Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATR3_LEIMU

TriTrypDb:

LmxM.36.4790

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATR3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	349	353	PF00656	0.517
CLV_C14_Caspase3-7	480	484	PF00656	0.536
CLV_C14_Caspase3-7	565	569	PF00656	0.747
CLV_C14_Caspase3-7	89	93	PF00656	0.706
CLV_C14_Caspase3-7	899	903	PF00656	0.675
CLV_NRD_NRD_1	141	143	PF00675	0.608
CLV_NRD_NRD_1	149	151	PF00675	0.618
CLV_NRD_NRD_1	199	201	PF00675	0.541
CLV_NRD_NRD_1	235	237	PF00675	0.569
CLV_NRD_NRD_1	320	322	PF00675	0.639
CLV_NRD_NRD_1	394	396	PF00675	0.595
CLV_NRD_NRD_1	452	454	PF00675	0.645
CLV_NRD_NRD_1	550	552	PF00675	0.534
CLV_NRD_NRD_1	583	585	PF00675	0.766
CLV_NRD_NRD_1	617	619	PF00675	0.565
CLV_NRD_NRD_1	675	677	PF00675	0.562
CLV_NRD_NRD_1	717	719	PF00675	0.730
CLV_NRD_NRD_1	757	759	PF00675	0.741
CLV_NRD_NRD_1	815	817	PF00675	0.560
CLV_NRD_NRD_1	889	891	PF00675	0.740
CLV_NRD_NRD_1	910	912	PF00675	0.716
CLV_PCSK_FUR_1	547	551	PF00082	0.727
CLV_PCSK_FUR_1	691	695	PF00082	0.500
CLV_PCSK_FUR_1	887	891	PF00082	0.731
CLV_PCSK_KEX2_1	140	142	PF00082	0.606
CLV_PCSK_KEX2_1	148	150	PF00082	0.577
CLV_PCSK_KEX2_1	234	236	PF00082	0.578
CLV_PCSK_KEX2_1	319	321	PF00082	0.655
CLV_PCSK_KEX2_1	394	396	PF00082	0.595
CLV_PCSK_KEX2_1	403	405	PF00082	0.589
CLV_PCSK_KEX2_1	451	453	PF00082	0.648
CLV_PCSK_KEX2_1	488	490	PF00082	0.658
CLV_PCSK_KEX2_1	549	551	PF00082	0.709
CLV_PCSK_KEX2_1	617	619	PF00082	0.680
CLV_PCSK_KEX2_1	693	695	PF00082	0.774
CLV_PCSK_KEX2_1	717	719	PF00082	0.730
CLV_PCSK_KEX2_1	757	759	PF00082	0.723
CLV_PCSK_KEX2_1	814	816	PF00082	0.608
CLV_PCSK_KEX2_1	886	888	PF00082	0.746
CLV_PCSK_KEX2_1	889	891	PF00082	0.730
CLV_PCSK_KEX2_1	910	912	PF00082	0.611
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.661
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.637
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.546
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.544
CLV_PCSK_PC1ET2_1	886	888	PF00082	0.761
CLV_PCSK_PC7_1	144	150	PF00082	0.591
CLV_PCSK_SKI1_1	124	128	PF00082	0.621
CLV_PCSK_SKI1_1	157	161	PF00082	0.630
CLV_PCSK_SKI1_1	395	399	PF00082	0.536
CLV_PCSK_SKI1_1	423	427	PF00082	0.619
CLV_PCSK_SKI1_1	453	457	PF00082	0.637
CLV_PCSK_SKI1_1	473	477	PF00082	0.726
CLV_PCSK_SKI1_1	488	492	PF00082	0.481
CLV_PCSK_SKI1_1	589	593	PF00082	0.670
CLV_Separin_Metazoa	682	686	PF03568	0.714
DEG_APCC_DBOX_1	549	557	PF00400	0.524
DEG_APCC_DBOX_1	827	835	PF00400	0.767
DEG_Kelch_Keap1_1	344	349	PF01344	0.576
