VPS9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATQ0_LEIMU

TriTrypDb:

LmxM.36.4660

Length:

933

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0030139	endocytic vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATQ0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0016192	vesicle-mediated transport	4	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7
GO:0140678	molecular function inhibitor activity	2	7
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.626
CLV_C14_Caspase3-7	5	9	PF00656	0.544
CLV_C14_Caspase3-7	818	822	PF00656	0.678
CLV_NRD_NRD_1	348	350	PF00675	0.526
CLV_NRD_NRD_1	430	432	PF00675	0.541
CLV_NRD_NRD_1	531	533	PF00675	0.486
CLV_NRD_NRD_1	605	607	PF00675	0.312
CLV_PCSK_FUR_1	603	607	PF00082	0.285
CLV_PCSK_KEX2_1	162	164	PF00082	0.382
CLV_PCSK_KEX2_1	430	432	PF00082	0.541
CLV_PCSK_KEX2_1	531	533	PF00082	0.455
CLV_PCSK_KEX2_1	605	607	PF00082	0.312
CLV_PCSK_KEX2_1	609	611	PF00082	0.312
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.382
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.340
CLV_PCSK_PC7_1	605	611	PF00082	0.340
CLV_PCSK_SKI1_1	118	122	PF00082	0.471
CLV_PCSK_SKI1_1	286	290	PF00082	0.488
CLV_PCSK_SKI1_1	513	517	PF00082	0.369
CLV_PCSK_SKI1_1	606	610	PF00082	0.291
CLV_PCSK_SKI1_1	613	617	PF00082	0.291
CLV_PCSK_SKI1_1	720	724	PF00082	0.637
CLV_PCSK_SKI1_1	745	749	PF00082	0.548
CLV_PCSK_SKI1_1	900	904	PF00082	0.452
CLV_PCSK_SKI1_1	926	930	PF00082	0.461
DEG_APCC_DBOX_1	223	231	PF00400	0.433
DEG_SCF_FBW7_1	491	498	PF00400	0.465
DEG_SPOP_SBC_1	854	858	PF00917	0.554
DOC_CDC14_PxL_1	251	259	PF14671	0.574
DOC_CYCLIN_RxL_1	536	545	PF00134	0.453
DOC_CYCLIN_RxL_1	896	905	PF00134	0.426
DOC_MAPK_gen_1	36	44	PF00069	0.436
DOC_MAPK_gen_1	896	904	PF00069	0.526
DOC_MAPK_MEF2A_6	200	209	PF00069	0.335
DOC_MAPK_MEF2A_6	589	598	PF00069	0.312
DOC_MAPK_MEF2A_6	73	82	PF00069	0.449
DOC_PP1_RVXF_1	645	652	PF00149	0.388
DOC_PP2B_LxvP_1	279	282	PF13499	0.671
DOC_PP2B_LxvP_1	42	45	PF13499	0.336
DOC_PP4_FxxP_1	577	580	PF00568	0.312
DOC_PP4_FxxP_1	661	664	PF00568	0.388
DOC_PP4_FxxP_1	837	840	PF00568	0.509
DOC_USP7_MATH_1	181	185	PF00917	0.590
DOC_USP7_MATH_1	407	411	PF00917	0.612
DOC_USP7_MATH_1	473	477	PF00917	0.476
DOC_USP7_MATH_1	665	669	PF00917	0.331
DOC_USP7_MATH_1	725	729	PF00917	0.550
DOC_USP7_MATH_1	804	808	PF00917	0.624
DOC_USP7_MATH_1	855	859	PF00917	0.562
DOC_USP7_UBL2_3	237	241	PF12436	0.487
DOC_USP7_UBL2_3	609	613	PF12436	0.315
DOC_WW_Pin1_4	365	370	PF00397	0.530
DOC_WW_Pin1_4	491	496	PF00397	0.420
DOC_WW_Pin1_4	576	581	PF00397	0.312
DOC_WW_Pin1_4	844	849	PF00397	0.699
