Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9ATR0_LEIMU

TriTrypDb:

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.421
CLV_NRD_NRD_1	204	206	PF00675	0.703
CLV_NRD_NRD_1	277	279	PF00675	0.383
CLV_NRD_NRD_1	288	290	PF00675	0.356
CLV_NRD_NRD_1	37	39	PF00675	0.401
CLV_NRD_NRD_1	597	599	PF00675	0.362
CLV_NRD_NRD_1	630	632	PF00675	0.730
CLV_NRD_NRD_1	634	636	PF00675	0.491
CLV_PCSK_FUR_1	631	635	PF00082	0.705
CLV_PCSK_KEX2_1	204	206	PF00082	0.621
CLV_PCSK_KEX2_1	277	279	PF00082	0.383
CLV_PCSK_KEX2_1	287	289	PF00082	0.377
CLV_PCSK_KEX2_1	37	39	PF00082	0.401
CLV_PCSK_KEX2_1	571	573	PF00082	0.472
CLV_PCSK_KEX2_1	597	599	PF00082	0.493
CLV_PCSK_KEX2_1	633	635	PF00082	0.570
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.368
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.376
CLV_PCSK_PC1ET2_1	633	635	PF00082	0.700
CLV_PCSK_SKI1_1	114	118	PF00082	0.472
CLV_PCSK_SKI1_1	26	30	PF00082	0.685
CLV_PCSK_SKI1_1	368	372	PF00082	0.318
CLV_PCSK_SKI1_1	403	407	PF00082	0.387
CLV_PCSK_SKI1_1	597	601	PF00082	0.368
CLV_PCSK_SKI1_1	608	612	PF00082	0.384
CLV_Separin_Metazoa	558	562	PF03568	0.494
DEG_APCC_DBOX_1	113	121	PF00400	0.301
DEG_APCC_DBOX_1	287	295	PF00400	0.441
DEG_APCC_DBOX_1	303	311	PF00400	0.531
DEG_APCC_DBOX_1	367	375	PF00400	0.435
DEG_APCC_DBOX_1	596	604	PF00400	0.362
DEG_APCC_DBOX_1	607	615	PF00400	0.375
DEG_APCC_DBOX_1	65	73	PF00400	0.560
DEG_Nend_Nbox_1	1	3	PF02207	0.418
DOC_CYCLIN_RxL_1	111	118	PF00134	0.482
DOC_CYCLIN_yClb5_NLxxxL_5	252	261	PF00134	0.233
DOC_CYCLIN_yCln2_LP_2	346	352	PF00134	0.454
DOC_MAPK_DCC_7	376	385	PF00069	0.243
DOC_MAPK_gen_1	287	296	PF00069	0.467
DOC_MAPK_gen_1	597	605	PF00069	0.342
DOC_MAPK_MEF2A_6	597	605	PF00069	0.441
DOC_PP1_RVXF_1	477	484	PF00149	0.444
DOC_PP2B_LxvP_1	346	349	PF13499	0.397
DOC_USP7_MATH_1	181	185	PF00917	0.636
DOC_USP7_MATH_1	19	23	PF00917	0.424
DOC_USP7_MATH_1	210	214	PF00917	0.685
DOC_USP7_MATH_1	226	230	PF00917	0.341
DOC_USP7_MATH_1	32	36	PF00917	0.378
DOC_USP7_MATH_1	411	415	PF00917	0.297
DOC_USP7_MATH_1	499	503	PF00917	0.460
DOC_USP7_MATH_1	599	603	PF00917	0.305
DOC_USP7_MATH_1	87	91	PF00917	0.489
DOC_USP7_UBL2_3	259	263	PF12436	0.468
DOC_WW_Pin1_4	107	112	PF00397	0.437
DOC_WW_Pin1_4	15	20	PF00397	0.525
DOC_WW_Pin1_4	198	203	PF00397	0.619
DOC_WW_Pin1_4	247	252	PF00397	0.515
LIG_14-3-3_CanoR_1	123	128	PF00244	0.566
LIG_14-3-3_CanoR_1	182	188	PF00244	0.709
LIG_14-3-3_CanoR_1	37	43	PF00244	0.567
LIG_14-3-3_CanoR_1	430	438	PF00244	0.480
LIG_14-3-3_CanoR_1	475	479	PF00244	0.456
LIG_14-3-3_CanoR_1	598	604	PF00244	0.289
LIG_Actin_WH2_2	65	82	PF00022	0.451
LIG_APCC_ABBA_1	529	534	PF00400	0.412
LIG_CtBP_PxDLS_1	454	458	PF00389	0.433
LIG_deltaCOP1_diTrp_1	391	396	PF00928	0.480
LIG_eIF4E_1	269	275	PF01652	0.375
LIG_eIF4E_1	366	372	PF01652	0.302
LIG_eIF4E_1	73	79	PF01652	0.405
LIG_FHA_1	230	236	PF00498	0.473
LIG_FHA_1	252	258	PF00498	0.472
