Related to elongation factor-2 kinase efk-1b isoform-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

related to elongation factor-2 kinase efk-1b isoform-like protein

Species:

Leishmania mexicana

UniProt:

E9ATN8_LEIMU

TriTrypDb:

LmxM.36.4550

Length:

861

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATN8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003676	nucleic acid binding	3	5
GO:0003746	translation elongation factor activity	4	5
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0008135	translation factor activity, RNA binding	3	5
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0045182	translation regulator activity	1	5
GO:0090079	translation regulator activity, nucleic acid binding	2	5
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.416
CLV_C14_Caspase3-7	159	163	PF00656	0.505
CLV_C14_Caspase3-7	325	329	PF00656	0.391
CLV_C14_Caspase3-7	40	44	PF00656	0.281
CLV_C14_Caspase3-7	412	416	PF00656	0.346
CLV_NRD_NRD_1	480	482	PF00675	0.607
CLV_NRD_NRD_1	554	556	PF00675	0.566
CLV_NRD_NRD_1	636	638	PF00675	0.527
CLV_PCSK_KEX2_1	480	482	PF00082	0.607
CLV_PCSK_KEX2_1	537	539	PF00082	0.610
CLV_PCSK_KEX2_1	554	556	PF00082	0.441
CLV_PCSK_KEX2_1	593	595	PF00082	0.471
CLV_PCSK_KEX2_1	636	638	PF00082	0.527
CLV_PCSK_KEX2_1	698	700	PF00082	0.459
CLV_PCSK_KEX2_1	97	99	PF00082	0.317
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.604
CLV_PCSK_PC1ET2_1	593	595	PF00082	0.471
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.459
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.290
CLV_PCSK_PC7_1	533	539	PF00082	0.565
CLV_PCSK_SKI1_1	199	203	PF00082	0.472
CLV_PCSK_SKI1_1	230	234	PF00082	0.311
CLV_PCSK_SKI1_1	251	255	PF00082	0.447
CLV_PCSK_SKI1_1	443	447	PF00082	0.554
CLV_PCSK_SKI1_1	555	559	PF00082	0.532
CLV_PCSK_SKI1_1	560	564	PF00082	0.460
CLV_PCSK_SKI1_1	593	597	PF00082	0.436
CLV_PCSK_SKI1_1	637	641	PF00082	0.391
CLV_PCSK_SKI1_1	712	716	PF00082	0.391
CLV_PCSK_SKI1_1	810	814	PF00082	0.346
CLV_PCSK_SKI1_1	832	836	PF00082	0.477
CLV_Separin_Metazoa	561	565	PF03568	0.439
DEG_APCC_DBOX_1	781	789	PF00400	0.346
DEG_Nend_UBRbox_2	1	3	PF02207	0.427
DEG_SPOP_SBC_1	402	406	PF00917	0.222
DOC_AGCK_PIF_1	45	50	PF00069	0.391
DOC_ANK_TNKS_1	38	45	PF00023	0.346
DOC_ANK_TNKS_1	851	858	PF00023	0.316
DOC_CYCLIN_RxL_1	440	451	PF00134	0.546
DOC_CYCLIN_RxL_1	554	567	PF00134	0.349
DOC_CYCLIN_RxL_1	816	828	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.391
DOC_MAPK_gen_1	140	149	PF00069	0.599
DOC_MAPK_gen_1	480	487	PF00069	0.484
DOC_MAPK_gen_1	593	599	PF00069	0.453
DOC_MAPK_gen_1	841	849	PF00069	0.426
DOC_MAPK_MEF2A_6	140	149	PF00069	0.599
DOC_MAPK_RevD_3	147	161	PF00069	0.491
