Transmembrane amino acid transporter protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane amino acid transporter protein- like protein

Species:

Leishmania mexicana

UniProt:

E9ATN2_LEIMU

TriTrypDb:

LmxM.36.4480

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ATN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATN2

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0015179	L-amino acid transmembrane transporter activity	6	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.766
CLV_C14_Caspase3-7	310	314	PF00656	0.276
CLV_C14_Caspase3-7	731	735	PF00656	0.631
CLV_NRD_NRD_1	128	130	PF00675	0.442
CLV_NRD_NRD_1	138	140	PF00675	0.438
CLV_NRD_NRD_1	221	223	PF00675	0.512
CLV_NRD_NRD_1	269	271	PF00675	0.356
CLV_NRD_NRD_1	272	274	PF00675	0.333
CLV_NRD_NRD_1	419	421	PF00675	0.292
CLV_NRD_NRD_1	497	499	PF00675	0.292
CLV_NRD_NRD_1	577	579	PF00675	0.262
CLV_NRD_NRD_1	612	614	PF00675	0.330
CLV_PCSK_FUR_1	270	274	PF00082	0.350
CLV_PCSK_KEX2_1	220	222	PF00082	0.510
CLV_PCSK_KEX2_1	268	270	PF00082	0.354
CLV_PCSK_KEX2_1	272	274	PF00082	0.326
CLV_PCSK_KEX2_1	368	370	PF00082	0.553
CLV_PCSK_KEX2_1	419	421	PF00082	0.292
CLV_PCSK_KEX2_1	497	499	PF00082	0.305
CLV_PCSK_KEX2_1	577	579	PF00082	0.262
CLV_PCSK_KEX2_1	612	614	PF00082	0.330
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.530
CLV_PCSK_PC7_1	268	274	PF00082	0.388
CLV_PCSK_SKI1_1	273	277	PF00082	0.292
CLV_PCSK_SKI1_1	470	474	PF00082	0.405
DEG_APCC_DBOX_1	106	114	PF00400	0.488
DEG_APCC_DBOX_1	496	504	PF00400	0.492
DEG_APCC_DBOX_1	747	755	PF00400	0.651
DEG_COP1_1	536	545	PF00400	0.405
DEG_Nend_UBRbox_3	1	3	PF02207	0.744
DEG_SCF_FBW7_1	171	177	PF00400	0.698
DEG_SCF_FBW7_2	580	586	PF00400	0.524
DEG_SPOP_SBC_1	160	164	PF00917	0.758
DEG_SPOP_SBC_1	179	183	PF00917	0.628
DEG_SPOP_SBC_1	248	252	PF00917	0.604
DOC_CKS1_1	171	176	PF01111	0.698
DOC_CKS1_1	580	585	PF01111	0.405
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.335
DOC_MAPK_gen_1	419	430	PF00069	0.466
DOC_MAPK_gen_1	469	476	PF00069	0.235
DOC_MAPK_gen_1	753	760	PF00069	0.493
DOC_MAPK_MEF2A_6	423	432	PF00069	0.466
DOC_MAPK_MEF2A_6	478	485	PF00069	0.381
DOC_PP1_RVXF_1	32	38	PF00149	0.600
DOC_PP1_RVXF_1	380	386	PF00149	0.262
DOC_PP2B_LxvP_1	118	121	PF13499	0.514
DOC_PP2B_LxvP_1	66	69	PF13499	0.335
DOC_PP4_FxxP_1	246	249	PF00568	0.754
DOC_PP4_FxxP_1	37	40	PF00568	0.568