LIG_FHA_1	382	388	PF00498	0.465
LIG_FHA_1	435	441	PF00498	0.451
LIG_FHA_1	496	502	PF00498	0.540
LIG_FHA_1	514	520	PF00498	0.310
LIG_FHA_1	83	89	PF00498	0.511
LIG_FHA_1	90	96	PF00498	0.539
LIG_FHA_2	152	158	PF00498	0.456
LIG_FHA_2	219	225	PF00498	0.400
LIG_FHA_2	238	244	PF00498	0.445
LIG_FHA_2	265	271	PF00498	0.525
LIG_FHA_2	320	326	PF00498	0.466
LIG_FHA_2	397	403	PF00498	0.475
LIG_FHA_2	44	50	PF00498	0.536
LIG_LIR_Apic_2	9	13	PF02991	0.427
LIG_LIR_Gen_1	100	109	PF02991	0.447
LIG_LIR_Gen_1	520	531	PF02991	0.387
LIG_LIR_Gen_1	552	560	PF02991	0.434
LIG_LIR_Nem_3	100	105	PF02991	0.519
LIG_LIR_Nem_3	157	162	PF02991	0.498
LIG_LIR_Nem_3	172	177	PF02991	0.545
LIG_LIR_Nem_3	520	526	PF02991	0.321
LIG_LIR_Nem_3	533	539	PF02991	0.320
LIG_LIR_Nem_3	552	556	PF02991	0.352
LIG_NRBOX	52	58	PF00104	0.618
LIG_NRBOX	74	80	PF00104	0.522
LIG_OCRL_FandH_1	294	306	PF00620	0.413
LIG_PCNA_yPIPBox_3	386	397	PF02747	0.464
LIG_PDZ_Class_3	640	645	PF00595	0.632
LIG_SH2_CRK	10	14	PF00017	0.431
LIG_SH2_CRK	102	106	PF00017	0.550
LIG_SH2_CRK	174	178	PF00017	0.610
LIG_SH2_CRK	377	381	PF00017	0.353
LIG_SH2_GRB2like	266	269	PF00017	0.502
LIG_SH2_NCK_1	377	381	PF00017	0.292
LIG_SH2_SRC	269	272	PF00017	0.389
LIG_SH2_STAP1	269	273	PF00017	0.440
LIG_SH2_STAP1	505	509	PF00017	0.472
LIG_SH2_STAP1	532	536	PF00017	0.430
LIG_SH2_STAT5	10	13	PF00017	0.433
LIG_SH2_STAT5	158	161	PF00017	0.443
LIG_SH2_STAT5	266	269	PF00017	0.423
LIG_SH2_STAT5	532	535	PF00017	0.406
LIG_SH3_1	10	16	PF00018	0.430
LIG_SH3_1	356	362	PF00018	0.436
LIG_SH3_3	10	16	PF00018	0.430
LIG_SH3_3	356	362	PF00018	0.436
LIG_SH3_3	376	382	PF00018	0.473
LIG_SH3_3	506	512	PF00018	0.286
LIG_SUMO_SIM_anti_2	305	312	PF11976	0.431
LIG_SUMO_SIM_par_1	84	90	PF11976	0.416
LIG_TRAF2_1	555	558	PF00917	0.424
LIG_UBA3_1	162	167	PF00899	0.439
LIG_UBA3_1	257	263	PF00899	0.461
LIG_WRC_WIRS_1	550	555	PF05994	0.377
MOD_CDC14_SPxK_1	201	204	PF00782	0.617
MOD_CDK_SPxK_1	198	204	PF00069	0.620
MOD_CDK_SPxxK_3	107	114	PF00069	0.452
MOD_CDK_SPxxK_3	198	205	PF00069	0.490
MOD_CK1_1	126	132	PF00069	0.620
MOD_CK1_1	229	235	PF00069	0.571
MOD_CK1_1	340	346	PF00069	0.490
MOD_CK1_1	513	519	PF00069	0.479
MOD_CK1_1	82	88	PF00069	0.479
MOD_CK1_1	89	95	PF00069	0.652
MOD_CK1_1	97	103	PF00069	0.548
MOD_CK2_1	130	136	PF00069	0.575
MOD_CK2_1	151	157	PF00069	0.479
MOD_CK2_1	227	233	PF00069	0.580
MOD_CK2_1	237	243	PF00069	0.592
MOD_CK2_1	247	253	PF00069	0.338
MOD_CK2_1	264	270	PF00069	0.515
MOD_CK2_1	396	402	PF00069	0.468
MOD_CK2_1	416	422	PF00069	0.599
MOD_CK2_1	43	49	PF00069	0.538
MOD_CK2_1	87	93	PF00069	0.540
MOD_Cter_Amidation	202	205	PF01082	0.493
MOD_GlcNHglycan	132	135	PF01048	0.728
MOD_GlcNHglycan	144	147	PF01048	0.607
MOD_GlcNHglycan	216	221	PF01048	0.636
MOD_GlcNHglycan	281	285	PF01048	0.435
MOD_GlcNHglycan	340	343	PF01048	0.403
MOD_GlcNHglycan	362	365	PF01048	0.479
MOD_GSK3_1	123	130	PF00069	0.596
MOD_GSK3_1	137	144	PF00069	0.659