DOC_PP1_RVXF_1	289	296	PF00149	0.391
DOC_PP1_RVXF_1	469	476	PF00149	0.461
DOC_PP1_RVXF_1	610	616	PF00149	0.391
DOC_PP1_RVXF_1	710	716	PF00149	0.346
DOC_PP4_FxxP_1	475	478	PF00568	0.461
DOC_PP4_FxxP_1	519	522	PF00568	0.672
DOC_USP7_MATH_1	185	189	PF00917	0.585
DOC_USP7_MATH_1	476	480	PF00917	0.554
DOC_USP7_MATH_1	488	492	PF00917	0.581
DOC_USP7_MATH_1	501	505	PF00917	0.539
DOC_USP7_MATH_1	507	511	PF00917	0.481
DOC_USP7_MATH_1	515	519	PF00917	0.504
DOC_USP7_MATH_1	547	551	PF00917	0.537
DOC_USP7_UBL2_3	537	541	PF12436	0.607
DOC_WW_Pin1_4	172	177	PF00397	0.605
DOC_WW_Pin1_4	341	346	PF00397	0.391
DOC_WW_Pin1_4	450	455	PF00397	0.496
DOC_WW_Pin1_4	474	479	PF00397	0.569
DOC_WW_Pin1_4	588	593	PF00397	0.367
DOC_WW_Pin1_4	689	694	PF00397	0.267
DOC_WW_Pin1_4	741	746	PF00397	0.346
LIG_14-3-3_CanoR_1	215	224	PF00244	0.519
LIG_14-3-3_CanoR_1	324	332	PF00244	0.391
LIG_14-3-3_CanoR_1	480	488	PF00244	0.640
LIG_14-3-3_CanoR_1	554	563	PF00244	0.529
LIG_14-3-3_CanoR_1	782	790	PF00244	0.222
LIG_14-3-3_CanoR_1	832	837	PF00244	0.377
LIG_Actin_RPEL_3	557	576	PF02755	0.448
LIG_APCC_ABBA_1	147	152	PF00400	0.601
LIG_APCC_ABBAyCdc20_2	146	152	PF00400	0.603
LIG_BIR_III_4	357	361	PF00653	0.391
LIG_BRCT_BRCA1_1	170	174	PF00533	0.591
LIG_BRCT_BRCA1_1	318	322	PF00533	0.391
LIG_BRCT_BRCA1_1	656	660	PF00533	0.391
LIG_BRCT_BRCA1_1	78	82	PF00533	0.360
LIG_BRCT_BRCA1_2	656	662	PF00533	0.391
LIG_Clathr_ClatBox_1	435	439	PF01394	0.405
LIG_CSL_BTD_1	589	592	PF09270	0.361
LIG_deltaCOP1_diTrp_1	587	596	PF00928	0.461
LIG_eIF4E_1	68	74	PF01652	0.391
LIG_FHA_1	134	140	PF00498	0.634
LIG_FHA_1	298	304	PF00498	0.267
LIG_FHA_1	509	515	PF00498	0.600
LIG_FHA_1	570	576	PF00498	0.495
LIG_FHA_1	708	714	PF00498	0.470
LIG_FHA_1	835	841	PF00498	0.498
LIG_FHA_2	165	171	PF00498	0.641
LIG_FHA_2	224	230	PF00498	0.378
LIG_FHA_2	323	329	PF00498	0.391
LIG_FHA_2	410	416	PF00498	0.346
LIG_FHA_2	556	562	PF00498	0.524
LIG_FHA_2	577	583	PF00498	0.442
LIG_FHA_2	616	622	PF00498	0.374
LIG_FHA_2	75	81	PF00498	0.391
LIG_FHA_2	784	790	PF00498	0.391
LIG_FHA_2	833	839	PF00498	0.462
LIG_Integrin_RGD_1	28	30	PF01839	0.612
LIG_LIR_Apic_2	474	478	PF02991	0.464
LIG_LIR_Apic_2	518	522	PF02991	0.666
LIG_LIR_Apic_2	572	577	PF02991	0.409
LIG_LIR_Gen_1	228	236	PF02991	0.495
LIG_LIR_Gen_1	260	270	PF02991	0.331
LIG_LIR_Gen_1	359	369	PF02991	0.357
LIG_LIR_Gen_1	371	378	PF02991	0.310
LIG_LIR_Gen_1	43	51	PF02991	0.376
LIG_LIR_Gen_1	646	656	PF02991	0.391
LIG_LIR_Gen_1	752	761	PF02991	0.480
LIG_LIR_Nem_3	132	138	PF02991	0.635
LIG_LIR_Nem_3	228	234	PF02991	0.497
LIG_LIR_Nem_3	260	266	PF02991	0.474
LIG_LIR_Nem_3	337	343	PF02991	0.391
LIG_LIR_Nem_3	359	364	PF02991	0.357
