Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATN3_LEIMU

TriTrypDb:

LmxM.36.4490

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATN3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0032259	methylation	2	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0043414	macromolecule methylation	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008276	protein methyltransferase activity	3	5
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901363	heterocyclic compound binding	2	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.710
CLV_C14_Caspase3-7	135	139	PF00656	0.464
CLV_C14_Caspase3-7	390	394	PF00656	0.548
CLV_NRD_NRD_1	229	231	PF00675	0.451
CLV_NRD_NRD_1	29	31	PF00675	0.607
CLV_NRD_NRD_1	460	462	PF00675	0.486
CLV_NRD_NRD_1	80	82	PF00675	0.769
CLV_PCSK_FUR_1	458	462	PF00082	0.517
CLV_PCSK_KEX2_1	229	231	PF00082	0.435
CLV_PCSK_KEX2_1	233	235	PF00082	0.415
CLV_PCSK_KEX2_1	29	31	PF00082	0.646
CLV_PCSK_KEX2_1	460	462	PF00082	0.507
CLV_PCSK_KEX2_1	80	82	PF00082	0.612
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.524
CLV_PCSK_PC7_1	229	235	PF00082	0.495
CLV_PCSK_SKI1_1	175	179	PF00082	0.392
CLV_PCSK_SKI1_1	230	234	PF00082	0.414
CLV_PCSK_SKI1_1	290	294	PF00082	0.567
CLV_PCSK_SKI1_1	427	431	PF00082	0.424
CLV_PCSK_SKI1_1	453	457	PF00082	0.473
CLV_PCSK_SKI1_1	506	510	PF00082	0.430
CLV_Separin_Metazoa	463	467	PF03568	0.424
DEG_APCC_DBOX_1	233	241	PF00400	0.539
DOC_ANK_TNKS_1	124	131	PF00023	0.713
DOC_CYCLIN_RxL_1	172	179	PF00134	0.549
DOC_CYCLIN_RxL_1	229	241	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.370
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.184
DOC_MAPK_gen_1	436	444	PF00069	0.512
DOC_MAPK_gen_1	488	497	PF00069	0.519
DOC_MAPK_MEF2A_6	466	475	PF00069	0.475
DOC_MAPK_MEF2A_6	490	499	PF00069	0.480
DOC_PP2B_PxIxI_1	468	474	PF00149	0.494
DOC_USP7_MATH_1	136	140	PF00917	0.705
DOC_USP7_MATH_1	288	292	PF00917	0.457
DOC_USP7_MATH_1	358	362	PF00917	0.385
DOC_USP7_MATH_1	47	51	PF00917	0.678
DOC_USP7_MATH_1	70	74	PF00917	0.702
DOC_WW_Pin1_4	168	173	PF00397	0.532
DOC_WW_Pin1_4	295	300	PF00397	0.682
DOC_WW_Pin1_4	349	354	PF00397	0.398
LIG_14-3-3_CanoR_1	290	299	PF00244	0.587
LIG_14-3-3_CanoR_1	355	363	PF00244	0.391
LIG_14-3-3_CanoR_1	46	52	PF00244	0.633
LIG_14-3-3_CanoR_1	56	63	PF00244	0.669
LIG_14-3-3_CanoR_1	81	91	PF00244	0.751
LIG_Actin_WH2_2	14	31	PF00022	0.589
LIG_Actin_WH2_2	65	82	PF00022	0.692
LIG_APCC_ABBA_1	495	500	PF00400	0.378
LIG_BRCT_BRCA1_1	251	255	PF00533	0.490
LIG_BRCT_BRCA1_1	360	364	PF00533	0.328
LIG_Clathr_ClatBox_1	142	146	PF01394	0.447
LIG_CtBP_PxDLS_1	15	19	PF00389	0.604