DOC_SPAK_OSR1_1	387	391	PF12202	0.294
DOC_USP7_MATH_1	180	184	PF00917	0.642
DOC_USP7_MATH_1	229	233	PF00917	0.714
DOC_USP7_MATH_1	242	246	PF00917	0.669
DOC_USP7_MATH_1	249	253	PF00917	0.561
DOC_USP7_MATH_1	304	308	PF00917	0.292
DOC_USP7_MATH_1	5	9	PF00917	0.676
DOC_USP7_MATH_1	511	515	PF00917	0.495
DOC_USP7_MATH_1	521	525	PF00917	0.525
DOC_USP7_MATH_1	543	547	PF00917	0.480
DOC_USP7_MATH_1	621	625	PF00917	0.545
DOC_USP7_MATH_1	635	639	PF00917	0.517
DOC_USP7_MATH_1	681	685	PF00917	0.374
DOC_USP7_MATH_1	719	723	PF00917	0.588
DOC_WW_Pin1_4	170	175	PF00397	0.740
DOC_WW_Pin1_4	541	546	PF00397	0.467
DOC_WW_Pin1_4	569	574	PF00397	0.492
DOC_WW_Pin1_4	579	584	PF00397	0.492
DOC_WW_Pin1_4	589	594	PF00397	0.463
DOC_WW_Pin1_4	604	609	PF00397	0.383
DOC_WW_Pin1_4	617	622	PF00397	0.411
DOC_WW_Pin1_4	653	658	PF00397	0.480
DOC_WW_Pin1_4	712	717	PF00397	0.545
LIG_14-3-3_CanoR_1	107	116	PF00244	0.525
LIG_14-3-3_CanoR_1	16	23	PF00244	0.640
LIG_14-3-3_CanoR_1	187	192	PF00244	0.634
LIG_14-3-3_CanoR_1	272	282	PF00244	0.492
LIG_14-3-3_CanoR_1	34	38	PF00244	0.667
LIG_14-3-3_CanoR_1	363	372	PF00244	0.292
LIG_14-3-3_CanoR_1	387	391	PF00244	0.325
LIG_14-3-3_CanoR_1	423	429	PF00244	0.508
LIG_14-3-3_CanoR_1	502	506	PF00244	0.502
LIG_14-3-3_CanoR_1	7	11	PF00244	0.661
LIG_BIR_III_4	103	107	PF00653	0.545
LIG_BIR_III_4	628	632	PF00653	0.570
LIG_BRCT_BRCA1_1	716	720	PF00533	0.624
LIG_BRCT_BRCA1_1	745	749	PF00533	0.601
LIG_deltaCOP1_diTrp_1	340	350	PF00928	0.492
LIG_FHA_1	109	115	PF00498	0.503
LIG_FHA_1	288	294	PF00498	0.258
LIG_FHA_1	323	329	PF00498	0.332
LIG_FHA_1	396	402	PF00498	0.324
LIG_FHA_1	44	50	PF00498	0.663
LIG_FHA_1	440	446	PF00498	0.453
LIG_FHA_1	537	543	PF00498	0.536
LIG_FHA_1	645	651	PF00498	0.471
LIG_FHA_1	658	664	PF00498	0.478
LIG_FHA_1	673	679	PF00498	0.335
LIG_FHA_2	131	137	PF00498	0.647
LIG_FHA_2	180	186	PF00498	0.766
LIG_FHA_2	236	242	PF00498	0.699
LIG_FHA_2	308	314	PF00498	0.292
LIG_FHA_2	507	513	PF00498	0.492
LIG_FHA_2	527	533	PF00498	0.466
LIG_GBD_Chelix_1	77	85	PF00786	0.278
LIG_LIR_Apic_2	243	249	PF02991	0.760
LIG_LIR_Apic_2	36	40	PF02991	0.564
LIG_LIR_Apic_2	404	410	PF02991	0.335
LIG_LIR_Apic_2	780	786	PF02991	0.430
LIG_LIR_Gen_1	251	262	PF02991	0.555
LIG_LIR_Gen_1	341	351	PF02991	0.492
LIG_LIR_Gen_1	352	362	PF02991	0.335
LIG_LIR_Gen_1	582	593	PF02991	0.619
LIG_LIR_Gen_1	619	629	PF02991	0.452
LIG_LIR_Gen_1	668	679	PF02991	0.313