LIG_LIR_Nem_3	36	41	PF02991	0.391
LIG_LIR_Nem_3	371	376	PF02991	0.310
LIG_LIR_Nem_3	43	48	PF02991	0.324
LIG_LIR_Nem_3	646	651	PF02991	0.391
LIG_LIR_Nem_3	700	705	PF02991	0.527
LIG_LIR_Nem_3	752	758	PF02991	0.480
LIG_MLH1_MIPbox_1	318	322	PF16413	0.391
LIG_NRBOX	431	437	PF00104	0.344
LIG_Pex14_2	660	664	PF04695	0.527
LIG_Pex14_2	846	850	PF04695	0.429
LIG_REV1ctd_RIR_1	319	328	PF16727	0.391
LIG_REV1ctd_RIR_1	700	710	PF16727	0.527
LIG_SH2_PTP2	200	203	PF00017	0.509
LIG_SH2_PTP2	574	577	PF00017	0.404
LIG_SH2_SRC	574	577	PF00017	0.404
LIG_SH2_STAP1	135	139	PF00017	0.636
LIG_SH2_STAP1	231	235	PF00017	0.429
LIG_SH2_STAP1	299	303	PF00017	0.373
LIG_SH2_STAP1	581	585	PF00017	0.453
LIG_SH2_STAT3	793	796	PF00017	0.391
LIG_SH2_STAT5	135	138	PF00017	0.634
LIG_SH2_STAT5	200	203	PF00017	0.509
LIG_SH2_STAT5	270	273	PF00017	0.389
LIG_SH2_STAT5	299	302	PF00017	0.281
LIG_SH2_STAT5	50	53	PF00017	0.391
LIG_SH2_STAT5	574	577	PF00017	0.530
LIG_SH2_STAT5	647	650	PF00017	0.527
LIG_SH2_STAT5	68	71	PF00017	0.218
LIG_SH3_3	198	204	PF00018	0.502
LIG_SH3_3	298	304	PF00018	0.346
LIG_SH3_3	332	338	PF00018	0.352
LIG_SH3_3	339	345	PF00018	0.364
LIG_SH3_3	482	488	PF00018	0.488
LIG_SH3_3	519	525	PF00018	0.667
LIG_SH3_3	528	534	PF00018	0.553
LIG_SUMO_SIM_par_1	682	687	PF11976	0.335
LIG_TRAF2_1	235	238	PF00917	0.491
LIG_TRAF2_1	526	529	PF00917	0.547
LIG_TRAF2_1	624	627	PF00917	0.222
LIG_TRAF2_1	858	861	PF00917	0.447
LIG_TRFH_1	252	256	PF08558	0.469
LIG_TRFH_1	68	72	PF08558	0.391
LIG_TYR_ITIM	198	203	PF00017	0.494
LIG_UBA3_1	562	568	PF00899	0.497
LIG_UBA3_1	849	854	PF00899	0.404
LIG_WRC_WIRS_1	516	521	PF05994	0.617
MOD_CDC14_SPxK_1	477	480	PF00782	0.526
MOD_CDK_SPK_2	588	593	PF00069	0.362
MOD_CDK_SPxK_1	474	480	PF00069	0.524
MOD_CDK_SPxK_1	588	594	PF00069	0.361
MOD_CDK_SPxxK_3	450	457	PF00069	0.493
MOD_CDK_SPxxK_3	474	481	PF00069	0.571
MOD_CK1_1	14	20	PF00069	0.613
MOD_CK1_1	169	175	PF00069	0.684
MOD_CK1_1	374	380	PF00069	0.391
MOD_CK1_1	46	52	PF00069	0.391
MOD_CK1_1	704	710	PF00069	0.527
MOD_CK1_1	762	768	PF00069	0.527
MOD_CK2_1	164	170	PF00069	0.660
MOD_CK2_1	493	499	PF00069	0.589
MOD_CK2_1	523	529	PF00069	0.547
MOD_CK2_1	555	561	PF00069	0.531
MOD_CK2_1	74	80	PF00069	0.391
MOD_CK2_1	783	789	PF00069	0.391
MOD_CK2_1	855	861	PF00069	0.404
MOD_CK2_1	87	93	PF00069	0.266
MOD_GlcNHglycan	120	123	PF01048	0.498
MOD_GlcNHglycan	162	165	PF01048	0.620
MOD_GlcNHglycan	218	221	PF01048	0.491
MOD_GlcNHglycan	328	331	PF01048	0.391
MOD_GlcNHglycan	380	383	PF01048	0.391
MOD_GlcNHglycan	405	408	PF01048	0.346
MOD_GlcNHglycan	505	508	PF01048	0.617
MOD_GlcNHglycan	542	545	PF01048	0.643
MOD_GlcNHglycan	549	552	PF01048	0.607
MOD_GlcNHglycan	89	92	PF01048	0.346
