Transmembrane protein 17B

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Predicted membrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATP4_LEIMU

TriTrypDb:

LmxM.36.4600

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ATP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_Separin_Metazoa	69	73	PF03568	0.281
DEG_APCC_DBOX_1	43	51	PF00400	0.214
DEG_APCC_DBOX_1	71	79	PF00400	0.397
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DOC_CDC14_PxL_1	94	102	PF14671	0.326
DOC_MAPK_gen_1	141	150	PF00069	0.557
DOC_MAPK_MEF2A_6	55	63	PF00069	0.324
DOC_WW_Pin1_4	12	17	PF00397	0.570
DOC_WW_Pin1_4	153	158	PF00397	0.575
LIG_14-3-3_CanoR_1	2	7	PF00244	0.602
LIG_Actin_WH2_2	126	143	PF00022	0.284
LIG_Clathr_ClatBox_1	127	131	PF01394	0.326
LIG_FHA_1	121	127	PF00498	0.267
LIG_FHA_1	66	72	PF00498	0.321
LIG_FHA_1	91	97	PF00498	0.342
LIG_GBD_Chelix_1	102	110	PF00786	0.326
LIG_GBD_Chelix_1	88	96	PF00786	0.326
LIG_LIR_Apic_2	29	35	PF02991	0.306
LIG_LIR_Gen_1	149	158	PF02991	0.613
LIG_LIR_Gen_1	26	36	PF02991	0.346
LIG_LIR_Nem_3	149	154	PF02991	0.542
LIG_LIR_Nem_3	26	31	PF02991	0.309
LIG_LIR_Nem_3	39	43	PF02991	0.216
LIG_LIR_Nem_3	83	88	PF02991	0.516
LIG_NRBOX	135	141	PF00104	0.172
LIG_NRBOX	17	23	PF00104	0.524
LIG_PALB2_WD40_1	33	41	PF16756	0.326
LIG_SH2_CRK	32	36	PF00017	0.346
LIG_SH2_PTP2	151	154	PF00017	0.592
LIG_SH2_STAT5	151	154	PF00017	0.569
LIG_SH2_STAT5	40	43	PF00017	0.437
LIG_SH3_3	95	101	PF00018	0.288
LIG_SUMO_SIM_anti_2	123	129	PF11976	0.287
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.172
LIG_SUMO_SIM_par_1	125	132	PF11976	0.269
LIG_SUMO_SIM_par_1	20	26	PF11976	0.475
MOD_CK1_1	153	159	PF00069	0.681
MOD_CK1_1	49	55	PF00069	0.335
MOD_GlcNHglycan	32	35	PF01048	0.481
MOD_GSK3_1	116	123	PF00069	0.325
MOD_GSK3_1	26	33	PF00069	0.362
MOD_NEK2_1	116	121	PF00069	0.315
MOD_NEK2_1	140	145	PF00069	0.536
MOD_NEK2_1	150	155	PF00069	0.556
MOD_NEK2_1	92	97	PF00069	0.284
MOD_PIKK_1	120	126	PF00454	0.397
MOD_PIKK_1	49	55	PF00454	0.288
MOD_PKA_2	140	146	PF00069	0.586
MOD_Plk_1	116	122	PF00069	0.324
MOD_Plk_4	23	29	PF00069	0.335
MOD_Plk_4	80	86	PF00069	0.494
MOD_ProDKin_1	12	18	PF00069	0.560
MOD_ProDKin_1	153	159	PF00069	0.583
TRG_ENDOCYTIC_2	151	154	PF00928	0.573
TRG_ENDOCYTIC_2	40	43	PF00928	0.325
TRG_ER_diArg_1	1	4	PF00400	0.636
TRG_NES_CRM1_1	99	112	PF08389	0.172

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM58	Leptomonas seymouri	61%	99%
A0A0S4JJP3	Bodo saltans	29%	100%
A0A1X0P0F4	Trypanosomatidae	35%	99%
A0A3R7LEN3	Trypanosoma rangeli	38%	100%
A0A3S7XBP1	Leishmania donovani	89%	100%
A4IDN9	Leishmania infantum	89%	100%
D0A4C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
Q4Q0V4	Leishmania major	88%	100%