PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATP3_LEIMU

TriTrypDb:

LmxM.36.4590

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATP3

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.607
CLV_C14_Caspase3-7	258	262	PF00656	0.598
CLV_C14_Caspase3-7	430	434	PF00656	0.647
CLV_C14_Caspase3-7	50	54	PF00656	0.547
CLV_C14_Caspase3-7	568	572	PF00656	0.648
CLV_C14_Caspase3-7	635	639	PF00656	0.594
CLV_NRD_NRD_1	249	251	PF00675	0.618
CLV_NRD_NRD_1	296	298	PF00675	0.560
CLV_NRD_NRD_1	402	404	PF00675	0.456
CLV_NRD_NRD_1	480	482	PF00675	0.271
CLV_NRD_NRD_1	497	499	PF00675	0.271
CLV_NRD_NRD_1	600	602	PF00675	0.482
CLV_NRD_NRD_1	618	620	PF00675	0.370
CLV_NRD_NRD_1	645	647	PF00675	0.595
CLV_NRD_NRD_1	678	680	PF00675	0.403
CLV_NRD_NRD_1	682	684	PF00675	0.463
CLV_NRD_NRD_1	754	756	PF00675	0.560
CLV_NRD_NRD_1	761	763	PF00675	0.556
CLV_NRD_NRD_1	797	799	PF00675	0.460
CLV_NRD_NRD_1	93	95	PF00675	0.684
CLV_PCSK_FUR_1	795	799	PF00082	0.459
CLV_PCSK_KEX2_1	110	112	PF00082	0.626
CLV_PCSK_KEX2_1	249	251	PF00082	0.620
CLV_PCSK_KEX2_1	298	300	PF00082	0.600
CLV_PCSK_KEX2_1	404	406	PF00082	0.458
CLV_PCSK_KEX2_1	480	482	PF00082	0.293
CLV_PCSK_KEX2_1	497	499	PF00082	0.271
CLV_PCSK_KEX2_1	647	649	PF00082	0.588
CLV_PCSK_KEX2_1	678	680	PF00082	0.403
CLV_PCSK_KEX2_1	682	684	PF00082	0.463
CLV_PCSK_KEX2_1	761	763	PF00082	0.536
CLV_PCSK_KEX2_1	797	799	PF00082	0.460
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.626
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.600
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.429
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.588
CLV_PCSK_PC7_1	678	684	PF00082	0.436
CLV_PCSK_SKI1_1	158	162	PF00082	0.441
CLV_PCSK_SKI1_1	181	185	PF00082	0.420
CLV_PCSK_SKI1_1	196	200	PF00082	0.536
DEG_APCC_DBOX_1	157	165	PF00400	0.431
DEG_APCC_DBOX_1	480	488	PF00400	0.520
DEG_SPOP_SBC_1	309	313	PF00917	0.653
DEG_SPOP_SBC_1	556	560	PF00917	0.500
DOC_CKS1_1	202	207	PF01111	0.641
DOC_CKS1_1	440	445	PF01111	0.560
DOC_CYCLIN_yClb3_PxF_3	439	445	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	548	554	PF00134	0.465
DOC_MAPK_gen_1	480	487	PF00069	0.399
DOC_MAPK_gen_1	716	725	PF00069	0.517
DOC_MAPK_MEF2A_6	480	489	PF00069	0.399
DOC_PP2B_LxvP_1	338	341	PF13499	0.675
DOC_PP2B_LxvP_1	465	468	PF13499	0.520
DOC_PP2B_LxvP_1	548	551	PF13499	0.461
DOC_PP2B_LxvP_1	741	744	PF13499	0.546
DOC_PP4_FxxP_1	126	129	PF00568	0.587
DOC_PP4_FxxP_1	381	384	PF00568	0.500
DOC_USP7_MATH_1	268	272	PF00917	0.519
