Small monomeric GTPase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATR7_LEIMU

TriTrypDb:

LmxM.36.4830

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.520
CLV_NRD_NRD_1	182	184	PF00675	0.567
CLV_NRD_NRD_1	223	225	PF00675	0.433
CLV_NRD_NRD_1	330	332	PF00675	0.535
CLV_NRD_NRD_1	342	344	PF00675	0.408
CLV_NRD_NRD_1	37	39	PF00675	0.402
CLV_NRD_NRD_1	464	466	PF00675	0.341
CLV_PCSK_KEX2_1	182	184	PF00082	0.523
CLV_PCSK_KEX2_1	223	225	PF00082	0.433
CLV_PCSK_KEX2_1	330	332	PF00082	0.511
CLV_PCSK_KEX2_1	342	344	PF00082	0.426
CLV_PCSK_KEX2_1	37	39	PF00082	0.402
CLV_PCSK_KEX2_1	464	466	PF00082	0.341
CLV_PCSK_KEX2_1	89	91	PF00082	0.464
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.464
CLV_PCSK_SKI1_1	206	210	PF00082	0.579
CLV_PCSK_SKI1_1	224	228	PF00082	0.385
CLV_PCSK_SKI1_1	240	244	PF00082	0.485
CLV_PCSK_SKI1_1	269	273	PF00082	0.481
CLV_PCSK_SKI1_1	32	36	PF00082	0.380
DEG_APCC_DBOX_1	205	213	PF00400	0.414
DEG_SPOP_SBC_1	120	124	PF00917	0.481
DOC_CYCLIN_yClb5_NLxxxL_5	309	318	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.441
DOC_MAPK_RevD_3	316	331	PF00069	0.553
DOC_PP1_RVXF_1	340	347	PF00149	0.489
DOC_PP4_FxxP_1	169	172	PF00568	0.526
DOC_USP7_MATH_1	11	15	PF00917	0.555
DOC_USP7_MATH_1	120	124	PF00917	0.622
DOC_USP7_MATH_1	260	264	PF00917	0.605
DOC_USP7_MATH_1	377	381	PF00917	0.472
DOC_USP7_MATH_1	61	65	PF00917	0.627
DOC_WW_Pin1_4	320	325	PF00397	0.543
DOC_WW_Pin1_4	57	62	PF00397	0.647
LIG_14-3-3_CanoR_1	182	187	PF00244	0.478
LIG_14-3-3_CanoR_1	223	232	PF00244	0.395
LIG_14-3-3_CanoR_1	237	243	PF00244	0.366
LIG_14-3-3_CanoR_1	262	268	PF00244	0.382
LIG_14-3-3_CanoR_1	419	425	PF00244	0.558
LIG_14-3-3_CanoR_1	90	95	PF00244	0.479
LIG_BRCT_BRCA1_1	337	341	PF00533	0.412
LIG_BRCT_BRCA1_1	354	358	PF00533	0.409
LIG_deltaCOP1_diTrp_1	234	238	PF00928	0.368
LIG_EH1_1	398	406	PF00400	0.516
LIG_FHA_1	139	145	PF00498	0.475
LIG_FHA_1	18	24	PF00498	0.404
LIG_FHA_1	225	231	PF00498	0.421
LIG_FHA_1	292	298	PF00498	0.625
LIG_FHA_1	31	37	PF00498	0.384
LIG_FHA_1	50	56	PF00498	0.604
LIG_FHA_1	78	84	PF00498	0.545
LIG_FHA_1	89	95	PF00498	0.513
LIG_FHA_1	96	102	PF00498	0.577
LIG_FHA_2	306	312	PF00498	0.514
LIG_FHA_2	421	427	PF00498	0.443
LIG_FHA_2	48	54	PF00498	0.571
LIG_FHA_2	67	73	PF00498	0.483
LIG_FHA_2	91	97	PF00498	0.557
LIG_LIR_Apic_2	168	172	PF02991	0.521
LIG_LIR_Gen_1	384	393	PF02991	0.438
LIG_LIR_LC3C_4	20	25	PF02991	0.366
LIG_LIR_Nem_3	189	195	PF02991	0.396
LIG_LIR_Nem_3	198	204	PF02991	0.461
LIG_LIR_Nem_3	234	239	PF02991	0.346
LIG_LIR_Nem_3	338	344	PF02991	0.449
LIG_LIR_Nem_3	355	361	PF02991	0.421
LIG_LIR_Nem_3	384	389	PF02991	0.444
LIG_PTB_Apo_2	127	134	PF02174	0.502
LIG_PTB_Apo_2	208	215	PF02174	0.395
LIG_PTB_Apo_2	38	45	PF02174	0.327
LIG_PTB_Phospho_1	127	133	PF10480	0.474
LIG_PTB_Phospho_1	208	214	PF10480	0.401
LIG_SH2_CRK	214	218	PF00017	0.339
LIG_SH2_NCK_1	110	114	PF00017	0.641
LIG_SH2_STAT3	118	121	PF00017	0.484
LIG_SH2_STAT3	157	160	PF00017	0.604
LIG_SH2_STAT5	118	121	PF00017	0.604
LIG_SH2_STAT5	231	234	PF00017	0.411
LIG_SH2_STAT5	399	402	PF00017	0.494
LIG_SH2_STAT5	8	11	PF00017	0.647
LIG_SH3_3	52	58	PF00018	0.629
LIG_SH3_3	96	102	PF00018	0.559
LIG_SUMO_SIM_anti_2	20	27	PF11976	0.383
