PKS_AT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania mexicana

UniProt:

E9ATR2_LEIMU

TriTrypDb:

LmxM.36.4780

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9ATR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.184
CLV_C14_Caspase3-7	79	83	PF00656	0.475
CLV_NRD_NRD_1	147	149	PF00675	0.362
CLV_NRD_NRD_1	25	27	PF00675	0.281
CLV_NRD_NRD_1	264	266	PF00675	0.384
CLV_NRD_NRD_1	288	290	PF00675	0.503
CLV_PCSK_KEX2_1	146	148	PF00082	0.432
CLV_PCSK_KEX2_1	159	161	PF00082	0.449
CLV_PCSK_KEX2_1	25	27	PF00082	0.281
CLV_PCSK_KEX2_1	264	266	PF00082	0.386
CLV_PCSK_KEX2_1	288	290	PF00082	0.450
CLV_PCSK_KEX2_1	313	315	PF00082	0.540
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.439
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.437
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.567
CLV_PCSK_PC7_1	284	290	PF00082	0.391
CLV_PCSK_SKI1_1	124	128	PF00082	0.348
CLV_PCSK_SKI1_1	182	186	PF00082	0.455
CLV_PCSK_SKI1_1	209	213	PF00082	0.461
CLV_PCSK_SKI1_1	26	30	PF00082	0.344
CLV_PCSK_SKI1_1	264	268	PF00082	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.569
DOC_CKS1_1	39	44	PF01111	0.449
DOC_MAPK_DCC_7	209	218	PF00069	0.415
DOC_MAPK_gen_1	179	188	PF00069	0.449
DOC_MAPK_gen_1	238	246	PF00069	0.498
DOC_MAPK_gen_1	25	31	PF00069	0.275
DOC_MAPK_MEF2A_6	209	218	PF00069	0.415
DOC_USP7_MATH_1	134	138	PF00917	0.432
DOC_USP7_MATH_1	30	34	PF00917	0.398
DOC_WW_Pin1_4	130	135	PF00397	0.395
DOC_WW_Pin1_4	173	178	PF00397	0.328
DOC_WW_Pin1_4	38	43	PF00397	0.449
LIG_14-3-3_CanoR_1	182	187	PF00244	0.420
LIG_14-3-3_CanoR_1	209	214	PF00244	0.461
LIG_BIR_III_2	231	235	PF00653	0.505
LIG_BIR_III_2	302	306	PF00653	0.420
LIG_BIR_III_4	242	246	PF00653	0.580
LIG_BRCT_BRCA1_1	136	140	PF00533	0.413
LIG_Clathr_ClatBox_1	139	143	PF01394	0.300
LIG_FHA_1	121	127	PF00498	0.365
LIG_FHA_1	183	189	PF00498	0.449
LIG_FHA_1	213	219	PF00498	0.451
LIG_FHA_1	246	252	PF00498	0.535
LIG_FHA_1	39	45	PF00498	0.452
LIG_FHA_2	185	191	PF00498	0.344
LIG_FHA_2	226	232	PF00498	0.195
LIG_FHA_2	256	262	PF00498	0.444
LIG_FHA_2	275	281	PF00498	0.532
LIG_Integrin_RGD_1	160	162	PF01839	0.449
LIG_LIR_Nem_3	190	196	PF02991	0.484
LIG_PCNA_PIPBox_1	275	284	PF02747	0.274
LIG_PDZ_Class_2	312	317	PF00595	0.734
LIG_RPA_C_Fungi	143	155	PF08784	0.184
LIG_SH2_STAP1	171	175	PF00017	0.475
LIG_SH2_STAP1	225	229	PF00017	0.475
LIG_SH2_STAT3	43	46	PF00017	0.383
LIG_SH2_STAT5	225	228	PF00017	0.475
LIG_SH2_STAT5	43	46	PF00017	0.363
LIG_SH3_3	208	214	PF00018	0.385
LIG_SH3_3	3	9	PF00018	0.495
LIG_SUMO_SIM_par_1	184	190	PF11976	0.449
LIG_SUMO_SIM_par_1	27	33	PF11976	0.449
LIG_TRAF2_1	187	190	PF00917	0.328
MOD_CDK_SPK_2	130	135	PF00069	0.342
MOD_CDK_SPxK_1	173	179	PF00069	0.328
MOD_CK1_1	133	139	PF00069	0.241
MOD_CK1_1	200	206	PF00069	0.452
MOD_CK1_1	220	226	PF00069	0.390
MOD_CK1_1	70	76	PF00069	0.398
MOD_CK2_1	184	190	PF00069	0.328
MOD_CK2_1	256	262	PF00069	0.441
MOD_CK2_1	30	36	PF00069	0.475
MOD_GlcNHglycan	101	104	PF01048	0.435
MOD_GlcNHglycan	69	72	PF01048	0.409
MOD_GSK3_1	130	137	PF00069	0.407
MOD_GSK3_1	138	145	PF00069	0.337
MOD_GSK3_1	178	185	PF00069	0.398
MOD_GSK3_1	200	207	PF00069	0.388
MOD_GSK3_1	217	224	PF00069	0.475
MOD_GSK3_1	251	258	PF00069	0.531
MOD_N-GLC_1	182	187	PF02516	0.475
MOD_NEK2_1	13	18	PF00069	0.508
MOD_NEK2_1	62	67	PF00069	0.449
MOD_NEK2_1	99	104	PF00069	0.329
MOD_NEK2_2	204	209	PF00069	0.460
MOD_PIKK_1	287	293	PF00454	0.321
MOD_PIKK_1	30	36	PF00454	0.449
MOD_PK_1	138	144	PF00069	0.398
MOD_PKA_2	178	184	PF00069	0.437
MOD_PKA_2	287	293	PF00069	0.460
MOD_Plk_1	162	168	PF00069	0.408
MOD_Plk_1	182	188	PF00069	0.180
MOD_Plk_1	221	227	PF00069	0.417
MOD_Plk_4	14	20	PF00069	0.473
MOD_Plk_4	212	218	PF00069	0.441
MOD_Plk_4	251	257	PF00069	0.445
MOD_Plk_4	294	300	PF00069	0.605
MOD_ProDKin_1	130	136	PF00069	0.395
MOD_ProDKin_1	173	179	PF00069	0.328
MOD_ProDKin_1	38	44	PF00069	0.449
MOD_SUMO_for_1	51	54	PF00179	0.398
TRG_ER_diArg_1	147	149	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFN3	Leptomonas seymouri	55%	100%
A0A0S4KFB4	Bodo saltans	39%	100%
A0A1X0P0E6	Trypanosomatidae	39%	97%
A0A3Q8IHR7	Leishmania donovani	87%	100%
A0A3R7MXS0	Trypanosoma rangeli	34%	98%
A4HPZ5	Leishmania braziliensis	73%	100%
A4IDQ6	Leishmania infantum	87%	100%
D0A4E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
Q4Q0T5	Leishmania major	89%	100%
V5BUR3	Trypanosoma cruzi	35%	98%