LIG_deltaCOP1_diTrp_1	206	213	PF00928	0.374
LIG_deltaCOP1_diTrp_1	274	279	PF00928	0.357
LIG_EH1_1	479	487	PF00400	0.514
LIG_FHA_1	311	317	PF00498	0.328
LIG_FHA_1	396	402	PF00498	0.506
LIG_FHA_1	426	432	PF00498	0.526
LIG_FHA_1	46	52	PF00498	0.689
LIG_FHA_2	146	152	PF00498	0.606
LIG_FHA_2	291	297	PF00498	0.453
LIG_FHA_2	328	334	PF00498	0.404
LIG_FHA_2	355	361	PF00498	0.342
LIG_FHA_2	388	394	PF00498	0.568
LIG_FHA_2	420	426	PF00498	0.460
LIG_Integrin_RGD_1	125	127	PF01839	0.711
LIG_LIR_Gen_1	354	364	PF02991	0.318
LIG_LIR_Gen_1	398	407	PF02991	0.412
LIG_LIR_Gen_1	412	421	PF02991	0.420
LIG_LIR_Gen_1	438	449	PF02991	0.444
LIG_LIR_Gen_1	90	98	PF02991	0.597
LIG_LIR_Nem_3	17	23	PF02991	0.555
LIG_LIR_Nem_3	184	189	PF02991	0.498
LIG_LIR_Nem_3	277	282	PF02991	0.460
LIG_LIR_Nem_3	361	367	PF02991	0.368
LIG_LIR_Nem_3	398	402	PF02991	0.361
LIG_LIR_Nem_3	412	417	PF02991	0.423
LIG_LIR_Nem_3	438	444	PF02991	0.446
LIG_LIR_Nem_3	489	495	PF02991	0.396
LIG_LIR_Nem_3	90	94	PF02991	0.683
LIG_MYND_1	265	269	PF01753	0.371
LIG_PTB_Apo_2	402	409	PF02174	0.364
LIG_PTB_Phospho_1	402	408	PF10480	0.362
LIG_SH2_CRK	282	286	PF00017	0.246
LIG_SH2_CRK	399	403	PF00017	0.505
LIG_SH2_PTP2	408	411	PF00017	0.397
LIG_SH2_PTP2	414	417	PF00017	0.434
LIG_SH2_SRC	248	251	PF00017	0.376
LIG_SH2_STAP1	183	187	PF00017	0.456
LIG_SH2_STAP1	282	286	PF00017	0.246
LIG_SH2_STAP1	399	403	PF00017	0.505
LIG_SH2_STAP1	41	45	PF00017	0.581
LIG_SH2_STAT3	501	504	PF00017	0.445
LIG_SH2_STAT5	102	105	PF00017	0.665
LIG_SH2_STAT5	248	251	PF00017	0.351
LIG_SH2_STAT5	284	287	PF00017	0.311
LIG_SH2_STAT5	356	359	PF00017	0.358
LIG_SH2_STAT5	408	411	PF00017	0.418
LIG_SH2_STAT5	414	417	PF00017	0.465
LIG_SH2_STAT5	441	444	PF00017	0.375
LIG_SH2_STAT5	71	74	PF00017	0.682
LIG_SH3_3	191	197	PF00018	0.584
LIG_SH3_3	400	406	PF00018	0.366
LIG_SH3_3	412	418	PF00018	0.435
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.510
LIG_SUMO_SIM_anti_2	330	337	PF11976	0.413
LIG_TRAF2_1	502	505	PF00917	0.576
LIG_TRAF2_2	373	378	PF00917	0.436
LIG_TRAF2_2	411	416	PF00917	0.432
LIG_UBA3_1	177	185	PF00899	0.539
LIG_WRC_WIRS_1	91	96	PF05994	0.462
MOD_CDC14_SPxK_1	302	305	PF00782	0.449
MOD_CDC14_SPxK_1	352	355	PF00782	0.398
MOD_CDK_SPK_2	168	173	PF00069	0.532
MOD_CDK_SPxK_1	299	305	PF00069	0.449
MOD_CDK_SPxK_1	349	355	PF00069	0.398
MOD_CDK_SPxxK_3	168	175	PF00069	0.385
MOD_CK1_1	107	113	PF00069	0.584
MOD_CK1_1	59	65	PF00069	0.602
MOD_CK1_1	90	96	PF00069	0.755
MOD_CK2_1	145	151	PF00069	0.566
MOD_CK2_1	168	174	PF00069	0.430
MOD_CK2_1	221	227	PF00069	0.594
MOD_CK2_1	232	238	PF00069	0.325
MOD_CK2_1	354	360	PF00069	0.461
MOD_CK2_1	419	425	PF00069	0.463
