t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATP5_LEIMU

TriTrypDb:

LmxM.36.4610

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ATP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.533
CLV_C14_Caspase3-7	148	152	PF00656	0.726
CLV_C14_Caspase3-7	290	294	PF00656	0.696
CLV_C14_Caspase3-7	386	390	PF00656	0.623
CLV_NRD_NRD_1	119	121	PF00675	0.394
CLV_NRD_NRD_1	15	17	PF00675	0.417
CLV_NRD_NRD_1	220	222	PF00675	0.485
CLV_NRD_NRD_1	252	254	PF00675	0.590
CLV_NRD_NRD_1	30	32	PF00675	0.429
CLV_PCSK_KEX2_1	119	121	PF00082	0.424
CLV_PCSK_KEX2_1	15	17	PF00082	0.478
CLV_PCSK_KEX2_1	176	178	PF00082	0.385
CLV_PCSK_KEX2_1	252	254	PF00082	0.557
CLV_PCSK_KEX2_1	30	32	PF00082	0.498
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.390
CLV_PCSK_PC7_1	172	178	PF00082	0.403
CLV_PCSK_SKI1_1	222	226	PF00082	0.346
CLV_PCSK_SKI1_1	308	312	PF00082	0.497
CLV_PCSK_SKI1_1	376	380	PF00082	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.647
DOC_CYCLIN_RxL_1	304	315	PF00134	0.694
DOC_MAPK_gen_1	176	182	PF00069	0.519
DOC_PP1_RVXF_1	231	238	PF00149	0.689
DOC_PP2B_LxvP_1	336	339	PF13499	0.619
DOC_PP2B_LxvP_1	353	356	PF13499	0.541
DOC_PP4_FxxP_1	446	449	PF00568	0.615
DOC_USP7_MATH_1	138	142	PF00917	0.797
DOC_USP7_MATH_1	14	18	PF00917	0.618
DOC_USP7_MATH_1	287	291	PF00917	0.749
DOC_USP7_MATH_1	40	44	PF00917	0.596
DOC_WW_Pin1_4	125	130	PF00397	0.552
DOC_WW_Pin1_4	17	22	PF00397	0.632
DOC_WW_Pin1_4	74	79	PF00397	0.611
LIG_14-3-3_CanoR_1	15	22	PF00244	0.661
LIG_14-3-3_CanoR_1	163	173	PF00244	0.627
LIG_14-3-3_CanoR_1	24	28	PF00244	0.623
LIG_14-3-3_CanoR_1	252	261	PF00244	0.787
LIG_14-3-3_CanoR_1	61	69	PF00244	0.529
LIG_BIR_III_4	245	249	PF00653	0.569
LIG_eIF4E_1	5	11	PF01652	0.610
LIG_FHA_1	268	274	PF00498	0.645
LIG_FHA_1	313	319	PF00498	0.687
LIG_FHA_1	39	45	PF00498	0.648
LIG_FHA_1	448	454	PF00498	0.533
LIG_FHA_1	61	67	PF00498	0.584
LIG_FHA_2	218	224	PF00498	0.585
LIG_FHA_2	32	38	PF00498	0.682
LIG_FHA_2	362	368	PF00498	0.627
LIG_GBD_Chelix_1	453	461	PF00786	0.349
LIG_LIR_Gen_1	236	244	PF02991	0.609
LIG_LIR_Gen_1	415	422	PF02991	0.571
LIG_LIR_Nem_3	236	240	PF02991	0.607
LIG_LIR_Nem_3	269	274	PF02991	0.677
LIG_LIR_Nem_3	415	421	PF02991	0.571
LIG_MYND_1	356	360	PF01753	0.649
LIG_NRBOX	452	458	PF00104	0.388
LIG_Pex14_1	121	125	PF04695	0.565
LIG_Pex14_2	267	271	PF04695	0.714
LIG_SH2_STAT5	255	258	PF00017	0.750
LIG_SH3_3	141	147	PF00018	0.628
LIG_SH3_3	436	442	PF00018	0.631
LIG_SUMO_SIM_par_1	94	101	PF11976	0.585