DEG_Nend_Nbox_1	1	3	PF02207	0.653
DOC_CYCLIN_RxL_1	584	597	PF00134	0.685
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.737
DOC_MAPK_gen_1	886	896	PF00069	0.732
DOC_MAPK_HePTP_8	299	311	PF00069	0.674
DOC_MAPK_MEF2A_6	302	311	PF00069	0.680
DOC_PP1_RVXF_1	890	897	PF00149	0.738
DOC_PP2B_LxvP_1	510	513	PF13499	0.741
DOC_PP2B_LxvP_1	574	577	PF13499	0.536
DOC_PP4_FxxP_1	117	120	PF00568	0.482
DOC_PP4_FxxP_1	769	772	PF00568	0.728
DOC_PP4_FxxP_1	784	787	PF00568	0.723
DOC_PP4_FxxP_1	916	919	PF00568	0.692
DOC_USP7_MATH_1	109	113	PF00917	0.790
DOC_USP7_MATH_1	212	216	PF00917	0.603
DOC_USP7_MATH_1	250	254	PF00917	0.599
DOC_USP7_MATH_1	33	37	PF00917	0.700
DOC_USP7_MATH_1	455	459	PF00917	0.720
DOC_USP7_MATH_1	505	509	PF00917	0.620
DOC_USP7_MATH_1	760	764	PF00917	0.685
DOC_USP7_MATH_1	775	779	PF00917	0.700
DOC_USP7_MATH_1	791	795	PF00917	0.678
DOC_USP7_MATH_1	849	853	PF00917	0.755
DOC_USP7_MATH_1	869	873	PF00917	0.474
DOC_USP7_MATH_1	906	910	PF00917	0.661
DOC_USP7_UBL2_3	201	205	PF12436	0.581
DOC_WW_Pin1_4	116	121	PF00397	0.590
DOC_WW_Pin1_4	222	227	PF00397	0.476
DOC_WW_Pin1_4	34	39	PF00397	0.593
DOC_WW_Pin1_4	466	471	PF00397	0.609
DOC_WW_Pin1_4	494	499	PF00397	0.583
DOC_WW_Pin1_4	516	521	PF00397	0.690
DOC_WW_Pin1_4	524	529	PF00397	0.698
DOC_WW_Pin1_4	554	559	PF00397	0.737
DOC_WW_Pin1_4	705	710	PF00397	0.781
DOC_WW_Pin1_4	721	726	PF00397	0.680
DOC_WW_Pin1_4	799	804	PF00397	0.511
DOC_WW_Pin1_4	82	87	PF00397	0.639
DOC_WW_Pin1_4	833	838	PF00397	0.774
DOC_WW_Pin1_4	855	860	PF00397	0.766
DOC_WW_Pin1_4	867	872	PF00397	0.661
DOC_WW_Pin1_4	99	104	PF00397	0.580
LIG_14-3-3_CanoR_1	284	291	PF00244	0.583
LIG_14-3-3_CanoR_1	319	328	PF00244	0.649
LIG_14-3-3_CanoR_1	410	419	PF00244	0.640
LIG_14-3-3_CanoR_1	453	463	PF00244	0.441
LIG_14-3-3_CanoR_1	489	498	PF00244	0.639
LIG_14-3-3_CanoR_1	50	54	PF00244	0.543
LIG_14-3-3_CanoR_1	549	554	PF00244	0.734
LIG_14-3-3_CanoR_1	589	594	PF00244	0.746
LIG_14-3-3_CanoR_1	634	641	PF00244	0.742
LIG_14-3-3_CanoR_1	703	708	PF00244	0.670
LIG_14-3-3_CanoR_1	718	726	PF00244	0.607
LIG_14-3-3_CanoR_1	74	78	PF00244	0.654
LIG_14-3-3_CanoR_1	761	770	PF00244	0.561
LIG_14-3-3_CanoR_1	862	871	PF00244	0.663
LIG_14-3-3_CanoR_1	889	895	PF00244	0.724
LIG_14-3-3_CanoR_1	911	917	PF00244	0.712
LIG_APCC_ABBAyCdc20_2	395	401	PF00400	0.655
LIG_APCC_Cbox_1	246	252	PF00515	0.450
LIG_APCC_Cbox_2	246	252	PF00515	0.450
LIG_BIR_III_4	305	309	PF00653	0.476
LIG_BIR_III_4	561	565	PF00653	0.528
LIG_BIR_III_4	818	822	PF00653	0.509
LIG_BRCT_BRCA1_1	75	79	PF00533	0.719
LIG_BRCT_BRCA1_1	892	896	PF00533	0.739
