AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania mexicana

UniProt:

E9ATQ4_LEIMU

TriTrypDb:

LmxM.36.4690

Length:

983

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATQ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	337	341	PF00656	0.608
CLV_C14_Caspase3-7	575	579	PF00656	0.569
CLV_C14_Caspase3-7	761	765	PF00656	0.558
CLV_C14_Caspase3-7	94	98	PF00656	0.620
CLV_NRD_NRD_1	179	181	PF00675	0.487
CLV_NRD_NRD_1	317	319	PF00675	0.411
CLV_NRD_NRD_1	373	375	PF00675	0.496
CLV_NRD_NRD_1	384	386	PF00675	0.397
CLV_NRD_NRD_1	539	541	PF00675	0.662
CLV_NRD_NRD_1	557	559	PF00675	0.771
CLV_NRD_NRD_1	59	61	PF00675	0.497
CLV_NRD_NRD_1	732	734	PF00675	0.669
CLV_NRD_NRD_1	780	782	PF00675	0.684
CLV_NRD_NRD_1	867	869	PF00675	0.480
CLV_NRD_NRD_1	9	11	PF00675	0.284
CLV_PCSK_FUR_1	371	375	PF00082	0.525
CLV_PCSK_KEX2_1	179	181	PF00082	0.487
CLV_PCSK_KEX2_1	317	319	PF00082	0.515
CLV_PCSK_KEX2_1	361	363	PF00082	0.502
CLV_PCSK_KEX2_1	371	373	PF00082	0.497
CLV_PCSK_KEX2_1	539	541	PF00082	0.662
CLV_PCSK_KEX2_1	61	63	PF00082	0.496
CLV_PCSK_KEX2_1	731	733	PF00082	0.677
CLV_PCSK_KEX2_1	867	869	PF00082	0.480
CLV_PCSK_KEX2_1	919	921	PF00082	0.448
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.490
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.496
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.677
CLV_PCSK_PC1ET2_1	919	921	PF00082	0.448
CLV_PCSK_SKI1_1	207	211	PF00082	0.310
CLV_PCSK_SKI1_1	386	390	PF00082	0.347
CLV_PCSK_SKI1_1	459	463	PF00082	0.697
CLV_PCSK_SKI1_1	507	511	PF00082	0.662
CLV_PCSK_SKI1_1	732	736	PF00082	0.656
CLV_PCSK_SKI1_1	91	95	PF00082	0.585
CLV_PCSK_SKI1_1	920	924	PF00082	0.354
DEG_APCC_DBOX_1	384	392	PF00400	0.565
DEG_APCC_DBOX_1	806	814	PF00400	0.342
DEG_Nend_UBRbox_3	1	3	PF02207	0.582
DEG_SCF_FBW7_2	431	438	PF00400	0.465
DEG_SCF_TRCP1_1	764	769	PF00400	0.405
DEG_SPOP_SBC_1	477	481	PF00917	0.442
DOC_CDC14_PxL_1	508	516	PF14671	0.495
DOC_CKS1_1	355	360	PF01111	0.709
DOC_CKS1_1	432	437	PF01111	0.464
DOC_CKS1_1	870	875	PF01111	0.682
DOC_CKS1_1	977	982	PF01111	0.651
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	907	913	PF00134	0.596
DOC_MAPK_DCC_7	785	794	PF00069	0.400
DOC_MAPK_DCC_7	902	911	PF00069	0.523
DOC_MAPK_gen_1	10	17	PF00069	0.449
DOC_MAPK_gen_1	385	392	PF00069	0.513
DOC_MAPK_HePTP_8	899	911	PF00069	0.563
DOC_MAPK_MEF2A_6	385	392	PF00069	0.491
DOC_MAPK_MEF2A_6	459	466	PF00069	0.490
DOC_MAPK_MEF2A_6	902	911	PF00069	0.545
DOC_MAPK_NFAT4_5	459	467	PF00069	0.530
DOC_PIKK_1	51	59	PF02985	0.657
DOC_PP1_RVXF_1	917	924	PF00149	0.635
DOC_PP2B_LxvP_1	402	405	PF13499	0.457