DOC_USP7_MATH_1	309	313	PF00917	0.681
DOC_USP7_MATH_1	333	337	PF00917	0.622
DOC_USP7_MATH_1	422	426	PF00917	0.439
DOC_WW_Pin1_4	172	177	PF00397	0.378
DOC_WW_Pin1_4	196	201	PF00397	0.560
DOC_WW_Pin1_4	310	315	PF00397	0.706
DOC_WW_Pin1_4	329	334	PF00397	0.505
DOC_WW_Pin1_4	352	357	PF00397	0.579
DOC_WW_Pin1_4	439	444	PF00397	0.595
DOC_WW_Pin1_4	552	557	PF00397	0.596
DOC_WW_Pin1_4	594	599	PF00397	0.387
DOC_WW_Pin1_4	639	644	PF00397	0.579
DOC_WW_Pin1_4	74	79	PF00397	0.678
LIG_14-3-3_CanoR_1	181	186	PF00244	0.415
LIG_14-3-3_CanoR_1	328	333	PF00244	0.608
LIG_14-3-3_CanoR_1	403	412	PF00244	0.420
LIG_14-3-3_CanoR_1	682	689	PF00244	0.441
LIG_14-3-3_CanoR_1	718	726	PF00244	0.505
LIG_14-3-3_CanoR_1	795	805	PF00244	0.445
LIG_Actin_WH2_2	482	499	PF00022	0.520
LIG_Actin_WH2_2	783	799	PF00022	0.470
LIG_BIR_II_1	1	5	PF00653	0.756
LIG_BIR_III_3	1	5	PF00653	0.621
LIG_CtBP_PxDLS_1	576	580	PF00389	0.632
LIG_FHA_1	197	203	PF00498	0.607
LIG_FHA_1	211	217	PF00498	0.654
LIG_FHA_1	305	311	PF00498	0.536
LIG_FHA_1	572	578	PF00498	0.683
LIG_FHA_1	629	635	PF00498	0.452
LIG_FHA_1	639	645	PF00498	0.581
LIG_FHA_1	764	770	PF00498	0.529
LIG_FHA_1	775	781	PF00498	0.480
LIG_FHA_2	182	188	PF00498	0.416
LIG_FHA_2	202	208	PF00498	0.557
LIG_FHA_2	32	38	PF00498	0.509
LIG_FHA_2	633	639	PF00498	0.571
LIG_FHA_2	797	803	PF00498	0.416
LIG_GBD_Chelix_1	626	634	PF00786	0.445
LIG_Integrin_isoDGR_2	242	244	PF01839	0.638
LIG_LIR_Gen_1	720	727	PF02991	0.533
LIG_LIR_Gen_1	745	754	PF02991	0.590
LIG_LIR_Gen_1	768	778	PF02991	0.498
LIG_LIR_Nem_3	187	191	PF02991	0.322
LIG_LIR_Nem_3	442	448	PF02991	0.483
LIG_LIR_Nem_3	720	725	PF02991	0.545
LIG_LIR_Nem_3	745	751	PF02991	0.591
LIG_NRBOX	629	635	PF00104	0.452
LIG_SH2_CRK	145	149	PF00017	0.573
LIG_SH2_CRK	98	102	PF00017	0.511
LIG_SH2_NCK_1	49	53	PF00017	0.528
LIG_SH2_NCK_1	748	752	PF00017	0.543
LIG_SH2_SRC	20	23	PF00017	0.546
LIG_SH2_SRC	399	402	PF00017	0.480
LIG_SH2_SRC	49	52	PF00017	0.528
LIG_SH2_SRC	748	751	PF00017	0.543
LIG_SH2_STAP1	27	31	PF00017	0.544
LIG_SH2_STAT5	159	162	PF00017	0.480
LIG_SH2_STAT5	185	188	PF00017	0.431
LIG_SH2_STAT5	190	193	PF00017	0.444
LIG_SH2_STAT5	20	23	PF00017	0.546
LIG_SH2_STAT5	423	426	PF00017	0.431
LIG_SH2_STAT5	492	495	PF00017	0.471
LIG_SH2_STAT5	599	602	PF00017	0.401
LIG_SH3_3	199	205	PF00018	0.660
LIG_SH3_3	382	388	PF00018	0.427
LIG_SH3_3	416	422	PF00018	0.363
LIG_SH3_3	434	440	PF00018	0.598
LIG_SH3_3	637	643	PF00018	0.543
LIG_SUMO_SIM_par_1	120	127	PF11976	0.509
LIG_SUMO_SIM_par_1	31	38	PF11976	0.513
