HRDC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2870), putative

Species:

Leishmania mexicana

UniProt:

E9ATN4_LEIMU

TriTrypDb:

LmxM.36.4500

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATN4

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	16
GO:0032886	regulation of microtubule-based process	4	16
GO:0050789	regulation of biological process	2	16
GO:0050794	regulation of cellular process	3	16
GO:0060632	regulation of microtubule-based movement	5	16
GO:0065007	biological regulation	1	16

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.453
CLV_C14_Caspase3-7	33	37	PF00656	0.496
CLV_C14_Caspase3-7	97	101	PF00656	0.443
CLV_NRD_NRD_1	223	225	PF00675	0.285
CLV_NRD_NRD_1	90	92	PF00675	0.525
CLV_PCSK_KEX2_1	7	9	PF00082	0.408
CLV_PCSK_KEX2_1	90	92	PF00082	0.504
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.408
DEG_APCC_DBOX_1	44	52	PF00400	0.452
DOC_CYCLIN_RxL_1	78	89	PF00134	0.512
DOC_MAPK_gen_1	186	196	PF00069	0.469
DOC_MAPK_gen_1	87	95	PF00069	0.509
DOC_MAPK_MEF2A_6	107	114	PF00069	0.470
DOC_MAPK_MEF2A_6	189	196	PF00069	0.468
DOC_PP1_RVXF_1	162	169	PF00149	0.536
DOC_PP1_RVXF_1	45	51	PF00149	0.391
DOC_USP7_MATH_1	116	120	PF00917	0.471
DOC_USP7_MATH_1	175	179	PF00917	0.487
DOC_USP7_MATH_1	198	202	PF00917	0.549
DOC_USP7_MATH_2	10	16	PF00917	0.572
DOC_USP7_UBL2_3	182	186	PF12436	0.478
DOC_USP7_UBL2_3	191	195	PF12436	0.468
DOC_USP7_UBL2_3	56	60	PF12436	0.438
DOC_USP7_UBL2_3	7	11	PF12436	0.445
LIG_14-3-3_CanoR_1	146	151	PF00244	0.432
LIG_14-3-3_CanoR_1	45	51	PF00244	0.497
LIG_14-3-3_CanoR_1	81	86	PF00244	0.508
LIG_CaM_IQ_9	216	232	PF13499	0.561
LIG_EH1_1	144	152	PF00400	0.509
LIG_FHA_1	191	197	PF00498	0.468
LIG_FHA_1	26	32	PF00498	0.507
LIG_FHA_1	33	39	PF00498	0.417
LIG_FHA_1	71	77	PF00498	0.492
LIG_FHA_2	133	139	PF00498	0.537
LIG_LIR_Apic_2	243	248	PF02991	0.491
LIG_LIR_Gen_1	15	26	PF02991	0.422
LIG_LIR_Gen_1	79	89	PF02991	0.439
LIG_LIR_Nem_3	15	21	PF02991	0.435
LIG_LIR_Nem_3	177	183	PF02991	0.525
LIG_LIR_Nem_3	79	85	PF02991	0.409
LIG_PCNA_PIPBox_1	215	224	PF02747	0.480
LIG_PCNA_yPIPBox_3	224	233	PF02747	0.523
LIG_PCNA_yPIPBox_3	90	103	PF02747	0.471
LIG_SH2_STAP1	14	18	PF00017	0.470
LIG_SH2_STAT3	223	226	PF00017	0.519
LIG_SH2_STAT5	183	186	PF00017	0.493
LIG_SH2_STAT5	71	74	PF00017	0.545
LIG_SH2_STAT5	82	85	PF00017	0.458
LIG_SH3_3	202	208	PF00018	0.484
LIG_TRAF2_1	10	13	PF00917	0.564
LIG_WW_3	203	207	PF00397	0.480
MOD_GlcNHglycan	117	121	PF01048	0.440
MOD_GlcNHglycan	161	164	PF01048	0.515
MOD_GlcNHglycan	169	172	PF01048	0.256
MOD_GlcNHglycan	199	203	PF01048	0.348
MOD_GlcNHglycan	242	245	PF01048	0.278
MOD_GSK3_1	21	28	PF00069	0.444
MOD_GSK3_1	236	243	PF00069	0.463
MOD_GSK3_1	81	88	PF00069	0.541
MOD_NEK2_1	167	172	PF00069	0.480
MOD_NEK2_1	21	26	PF00069	0.376
MOD_NEK2_1	240	245	PF00069	0.547
MOD_NEK2_1	41	46	PF00069	0.411
MOD_NEK2_2	257	262	PF00069	0.506
MOD_PKA_2	175	181	PF00069	0.487
MOD_PKA_2	46	52	PF00069	0.458
MOD_Plk_1	236	242	PF00069	0.480
MOD_Plk_4	146	152	PF00069	0.422
MOD_Plk_4	46	52	PF00069	0.509
MOD_SUMO_for_1	10	13	PF00179	0.498
MOD_SUMO_rev_2	207	214	PF00179	0.480
MOD_SUMO_rev_2	227	232	PF00179	0.339
TRG_DiLeu_BaEn_1	98	103	PF01217	0.448
TRG_ENDOCYTIC_2	18	21	PF00928	0.402
TRG_ENDOCYTIC_2	82	85	PF00928	0.408
TRG_ER_diArg_1	45	48	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY2	Leptomonas seymouri	84%	100%
A0A0S4JE13	Bodo saltans	21%	92%
A0A0S4JRV9	Bodo saltans	57%	100%
A0A1X0P0N8	Trypanosomatidae	65%	100%
A0A3Q8IRH9	Leishmania donovani	96%	100%
A0A3R7NWF2	Trypanosoma rangeli	66%	100%
A0A422MZF7	Trypanosoma rangeli	23%	92%
A4HPL6	Leishmania braziliensis	24%	79%
A4HPW7	Leishmania braziliensis	94%	100%
A4IDM9	Leishmania infantum	96%	100%
D0A4B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
Q4Q0W4	Leishmania major	96%	100%
V5B520	Trypanosoma cruzi	67%	100%
V5B6Z0	Trypanosoma cruzi	24%	94%