LIG_TRAF2_1	183	186	PF00917	0.591
LIG_TRAF2_1	364	367	PF00917	0.561
MOD_CDK_SPxxK_3	17	24	PF00069	0.602
MOD_CK1_1	17	23	PF00069	0.669
MOD_CK1_1	401	407	PF00069	0.524
MOD_CK1_1	43	49	PF00069	0.578
MOD_CK1_1	97	103	PF00069	0.535
MOD_CK2_1	180	186	PF00069	0.631
MOD_CK2_1	217	223	PF00069	0.663
MOD_CK2_1	31	37	PF00069	0.658
MOD_CK2_1	314	320	PF00069	0.666
MOD_CK2_1	361	367	PF00069	0.592
MOD_CK2_1	434	440	PF00069	0.511
MOD_CK2_1	6	12	PF00069	0.589
MOD_CK2_1	88	94	PF00069	0.554
MOD_GlcNHglycan	130	133	PF01048	0.465
MOD_GlcNHglycan	155	158	PF01048	0.456
MOD_GlcNHglycan	17	20	PF01048	0.443
MOD_GlcNHglycan	293	296	PF01048	0.436
MOD_GlcNHglycan	385	388	PF01048	0.340
MOD_GlcNHglycan	66	69	PF01048	0.388
MOD_GSK3_1	107	114	PF00069	0.523
MOD_GSK3_1	128	135	PF00069	0.705
MOD_GSK3_1	287	294	PF00069	0.636
MOD_GSK3_1	340	347	PF00069	0.668
MOD_GSK3_1	398	405	PF00069	0.535
MOD_GSK3_1	40	47	PF00069	0.575
MOD_GSK3_1	412	419	PF00069	0.559
MOD_GSK3_1	60	67	PF00069	0.413
MOD_GSK3_1	94	101	PF00069	0.487
MOD_N-GLC_1	125	130	PF02516	0.352
MOD_N-GLC_1	334	339	PF02516	0.462
MOD_NEK2_1	1	6	PF00069	0.637
MOD_NEK2_1	105	110	PF00069	0.480
MOD_NEK2_1	267	272	PF00069	0.707
MOD_NEK2_1	344	349	PF00069	0.679
MOD_NEK2_1	44	49	PF00069	0.578
MOD_NEK2_1	463	468	PF00069	0.202
MOD_NEK2_1	96	101	PF00069	0.478
MOD_NEK2_2	281	286	PF00069	0.678
MOD_PIKK_1	398	404	PF00454	0.536
MOD_PKA_1	15	21	PF00069	0.586
MOD_PKA_2	14	20	PF00069	0.651
MOD_PKA_2	214	220	PF00069	0.492
MOD_PKA_2	23	29	PF00069	0.614
MOD_PKA_2	329	335	PF00069	0.626
MOD_PKA_2	60	66	PF00069	0.521
MOD_Plk_1	1	7	PF00069	0.627
MOD_Plk_1	238	244	PF00069	0.557
MOD_Plk_1	334	340	PF00069	0.618
MOD_Plk_1	398	404	PF00069	0.546
MOD_Plk_4	40	46	PF00069	0.629
MOD_Plk_4	402	408	PF00069	0.549
MOD_ProDKin_1	125	131	PF00069	0.554
MOD_ProDKin_1	17	23	PF00069	0.635
MOD_ProDKin_1	74	80	PF00069	0.607
MOD_SUMO_rev_2	145	154	PF00179	0.693
MOD_SUMO_rev_2	386	393	PF00179	0.544
TRG_DiLeu_BaEn_1	416	421	PF01217	0.611
TRG_DiLeu_BaEn_4	366	372	PF01217	0.550
TRG_ER_diArg_1	119	121	PF00400	0.611
TRG_ER_diArg_1	122	125	PF00400	0.629
TRG_ER_diArg_1	30	33	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ6	Leptomonas seymouri	51%	100%
A0A0S4JSZ1	Bodo saltans	32%	100%
A0A3Q8IJ09	Leishmania donovani	85%	100%
A0A422P578	Trypanosoma rangeli	33%	100%
A4HPX8	Leishmania braziliensis	72%	100%
A4IDP0	Leishmania infantum	85%	100%
D0A4C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q0V3	Leishmania major	85%	100%
V5BUS9	Trypanosoma cruzi	34%	100%