DOC_PP2B_LxvP_1	462	465	PF13499	0.580
DOC_PP2B_LxvP_1	907	910	PF13499	0.605
DOC_USP7_MATH_1	102	106	PF00917	0.757
DOC_USP7_MATH_1	112	116	PF00917	0.727
DOC_USP7_MATH_1	169	173	PF00917	0.648
DOC_USP7_MATH_1	178	182	PF00917	0.730
DOC_USP7_MATH_1	276	280	PF00917	0.607
DOC_USP7_MATH_1	417	421	PF00917	0.456
DOC_USP7_MATH_1	477	481	PF00917	0.588
DOC_USP7_MATH_1	596	600	PF00917	0.563
DOC_USP7_MATH_1	748	752	PF00917	0.586
DOC_USP7_MATH_1	78	82	PF00917	0.764
DOC_USP7_MATH_1	799	803	PF00917	0.516
DOC_USP7_MATH_1	819	823	PF00917	0.284
DOC_USP7_MATH_1	842	846	PF00917	0.714
DOC_USP7_MATH_1	871	875	PF00917	0.683
DOC_USP7_MATH_1	877	881	PF00917	0.682
DOC_USP7_UBL2_3	959	963	PF12436	0.555
DOC_WW_Pin1_4	113	118	PF00397	0.764
DOC_WW_Pin1_4	165	170	PF00397	0.685
DOC_WW_Pin1_4	269	274	PF00397	0.716
DOC_WW_Pin1_4	354	359	PF00397	0.735
DOC_WW_Pin1_4	431	436	PF00397	0.469
DOC_WW_Pin1_4	473	478	PF00397	0.606
DOC_WW_Pin1_4	524	529	PF00397	0.455
DOC_WW_Pin1_4	795	800	PF00397	0.431
DOC_WW_Pin1_4	85	90	PF00397	0.724
DOC_WW_Pin1_4	869	874	PF00397	0.682
DOC_WW_Pin1_4	976	981	PF00397	0.585
LIG_14-3-3_CanoR_1	134	138	PF00244	0.637
LIG_14-3-3_CanoR_1	333	339	PF00244	0.704
LIG_14-3-3_CanoR_1	362	370	PF00244	0.710
LIG_14-3-3_CanoR_1	385	389	PF00244	0.405
LIG_14-3-3_CanoR_1	422	428	PF00244	0.558
LIG_14-3-3_CanoR_1	539	546	PF00244	0.486
LIG_14-3-3_CanoR_1	598	604	PF00244	0.513
LIG_14-3-3_CanoR_1	767	771	PF00244	0.499
LIG_14-3-3_CanoR_1	773	777	PF00244	0.492
LIG_14-3-3_CanoR_1	785	790	PF00244	0.485
LIG_14-3-3_CanoR_1	91	100	PF00244	0.788
LIG_Actin_WH2_2	803	818	PF00022	0.330
LIG_APCC_ABBA_1	510	515	PF00400	0.450
LIG_BIR_III_2	323	327	PF00653	0.586
LIG_BIR_III_2	97	101	PF00653	0.624
LIG_BRCT_BRCA1_1	752	756	PF00533	0.581
LIG_eIF4E_1	205	211	PF01652	0.528
LIG_FHA_1	204	210	PF00498	0.648
LIG_FHA_1	21	27	PF00498	0.535
LIG_FHA_1	385	391	PF00498	0.405
LIG_FHA_1	635	641	PF00498	0.564
LIG_FHA_1	784	790	PF00498	0.469
LIG_FHA_1	810	816	PF00498	0.453
LIG_FHA_1	870	876	PF00498	0.684
LIG_FHA_2	145	151	PF00498	0.549
LIG_FHA_2	153	159	PF00498	0.481
LIG_FHA_2	92	98	PF00498	0.640
LIG_FHA_2	977	983	PF00498	0.660
LIG_GBD_Chelix_1	965	973	PF00786	0.330
LIG_LIR_Apic_2	204	208	PF02991	0.568
LIG_LIR_Apic_2	900	906	PF02991	0.598
LIG_LIR_Gen_1	141	149	PF02991	0.554
LIG_LIR_Gen_1	387	397	PF02991	0.214
LIG_LIR_Gen_1	628	634	PF02991	0.464
LIG_LIR_Gen_1	802	813	PF02991	0.370
LIG_LIR_Nem_3	141	145	PF02991	0.560
LIG_LIR_Nem_3	214	218	PF02991	0.516
LIG_LIR_Nem_3	37	42	PF02991	0.533
LIG_LIR_Nem_3	387	392	PF02991	0.214
LIG_LIR_Nem_3	628	633	PF02991	0.607