LIG_eIF4E_1	826	832	PF01652	0.765
LIG_FHA_1	165	171	PF00498	0.679
LIG_FHA_1	223	229	PF00498	0.573
LIG_FHA_1	291	297	PF00498	0.581
LIG_FHA_1	424	430	PF00498	0.701
LIG_FHA_1	470	476	PF00498	0.601
LIG_FHA_1	538	544	PF00498	0.798
LIG_FHA_1	588	594	PF00498	0.563
LIG_FHA_1	684	690	PF00498	0.680
LIG_FHA_1	7	13	PF00498	0.815
LIG_FHA_1	799	805	PF00498	0.794
LIG_FHA_2	50	56	PF00498	0.362
LIG_FHA_2	633	639	PF00498	0.610
LIG_FHA_2	741	747	PF00498	0.639
LIG_FHA_2	87	93	PF00498	0.789
LIG_FHA_2	9	15	PF00498	0.719
LIG_HCF-1_HBM_1	597	600	PF13415	0.553
LIG_Integrin_isoDGR_2	421	423	PF01839	0.530
LIG_Integrin_RGD_1	816	818	PF01839	0.624
LIG_IRF3_LxIS_1	307	312	PF10401	0.696
LIG_LIR_Apic_2	116	120	PF02991	0.484
LIG_LIR_Apic_2	915	919	PF02991	0.770
LIG_LIR_Gen_1	830	840	PF02991	0.704
LIG_LIR_Nem_3	366	370	PF02991	0.486
LIG_LIR_Nem_3	830	835	PF02991	0.703
LIG_MYND_1	466	470	PF01753	0.601
LIG_NRBOX	295	301	PF00104	0.643
LIG_Pex14_2	388	392	PF04695	0.550
LIG_RPA_C_Fungi	441	453	PF08784	0.627
LIG_SH2_CRK	367	371	PF00017	0.473
LIG_SH2_CRK	826	830	PF00017	0.763
LIG_SH2_GRB2like	439	442	PF00017	0.424
LIG_SH2_NCK_1	258	262	PF00017	0.360
LIG_SH2_NCK_1	511	515	PF00017	0.733
LIG_SH2_NCK_1	826	830	PF00017	0.686
LIG_SH2_SRC	258	261	PF00017	0.361
LIG_SH2_SRC	399	402	PF00017	0.647
LIG_SH2_SRC	511	514	PF00017	0.738
LIG_SH2_SRC	774	777	PF00017	0.508
LIG_SH2_STAP1	171	175	PF00017	0.706
LIG_SH2_STAP1	258	262	PF00017	0.360
LIG_SH2_STAP1	326	330	PF00017	0.625
LIG_SH2_STAT3	474	477	PF00017	0.603
LIG_SH2_STAT3	600	603	PF00017	0.550
LIG_SH2_STAT5	10	13	PF00017	0.629
LIG_SH2_STAT5	474	477	PF00017	0.585
LIG_SH3_1	460	466	PF00018	0.606
LIG_SH3_3	301	307	PF00018	0.667
LIG_SH3_3	32	38	PF00018	0.462
LIG_SH3_3	357	363	PF00018	0.742
LIG_SH3_3	460	466	PF00018	0.629
LIG_SH3_3	684	690	PF00018	0.759
LIG_SH3_3	72	78	PF00018	0.640
LIG_SH3_3	764	770	PF00018	0.717
LIG_SH3_3	797	803	PF00018	0.592
LIG_SUMO_SIM_par_1	589	594	PF11976	0.672
LIG_SUMO_SIM_par_1	805	812	PF11976	0.517
LIG_TRAF2_1	182	185	PF00917	0.499
LIG_TRAF2_1	413	416	PF00917	0.644
LIG_TRAF2_1	622	625	PF00917	0.620
LIG_WRC_WIRS_1	114	119	PF05994	0.486
MOD_CDC14_SPxK_1	102	105	PF00782	0.611
MOD_CDK_SPK_2	554	559	PF00069	0.737
MOD_CDK_SPxK_1	494	500	PF00069	0.525
MOD_CDK_SPxK_1	705	711	PF00069	0.698
MOD_CDK_SPxK_1	99	105	PF00069	0.616
MOD_CDK_SPxxK_3	222	229	PF00069	0.475
MOD_CDK_SPxxK_3	466	473	PF00069	0.710
MOD_CDK_SPxxK_3	855	862	PF00069	0.737
MOD_CK1_1	116	122	PF00069	0.755
MOD_CK1_1	274	280	PF00069	0.616
MOD_CK1_1	312	318	PF00069	0.693
