PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania mexicana

UniProt:

E9ATP0_LEIMU

TriTrypDb:

LmxM.36.4560

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.525
CLV_C14_Caspase3-7	581	585	PF00656	0.383
CLV_NRD_NRD_1	410	412	PF00675	0.447
CLV_NRD_NRD_1	473	475	PF00675	0.548
CLV_NRD_NRD_1	520	522	PF00675	0.296
CLV_PCSK_KEX2_1	410	412	PF00082	0.461
CLV_PCSK_KEX2_1	475	477	PF00082	0.502
CLV_PCSK_KEX2_1	520	522	PF00082	0.306
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.443
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.502
CLV_PCSK_SKI1_1	380	384	PF00082	0.580
CLV_PCSK_SKI1_1	412	416	PF00082	0.405
CLV_PCSK_SKI1_1	549	553	PF00082	0.296
CLV_Separin_Metazoa	565	569	PF03568	0.296
DEG_APCC_DBOX_1	11	19	PF00400	0.507
DOC_CYCLIN_RxL_1	189	200	PF00134	0.617
DOC_CYCLIN_RxL_1	32	43	PF00134	0.436
DOC_MAPK_gen_1	376	384	PF00069	0.582
DOC_MAPK_gen_1	474	483	PF00069	0.455
DOC_MAPK_gen_1	572	582	PF00069	0.296
DOC_MAPK_JIP1_4	378	384	PF00069	0.577
DOC_MAPK_MEF2A_6	400	409	PF00069	0.363
DOC_MAPK_MEF2A_6	435	443	PF00069	0.355
DOC_MAPK_MEF2A_6	474	483	PF00069	0.455
DOC_PP1_RVXF_1	547	554	PF00149	0.296
DOC_PP4_MxPP_1	206	209	PF00568	0.611
DOC_USP7_MATH_1	127	131	PF00917	0.657
DOC_USP7_MATH_1	234	238	PF00917	0.500
DOC_USP7_MATH_1	274	278	PF00917	0.547
DOC_USP7_MATH_1	399	403	PF00917	0.402
DOC_USP7_MATH_1	4	8	PF00917	0.490
DOC_USP7_MATH_1	463	467	PF00917	0.587
DOC_USP7_MATH_1	470	474	PF00917	0.514
DOC_WW_Pin1_4	105	110	PF00397	0.650
DOC_WW_Pin1_4	115	120	PF00397	0.569
DOC_WW_Pin1_4	185	190	PF00397	0.592
DOC_WW_Pin1_4	200	205	PF00397	0.636
DOC_WW_Pin1_4	245	250	PF00397	0.659
DOC_WW_Pin1_4	298	303	PF00397	0.619
DOC_WW_Pin1_4	321	326	PF00397	0.619
DOC_WW_Pin1_4	334	339	PF00397	0.532
DOC_WW_Pin1_4	388	393	PF00397	0.492
DOC_WW_Pin1_4	60	65	PF00397	0.531
LIG_14-3-3_CanoR_1	153	162	PF00244	0.495
LIG_14-3-3_CanoR_1	263	271	PF00244	0.547
LIG_14-3-3_CanoR_1	400	407	PF00244	0.367
LIG_14-3-3_CanoR_1	501	508	PF00244	0.296
LIG_Actin_WH2_2	485	503	PF00022	0.430
LIG_BIR_III_4	339	343	PF00653	0.631
LIG_BRCT_BRCA1_1	225	229	PF00533	0.601
LIG_BRCT_BRCA1_1	275	279	PF00533	0.626
LIG_FHA_1	126	132	PF00498	0.616
LIG_FHA_1	250	256	PF00498	0.593
LIG_FHA_1	34	40	PF00498	0.407
LIG_FHA_1	365	371	PF00498	0.479
LIG_FHA_2	512	518	PF00498	0.296
LIG_LIR_Apic_2	419	425	PF02991	0.387
LIG_LIR_Gen_1	40	48	PF02991	0.428
LIG_LIR_Gen_1	427	434	PF02991	0.393