DOC_WW_Pin1_4	882	887	PF00397	0.673
DOC_WW_Pin1_4	91	96	PF00397	0.841
LIG_14-3-3_CanoR_1	200	206	PF00244	0.348
LIG_14-3-3_CanoR_1	339	346	PF00244	0.611
LIG_14-3-3_CanoR_1	349	353	PF00244	0.585
LIG_14-3-3_CanoR_1	446	451	PF00244	0.412
LIG_14-3-3_CanoR_1	46	51	PF00244	0.389
LIG_14-3-3_CanoR_1	496	504	PF00244	0.597
LIG_14-3-3_CanoR_1	513	520	PF00244	0.273
LIG_14-3-3_CanoR_1	647	652	PF00244	0.312
LIG_14-3-3_CanoR_1	752	761	PF00244	0.545
LIG_BIR_III_2	262	266	PF00653	0.482
LIG_BIR_III_2	553	557	PF00653	0.391
LIG_BRCT_BRCA1_1	109	113	PF00533	0.468
LIG_BRCT_BRCA1_1	232	236	PF00533	0.371
LIG_BRCT_BRCA1_1	680	684	PF00533	0.353
LIG_BRCT_BRCA1_1	78	82	PF00533	0.517
LIG_BRCT_BRCA1_1	872	876	PF00533	0.484
LIG_Clathr_ClatBox_1	133	137	PF01394	0.378
LIG_Clathr_ClatBox_1	541	545	PF01394	0.500
LIG_FHA_1	124	130	PF00498	0.346
LIG_FHA_1	246	252	PF00498	0.610
LIG_FHA_1	304	310	PF00498	0.622
LIG_FHA_1	355	361	PF00498	0.521
LIG_FHA_1	39	45	PF00498	0.276
LIG_FHA_1	492	498	PF00498	0.498
LIG_FHA_1	514	520	PF00498	0.462
LIG_FHA_1	836	842	PF00498	0.687
LIG_FHA_1	860	866	PF00498	0.503
LIG_FHA_2	343	349	PF00498	0.484
LIG_FHA_2	497	503	PF00498	0.353
LIG_FHA_2	741	747	PF00498	0.610
LIG_FHA_2	787	793	PF00498	0.578
LIG_FHA_2	912	918	PF00498	0.435
LIG_LIR_Apic_2	371	375	PF02991	0.497
LIG_LIR_Apic_2	575	580	PF02991	0.312
LIG_LIR_Apic_2	659	664	PF02991	0.388
LIG_LIR_Apic_2	836	840	PF02991	0.509
LIG_LIR_Gen_1	130	139	PF02991	0.399
LIG_LIR_Gen_1	438	448	PF02991	0.440
LIG_LIR_Gen_1	478	484	PF02991	0.471
LIG_LIR_Gen_1	517	526	PF02991	0.392
LIG_LIR_Gen_1	909	918	PF02991	0.425
LIG_LIR_Nem_3	126	131	PF02991	0.354
LIG_LIR_Nem_3	142	147	PF02991	0.413
LIG_LIR_Nem_3	428	432	PF02991	0.460
LIG_LIR_Nem_3	438	444	PF02991	0.456
LIG_LIR_Nem_3	478	483	PF02991	0.478
LIG_LIR_Nem_3	517	523	PF02991	0.385
LIG_LIR_Nem_3	847	853	PF02991	0.489
LIG_LIR_Nem_3	909	913	PF02991	0.433
LIG_PCNA_yPIPBox_3	503	515	PF02747	0.444
LIG_Pex14_2	440	444	PF04695	0.474
LIG_Pex14_2	635	639	PF04695	0.312
LIG_PTB_Apo_2	138	145	PF02174	0.513
LIG_PTB_Apo_2	651	658	PF02174	0.312
LIG_PTB_Phospho_1	651	657	PF10480	0.312
LIG_REV1ctd_RIR_1	574	579	PF16727	0.312
LIG_SH2_CRK	131	135	PF00017	0.358
LIG_SH2_CRK	372	376	PF00017	0.498
LIG_SH2_CRK	429	433	PF00017	0.427
LIG_SH2_CRK	520	524	PF00017	0.384
LIG_SH2_NCK_1	331	335	PF00017	0.636
LIG_SH2_NCK_1	372	376	PF00017	0.498
LIG_SH2_STAP1	277	281	PF00017	0.626
LIG_SH2_STAT5	327	330	PF00017	0.646
LIG_SH2_STAT5	331	334	PF00017	0.593
LIG_SH2_STAT5	463	466	PF00017	0.585
LIG_SH2_STAT5	514	517	PF00017	0.366
LIG_SH2_STAT5	58	61	PF00017	0.507
LIG_SH2_STAT5	657	660	PF00017	0.342