LIG_LIR_Gen_1	695	705	PF02991	0.335
LIG_LIR_Gen_1	746	757	PF02991	0.478
LIG_LIR_Gen_1	776	787	PF02991	0.507
LIG_LIR_Gen_1	88	98	PF02991	0.329
LIG_LIR_LC3C_4	427	430	PF02991	0.405
LIG_LIR_Nem_3	251	257	PF02991	0.560
LIG_LIR_Nem_3	286	291	PF02991	0.365
LIG_LIR_Nem_3	318	324	PF02991	0.340
LIG_LIR_Nem_3	341	347	PF02991	0.492
LIG_LIR_Nem_3	352	358	PF02991	0.335
LIG_LIR_Nem_3	371	375	PF02991	0.292
LIG_LIR_Nem_3	379	383	PF02991	0.297
LIG_LIR_Nem_3	582	588	PF02991	0.576
LIG_LIR_Nem_3	619	625	PF02991	0.452
LIG_LIR_Nem_3	668	674	PF02991	0.313
LIG_LIR_Nem_3	695	700	PF02991	0.335
LIG_LIR_Nem_3	746	752	PF02991	0.576
LIG_LIR_Nem_3	776	782	PF02991	0.478
LIG_LIR_Nem_3	88	93	PF02991	0.422
LIG_LIR_Nem_3	94	99	PF02991	0.504
LIG_LYPXL_yS_3	372	375	PF13949	0.292
LIG_NRBOX	756	762	PF00104	0.389
LIG_NRBOX	80	86	PF00104	0.335
LIG_Pex14_2	485	489	PF04695	0.335
LIG_SH2_CRK	254	258	PF00017	0.555
LIG_SH2_CRK	271	275	PF00017	0.537
LIG_SH2_CRK	288	292	PF00017	0.300
LIG_SH2_CRK	294	298	PF00017	0.335
LIG_SH2_CRK	370	374	PF00017	0.336
LIG_SH2_CRK	380	384	PF00017	0.266
LIG_SH2_CRK	407	411	PF00017	0.499
LIG_SH2_CRK	96	100	PF00017	0.453
LIG_SH2_NCK_1	407	411	PF00017	0.492
LIG_SH2_SRC	370	373	PF00017	0.376
LIG_SH2_STAP1	294	298	PF00017	0.335
LIG_SH2_STAP1	585	589	PF00017	0.621
LIG_SH2_STAP1	779	783	PF00017	0.409
LIG_SH2_STAT3	119	122	PF00017	0.540
LIG_SH2_STAT3	364	367	PF00017	0.292
LIG_SH2_STAT5	127	130	PF00017	0.590
LIG_SH2_STAT5	308	311	PF00017	0.334
LIG_SH2_STAT5	320	323	PF00017	0.295
LIG_SH2_STAT5	355	358	PF00017	0.335
LIG_SH2_STAT5	411	414	PF00017	0.492
LIG_SH2_STAT5	447	450	PF00017	0.335
LIG_SH2_STAT5	73	76	PF00017	0.490
LIG_SH2_STAT5	96	99	PF00017	0.335
LIG_SH3_3	168	174	PF00018	0.738
LIG_SH3_3	427	433	PF00018	0.492
LIG_SH3_3	451	457	PF00018	0.376
LIG_SH3_3	539	545	PF00018	0.405
LIG_SH3_3	651	657	PF00018	0.482
LIG_SH3_3	710	716	PF00018	0.453
LIG_SUFU_1	563	570	PF12470	0.405
LIG_SUMO_SIM_anti_2	660	668	PF11976	0.492
LIG_SUMO_SIM_par_1	289	295	PF11976	0.258
LIG_SUMO_SIM_par_1	490	496	PF11976	0.335
LIG_SUMO_SIM_par_1	504	509	PF11976	0.492
LIG_SUMO_SIM_par_1	646	651	PF11976	0.492
LIG_SUMO_SIM_par_1	82	89	PF11976	0.330
LIG_TRAF2_1	262	265	PF00917	0.566
LIG_TRAF2_1	41	44	PF00917	0.565
LIG_TRFH_1	116	120	PF08558	0.508
LIG_TYR_ITIM	292	297	PF00017	0.335
LIG_UBA3_1	751	755	PF00899	0.585
LIG_WRC_WIRS_1	396	401	PF05994	0.335