MOD_CK1_1	344	350	PF00069	0.716
MOD_CK1_1	469	475	PF00069	0.652
MOD_CK1_1	494	500	PF00069	0.726
MOD_CK1_1	5	11	PF00069	0.677
MOD_CK1_1	552	558	PF00069	0.752
MOD_CK1_1	697	703	PF00069	0.699
MOD_CK1_1	830	836	PF00069	0.699
MOD_CK2_1	26	32	PF00069	0.775
MOD_CK2_1	289	295	PF00069	0.620
MOD_CK2_1	455	461	PF00069	0.678
MOD_CK2_1	49	55	PF00069	0.366
MOD_CK2_1	721	727	PF00069	0.727
MOD_CK2_1	740	746	PF00069	0.704
MOD_CK2_1	8	14	PF00069	0.742
MOD_CK2_1	892	898	PF00069	0.810
MOD_GlcNHglycan	111	114	PF01048	0.792
MOD_GlcNHglycan	273	276	PF01048	0.623
MOD_GlcNHglycan	286	289	PF01048	0.622
MOD_GlcNHglycan	314	317	PF01048	0.761
MOD_GlcNHglycan	346	349	PF01048	0.666
MOD_GlcNHglycan	457	460	PF01048	0.694
MOD_GlcNHglycan	493	496	PF01048	0.722
MOD_GlcNHglycan	663	666	PF01048	0.612
MOD_GlcNHglycan	840	843	PF01048	0.727
MOD_GlcNHglycan	846	849	PF01048	0.766
MOD_GlcNHglycan	851	854	PF01048	0.789
MOD_GlcNHglycan	86	89	PF01048	0.582
MOD_GlcNHglycan	871	874	PF01048	0.621
MOD_GlcNHglycan	883	886	PF01048	0.815
MOD_GlcNHglycan	925	928	PF01048	0.703
MOD_GSK3_1	109	116	PF00069	0.758
MOD_GSK3_1	2	9	PF00069	0.797
MOD_GSK3_1	212	219	PF00069	0.674
MOD_GSK3_1	307	314	PF00069	0.705
MOD_GSK3_1	368	375	PF00069	0.612
MOD_GSK3_1	522	529	PF00069	0.760
MOD_GSK3_1	649	656	PF00069	0.529
MOD_GSK3_1	694	701	PF00069	0.703
MOD_GSK3_1	80	87	PF00069	0.670
MOD_GSK3_1	863	870	PF00069	0.749
MOD_LATS_1	524	530	PF00433	0.761
MOD_LATS_1	587	593	PF00433	0.696
MOD_LATS_1	692	698	PF00433	0.502
MOD_LATS_1	888	894	PF00433	0.614
MOD_N-GLC_1	164	169	PF02516	0.736
MOD_N-GLC_1	300	305	PF02516	0.698
MOD_N-GLC_1	342	347	PF02516	0.688
MOD_N-GLC_1	537	542	PF02516	0.672
MOD_N-GLC_1	697	702	PF02516	0.638
MOD_N-GLC_1	890	895	PF02516	0.810
MOD_NEK2_1	309	314	PF00069	0.697
MOD_NEK2_1	328	333	PF00069	0.499
MOD_NEK2_1	409	414	PF00069	0.684
MOD_NEK2_1	683	688	PF00069	0.715
MOD_NEK2_1	73	78	PF00069	0.633
MOD_NEK2_1	874	879	PF00069	0.777
MOD_NEK2_1	881	886	PF00069	0.717
MOD_PIKK_1	213	219	PF00454	0.678
MOD_PIKK_1	26	32	PF00454	0.825
MOD_PIKK_1	411	417	PF00454	0.509
MOD_PIKK_1	489	495	PF00454	0.717
MOD_PIKK_1	526	532	PF00454	0.787
MOD_PIKK_1	761	767	PF00454	0.782
MOD_PK_1	890	896	PF00069	0.733
MOD_PKA_1	319	325	PF00069	0.595
MOD_PKA_1	488	494	PF00069	0.705
MOD_PKA_1	549	555	PF00069	0.798
MOD_PKA_2	319	325	PF00069	0.654
MOD_PKA_2	409	415	PF00069	0.619
MOD_PKA_2	488	494	PF00069	0.705
MOD_PKA_2	49	55	PF00069	0.546
MOD_PKA_2	549	555	PF00069	0.633
MOD_PKA_2	702	708	PF00069	0.686
MOD_PKA_2	719	725	PF00069	0.534
MOD_PKA_2	73	79	PF00069	0.670
