PIG-P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PIG-P, putative

Species:

Leishmania mexicana

UniProt:

E9ATQ9_LEIMU

TriTrypDb:

LmxM.36.4750

Length:

156

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ATQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	9
GO:0006505	GPI anchor metabolic process	6	9
GO:0006506	GPI anchor biosynthetic process	6	9
GO:0006629	lipid metabolic process	3	9
GO:0006643	membrane lipid metabolic process	4	9
GO:0006644	phospholipid metabolic process	4	9
GO:0006650	glycerophospholipid metabolic process	5	9
GO:0006661	phosphatidylinositol biosynthetic process	6	9
GO:0006664	glycolipid metabolic process	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0008610	lipid biosynthetic process	4	9
GO:0008654	phospholipid biosynthetic process	5	9
GO:0009058	biosynthetic process	2	9
GO:0009247	glycolipid biosynthetic process	5	9
GO:0009987	cellular process	1	9
GO:0019538	protein metabolic process	3	9
GO:0019637	organophosphate metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044255	cellular lipid metabolic process	3	9
GO:0045017	glycerolipid biosynthetic process	4	9
GO:0046467	membrane lipid biosynthetic process	4	9
GO:0046474	glycerophospholipid biosynthetic process	5	9
GO:0046486	glycerolipid metabolic process	4	9
GO:0046488	phosphatidylinositol metabolic process	6	9
GO:0071704	organic substance metabolic process	2	9
GO:0090407	organophosphate biosynthetic process	4	9
GO:1901135	carbohydrate derivative metabolic process	3	9
GO:1901137	carbohydrate derivative biosynthetic process	4	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901576	organic substance biosynthetic process	3	9
GO:1903509	liposaccharide metabolic process	4	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008194	UDP-glycosyltransferase activity	4	9
GO:0008375	acetylglucosaminyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016757	glycosyltransferase activity	3	9
GO:0016758	hexosyltransferase activity	4	9
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	6	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.467
CLV_NRD_NRD_1	139	141	PF00675	0.352
CLV_NRD_NRD_1	151	153	PF00675	0.387
CLV_PCSK_KEX2_1	139	141	PF00082	0.352
CLV_PCSK_KEX2_1	151	153	PF00082	0.387
CLV_PCSK_PC7_1	135	141	PF00082	0.308
CLV_PCSK_SKI1_1	86	90	PF00082	0.313
DEG_MDM2_SWIB_1	68	76	PF02201	0.418
DEG_SPOP_SBC_1	105	109	PF00917	0.501
DOC_PP2B_PxIxI_1	56	62	PF00149	0.349
DOC_USP7_MATH_1	105	109	PF00917	0.472
LIG_14-3-3_CanoR_1	135	141	PF00244	0.508
LIG_14-3-3_CanoR_1	41	47	PF00244	0.354
LIG_14-3-3_CanoR_1	86	95	PF00244	0.524
LIG_FHA_1	25	31	PF00498	0.390
LIG_FHA_1	68	74	PF00498	0.324
LIG_FHA_1	77	83	PF00498	0.424
LIG_FHA_2	87	93	PF00498	0.486
LIG_LIR_Gen_1	69	77	PF02991	0.308
LIG_LIR_Nem_3	49	54	PF02991	0.265
LIG_LIR_Nem_3	69	75	PF02991	0.328
LIG_Pex14_2	68	72	PF04695	0.360
LIG_SH2_STAT5	28	31	PF00017	0.319
LIG_SH2_STAT5	67	70	PF00017	0.311
LIG_SH3_3	112	118	PF00018	0.533
LIG_SH3_3	51	57	PF00018	0.284
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.418
LIG_SUMO_SIM_anti_2	69	79	PF11976	0.352
LIG_SUMO_SIM_par_1	116	123	PF11976	0.484
LIG_SUMO_SIM_par_1	18	25	PF11976	0.374
LIG_SUMO_SIM_par_1	69	79	PF11976	0.418
MOD_CK1_1	107	113	PF00069	0.477
MOD_CK1_1	120	126	PF00069	0.371
MOD_Cter_Amidation	149	152	PF01082	0.475
MOD_GlcNHglycan	136	139	PF01048	0.498
MOD_GSK3_1	76	83	PF00069	0.459
MOD_GSK3_1	86	93	PF00069	0.453
MOD_NEK2_1	104	109	PF00069	0.528
MOD_NEK2_1	15	20	PF00069	0.374
MOD_NEK2_1	42	47	PF00069	0.327
MOD_NEK2_1	68	73	PF00069	0.339
MOD_NEK2_1	76	81	PF00069	0.468
MOD_PIKK_1	2	8	PF00454	0.653
MOD_PKA_1	139	145	PF00069	0.521
MOD_PKA_2	134	140	PF00069	0.503
MOD_Plk_4	15	21	PF00069	0.346
MOD_Plk_4	42	48	PF00069	0.284
MOD_Plk_4	68	74	PF00069	0.324
MOD_SUMO_rev_2	90	95	PF00179	0.513
TRG_ENDOCYTIC_2	51	54	PF00928	0.275
TRG_ER_diArg_1	139	141	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P0	Leptomonas seymouri	84%	100%
A0A0S4JL03	Bodo saltans	46%	100%
A0A1X0P0P7	Trypanosomatidae	52%	100%
A0A3Q8ILG4	Leishmania donovani	95%	100%
A0A3R7KSY5	Trypanosoma rangeli	51%	100%
A4HPZ2	Leishmania braziliensis	88%	74%
A4IDQ3	Leishmania infantum	95%	100%
D0A4E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
P57054	Homo sapiens	30%	99%
Q4Q0T8	Leishmania major	95%	100%
Q5R946	Pongo abelii	29%	100%
Q9JHG1	Mus musculus	29%	100%