LIG_WRC_WIRS_1	447	452	PF05994	0.335
LIG_WRC_WIRS_1	779	784	PF05994	0.416
LIG_WRC_WIRS_1	87	92	PF05994	0.389
MOD_CK1_1	169	175	PF00069	0.747
MOD_CK1_1	203	209	PF00069	0.762
MOD_CK1_1	232	238	PF00069	0.765
MOD_CK1_1	250	256	PF00069	0.588
MOD_CK1_1	307	313	PF00069	0.292
MOD_CK1_1	33	39	PF00069	0.646
MOD_CK1_1	493	499	PF00069	0.336
MOD_CK1_1	607	613	PF00069	0.521
MOD_CK1_1	624	630	PF00069	0.439
MOD_CK1_1	743	749	PF00069	0.574
MOD_CK2_1	106	112	PF00069	0.532
MOD_CK2_1	130	136	PF00069	0.676
MOD_CK2_1	224	230	PF00069	0.785
MOD_CK2_1	506	512	PF00069	0.404
MOD_CK2_1	526	532	PF00069	0.466
MOD_CK2_1	552	558	PF00069	0.440
MOD_CK2_1	627	633	PF00069	0.553
MOD_Cter_Amidation	218	221	PF01082	0.431
MOD_Cter_Amidation	610	613	PF01082	0.308
MOD_GlcNHglycan	182	185	PF01048	0.486
MOD_GlcNHglycan	234	237	PF01048	0.498
MOD_GlcNHglycan	512	516	PF01048	0.280
MOD_GlcNHglycan	523	526	PF01048	0.325
MOD_GlcNHglycan	552	555	PF01048	0.271
MOD_GlcNHglycan	567	570	PF01048	0.229
MOD_GlcNHglycan	609	612	PF01048	0.324
MOD_GlcNHglycan	628	632	PF01048	0.276
MOD_GlcNHglycan	641	644	PF01048	0.240
MOD_GlcNHglycan	683	686	PF01048	0.576
MOD_GlcNHglycan	716	719	PF01048	0.406
MOD_GlcNHglycan	721	724	PF01048	0.392
MOD_GlcNHglycan	730	733	PF01048	0.421
MOD_GlcNHglycan	737	740	PF01048	0.411
MOD_GSK3_1	102	109	PF00069	0.525
MOD_GSK3_1	130	137	PF00069	0.580
MOD_GSK3_1	15	22	PF00069	0.682
MOD_GSK3_1	166	173	PF00069	0.713
MOD_GSK3_1	174	181	PF00069	0.639
MOD_GSK3_1	283	290	PF00069	0.258
MOD_GSK3_1	43	50	PF00069	0.588
MOD_GSK3_1	541	548	PF00069	0.539
MOD_GSK3_1	565	572	PF00069	0.449
MOD_GSK3_1	617	624	PF00069	0.479
MOD_GSK3_1	635	642	PF00069	0.588
MOD_GSK3_1	653	660	PF00069	0.431
MOD_GSK3_1	740	747	PF00069	0.632
MOD_N-GLC_1	589	594	PF02516	0.302
MOD_NEK2_1	315	320	PF00069	0.318
MOD_NEK2_1	331	336	PF00069	0.393
MOD_NEK2_1	342	347	PF00069	0.492
MOD_NEK2_1	386	391	PF00069	0.341
MOD_NEK2_1	401	406	PF00069	0.435
MOD_NEK2_1	424	429	PF00069	0.492
MOD_NEK2_1	588	593	PF00069	0.572
MOD_NEK2_1	672	677	PF00069	0.424
MOD_NEK2_1	692	697	PF00069	0.183
MOD_NEK2_1	72	77	PF00069	0.366
MOD_NEK2_1	85	90	PF00069	0.335
MOD_NEK2_2	91	96	PF00069	0.493
MOD_PIKK_1	15	21	PF00454	0.653
MOD_PIKK_1	229	235	PF00454	0.642
MOD_PIKK_1	363	369	PF00454	0.292
MOD_PIKK_1	635	641	PF00454	0.475
MOD_PKA_2	106	112	PF00069	0.532
MOD_PKA_2	15	21	PF00069	0.580
MOD_PKA_2	160	166	PF00069	0.758
