Peptidase_S9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Esterase PHB depolymerase, putative

Species:

Leishmania mexicana

UniProt:

E9ATP8_LEIMU

TriTrypDb:

LmxM.36.4640

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005576	extracellular region	2	5
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ATP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATP8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6
GO:0008233	peptidase activity	3	1
GO:0008236	serine-type peptidase activity	4	1
GO:0017171	serine hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0030600	feruloyl esterase activity	5	1
GO:0052689	carboxylic ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.429
CLV_C14_Caspase3-7	475	479	PF00656	0.443
CLV_NRD_NRD_1	30	32	PF00675	0.531
CLV_NRD_NRD_1	366	368	PF00675	0.678
CLV_NRD_NRD_1	417	419	PF00675	0.642
CLV_NRD_NRD_1	430	432	PF00675	0.724
CLV_NRD_NRD_1	434	436	PF00675	0.734
CLV_NRD_NRD_1	444	446	PF00675	0.654
CLV_NRD_NRD_1	515	517	PF00675	0.764
CLV_PCSK_FUR_1	415	419	PF00082	0.607
CLV_PCSK_KEX2_1	366	368	PF00082	0.650
CLV_PCSK_KEX2_1	417	419	PF00082	0.644
CLV_PCSK_KEX2_1	430	432	PF00082	0.726
CLV_PCSK_KEX2_1	434	436	PF00082	0.737
CLV_PCSK_KEX2_1	444	446	PF00082	0.652
CLV_PCSK_KEX2_1	515	517	PF00082	0.764
CLV_PCSK_PC7_1	430	436	PF00082	0.721
CLV_PCSK_SKI1_1	173	177	PF00082	0.530
CLV_PCSK_SKI1_1	31	35	PF00082	0.512
CLV_PCSK_SKI1_1	435	439	PF00082	0.767
CLV_Separin_Metazoa	550	554	PF03568	0.456
DEG_Nend_Nbox_1	1	3	PF02207	0.597
DOC_CKS1_1	75	80	PF01111	0.426
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.473
DOC_MAPK_gen_1	121	129	PF00069	0.447
DOC_MAPK_gen_1	515	522	PF00069	0.562
DOC_MAPK_gen_1	527	534	PF00069	0.482
DOC_MAPK_JIP1_4	157	163	PF00069	0.352
DOC_MAPK_MEF2A_6	157	165	PF00069	0.389
DOC_MAPK_MEF2A_6	187	195	PF00069	0.221
DOC_PP2B_LxvP_1	26	29	PF13499	0.740
DOC_PP2B_LxvP_1	52	55	PF13499	0.491
DOC_USP7_MATH_1	268	272	PF00917	0.352
DOC_USP7_UBL2_3	463	467	PF12436	0.565
DOC_WW_Pin1_4	146	151	PF00397	0.352
DOC_WW_Pin1_4	367	372	PF00397	0.456
DOC_WW_Pin1_4	417	422	PF00397	0.402
DOC_WW_Pin1_4	536	541	PF00397	0.445
DOC_WW_Pin1_4	74	79	PF00397	0.476
LIG_14-3-3_CanoR_1	267	273	PF00244	0.426
LIG_14-3-3_CanoR_1	301	305	PF00244	0.395
LIG_BIR_III_2	155	159	PF00653	0.221
LIG_BIR_III_4	177	181	PF00653	0.330
LIG_BRCT_BRCA1_1	485	489	PF00533	0.554
LIG_BRCT_BRCA1_1	79	83	PF00533	0.481
LIG_EH1_1	82	90	PF00400	0.465
LIG_eIF4E_1	390	396	PF01652	0.421
LIG_EVH1_2	381	385	PF00568	0.421
LIG_FHA_1	288	294	PF00498	0.395
LIG_FHA_1	300	306	PF00498	0.278
LIG_FHA_1	537	543	PF00498	0.475
LIG_FHA_2	181	187	PF00498	0.221
LIG_FHA_2	371	377	PF00498	0.469
LIG_FHA_2	381	387	PF00498	0.550
LIG_FHA_2	397	403	PF00498	0.436
LIG_FHA_2	455	461	PF00498	0.504
LIG_LIR_Apic_2	145	150	PF02991	0.344
LIG_LIR_Gen_1	188	195	PF02991	0.352
LIG_LIR_Nem_3	128	132	PF02991	0.423
LIG_LIR_Nem_3	179	184	PF02991	0.395
LIG_LIR_Nem_3	188	193	PF02991	0.248
LIG_NRBOX	516	522	PF00104	0.431
LIG_PCNA_yPIPBox_3	82	90	PF02747	0.422
LIG_PTB_Apo_2	353	360	PF02174	0.440
LIG_PTB_Phospho_1	353	359	PF10480	0.438
LIG_SH2_GRB2like	354	357	PF00017	0.437
LIG_SH2_STAP1	359	363	PF00017	0.283
LIG_SH2_STAP1	572	576	PF00017	0.255
LIG_SH2_STAT5	100	103	PF00017	0.478
LIG_SH2_STAT5	142	145	PF00017	0.450
LIG_SH2_STAT5	201	204	PF00017	0.352
LIG_SH2_STAT5	354	357	PF00017	0.437