MOD_PKA_2	760	766	PF00069	0.488
MOD_PKA_2	827	833	PF00069	0.763
MOD_PKA_2	879	885	PF00069	0.746
MOD_PKB_1	547	555	PF00069	0.732
MOD_PKB_1	632	640	PF00069	0.728
MOD_PKB_1	718	726	PF00069	0.624
MOD_PKB_1	890	898	PF00069	0.732
MOD_Plk_1	289	295	PF00069	0.560
MOD_Plk_1	300	306	PF00069	0.693
MOD_Plk_1	5	11	PF00069	0.805
MOD_Plk_1	627	633	PF00069	0.704
MOD_Plk_1	890	896	PF00069	0.782
MOD_Plk_2-3	290	296	PF00069	0.519
MOD_Plk_2-3	49	55	PF00069	0.366
MOD_Plk_4	216	222	PF00069	0.712
MOD_Plk_4	827	833	PF00069	0.691
MOD_Plk_4	892	898	PF00069	0.713
MOD_ProDKin_1	116	122	PF00069	0.588
MOD_ProDKin_1	222	228	PF00069	0.480
MOD_ProDKin_1	34	40	PF00069	0.584
MOD_ProDKin_1	466	472	PF00069	0.607
MOD_ProDKin_1	494	500	PF00069	0.586
MOD_ProDKin_1	516	522	PF00069	0.693
MOD_ProDKin_1	524	530	PF00069	0.696
MOD_ProDKin_1	554	560	PF00069	0.738
MOD_ProDKin_1	705	711	PF00069	0.782
MOD_ProDKin_1	721	727	PF00069	0.680
MOD_ProDKin_1	799	805	PF00069	0.502
MOD_ProDKin_1	82	88	PF00069	0.640
MOD_ProDKin_1	833	839	PF00069	0.774
MOD_ProDKin_1	855	861	PF00069	0.768
MOD_ProDKin_1	867	873	PF00069	0.659
MOD_ProDKin_1	99	105	PF00069	0.581
MOD_SUMO_for_1	402	405	PF00179	0.574
MOD_SUMO_rev_2	197	207	PF00179	0.524
MOD_SUMO_rev_2	361	366	PF00179	0.500
MOD_SUMO_rev_2	616	623	PF00179	0.620
TRG_DiLeu_BaEn_1	295	300	PF01217	0.640
TRG_DiLeu_BaEn_1	679	684	PF01217	0.699
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.524
TRG_ENDOCYTIC_2	190	193	PF00928	0.651
TRG_ENDOCYTIC_2	367	370	PF00928	0.485
TRG_ENDOCYTIC_2	399	402	PF00928	0.522
TRG_ENDOCYTIC_2	42	45	PF00928	0.636
TRG_ER_diArg_1	139	142	PF00400	0.613
TRG_ER_diArg_1	148	150	PF00400	0.616
TRG_ER_diArg_1	234	236	PF00400	0.521
TRG_ER_diArg_1	319	321	PF00400	0.598
TRG_ER_diArg_1	334	337	PF00400	0.573
TRG_ER_diArg_1	393	395	PF00400	0.599
TRG_ER_diArg_1	451	453	PF00400	0.720
TRG_ER_diArg_1	547	550	PF00400	0.724
TRG_ER_diArg_1	631	634	PF00400	0.691
TRG_ER_diArg_1	716	718	PF00400	0.726
TRG_ER_diArg_1	757	759	PF00400	0.547
TRG_ER_diArg_1	878	881	PF00400	0.697
TRG_ER_diArg_1	887	890	PF00400	0.790
TRG_NLS_MonoExtC_3	885	890	PF00514	0.728
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	589	594	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	747	751	PF00026	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T1	Leptomonas seymouri	42%	97%
A0A3S7XBQ9	Leishmania donovani	85%	100%
A4HPZ6	Leishmania braziliensis	68%	99%
A4IDQ7	Leishmania infantum	85%	100%
D0A4F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q0T4	Leishmania major	83%	100%