LIG_LIR_Nem_3	655	660	PF02991	0.571
LIG_LIR_Nem_3	754	760	PF02991	0.481
LIG_LIR_Nem_3	802	808	PF02991	0.370
LIG_LIR_Nem_3	863	869	PF02991	0.727
LIG_LIR_Nem_3	926	931	PF02991	0.546
LIG_LYPXL_yS_3	163	166	PF13949	0.580
LIG_NRBOX	144	150	PF00104	0.632
LIG_PDZ_Class_2	978	983	PF00595	0.628
LIG_Pex14_2	121	125	PF04695	0.681
LIG_Pex14_2	133	137	PF04695	0.631
LIG_Pex14_2	16	20	PF04695	0.542
LIG_REV1ctd_RIR_1	228	237	PF16727	0.433
LIG_REV1ctd_RIR_1	953	964	PF16727	0.545
LIG_SH2_CRK	205	209	PF00017	0.644
LIG_SH2_CRK	39	43	PF00017	0.517
LIG_SH2_CRK	657	661	PF00017	0.626
LIG_SH2_CRK	736	740	PF00017	0.428
LIG_SH2_CRK	866	870	PF00017	0.733
LIG_SH2_CRK	935	939	PF00017	0.548
LIG_SH2_NCK_1	657	661	PF00017	0.581
LIG_SH2_SRC	657	660	PF00017	0.408
LIG_SH2_STAP1	221	225	PF00017	0.519
LIG_SH2_STAT3	427	430	PF00017	0.459
LIG_SH2_STAT3	931	934	PF00017	0.536
LIG_SH2_STAT5	205	208	PF00017	0.569
LIG_SH2_STAT5	242	245	PF00017	0.601
LIG_SH2_STAT5	513	516	PF00017	0.456
LIG_SH2_STAT5	805	808	PF00017	0.335
LIG_SH2_STAT5	903	906	PF00017	0.567
LIG_SH2_STAT5	931	934	PF00017	0.552
LIG_SH3_1	352	358	PF00018	0.698
LIG_SH3_1	867	873	PF00018	0.680
LIG_SH3_3	163	169	PF00018	0.744
LIG_SH3_3	352	358	PF00018	0.698
LIG_SH3_3	41	47	PF00018	0.607
LIG_SH3_3	429	435	PF00018	0.472
LIG_SH3_3	495	501	PF00018	0.521
LIG_SH3_3	653	659	PF00018	0.451
LIG_SH3_3	736	742	PF00018	0.459
LIG_SH3_3	867	873	PF00018	0.680
LIG_SH3_3	886	892	PF00018	0.672
LIG_SH3_3	902	908	PF00018	0.546
LIG_SH3_3	971	977	PF00018	0.575
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.630
LIG_SUMO_SIM_par_1	144	150	PF11976	0.630
LIG_SUMO_SIM_par_1	232	238	PF11976	0.508
LIG_SUMO_SIM_par_1	670	677	PF11976	0.498
LIG_SUMO_SIM_par_1	816	822	PF11976	0.389
LIG_TYR_ITIM	219	224	PF00017	0.366
LIG_TYR_ITIM	734	739	PF00017	0.527
LIG_TYR_ITSM	35	42	PF00017	0.363
LIG_UBA3_1	508	516	PF00899	0.683
LIG_UBA3_1	911	919	PF00899	0.370
LIG_WW_1	202	205	PF00397	0.541
MOD_CDC14_SPxK_1	88	91	PF00782	0.589
MOD_CDK_SPxK_1	85	91	PF00069	0.585
MOD_CDK_SPxxK_3	354	361	PF00069	0.611
MOD_CK1_1	106	112	PF00069	0.714
MOD_CK1_1	165	171	PF00069	0.571
MOD_CK1_1	353	359	PF00069	0.701
MOD_CK1_1	363	369	PF00069	0.602
MOD_CK1_1	476	482	PF00069	0.728
MOD_CK1_1	560	566	PF00069	0.681
MOD_CK1_1	576	582	PF00069	0.564
MOD_CK1_1	599	605	PF00069	0.680
MOD_CK1_1	632	638	PF00069	0.600
MOD_CK1_1	719	725	PF00069	0.632
MOD_CK1_1	751	757	PF00069	0.618
MOD_CK1_1	765	771	PF00069	0.785
MOD_CK1_1	772	778	PF00069	0.607
MOD_CK1_1	783	789	PF00069	0.568
MOD_CK1_1	85	91	PF00069	0.594
MOD_CK1_1	851	857	PF00069	0.612
