Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATR9_LEIMU

TriTrypDb:

LmxM.36.4850

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.582
CLV_C14_Caspase3-7	98	102	PF00656	0.596
CLV_NRD_NRD_1	221	223	PF00675	0.515
CLV_NRD_NRD_1	396	398	PF00675	0.441
CLV_NRD_NRD_1	435	437	PF00675	0.375
CLV_NRD_NRD_1	440	442	PF00675	0.377
CLV_NRD_NRD_1	444	446	PF00675	0.451
CLV_NRD_NRD_1	549	551	PF00675	0.487
CLV_PCSK_KEX2_1	221	223	PF00082	0.306
CLV_PCSK_KEX2_1	396	398	PF00082	0.414
CLV_PCSK_KEX2_1	434	436	PF00082	0.391
CLV_PCSK_KEX2_1	440	442	PF00082	0.372
CLV_PCSK_KEX2_1	444	446	PF00082	0.437
CLV_PCSK_KEX2_1	549	551	PF00082	0.504
CLV_PCSK_PC7_1	436	442	PF00082	0.380
CLV_PCSK_SKI1_1	227	231	PF00082	0.463
CLV_PCSK_SKI1_1	380	384	PF00082	0.474
CLV_PCSK_SKI1_1	445	449	PF00082	0.561
CLV_PCSK_SKI1_1	539	543	PF00082	0.557
DEG_APCC_DBOX_1	414	422	PF00400	0.475
DEG_APCC_DBOX_1	483	491	PF00400	0.526
DEG_SCF_FBW7_1	263	269	PF00400	0.522
DEG_SPOP_SBC_1	22	26	PF00917	0.471
DEG_SPOP_SBC_1	252	256	PF00917	0.449
DOC_AGCK_PIF_2	119	124	PF00069	0.486
DOC_CKS1_1	263	268	PF01111	0.609
DOC_CYCLIN_RxL_1	325	337	PF00134	0.486
DOC_CYCLIN_RxL_1	536	545	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.428
DOC_MAPK_gen_1	401	408	PF00069	0.462
DOC_MAPK_gen_1	440	450	PF00069	0.463
DOC_MAPK_JIP1_4	211	217	PF00069	0.475
DOC_MAPK_MEF2A_6	211	219	PF00069	0.478
DOC_PP1_RVXF_1	476	482	PF00149	0.506
DOC_PP2B_LxvP_1	302	305	PF13499	0.441
DOC_PP2B_LxvP_1	483	486	PF13499	0.497
DOC_PP2B_LxvP_1	581	584	PF13499	0.569
DOC_PP4_FxxP_1	113	116	PF00568	0.567
DOC_USP7_MATH_1	252	256	PF00917	0.563
DOC_USP7_MATH_1	257	261	PF00917	0.609
DOC_USP7_MATH_1	315	319	PF00917	0.481
DOC_USP7_MATH_1	486	490	PF00917	0.518
DOC_USP7_MATH_1	525	529	PF00917	0.603
DOC_USP7_MATH_1	554	558	PF00917	0.518
DOC_USP7_UBL2_3	325	329	PF12436	0.455
DOC_WW_Pin1_4	103	108	PF00397	0.703
DOC_WW_Pin1_4	262	267	PF00397	0.609
DOC_WW_Pin1_4	27	32	PF00397	0.640
DOC_WW_Pin1_4	57	62	PF00397	0.683
DOC_WW_Pin1_4	579	584	PF00397	0.706
DOC_WW_Pin1_4	590	595	PF00397	0.593
DOC_WW_Pin1_4	91	96	PF00397	0.491
LIG_14-3-3_CanoR_1	227	232	PF00244	0.287
LIG_14-3-3_CanoR_1	242	251	PF00244	0.415
LIG_14-3-3_CanoR_1	271	276	PF00244	0.589
LIG_14-3-3_CanoR_1	292	299	PF00244	0.435
LIG_14-3-3_CanoR_1	338	344	PF00244	0.487
LIG_14-3-3_CanoR_1	415	425	PF00244	0.526
LIG_14-3-3_CanoR_1	521	530	PF00244	0.625
LIG_14-3-3_CanoR_1	555	561	PF00244	0.587
LIG_APCC_ABBAyCdc20_2	602	608	PF00400	0.501
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	40	44	PF00533	0.631
