0.412
LIG_RPA_C_Fungi	260	272	PF08784	0.334
LIG_SH2_NCK_1	31	35	PF00017	0.422
LIG_SH2_SRC	297	300	PF00017	0.661
LIG_SH2_SRC	41	44	PF00017	0.419
LIG_SH2_SRC	63	66	PF00017	0.359
LIG_SH2_STAT5	275	278	PF00017	0.467
LIG_SH2_STAT5	297	300	PF00017	0.549
LIG_SH2_STAT5	41	44	PF00017	0.342
LIG_SH2_STAT5	63	66	PF00017	0.338
LIG_SH2_STAT5	85	88	PF00017	0.295
LIG_SH3_3	95	101	PF00018	0.295
LIG_SUMO_SIM_par_1	104	109	PF11976	0.155
LIG_SUMO_SIM_par_1	146	152	PF11976	0.359
MOD_CK1_1	171	177	PF00069	0.498
MOD_CK2_1	224	230	PF00069	0.288
MOD_CK2_1	29	35	PF00069	0.430
MOD_GlcNHglycan	145	148	PF01048	0.353
MOD_GlcNHglycan	164	167	PF01048	0.521
MOD_GlcNHglycan	234	237	PF01048	0.518
MOD_GSK3_1	102	109	PF00069	0.318
MOD_GSK3_1	143	150	PF00069	0.378
MOD_GSK3_1	279	286	PF00069	0.586
MOD_GSK3_1	45	52	PF00069	0.337
MOD_GSK3_1	76	83	PF00069	0.363
MOD_GSK3_1	89	96	PF00069	0.239
MOD_NEK2_1	106	111	PF00069	0.268
MOD_NEK2_1	151	156	PF00069	0.343
MOD_NEK2_1	16	21	PF00069	0.502
MOD_NEK2_1	168	173	PF00069	0.521
MOD_NEK2_1	45	50	PF00069	0.399
MOD_NEK2_1	84	89	PF00069	0.339
MOD_PIKK_1	106	112	PF00454	0.141
MOD_PIKK_1	45	51	PF00454	0.335
MOD_PKA_2	162	168	PF00069	0.487
MOD_PKA_2	171	177	PF00069	0.458
MOD_PKA_2	186	192	PF00069	0.348
MOD_Plk_1	283	289	PF00069	0.647
MOD_Plk_4	125	131	PF00069	0.298
MOD_Plk_4	16	22	PF00069	0.403
MOD_Plk_4	80	86	PF00069	0.296
MOD_ProDKin_1	270	276	PF00069	0.609
MOD_ProDKin_1	277	283	PF00069	0.627
MOD_ProDKin_1	30	36	PF00069	0.386
MOD_SUMO_for_1	158	161	PF00179	0.211
TRG_ENDOCYTIC_2	209	212	PF00928	0.441
TRG_ENDOCYTIC_2	252	255	PF00928	0.472
TRG_ER_diArg_1	192	195	PF00400	0.357
TRG_ER_diArg_1	263	265	PF00400	0.559
TRG_NES_CRM1_1	51	65	PF08389	0.251
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJD4	Leptomonas seymouri	61%	96%
A0A0S4JHJ7	Bodo saltans	38%	81%
A0A1X0NUQ9	Trypanosomatidae	36%	72%
A0A1X0P4D9	Trypanosomatidae	44%	100%
A0A3Q8IC25	Leishmania donovani	30%	100%
A0A3Q8IWC9	Leishmania donovani	92%	100%
A0A3R7KFT3	Trypanosoma rangeli	32%	68%
A0A422NC68	Trypanosoma rangeli	45%	100%
A4HDF9	Leishmania braziliensis	31%	100%
A4HQ05	Leishmania braziliensis	76%	100%
A4I0U0	Leishmania infantum	30%	100%
A4IDR6	Leishmania infantum	92%	100%
D0A8W7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A9U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	71%
E9AWU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q09JZ4	Chlamydomonas reinhardtii	32%	72%
Q15435	Homo sapiens	24%	87%
Q3T0W4	Bos taurus	26%	87%
Q3UM45	Mus musculus	24%	87%
Q4Q0S4	Leishmania major	91%	100%
Q4QAN0	Leishmania major	31%	100%
Q5RFS7	Pongo abelii	24%	87%
Q6DIQ3	Xenopus tropicalis	27%	90%