LIG_LIR_Gen_1	78	87	PF02991	0.582
LIG_LIR_LC3C_4	438	443	PF02991	0.331
LIG_LIR_Nem_3	282	288	PF02991	0.472
LIG_LIR_Nem_3	40	44	PF02991	0.436
LIG_LIR_Nem_3	427	431	PF02991	0.388
LIG_LIR_Nem_3	562	566	PF02991	0.296
LIG_LIR_Nem_3	78	83	PF02991	0.625
LIG_PCNA_yPIPBox_3	153	162	PF02747	0.645
LIG_PDZ_Class_2	580	585	PF00595	0.371
LIG_SH2_GRB2like	72	75	PF00017	0.627
LIG_SH2_PTP2	422	425	PF00017	0.378
LIG_SH2_PTP2	428	431	PF00017	0.354
LIG_SH2_SRC	428	431	PF00017	0.354
LIG_SH2_STAP1	305	309	PF00017	0.620
LIG_SH2_STAT3	555	558	PF00017	0.296
LIG_SH2_STAT5	161	164	PF00017	0.651
LIG_SH2_STAT5	305	308	PF00017	0.658
LIG_SH2_STAT5	422	425	PF00017	0.378
LIG_SH2_STAT5	428	431	PF00017	0.354
LIG_SH2_STAT5	444	447	PF00017	0.357
LIG_SH3_3	116	122	PF00018	0.621
LIG_SH3_3	184	190	PF00018	0.722
LIG_SH3_3	201	207	PF00018	0.573
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.594
LIG_SUMO_SIM_par_1	256	262	PF11976	0.594
LIG_SUMO_SIM_par_1	536	541	PF11976	0.296
LIG_TYR_ITIM	39	44	PF00017	0.439
LIG_WRC_WIRS_1	571	576	PF05994	0.296
MOD_CDK_SPxK_1	115	121	PF00069	0.620
MOD_CDK_SPxK_1	185	191	PF00069	0.652
MOD_CDK_SPxK_1	388	394	PF00069	0.552
MOD_CDK_SPxxK_3	185	192	PF00069	0.575
MOD_CDK_SPxxK_3	321	328	PF00069	0.620
MOD_CK1_1	151	157	PF00069	0.597
MOD_CK1_1	178	184	PF00069	0.725
MOD_CK1_1	197	203	PF00069	0.524
MOD_CK1_1	237	243	PF00069	0.562
MOD_CK1_1	466	472	PF00069	0.481
MOD_CK1_1	78	84	PF00069	0.622
MOD_CK2_1	140	146	PF00069	0.555
MOD_CK2_1	253	259	PF00069	0.550
MOD_CK2_1	280	286	PF00069	0.474
MOD_CK2_1	37	43	PF00069	0.441
MOD_CK2_1	398	404	PF00069	0.443
MOD_CK2_1	511	517	PF00069	0.296
MOD_GlcNHglycan	109	112	PF01048	0.558
MOD_GlcNHglycan	150	153	PF01048	0.585
MOD_GlcNHglycan	155	158	PF01048	0.554
MOD_GlcNHglycan	218	221	PF01048	0.593
MOD_GlcNHglycan	225	228	PF01048	0.617
MOD_GlcNHglycan	267	270	PF01048	0.568
MOD_GlcNHglycan	276	279	PF01048	0.509
MOD_GlcNHglycan	343	346	PF01048	0.736
MOD_GlcNHglycan	459	462	PF01048	0.594
MOD_GlcNHglycan	470	473	PF01048	0.604
MOD_GlcNHglycan	80	83	PF01048	0.657
MOD_GlcNHglycan	87	90	PF01048	0.758
MOD_GlcNHglycan	94	97	PF01048	0.517
MOD_GSK3_1	121	128	PF00069	0.603
MOD_GSK3_1	237	244	PF00069	0.704
MOD_GSK3_1	245	252	PF00069	0.567
MOD_GSK3_1	270	277	PF00069	0.615
MOD_GSK3_1	292	299	PF00069	0.585
MOD_GSK3_1	33	40	PF00069	0.404
MOD_GSK3_1	462	469	PF00069	0.557
MOD_GSK3_1	60	67	PF00069	0.548
MOD_N-GLC_1	115	120	PF02516	0.622
MOD_N-GLC_1	200	205	PF02516	0.690