MOD_CK2_1	144	150	PF00069	0.414
MOD_CK2_1	152	158	PF00069	0.269
MOD_CK2_1	291	297	PF00069	0.797
MOD_CK2_1	647	653	PF00069	0.782
MOD_CK2_1	678	684	PF00069	0.636
MOD_CK2_1	976	982	PF00069	0.555
MOD_CMANNOS	800	803	PF00535	0.531
MOD_Cter_Amidation	315	318	PF01082	0.501
MOD_Cter_Amidation	537	540	PF01082	0.599
MOD_GlcNHglycan	108	111	PF01048	0.641
MOD_GlcNHglycan	176	179	PF01048	0.614
MOD_GlcNHglycan	180	183	PF01048	0.639
MOD_GlcNHglycan	258	261	PF01048	0.741
MOD_GlcNHglycan	280	283	PF01048	0.515
MOD_GlcNHglycan	291	294	PF01048	0.782
MOD_GlcNHglycan	352	355	PF01048	0.661
MOD_GlcNHglycan	419	422	PF01048	0.507
MOD_GlcNHglycan	480	483	PF01048	0.737
MOD_GlcNHglycan	5	8	PF01048	0.423
MOD_GlcNHglycan	524	527	PF01048	0.661
MOD_GlcNHglycan	536	539	PF01048	0.651
MOD_GlcNHglycan	562	565	PF01048	0.695
MOD_GlcNHglycan	598	601	PF01048	0.695
MOD_GlcNHglycan	645	648	PF01048	0.646
MOD_GlcNHglycan	650	653	PF01048	0.653
MOD_GlcNHglycan	764	767	PF01048	0.557
MOD_GlcNHglycan	844	847	PF01048	0.697
MOD_GlcNHglycan	94	97	PF01048	0.744
MOD_GSK3_1	102	109	PF00069	0.697
MOD_GSK3_1	152	159	PF00069	0.432
MOD_GSK3_1	165	172	PF00069	0.612
MOD_GSK3_1	174	181	PF00069	0.686
MOD_GSK3_1	186	193	PF00069	0.725
MOD_GSK3_1	350	357	PF00069	0.742
MOD_GSK3_1	417	424	PF00069	0.480
MOD_GSK3_1	473	480	PF00069	0.686
MOD_GSK3_1	553	560	PF00069	0.662
MOD_GSK3_1	572	579	PF00069	0.668
MOD_GSK3_1	643	650	PF00069	0.619
MOD_GSK3_1	674	681	PF00069	0.638
MOD_GSK3_1	682	689	PF00069	0.636
MOD_GSK3_1	690	697	PF00069	0.611
MOD_GSK3_1	717	724	PF00069	0.676
MOD_GSK3_1	746	753	PF00069	0.611
MOD_GSK3_1	762	769	PF00069	0.532
MOD_GSK3_1	78	85	PF00069	0.628
MOD_GSK3_1	780	787	PF00069	0.609
MOD_GSK3_1	795	802	PF00069	0.552
MOD_GSK3_1	827	834	PF00069	0.686
MOD_GSK3_1	838	845	PF00069	0.600
MOD_GSK3_1	848	855	PF00069	0.609
MOD_GSK3_1	856	863	PF00069	0.634
MOD_N-GLC_1	102	107	PF02516	0.599
MOD_N-GLC_1	289	294	PF02516	0.701
MOD_N-GLC_1	417	422	PF02516	0.402
MOD_N-GLC_1	440	445	PF02516	0.530
MOD_N-GLC_1	573	578	PF02516	0.490
MOD_N-GLC_1	783	788	PF02516	0.658
MOD_NEK2_1	121	126	PF00069	0.528
MOD_NEK2_1	133	138	PF00069	0.602
MOD_NEK2_1	291	296	PF00069	0.763
MOD_NEK2_1	301	306	PF00069	0.604
MOD_NEK2_1	440	445	PF00069	0.530
MOD_NEK2_1	517	522	PF00069	0.644
MOD_NEK2_1	533	538	PF00069	0.587
MOD_NEK2_1	674	679	PF00069	0.625
MOD_NEK2_1	682	687	PF00069	0.633
MOD_NEK2_1	716	721	PF00069	0.674
MOD_NEK2_1	780	785	PF00069	0.591
MOD_NEK2_2	678	683	PF00069	0.514
MOD_NEK2_2	861	866	PF00069	0.578
MOD_PIKK_1	276	282	PF00454	0.465
MOD_PIKK_1	363	369	PF00454	0.681
MOD_PIKK_1	828	834	PF00454	0.553