MOD_CK2_1	81	87	PF00069	0.704
MOD_CMANNOS	276	279	PF00535	0.359
MOD_GlcNHglycan	133	137	PF01048	0.760
MOD_GlcNHglycan	161	164	PF01048	0.542
MOD_GlcNHglycan	325	328	PF01048	0.407
MOD_GlcNHglycan	378	381	PF01048	0.641
MOD_GlcNHglycan	511	514	PF01048	0.385
MOD_GlcNHglycan	84	87	PF01048	0.678
MOD_GlcNHglycan	94	97	PF01048	0.651
MOD_GSK3_1	132	139	PF00069	0.706
MOD_GSK3_1	270	277	PF00069	0.377
MOD_GSK3_1	288	295	PF00069	0.552
MOD_GSK3_1	323	330	PF00069	0.449
MOD_GSK3_1	354	361	PF00069	0.455
MOD_GSK3_1	376	383	PF00069	0.688
MOD_GSK3_1	419	426	PF00069	0.476
MOD_GSK3_1	47	54	PF00069	0.673
MOD_GSK3_1	59	66	PF00069	0.567
MOD_GSK3_1	92	99	PF00069	0.749
MOD_N-GLC_1	107	112	PF02516	0.753
MOD_N-GLC_1	136	141	PF02516	0.690
MOD_NEK2_1	159	164	PF00069	0.407
MOD_NEK2_1	280	285	PF00069	0.302
MOD_NEK2_1	40	45	PF00069	0.624
MOD_NEK2_1	486	491	PF00069	0.443
MOD_NEK2_1	51	56	PF00069	0.617
MOD_NEK2_1	63	68	PF00069	0.720
MOD_PIKK_1	249	255	PF00454	0.487
MOD_PKA_1	80	86	PF00069	0.482
MOD_PKA_2	221	227	PF00069	0.590
MOD_PKA_2	23	29	PF00069	0.483
MOD_PKA_2	339	345	PF00069	0.475
MOD_PKA_2	354	360	PF00069	0.228
MOD_PKA_2	435	441	PF00069	0.498
MOD_PKA_2	45	51	PF00069	0.660
MOD_PKA_2	80	86	PF00069	0.654
MOD_PKB_1	44	52	PF00069	0.531
MOD_PKB_1	56	64	PF00069	0.645
MOD_Plk_1	136	142	PF00069	0.594
MOD_Plk_1	288	294	PF00069	0.307
MOD_Plk_1	59	65	PF00069	0.571
MOD_Plk_2-3	146	152	PF00069	0.670
MOD_Plk_2-3	87	93	PF00069	0.608
MOD_Plk_4	190	196	PF00069	0.602
MOD_Plk_4	244	250	PF00069	0.446
MOD_Plk_4	280	286	PF00069	0.236
MOD_Plk_4	47	53	PF00069	0.672
MOD_ProDKin_1	168	174	PF00069	0.525
MOD_ProDKin_1	295	301	PF00069	0.670
MOD_ProDKin_1	349	355	PF00069	0.398
MOD_SUMO_rev_2	144	154	PF00179	0.642
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.382
TRG_ENDOCYTIC_2	183	186	PF00928	0.454
TRG_ENDOCYTIC_2	282	285	PF00928	0.480
TRG_ENDOCYTIC_2	356	359	PF00928	0.314
TRG_ENDOCYTIC_2	399	402	PF00928	0.442
TRG_ENDOCYTIC_2	414	417	PF00928	0.336
TRG_ENDOCYTIC_2	441	444	PF00928	0.364
TRG_ENDOCYTIC_2	91	94	PF00928	0.685
TRG_ER_diArg_1	28	30	PF00400	0.643
TRG_ER_diArg_1	457	460	PF00400	0.567
TRG_ER_diArg_1	55	58	PF00400	0.736
TRG_ER_diArg_1	79	81	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXT0	Leptomonas seymouri	56%	100%
A0A0S4K087	Bodo saltans	49%	100%
A0A1X0P0C0	Trypanosomatidae	49%	100%
A0A3R7N4Z4	Trypanosoma rangeli	48%	100%
A0A3S7XBK9	Leishmania donovani	88%	100%
A4HPW6	Leishmania braziliensis	72%	97%
A4IDM8	Leishmania infantum	89%	100%
D0A4B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4Q0W5	Leishmania major	87%	100%
V5DLL0	Trypanosoma cruzi	50%	100%