LIG_SH2_STAT5	363	366	PF00017	0.378
LIG_SH2_STAT5	57	60	PF00017	0.580
LIG_SH2_STAT5	572	575	PF00017	0.472
LIG_SH3_1	114	120	PF00018	0.464
LIG_SH3_3	114	120	PF00018	0.508
LIG_SH3_3	138	144	PF00018	0.388
LIG_SH3_3	310	316	PF00018	0.265
LIG_SH3_3	375	381	PF00018	0.465
LIG_SH3_3	72	78	PF00018	0.403
LIG_SUMO_SIM_anti_2	547	553	PF11976	0.454
LIG_SUMO_SIM_anti_2	69	77	PF11976	0.467
LIG_TRAF2_1	501	504	PF00917	0.518
LIG_TRAF2_1	67	70	PF00917	0.371
LIG_TRFH_1	489	493	PF08558	0.741
LIG_UBA3_1	164	173	PF00899	0.473
LIG_WRC_WIRS_1	126	131	PF05994	0.547
LIG_WW_3	28	32	PF00397	0.669
MOD_CDK_SPK_2	536	541	PF00069	0.529
MOD_CK1_1	103	109	PF00069	0.565
MOD_CK1_1	12	18	PF00069	0.677
MOD_CK1_1	146	152	PF00069	0.609
MOD_CK1_1	370	376	PF00069	0.551
MOD_CK1_1	42	48	PF00069	0.275
MOD_CK1_1	479	485	PF00069	0.535
MOD_CK1_1	74	80	PF00069	0.679
MOD_CK2_1	180	186	PF00069	0.230
MOD_CK2_1	370	376	PF00069	0.693
MOD_CK2_1	380	386	PF00069	0.712
MOD_CK2_1	417	423	PF00069	0.501
MOD_CK2_1	454	460	PF00069	0.625
MOD_CK2_1	479	485	PF00069	0.535
MOD_CK2_1	544	550	PF00069	0.613
MOD_DYRK1A_RPxSP_1	367	371	PF00069	0.499
MOD_GlcNHglycan	272	275	PF01048	0.412
MOD_GlcNHglycan	399	402	PF01048	0.619
MOD_GlcNHglycan	474	477	PF01048	0.546
MOD_GSK3_1	142	149	PF00069	0.343
MOD_GSK3_1	176	183	PF00069	0.342
MOD_GSK3_1	191	198	PF00069	0.479
MOD_GSK3_1	295	302	PF00069	0.501
MOD_GSK3_1	344	351	PF00069	0.664
MOD_GSK3_1	367	374	PF00069	0.626
MOD_GSK3_1	472	479	PF00069	0.647
MOD_GSK3_1	566	573	PF00069	0.296
MOD_GSK3_1	9	16	PF00069	0.673
MOD_GSK3_1	99	106	PF00069	0.578
MOD_N-GLC_1	345	350	PF02516	0.544
MOD_N-GLC_1	397	402	PF02516	0.700
MOD_N-GLC_1	479	484	PF02516	0.589
MOD_N-GLC_2	339	341	PF02516	0.473
MOD_NEK2_1	176	181	PF00069	0.501
MOD_NEK2_1	232	237	PF00069	0.473
MOD_NEK2_1	521	526	PF00069	0.525
MOD_NEK2_2	296	301	PF00069	0.321
MOD_NEK2_2	354	359	PF00069	0.376
MOD_PIKK_1	131	137	PF00454	0.342
MOD_PIKK_1	499	505	PF00454	0.738
MOD_PKA_1	31	37	PF00069	0.636
MOD_PKA_1	430	436	PF00069	0.604
MOD_PKA_2	300	306	PF00069	0.473
MOD_PKA_2	430	436	PF00069	0.659
MOD_PKA_2	443	449	PF00069	0.585
MOD_PKA_2	535	541	PF00069	0.533
MOD_Plk_1	238	244	PF00069	0.412
MOD_Plk_1	345	351	PF00069	0.504
MOD_Plk_1	425	431	PF00069	0.491
MOD_Plk_1	570	576	PF00069	0.284
MOD_Plk_1	69	75	PF00069	0.399
MOD_Plk_1	9	15	PF00069	0.582
MOD_Plk_2-3	544	550	PF00069	0.354
MOD_Plk_4	100	106	PF00069	0.542
MOD_Plk_4	122	128	PF00069	0.603
MOD_Plk_4	300	306	PF00069	0.473
MOD_Plk_4	324	330	PF00069	0.412
MOD_Plk_4	354	360	PF00069	0.436
MOD_Plk_4	469	475	PF00069	0.600
MOD_ProDKin_1	146	152	PF00069	0.426
MOD_ProDKin_1	367	373	PF00069	0.565
MOD_ProDKin_1	417	423	PF00069	0.483
MOD_ProDKin_1	536	542	PF00069	0.526
MOD_ProDKin_1	74	80	PF00069	0.591
MOD_SUMO_for_1	440	443	PF00179	0.475
MOD_SUMO_rev_2	149	159	PF00179	0.370
MOD_SUMO_rev_2	464	473	PF00179	0.691
MOD_SUMO_rev_2	479	489	PF00179	0.580
TRG_DiLeu_BaEn_1	432	437	PF01217	0.467
TRG_DiLeu_BaEn_2	185	191	PF01217	0.412
TRG_ER_diArg_1	365	367	PF00400	0.480
TRG_ER_diArg_1	417	419	PF00400	0.533
TRG_ER_diArg_1	429	431	PF00400	0.585
TRG_ER_diArg_1	434	436	PF00400	0.583
TRG_ER_diArg_1	444	447	PF00400	0.516
TRG_ER_diArg_1	515	517	PF00400	0.736
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XBJ7	Leishmania donovani	80%	100%
A4HPY1	Leishmania braziliensis	56%	100%
A4IDP2	Leishmania infantum	79%	100%
Q4Q0V0	Leishmania major	75%	99%