LIG_Clathr_ClatBox_1	278	282	PF01394	0.469
LIG_Clathr_ClatBox_1	541	545	PF01394	0.545
LIG_FHA_1	106	112	PF00498	0.688
LIG_FHA_1	149	155	PF00498	0.535
LIG_FHA_1	177	183	PF00498	0.542
LIG_FHA_1	263	269	PF00498	0.665
LIG_FHA_1	3	9	PF00498	0.540
LIG_FHA_1	326	332	PF00498	0.396
LIG_FHA_1	377	383	PF00498	0.457
LIG_FHA_1	451	457	PF00498	0.503
LIG_FHA_1	530	536	PF00498	0.587
LIG_FHA_2	192	198	PF00498	0.538
LIG_FHA_2	358	364	PF00498	0.489
LIG_FHA_2	497	503	PF00498	0.585
LIG_FHA_2	96	102	PF00498	0.498
LIG_GBD_Chelix_1	408	416	PF00786	0.441
LIG_GBD_Chelix_1	497	505	PF00786	0.553
LIG_LIR_Gen_1	123	130	PF02991	0.476
LIG_LIR_Gen_1	161	169	PF02991	0.575
LIG_LIR_Gen_1	41	52	PF02991	0.468
LIG_LIR_Gen_1	452	462	PF02991	0.473
LIG_LIR_Nem_3	123	127	PF02991	0.458
LIG_LIR_Nem_3	161	165	PF02991	0.612
LIG_LIR_Nem_3	274	278	PF02991	0.506
LIG_LIR_Nem_3	41	47	PF02991	0.503
LIG_LIR_Nem_3	452	458	PF02991	0.507
LIG_MYND_1	488	492	PF01753	0.516
LIG_MYND_1	61	65	PF01753	0.583
LIG_Pex14_1	162	166	PF04695	0.617
LIG_Rb_pABgroove_1	116	124	PF01858	0.456
LIG_RPA_C_Fungi	431	443	PF08784	0.314
LIG_SH2_NCK_1	575	579	PF00017	0.568
LIG_SH2_STAT3	391	394	PF00017	0.461
LIG_SH2_STAT5	19	22	PF00017	0.617
LIG_SH2_STAT5	356	359	PF00017	0.522
LIG_SH2_STAT5	391	394	PF00017	0.461
LIG_SH2_STAT5	482	485	PF00017	0.475
LIG_SH2_STAT5	523	526	PF00017	0.512
LIG_SH3_3	104	110	PF00018	0.735
LIG_SH3_3	260	266	PF00018	0.557
LIG_SH3_3	588	594	PF00018	0.552
LIG_SH3_3	62	68	PF00018	0.646
LIG_SUMO_SIM_anti_2	138	145	PF11976	0.532
LIG_SUMO_SIM_par_1	141	147	PF11976	0.626
LIG_SUMO_SIM_par_1	274	280	PF11976	0.586
LIG_SUMO_SIM_par_1	303	310	PF11976	0.595
LIG_SUMO_SIM_par_1	446	454	PF11976	0.644
LIG_TRAF2_1	194	197	PF00917	0.556
LIG_TRAF2_1	339	342	PF00917	0.534
LIG_TRAF2_1	585	588	PF00917	0.484
LIG_UBA3_1	77	83	PF00899	0.497
LIG_WRC_WIRS_1	462	467	PF05994	0.459
MOD_CDC14_SPxK_1	30	33	PF00782	0.663
MOD_CDK_SPxK_1	27	33	PF00069	0.662
MOD_CK1_1	176	182	PF00069	0.705
MOD_CK1_1	2	8	PF00069	0.586
MOD_CK1_1	255	261	PF00069	0.645
MOD_CK1_1	284	290	PF00069	0.594
MOD_CK1_1	40	46	PF00069	0.683
MOD_CK1_1	414	420	PF00069	0.574
MOD_CK1_1	56	62	PF00069	0.554
MOD_CK1_1	593	599	PF00069	0.758
MOD_CK2_1	191	197	PF00069	0.596
MOD_CK2_1	362	368	PF00069	0.503
MOD_CK2_1	560	566	PF00069	0.624
MOD_GlcNHglycan	1	4	PF01048	0.724
MOD_GlcNHglycan	101	104	PF01048	0.675
MOD_GlcNHglycan	131	135	PF01048	0.506
MOD_GlcNHglycan	166	169	PF01048	0.623
MOD_GlcNHglycan	257	260	PF01048	0.753
MOD_GlcNHglycan	268	271	PF01048	0.651