LIG_SUMO_SIM_par_1	20	27	PF11976	0.383
LIG_TRAF2_1	423	426	PF00917	0.522
LIG_TYR_ITIM	212	217	PF00017	0.361
MOD_CK1_1	124	130	PF00069	0.560
MOD_CK1_1	165	171	PF00069	0.620
MOD_CK1_1	225	231	PF00069	0.532
MOD_CK1_1	241	247	PF00069	0.330
MOD_CK1_1	263	269	PF00069	0.459
MOD_CK1_1	3	9	PF00069	0.633
MOD_CK1_1	305	311	PF00069	0.566
MOD_CK1_1	323	329	PF00069	0.558
MOD_CK1_1	444	450	PF00069	0.499
MOD_CK1_1	48	54	PF00069	0.559
MOD_CK2_1	11	17	PF00069	0.573
MOD_CK2_1	420	426	PF00069	0.420
MOD_CK2_1	48	54	PF00069	0.576
MOD_CMANNOS	235	238	PF00535	0.359
MOD_GlcNHglycan	106	109	PF01048	0.496
MOD_GlcNHglycan	11	14	PF01048	0.560
MOD_GlcNHglycan	152	155	PF01048	0.645
MOD_GlcNHglycan	176	179	PF01048	0.580
MOD_GlcNHglycan	243	246	PF01048	0.454
MOD_GlcNHglycan	300	303	PF01048	0.547
MOD_GlcNHglycan	53	58	PF01048	0.661
MOD_GSK3_1	116	123	PF00069	0.563
MOD_GSK3_1	182	189	PF00069	0.482
MOD_GSK3_1	222	229	PF00069	0.432
MOD_GSK3_1	26	33	PF00069	0.569
MOD_GSK3_1	298	305	PF00069	0.560
MOD_GSK3_1	44	51	PF00069	0.422
MOD_GSK3_1	444	451	PF00069	0.446
MOD_GSK3_1	53	60	PF00069	0.625
MOD_LATS_1	222	228	PF00433	0.399
MOD_N-GLC_1	165	170	PF02516	0.621
MOD_N-GLC_1	444	449	PF02516	0.576
MOD_N-GLC_2	146	148	PF02516	0.474
MOD_NEK2_1	1	6	PF00069	0.496
MOD_NEK2_1	104	109	PF00069	0.601
MOD_NEK2_1	162	167	PF00069	0.578
MOD_NEK2_1	195	200	PF00069	0.453
MOD_NEK2_1	226	231	PF00069	0.442
MOD_NEK2_1	272	277	PF00069	0.380
MOD_NEK2_1	359	364	PF00069	0.614
MOD_NEK2_1	415	420	PF00069	0.494
MOD_NEK2_1	432	437	PF00069	0.371
MOD_NEK2_1	44	49	PF00069	0.508
MOD_NEK2_1	88	93	PF00069	0.451
MOD_NEK2_1	95	100	PF00069	0.546
MOD_NEK2_2	238	243	PF00069	0.356
MOD_NEK2_2	293	298	PF00069	0.523
MOD_PIKK_1	272	278	PF00454	0.459
MOD_PIKK_1	325	331	PF00454	0.595
MOD_PIKK_1	432	438	PF00454	0.409
MOD_PIKK_1	61	67	PF00454	0.685
MOD_PKA_1	182	188	PF00069	0.483
MOD_PKA_1	89	95	PF00069	0.469
MOD_PKA_2	148	154	PF00069	0.479
MOD_PKA_2	17	23	PF00069	0.437
MOD_PKA_2	182	188	PF00069	0.462
MOD_PKA_2	222	228	PF00069	0.464
MOD_PKA_2	261	267	PF00069	0.406
MOD_PKA_2	89	95	PF00069	0.469
MOD_Plk_1	165	171	PF00069	0.620
MOD_Plk_1	26	32	PF00069	0.595
MOD_Plk_1	305	311	PF00069	0.580
MOD_Plk_1	444	450	PF00069	0.508
MOD_Plk_1	45	51	PF00069	0.430
MOD_Plk_1	95	101	PF00069	0.606
MOD_Plk_4	121	127	PF00069	0.564
MOD_Plk_4	182	188	PF00069	0.527
MOD_Plk_4	226	232	PF00069	0.437
MOD_Plk_4	30	36	PF00069	0.380
MOD_Plk_4	305	311	PF00069	0.588
MOD_Plk_4	90	96	PF00069	0.476
MOD_ProDKin_1	320	326	PF00069	0.540
MOD_ProDKin_1	57	63	PF00069	0.650
MOD_SUMO_for_1	428	431	PF00179	0.487
MOD_SUMO_rev_2	311	318	PF00179	0.513
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.396
TRG_ENDOCYTIC_2	201	204	PF00928	0.443
TRG_ENDOCYTIC_2	214	217	PF00928	0.341
TRG_ENDOCYTIC_2	236	239	PF00928	0.389
TRG_ER_diArg_1	181	183	PF00400	0.534
TRG_ER_diArg_1	341	343	PF00400	0.490
TRG_ER_diArg_1	36	38	PF00400	0.402
TRG_ER_diArg_1	371	374	PF00400	0.576
TRG_ER_diArg_1	463	465	PF00400	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I895	Leptomonas seymouri	56%	95%
A0A3Q8IRK5	Leishmania donovani	86%	100%
A4HQ00	Leishmania braziliensis	70%	100%
A4IDR1	Leishmania infantum	86%	100%
Q4Q0T0	Leishmania major	86%	100%