MOD_GSK3_1	15	22	PF00069	0.439
MOD_GSK3_1	212	219	PF00069	0.761
MOD_GSK3_1	247	254	PF00069	0.503
MOD_GSK3_1	315	322	PF00069	0.561
MOD_GSK3_1	32	39	PF00069	0.466
MOD_GSK3_1	336	343	PF00069	0.518
MOD_GSK3_1	495	502	PF00069	0.409
MOD_GSK3_1	518	525	PF00069	0.427
MOD_GSK3_1	82	89	PF00069	0.453
MOD_LATS_1	395	401	PF00433	0.375
MOD_N-GLC_1	107	112	PF02516	0.633
MOD_N-GLC_1	264	269	PF02516	0.495
MOD_N-GLC_1	337	342	PF02516	0.530
MOD_N-GLC_1	82	87	PF02516	0.483
MOD_NEK2_1	112	117	PF00069	0.337
MOD_NEK2_1	127	132	PF00069	0.571
MOD_NEK2_1	227	232	PF00069	0.565
MOD_NEK2_1	257	262	PF00069	0.453
MOD_NEK2_1	264	269	PF00069	0.507
MOD_NEK2_1	36	41	PF00069	0.527
MOD_NEK2_1	370	375	PF00069	0.433
MOD_NEK2_1	416	421	PF00069	0.407
MOD_NEK2_1	43	48	PF00069	0.550
MOD_NEK2_1	455	460	PF00069	0.508
MOD_NEK2_1	487	492	PF00069	0.365
MOD_NEK2_1	567	572	PF00069	0.529
MOD_NEK2_1	57	62	PF00069	0.616
MOD_NEK2_1	6	11	PF00069	0.412
MOD_NEK2_1	621	626	PF00069	0.597
MOD_NEK2_1	86	91	PF00069	0.631
MOD_NEK2_1	94	99	PF00069	0.475
MOD_NEK2_2	32	37	PF00069	0.391
MOD_NEK2_2	474	479	PF00069	0.462
MOD_NEK2_2	505	510	PF00069	0.415
MOD_PIKK_1	19	25	PF00454	0.488
MOD_PIKK_1	340	346	PF00454	0.488
MOD_PIKK_1	542	548	PF00454	0.559
MOD_PIKK_1	621	627	PF00454	0.485
MOD_PKA_1	634	640	PF00069	0.504
MOD_PKA_2	181	187	PF00069	0.580
MOD_PKA_2	303	309	PF00069	0.495
MOD_PKA_2	36	42	PF00069	0.506
MOD_PKA_2	429	435	PF00069	0.472
MOD_PKA_2	474	480	PF00069	0.429
MOD_PKA_2	634	640	PF00069	0.619
MOD_Plk_1	190	196	PF00069	0.757
MOD_Plk_1	48	54	PF00069	0.553
MOD_Plk_1	82	88	PF00069	0.399
MOD_Plk_2-3	515	521	PF00069	0.473
MOD_Plk_4	303	309	PF00069	0.403
MOD_Plk_4	411	417	PF00069	0.424
MOD_Plk_4	448	454	PF00069	0.375
MOD_Plk_4	518	524	PF00069	0.418
MOD_ProDKin_1	107	113	PF00069	0.434
MOD_ProDKin_1	15	21	PF00069	0.524
MOD_ProDKin_1	198	204	PF00069	0.620
MOD_ProDKin_1	247	253	PF00069	0.509
TRG_DiLeu_BaEn_1	253	258	PF01217	0.332
TRG_DiLeu_BaEn_1	270	275	PF01217	0.378
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.496
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.619
TRG_ENDOCYTIC_2	102	105	PF00928	0.427
TRG_ENDOCYTIC_2	174	177	PF00928	0.619
TRG_ENDOCYTIC_2	377	380	PF00928	0.350
TRG_ENDOCYTIC_2	638	641	PF00928	0.636
TRG_ER_diArg_1	36	38	PF00400	0.402
TRG_NES_CRM1_1	517	530	PF08389	0.447
TRG_NES_CRM1_1	68	81	PF08389	0.545
TRG_NLS_Bipartite_1	619	637	PF00514	0.629
TRG_NLS_MonoCore_2	630	635	PF00514	0.700
TRG_NLS_MonoExtC_3	630	635	PF00514	0.511
TRG_NLS_MonoExtN_4	631	637	PF00514	0.701
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX5	Leptomonas seymouri	56%	100%
A0A1X0P0I1	Trypanosomatidae	35%	100%
A0A3Q8IKW8	Leishmania donovani	90%	100%
A0A3R7LEP3	Trypanosoma rangeli	36%	100%
A4HPZ3	Leishmania braziliensis	77%	96%
A4IDQ4	Leishmania infantum	90%	100%
D0A4E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q0T7	Leishmania major	87%	100%
V5B501	Trypanosoma cruzi	34%	100%