MOD_GSK3_1	160	167	PF00069	0.637
MOD_GSK3_1	168	175	PF00069	0.572
MOD_GSK3_1	20	27	PF00069	0.481
MOD_GSK3_1	214	221	PF00069	0.463
MOD_GSK3_1	322	329	PF00069	0.374
MOD_GSK3_1	341	348	PF00069	0.263
MOD_GSK3_1	374	381	PF00069	0.391
MOD_GSK3_1	46	53	PF00069	0.391
MOD_GSK3_1	476	483	PF00069	0.599
MOD_GSK3_1	493	500	PF00069	0.517
MOD_GSK3_1	501	508	PF00069	0.631
MOD_GSK3_1	536	543	PF00069	0.527
MOD_GSK3_1	697	704	PF00069	0.521
MOD_GSK3_1	762	769	PF00069	0.527
MOD_N-GLC_1	402	407	PF02516	0.391
MOD_N-GLC_1	448	453	PF02516	0.385
MOD_N-GLC_1	783	788	PF02516	0.222
MOD_N-GLC_2	739	741	PF02516	0.391
MOD_NEK2_1	108	113	PF00069	0.526
MOD_NEK2_1	11	16	PF00069	0.609
MOD_NEK2_1	214	219	PF00069	0.485
MOD_NEK2_1	24	29	PF00069	0.503
MOD_NEK2_1	322	327	PF00069	0.378
MOD_NEK2_1	378	383	PF00069	0.391
MOD_NEK2_1	615	620	PF00069	0.222
MOD_NEK2_2	101	106	PF00069	0.391
MOD_NEK2_2	138	143	PF00069	0.585
MOD_NEK2_2	297	302	PF00069	0.222
MOD_NEK2_2	635	640	PF00069	0.391
MOD_PIKK_1	493	499	PF00454	0.578
MOD_PIKK_1	524	530	PF00454	0.489
MOD_PIKK_1	555	561	PF00454	0.564
MOD_PKA_1	160	166	PF00069	0.576
MOD_PKA_1	480	486	PF00069	0.605
MOD_PKA_2	214	220	PF00069	0.498
MOD_PKA_2	323	329	PF00069	0.391
MOD_PKA_2	480	486	PF00069	0.650
MOD_PKA_2	553	559	PF00069	0.554
MOD_PKA_2	635	641	PF00069	0.391
MOD_PKA_2	723	729	PF00069	0.380
MOD_PKA_2	815	821	PF00069	0.391
MOD_PKB_1	830	838	PF00069	0.389
MOD_Plk_1	20	26	PF00069	0.491
MOD_Plk_1	586	592	PF00069	0.482
MOD_Plk_1	625	631	PF00069	0.222
MOD_Plk_1	749	755	PF00069	0.391
MOD_Plk_2-3	789	795	PF00069	0.391
MOD_Plk_4	28	34	PF00069	0.463
MOD_Plk_4	490	496	PF00069	0.506
MOD_Plk_4	515	521	PF00069	0.658
MOD_Plk_4	570	576	PF00069	0.303
MOD_Plk_4	625	631	PF00069	0.346
MOD_Plk_4	655	661	PF00069	0.319
MOD_ProDKin_1	172	178	PF00069	0.605
MOD_ProDKin_1	341	347	PF00069	0.391
MOD_ProDKin_1	450	456	PF00069	0.490
MOD_ProDKin_1	474	480	PF00069	0.569
MOD_ProDKin_1	588	594	PF00069	0.367
MOD_ProDKin_1	689	695	PF00069	0.267
MOD_ProDKin_1	741	747	PF00069	0.346
MOD_SUMO_rev_2	838	842	PF00179	0.458
TRG_AP2beta_CARGO_1	43	52	PF09066	0.346
TRG_DiLeu_BaEn_1	770	775	PF01217	0.346
TRG_ENDOCYTIC_2	200	203	PF00928	0.509
TRG_ENDOCYTIC_2	231	234	PF00928	0.465
TRG_ENDOCYTIC_2	263	266	PF00928	0.470
TRG_ENDOCYTIC_2	38	41	PF00928	0.391
TRG_ER_diArg_1	248	251	PF00400	0.487
TRG_ER_diArg_1	480	482	PF00400	0.607
TRG_ER_diArg_1	51	54	PF00400	0.346
TRG_ER_diArg_1	635	637	PF00400	0.527
TRG_ER_diArg_1	813	816	PF00400	0.346
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IWB8	Leishmania donovani	86%	75%
A4HPX2	Leishmania braziliensis	69%	100%
A4IDN4	Leishmania infantum	86%	75%
Q4Q0V9	Leishmania major	85%	100%