LIG_SH2_STAT5	673	676	PF00017	0.312
LIG_SH3_3	108	114	PF00018	0.647
LIG_SH3_3	196	202	PF00018	0.636
LIG_SH3_3	249	255	PF00018	0.660
LIG_SH3_3	316	322	PF00018	0.685
LIG_SH3_3	704	710	PF00018	0.571
LIG_SH3_3	843	849	PF00018	0.635
LIG_Sin3_3	639	646	PF02671	0.312
LIG_SUMO_SIM_anti_2	502	509	PF11976	0.427
LIG_SUMO_SIM_anti_2	789	795	PF11976	0.572
LIG_SUMO_SIM_par_1	306	313	PF11976	0.623
LIG_SUMO_SIM_par_1	838	844	PF11976	0.684
LIG_TRAF2_1	668	671	PF00917	0.312
LIG_TRAF2_1	782	785	PF00917	0.601
LIG_TRAF2_2	95	100	PF00917	0.668
LIG_TYR_ITIM	129	134	PF00017	0.352
LIG_UBA3_1	207	212	PF00899	0.408
LIG_UBA3_1	29	36	PF00899	0.409
MOD_CDK_SPK_2	491	496	PF00069	0.468
MOD_CDK_SPK_2	576	581	PF00069	0.312
MOD_CDK_SPxxK_3	576	583	PF00069	0.312
MOD_CK1_1	142	148	PF00069	0.408
MOD_CK1_1	184	190	PF00069	0.632
MOD_CK1_1	280	286	PF00069	0.598
MOD_CK1_1	3	9	PF00069	0.463
MOD_CK1_1	342	348	PF00069	0.620
MOD_CK1_1	354	360	PF00069	0.561
MOD_CK1_1	373	379	PF00069	0.787
MOD_CK1_1	392	398	PF00069	0.590
MOD_CK1_1	67	73	PF00069	0.685
MOD_CK1_1	772	778	PF00069	0.581
MOD_CK1_1	815	821	PF00069	0.600
MOD_CK1_1	870	876	PF00069	0.548
MOD_CK1_1	891	897	PF00069	0.705
MOD_CK2_1	150	156	PF00069	0.485
MOD_CK2_1	28	34	PF00069	0.419
MOD_CK2_1	301	307	PF00069	0.625
MOD_CK2_1	342	348	PF00069	0.599
MOD_CK2_1	439	445	PF00069	0.461
MOD_CK2_1	496	502	PF00069	0.358
MOD_CK2_1	524	530	PF00069	0.473
MOD_CK2_1	576	582	PF00069	0.312
MOD_CK2_1	665	671	PF00069	0.388
MOD_CK2_1	911	917	PF00069	0.445
MOD_Cter_Amidation	811	814	PF01082	0.530
MOD_GlcNHglycan	183	186	PF01048	0.593
MOD_GlcNHglycan	232	235	PF01048	0.517
MOD_GlcNHglycan	279	282	PF01048	0.726
MOD_GlcNHglycan	353	356	PF01048	0.794
MOD_GlcNHglycan	392	395	PF01048	0.649
MOD_GlcNHglycan	619	622	PF01048	0.308
MOD_GlcNHglycan	69	73	PF01048	0.633
MOD_GlcNHglycan	703	706	PF01048	0.793
MOD_GlcNHglycan	715	718	PF01048	0.568
MOD_GlcNHglycan	729	732	PF01048	0.580
MOD_GlcNHglycan	777	780	PF01048	0.552
MOD_GlcNHglycan	814	817	PF01048	0.624
MOD_GlcNHglycan	857	860	PF01048	0.605
MOD_GSK3_1	184	191	PF00069	0.643
MOD_GSK3_1	243	250	PF00069	0.536
MOD_GSK3_1	293	300	PF00069	0.744
MOD_GSK3_1	301	308	PF00069	0.594
MOD_GSK3_1	344	351	PF00069	0.773
MOD_GSK3_1	395	402	PF00069	0.661
MOD_GSK3_1	458	465	PF00069	0.475
MOD_GSK3_1	491	498	PF00069	0.488
MOD_GSK3_1	64	71	PF00069	0.616
MOD_GSK3_1	665	672	PF00069	0.388
MOD_GSK3_1	674	681	PF00069	0.422
MOD_GSK3_1	697	704	PF00069	0.634
MOD_GSK3_1	829	836	PF00069	0.675
MOD_GSK3_1	849	856	PF00069	0.526
MOD_GSK3_1	866	873	PF00069	0.489
MOD_GSK3_1	888	895	PF00069	0.646
MOD_GSK3_1	902	909	PF00069	0.410