LIG_SUMO_SIM_par_1	573	582	PF11976	0.564
LIG_SUMO_SIM_par_1	732	738	PF11976	0.493
LIG_TRAF2_1	744	747	PF00917	0.544
LIG_TYR_ITIM	96	101	PF00017	0.513
MOD_CDK_SPK_2	201	206	PF00069	0.642
MOD_CDK_SPK_2	552	557	PF00069	0.547
MOD_CDK_SPxxK_3	310	317	PF00069	0.642
MOD_CDK_SPxxK_3	594	601	PF00069	0.453
MOD_CDK_SPxxK_3	639	646	PF00069	0.583
MOD_CK1_1	175	181	PF00069	0.372
MOD_CK1_1	215	221	PF00069	0.613
MOD_CK1_1	226	232	PF00069	0.661
MOD_CK1_1	289	295	PF00069	0.587
MOD_CK1_1	312	318	PF00069	0.734
MOD_CK1_1	555	561	PF00069	0.566
MOD_CK1_1	570	576	PF00069	0.572
MOD_CK1_1	578	584	PF00069	0.599
MOD_CK1_1	611	617	PF00069	0.657
MOD_CK1_1	763	769	PF00069	0.527
MOD_CK1_1	85	91	PF00069	0.643
MOD_CK2_1	181	187	PF00069	0.416
MOD_CK2_1	31	37	PF00069	0.565
MOD_CK2_1	463	469	PF00069	0.520
MOD_CK2_1	796	802	PF00069	0.420
MOD_Cter_Amidation	617	620	PF01082	0.424
MOD_DYRK1A_RPxSP_1	196	200	PF00069	0.558
MOD_GlcNHglycan	257	260	PF01048	0.619
MOD_GlcNHglycan	282	285	PF01048	0.689
MOD_GlcNHglycan	291	294	PF01048	0.700
MOD_GlcNHglycan	335	338	PF01048	0.647
MOD_GlcNHglycan	348	352	PF01048	0.633
MOD_GlcNHglycan	405	408	PF01048	0.445
MOD_GlcNHglycan	425	428	PF01048	0.383
MOD_GlcNHglycan	449	452	PF01048	0.571
MOD_GlcNHglycan	514	517	PF01048	0.231
MOD_GlcNHglycan	559	562	PF01048	0.635
MOD_GlcNHglycan	613	616	PF01048	0.518
MOD_GlcNHglycan	685	688	PF01048	0.484
MOD_GlcNHglycan	712	715	PF01048	0.559
MOD_GlcNHglycan	72	75	PF01048	0.646
MOD_GlcNHglycan	762	765	PF01048	0.539
MOD_GlcNHglycan	88	91	PF01048	0.695
MOD_GlcNHglycan	98	101	PF01048	0.641
MOD_GSK3_1	225	232	PF00069	0.701
MOD_GSK3_1	276	283	PF00069	0.626
MOD_GSK3_1	300	307	PF00069	0.716
MOD_GSK3_1	308	315	PF00069	0.669
MOD_GSK3_1	329	336	PF00069	0.734
MOD_GSK3_1	5	12	PF00069	0.539
MOD_GSK3_1	526	533	PF00069	0.444
MOD_GSK3_1	552	559	PF00069	0.646
MOD_GSK3_1	566	573	PF00069	0.663
MOD_GSK3_1	575	582	PF00069	0.565
MOD_GSK3_1	583	590	PF00069	0.571
MOD_GSK3_1	604	611	PF00069	0.438
MOD_GSK3_1	628	635	PF00069	0.452
MOD_GSK3_1	70	77	PF00069	0.706
MOD_GSK3_1	717	724	PF00069	0.520
MOD_GSK3_1	82	89	PF00069	0.551
MOD_LATS_1	326	332	PF00433	0.652
MOD_LATS_1	401	407	PF00433	0.485
MOD_N-GLC_1	172	177	PF02516	0.343
MOD_N-GLC_1	591	596	PF02516	0.452
MOD_NEK2_1	230	235	PF00069	0.683
MOD_NEK2_1	276	281	PF00069	0.540
MOD_NEK2_1	365	370	PF00069	0.296
MOD_NEK2_1	454	459	PF00069	0.398
MOD_NEK2_1	530	535	PF00069	0.471
MOD_NEK2_1	579	584	PF00069	0.601
MOD_NEK2_1	587	592	PF00069	0.490
MOD_NEK2_1	628	633	PF00069	0.451
MOD_NEK2_1	796	801	PF00069	0.557