MOD_N-GLC_1	234	239	PF02516	0.646
MOD_N-GLC_1	264	269	PF02516	0.602
MOD_N-GLC_1	340	345	PF02516	0.540
MOD_N-GLC_1	495	500	PF02516	0.396
MOD_NEK2_1	131	136	PF00069	0.595
MOD_NEK2_1	148	153	PF00069	0.585
MOD_NEK2_1	194	199	PF00069	0.616
MOD_NEK2_1	221	226	PF00069	0.763
MOD_NEK2_1	229	234	PF00069	0.662
MOD_NEK2_1	264	269	PF00069	0.576
MOD_NEK2_1	366	371	PF00069	0.499
MOD_NEK2_1	37	42	PF00069	0.441
MOD_NEK2_1	483	488	PF00069	0.436
MOD_NEK2_1	511	516	PF00069	0.296
MOD_NEK2_1	531	536	PF00069	0.306
MOD_NEK2_1	570	575	PF00069	0.296
MOD_NEK2_1	92	97	PF00069	0.550
MOD_NEK2_2	354	359	PF00069	0.531
MOD_PIKK_1	194	200	PF00454	0.630
MOD_PIKK_1	249	255	PF00454	0.564
MOD_PIKK_1	296	302	PF00454	0.634
MOD_PIKK_1	313	319	PF00454	0.561
MOD_PIKK_1	4	10	PF00454	0.485
MOD_PIKK_1	511	517	PF00454	0.329
MOD_PKA_1	549	555	PF00069	0.296
MOD_PKA_2	399	405	PF00069	0.404
MOD_Plk_1	221	227	PF00069	0.555
MOD_Plk_1	531	537	PF00069	0.296
MOD_Plk_4	14	20	PF00069	0.437
MOD_Plk_4	241	247	PF00069	0.623
MOD_Plk_4	253	259	PF00069	0.550
MOD_Plk_4	280	286	PF00069	0.474
MOD_Plk_4	424	430	PF00069	0.429
MOD_Plk_4	495	501	PF00069	0.282
MOD_Plk_4	549	555	PF00069	0.296
MOD_Plk_4	75	81	PF00069	0.595
MOD_ProDKin_1	105	111	PF00069	0.651
MOD_ProDKin_1	115	121	PF00069	0.567
MOD_ProDKin_1	185	191	PF00069	0.595
MOD_ProDKin_1	200	206	PF00069	0.635
MOD_ProDKin_1	245	251	PF00069	0.656
MOD_ProDKin_1	298	304	PF00069	0.619
MOD_ProDKin_1	321	327	PF00069	0.618
MOD_ProDKin_1	334	340	PF00069	0.533
MOD_ProDKin_1	388	394	PF00069	0.493
MOD_ProDKin_1	60	66	PF00069	0.537
MOD_SUMO_rev_2	541	551	PF00179	0.296
TRG_DiLeu_BaEn_1	437	442	PF01217	0.335
TRG_ENDOCYTIC_2	285	288	PF00928	0.489
TRG_ENDOCYTIC_2	41	44	PF00928	0.437
TRG_ENDOCYTIC_2	428	431	PF00928	0.354
TRG_ENDOCYTIC_2	571	574	PF00928	0.296
TRG_ENDOCYTIC_2	72	75	PF00928	0.568
TRG_ER_diArg_1	376	379	PF00400	0.586
TRG_ER_diArg_1	411	414	PF00400	0.433
TRG_ER_diArg_1	51	54	PF00400	0.411
TRG_ER_diArg_1	574	577	PF00400	0.296
TRG_NES_CRM1_1	13	28	PF08389	0.411
TRG_NES_CRM1_1	43	57	PF08389	0.425
TRG_NLS_MonoCore_2	409	414	PF00514	0.374
TRG_NLS_MonoCore_2	473	478	PF00514	0.526
TRG_NLS_MonoExtN_4	410	415	PF00514	0.378
TRG_NLS_MonoExtN_4	474	479	PF00514	0.506
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P823	Leptomonas seymouri	61%	95%
A0A3Q8ILF1	Leishmania donovani	94%	100%
A4HPX4	Leishmania braziliensis	79%	100%
Q4Q0V8	Leishmania major	92%	100%