MOD_PKA_2	25	31	PF00069	0.521
MOD_PKA_2	33	39	PF00069	0.670
MOD_PKA_2	386	392	PF00069	0.276
MOD_PKA_2	501	507	PF00069	0.492
MOD_PKA_2	521	527	PF00069	0.576
MOD_PKA_2	6	12	PF00069	0.678
MOD_Plk_1	203	209	PF00069	0.796
MOD_Plk_1	242	248	PF00069	0.622
MOD_Plk_1	511	517	PF00069	0.498
MOD_Plk_1	657	663	PF00069	0.576
MOD_Plk_2-3	200	206	PF00069	0.752
MOD_Plk_4	203	209	PF00069	0.639
MOD_Plk_4	242	248	PF00069	0.691
MOD_Plk_4	287	293	PF00069	0.318
MOD_Plk_4	304	310	PF00069	0.343
MOD_Plk_4	343	349	PF00069	0.492
MOD_Plk_4	424	430	PF00069	0.451
MOD_Plk_4	49	55	PF00069	0.505
MOD_Plk_4	501	507	PF00069	0.496
MOD_Plk_4	56	62	PF00069	0.300
MOD_Plk_4	6	12	PF00069	0.612
MOD_Plk_4	658	664	PF00069	0.572
MOD_Plk_4	673	679	PF00069	0.239
MOD_Plk_4	692	698	PF00069	0.335
MOD_Plk_4	73	79	PF00069	0.335
MOD_Plk_4	773	779	PF00069	0.389
MOD_ProDKin_1	170	176	PF00069	0.741
MOD_ProDKin_1	541	547	PF00069	0.467
MOD_ProDKin_1	569	575	PF00069	0.492
MOD_ProDKin_1	579	585	PF00069	0.492
MOD_ProDKin_1	589	595	PF00069	0.463
MOD_ProDKin_1	604	610	PF00069	0.383
MOD_ProDKin_1	617	623	PF00069	0.411
MOD_ProDKin_1	653	659	PF00069	0.480
MOD_ProDKin_1	712	718	PF00069	0.547
MOD_SUMO_rev_2	198	203	PF00179	0.630
MOD_SUMO_rev_2	336	345	PF00179	0.489
MOD_SUMO_rev_2	731	738	PF00179	0.635
TRG_DiLeu_BaEn_1	243	248	PF01217	0.608
TRG_DiLeu_BaEn_1	512	517	PF01217	0.404
TRG_DiLeu_BaEn_1	668	673	PF01217	0.335
TRG_DiLeu_LyEn_5	570	575	PF01217	0.492
TRG_ENDOCYTIC_2	254	257	PF00928	0.561
TRG_ENDOCYTIC_2	271	274	PF00928	0.541
TRG_ENDOCYTIC_2	288	291	PF00928	0.300
TRG_ENDOCYTIC_2	294	297	PF00928	0.335
TRG_ENDOCYTIC_2	320	323	PF00928	0.335
TRG_ENDOCYTIC_2	355	358	PF00928	0.335
TRG_ENDOCYTIC_2	372	375	PF00928	0.309
TRG_ENDOCYTIC_2	380	383	PF00928	0.305
TRG_ENDOCYTIC_2	413	416	PF00928	0.495
TRG_ENDOCYTIC_2	422	425	PF00928	0.502
TRG_ENDOCYTIC_2	447	450	PF00928	0.335
TRG_ENDOCYTIC_2	585	588	PF00928	0.621
TRG_ENDOCYTIC_2	779	782	PF00928	0.451
TRG_ENDOCYTIC_2	96	99	PF00928	0.335
TRG_ER_diArg_1	220	222	PF00400	0.708
TRG_ER_diArg_1	268	270	PF00400	0.554
TRG_ER_diArg_1	271	273	PF00400	0.539
TRG_ER_diArg_1	419	421	PF00400	0.492
TRG_ER_diArg_1	612	614	PF00400	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ5	Leptomonas seymouri	55%	99%
A0A3S7XBM8	Leishmania donovani	84%	100%
A4HPW5	Leishmania braziliensis	68%	99%
A4IDM7	Leishmania infantum	84%	100%
Q4Q0W6	Leishmania major	85%	99%