MOD_NEK2_1	96	101	PF00069	0.540
MOD_NEK2_2	526	531	PF00069	0.399
MOD_PIKK_1	276	282	PF00454	0.602
MOD_PIKK_1	5	11	PF00454	0.484
MOD_PIKK_1	571	577	PF00454	0.641
MOD_PK_1	797	803	PF00069	0.517
MOD_PKA_1	14	20	PF00069	0.546
MOD_PKA_1	403	409	PF00069	0.426
MOD_PKA_1	682	688	PF00069	0.476
MOD_PKA_1	797	803	PF00069	0.449
MOD_PKA_2	112	118	PF00069	0.737
MOD_PKA_2	127	133	PF00069	0.603
MOD_PKA_2	243	249	PF00069	0.832
MOD_PKA_2	365	371	PF00069	0.418
MOD_PKA_2	556	562	PF00069	0.631
MOD_PKA_2	682	688	PF00069	0.476
MOD_PKA_2	717	723	PF00069	0.523
MOD_PKA_2	760	766	PF00069	0.543
MOD_PKA_2	796	802	PF00069	0.451
MOD_PKA_2	86	92	PF00069	0.672
MOD_PKB_1	795	803	PF00069	0.451
MOD_Plk_1	701	707	PF00069	0.472
MOD_Plk_2-3	112	118	PF00069	0.564
MOD_Plk_2-3	537	543	PF00069	0.471
MOD_Plk_4	181	187	PF00069	0.467
MOD_Plk_4	190	196	PF00069	0.430
MOD_Plk_4	207	213	PF00069	0.713
MOD_Plk_4	230	236	PF00069	0.511
MOD_Plk_4	31	37	PF00069	0.516
MOD_Plk_4	394	400	PF00069	0.513
MOD_Plk_4	583	589	PF00069	0.521
MOD_Plk_4	721	727	PF00069	0.484
MOD_ProDKin_1	172	178	PF00069	0.373
MOD_ProDKin_1	196	202	PF00069	0.568
MOD_ProDKin_1	310	316	PF00069	0.706
MOD_ProDKin_1	329	335	PF00069	0.504
MOD_ProDKin_1	352	358	PF00069	0.576
MOD_ProDKin_1	439	445	PF00069	0.594
MOD_ProDKin_1	552	558	PF00069	0.599
MOD_ProDKin_1	594	600	PF00069	0.383
MOD_ProDKin_1	639	645	PF00069	0.581
MOD_ProDKin_1	74	80	PF00069	0.674
MOD_SUMO_for_1	101	104	PF00179	0.632
MOD_SUMO_for_1	109	112	PF00179	0.599
MOD_SUMO_rev_2	77	85	PF00179	0.615
TRG_ENDOCYTIC_2	145	148	PF00928	0.575
TRG_ENDOCYTIC_2	49	52	PF00928	0.528
TRG_ENDOCYTIC_2	748	751	PF00928	0.543
TRG_ENDOCYTIC_2	770	773	PF00928	0.644
TRG_ENDOCYTIC_2	98	101	PF00928	0.511
TRG_ER_diArg_1	156	159	PF00400	0.399
TRG_ER_diArg_1	296	299	PF00400	0.536
TRG_ER_diArg_1	479	481	PF00400	0.471
TRG_ER_diArg_1	496	498	PF00400	0.471
TRG_ER_diArg_1	645	648	PF00400	0.594
TRG_ER_diArg_1	650	653	PF00400	0.556
TRG_ER_diArg_1	696	699	PF00400	0.608
TRG_ER_diArg_1	795	798	PF00400	0.469
TRG_NES_CRM1_1	732	747	PF08389	0.512
TRG_NLS_MonoExtC_3	296	302	PF00514	0.532
TRG_NLS_MonoExtC_3	43	48	PF00514	0.416
TRG_NLS_MonoExtC_3	645	650	PF00514	0.591
TRG_NLS_MonoExtN_4	643	650	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	698	702	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA05	Leptomonas seymouri	55%	97%
A0A3Q8IHQ6	Leishmania donovani	86%	100%
A4HPX7	Leishmania braziliensis	71%	100%
A4IDN8	Leishmania infantum	85%	100%
Q4Q0V5	Leishmania major	86%	100%