MOD_N-GLC_1	270	275	PF02516	0.517
MOD_N-GLC_1	524	529	PF02516	0.449
MOD_N-GLC_1	891	896	PF02516	0.631
MOD_N-GLC_1	906	911	PF02516	0.391
MOD_N-GLC_2	146	148	PF02516	0.301
MOD_N-GLC_2	299	301	PF02516	0.629
MOD_NEK2_1	20	25	PF00069	0.456
MOD_NEK2_1	230	235	PF00069	0.576
MOD_NEK2_1	247	252	PF00069	0.692
MOD_NEK2_1	370	375	PF00069	0.600
MOD_NEK2_1	59	64	PF00069	0.568
MOD_NEK2_1	678	683	PF00069	0.388
MOD_NEK2_1	902	907	PF00069	0.432
MOD_NEK2_2	715	720	PF00069	0.648
MOD_OFUCOSY	586	591	PF10250	0.388
MOD_PIKK_1	902	908	PF00454	0.427
MOD_PK_1	107	113	PF00069	0.485
MOD_PKA_2	150	156	PF00069	0.485
MOD_PKA_2	181	187	PF00069	0.548
MOD_PKA_2	223	229	PF00069	0.363
MOD_PKA_2	348	354	PF00069	0.511
MOD_PKA_2	395	401	PF00069	0.493
MOD_PKA_2	495	501	PF00069	0.540
MOD_PKA_2	502	508	PF00069	0.420
MOD_PKA_2	64	70	PF00069	0.682
MOD_PKB_1	337	345	PF00069	0.594
MOD_PKB_1	645	653	PF00069	0.312
MOD_Plk_1	342	348	PF00069	0.717
MOD_Plk_1	669	675	PF00069	0.312
MOD_Plk_1	772	778	PF00069	0.545
MOD_Plk_1	867	873	PF00069	0.588
MOD_Plk_1	906	912	PF00069	0.441
MOD_Plk_2-3	911	917	PF00069	0.445
MOD_Plk_4	20	26	PF00069	0.480
MOD_Plk_4	247	253	PF00069	0.657
MOD_Plk_4	348	354	PF00069	0.501
MOD_Plk_4	38	44	PF00069	0.282
MOD_Plk_4	475	481	PF00069	0.441
MOD_Plk_4	502	508	PF00069	0.533
MOD_Plk_4	647	653	PF00069	0.312
MOD_Plk_4	678	684	PF00069	0.444
MOD_Plk_4	76	82	PF00069	0.456
MOD_Plk_4	786	792	PF00069	0.636
MOD_ProDKin_1	365	371	PF00069	0.529
MOD_ProDKin_1	491	497	PF00069	0.415
MOD_ProDKin_1	576	582	PF00069	0.312
MOD_ProDKin_1	844	850	PF00069	0.649
MOD_ProDKin_1	882	888	PF00069	0.675
MOD_ProDKin_1	91	97	PF00069	0.843
MOD_SUMO_for_1	102	105	PF00179	0.523
MOD_SUMO_for_1	236	239	PF00179	0.410
MOD_SUMO_rev_2	233	243	PF00179	0.541
MOD_SUMO_rev_2	342	352	PF00179	0.508
TRG_DiLeu_BaEn_1	443	448	PF01217	0.474
TRG_DiLeu_BaEn_1	924	929	PF01217	0.517
TRG_DiLeu_BaEn_4	670	676	PF01217	0.340
TRG_ENDOCYTIC_2	131	134	PF00928	0.347
TRG_ENDOCYTIC_2	331	334	PF00928	0.635
TRG_ENDOCYTIC_2	429	432	PF00928	0.471
TRG_ENDOCYTIC_2	441	444	PF00928	0.420
TRG_ENDOCYTIC_2	480	483	PF00928	0.396
TRG_ENDOCYTIC_2	520	523	PF00928	0.463
TRG_ER_diArg_1	179	182	PF00400	0.577
TRG_ER_diArg_1	429	431	PF00400	0.516
TRG_ER_diArg_1	602	605	PF00400	0.285
TRG_ER_diArg_1	644	647	PF00400	0.312
TRG_ER_diArg_1	896	899	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	926	931	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P3	Leptomonas seymouri	44%	92%
A0A3S7XBS1	Leishmania donovani	87%	100%
A4HPY3	Leishmania braziliensis	64%	100%
A4IDP4	Leishmania infantum	87%	100%
Q4Q0U8	Leishmania major	84%	100%