MOD_PIKK_1	897	903	PF00454	0.639
MOD_PKA_1	10	16	PF00069	0.279
MOD_PKA_1	539	545	PF00069	0.522
MOD_PKA_2	133	139	PF00069	0.542
MOD_PKA_2	178	184	PF00069	0.739
MOD_PKA_2	332	338	PF00069	0.681
MOD_PKA_2	384	390	PF00069	0.214
MOD_PKA_2	421	427	PF00069	0.555
MOD_PKA_2	522	528	PF00069	0.698
MOD_PKA_2	539	545	PF00069	0.603
MOD_PKA_2	557	563	PF00069	0.640
MOD_PKA_2	682	688	PF00069	0.649
MOD_PKA_2	766	772	PF00069	0.632
MOD_PKA_2	780	786	PF00069	0.585
MOD_PKB_1	227	235	PF00069	0.363
MOD_Plk_1	440	446	PF00069	0.535
MOD_Plk_1	694	700	PF00069	0.664
MOD_Plk_1	877	883	PF00069	0.723
MOD_Plk_2-3	144	150	PF00069	0.414
MOD_Plk_4	10	16	PF00069	0.518
MOD_Plk_4	144	150	PF00069	0.430
MOD_Plk_4	326	332	PF00069	0.648
MOD_Plk_4	334	340	PF00069	0.663
MOD_Plk_4	384	390	PF00069	0.275
MOD_Plk_4	694	700	PF00069	0.537
MOD_Plk_4	752	758	PF00069	0.598
MOD_Plk_4	772	778	PF00069	0.602
MOD_Plk_4	799	805	PF00069	0.614
MOD_Plk_4	809	815	PF00069	0.335
MOD_Plk_4	819	825	PF00069	0.183
MOD_Plk_4	861	867	PF00069	0.581
MOD_Plk_4	927	933	PF00069	0.522
MOD_ProDKin_1	113	119	PF00069	0.715
MOD_ProDKin_1	165	171	PF00069	0.600
MOD_ProDKin_1	269	275	PF00069	0.644
MOD_ProDKin_1	354	360	PF00069	0.672
MOD_ProDKin_1	431	437	PF00069	0.579
MOD_ProDKin_1	473	479	PF00069	0.776
MOD_ProDKin_1	524	530	PF00069	0.565
MOD_ProDKin_1	795	801	PF00069	0.521
MOD_ProDKin_1	85	91	PF00069	0.665
MOD_ProDKin_1	869	875	PF00069	0.604
MOD_ProDKin_1	976	982	PF00069	0.478
MOD_SUMO_for_1	283	286	PF00179	0.472
MOD_SUMO_rev_2	471	476	PF00179	0.604
MOD_SUMO_rev_2	599	608	PF00179	0.688
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.496
TRG_ENDOCYTIC_2	163	166	PF00928	0.459
TRG_ENDOCYTIC_2	221	224	PF00928	0.370
TRG_ENDOCYTIC_2	39	42	PF00928	0.371
TRG_ENDOCYTIC_2	393	396	PF00928	0.335
TRG_ENDOCYTIC_2	657	660	PF00928	0.801
TRG_ENDOCYTIC_2	736	739	PF00928	0.549
TRG_ENDOCYTIC_2	757	760	PF00928	0.600
TRG_ENDOCYTIC_2	805	808	PF00928	0.453
TRG_ENDOCYTIC_2	866	869	PF00928	0.673
TRG_ER_diArg_1	227	230	PF00400	0.394
TRG_ER_diArg_1	317	319	PF00400	0.586
TRG_ER_diArg_1	370	373	PF00400	0.599
TRG_ER_diArg_1	539	541	PF00400	0.526
TRG_ER_diArg_1	59	62	PF00400	0.623
TRG_ER_diArg_1	732	734	PF00400	0.696
TRG_ER_diArg_1	866	868	PF00400	0.596
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	539	543	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	732	737	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A1	Leptomonas seymouri	47%	91%
A0A3Q8IPH9	Leishmania donovani	86%	99%
A4HPY7	Leishmania braziliensis	68%	100%
A4IDP8	Leishmania infantum	86%	99%
Q4Q0U4	Leishmania major	83%	100%