MOD_GlcNHglycan	363	367	PF01048	0.510
MOD_GlcNHglycan	55	58	PF01048	0.744
MOD_GlcNHglycan	556	559	PF01048	0.573
MOD_GSK3_1	173	180	PF00069	0.623
MOD_GSK3_1	23	30	PF00069	0.590
MOD_GSK3_1	242	249	PF00069	0.540
MOD_GSK3_1	251	258	PF00069	0.573
MOD_GSK3_1	262	269	PF00069	0.544
MOD_GSK3_1	333	340	PF00069	0.514
MOD_GSK3_1	517	524	PF00069	0.500
MOD_GSK3_1	525	532	PF00069	0.456
MOD_GSK3_1	53	60	PF00069	0.718
MOD_GSK3_1	586	593	PF00069	0.699
MOD_GSK3_1	91	98	PF00069	0.612
MOD_GSK3_1	99	106	PF00069	0.628
MOD_N-GLC_1	347	352	PF02516	0.432
MOD_N-GLC_1	37	42	PF02516	0.668
MOD_NEK2_1	12	17	PF00069	0.550
MOD_NEK2_1	130	135	PF00069	0.493
MOD_NEK2_1	215	220	PF00069	0.541
MOD_NEK2_1	411	416	PF00069	0.447
MOD_NEK2_1	535	540	PF00069	0.448
MOD_NEK2_1	586	591	PF00069	0.773
MOD_NEK2_2	48	53	PF00069	0.512
MOD_PIKK_1	390	396	PF00454	0.461
MOD_PIKK_1	463	469	PF00454	0.492
MOD_PKA_2	291	297	PF00069	0.456
MOD_PKA_2	337	343	PF00069	0.595
MOD_PKA_2	414	420	PF00069	0.491
MOD_PKA_2	554	560	PF00069	0.499
MOD_Plk_1	294	300	PF00069	0.547
MOD_Plk_1	37	43	PF00069	0.597
MOD_Plk_1	517	523	PF00069	0.586
MOD_Plk_2-3	123	129	PF00069	0.462
MOD_Plk_2-3	337	343	PF00069	0.486
MOD_Plk_4	215	221	PF00069	0.564
MOD_Plk_4	315	321	PF00069	0.542
MOD_Plk_4	486	492	PF00069	0.532
MOD_Plk_4	496	502	PF00069	0.466
MOD_Plk_4	586	592	PF00069	0.612
MOD_ProDKin_1	103	109	PF00069	0.702
MOD_ProDKin_1	262	268	PF00069	0.610
MOD_ProDKin_1	27	33	PF00069	0.642
MOD_ProDKin_1	57	63	PF00069	0.684
MOD_ProDKin_1	579	585	PF00069	0.711
MOD_ProDKin_1	590	596	PF00069	0.593
MOD_ProDKin_1	91	97	PF00069	0.491
MOD_SUMO_for_1	402	405	PF00179	0.393
TRG_DiLeu_BaEn_1	139	144	PF01217	0.468
TRG_DiLeu_BaEn_1	428	433	PF01217	0.450
TRG_DiLeu_BaEn_1	512	517	PF01217	0.550
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.517
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.559
TRG_ENDOCYTIC_2	124	127	PF00928	0.482
TRG_ER_diArg_1	220	222	PF00400	0.293
TRG_ER_diArg_1	395	397	PF00400	0.401
TRG_ER_diArg_1	421	424	PF00400	0.497
TRG_ER_diArg_1	433	436	PF00400	0.384
TRG_ER_diArg_1	439	441	PF00400	0.367
TRG_ER_diArg_1	549	551	PF00400	0.490
TRG_NES_CRM1_1	207	223	PF08389	0.508
TRG_NES_CRM1_1	461	472	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N7	Leptomonas seymouri	50%	98%
A0A1X0P1Y3	Trypanosomatidae	25%	100%
A0A3Q8IJM8	Leishmania donovani	91%	100%
A4HQ02	Leishmania braziliensis	78%	100%
A4IDR3	Leishmania infantum	91%	100%
D0A4F5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q0S8	Leishmania major	90%	100%