Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania mexicana

UniProt:

E9ATN1_LEIMU

TriTrypDb:

LmxM.36.4470

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATN1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.466
CLV_NRD_NRD_1	268	270	PF00675	0.632
CLV_NRD_NRD_1	28	30	PF00675	0.222
CLV_NRD_NRD_1	61	63	PF00675	0.267
CLV_PCSK_KEX2_1	249	251	PF00082	0.529
CLV_PCSK_KEX2_1	28	30	PF00082	0.235
CLV_PCSK_KEX2_1	61	63	PF00082	0.265
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.529
CLV_PCSK_PC7_1	245	251	PF00082	0.537
CLV_PCSK_SKI1_1	191	195	PF00082	0.545
CLV_PCSK_SKI1_1	236	240	PF00082	0.498
CLV_PCSK_SKI1_1	29	33	PF00082	0.248
CLV_PCSK_SKI1_1	99	103	PF00082	0.508
DEG_SCF_FBW7_2	160	167	PF00400	0.418
DEG_SPOP_SBC_1	16	20	PF00917	0.143
DOC_MAPK_gen_1	127	136	PF00069	0.370
DOC_PP2B_LxvP_1	12	15	PF13499	0.368
DOC_USP7_MATH_1	15	19	PF00917	0.264
DOC_USP7_MATH_1	165	169	PF00917	0.481
DOC_USP7_MATH_1	244	248	PF00917	0.648
DOC_USP7_MATH_1	75	79	PF00917	0.540
DOC_USP7_UBL2_3	236	240	PF12436	0.542
DOC_USP7_UBL2_3	266	270	PF12436	0.677
DOC_WW_Pin1_4	160	165	PF00397	0.571
DOC_WW_Pin1_4	168	173	PF00397	0.517
LIG_14-3-3_CanoR_1	149	155	PF00244	0.563
LIG_14-3-3_CanoR_1	221	227	PF00244	0.589
LIG_FHA_1	18	24	PF00498	0.243
LIG_FHA_1	66	72	PF00498	0.417
LIG_FHA_2	151	157	PF00498	0.516
LIG_FHA_2	255	261	PF00498	0.433
LIG_LIR_Gen_1	224	233	PF02991	0.480
LIG_LIR_Gen_1	50	59	PF02991	0.342
LIG_LIR_Nem_3	100	105	PF02991	0.393
LIG_LIR_Nem_3	24	30	PF02991	0.331
LIG_LIR_Nem_3	44	49	PF02991	0.140
LIG_LIR_Nem_3	50	56	PF02991	0.246
LIG_NRP_CendR_1	273	275	PF00754	0.546
LIG_Pex14_2	70	74	PF04695	0.325
LIG_SH2_CRK	27	31	PF00017	0.189
LIG_SH2_CRK	53	57	PF00017	0.248
LIG_SH2_CRK	9	13	PF00017	0.281
LIG_SH2_STAP1	226	230	PF00017	0.588
LIG_SH2_STAT5	133	136	PF00017	0.530
LIG_SH2_STAT5	237	240	PF00017	0.491
LIG_TRAF2_1	108	111	PF00917	0.357
LIG_UBA3_1	229	236	PF00899	0.447
LIG_WRC_WIRS_1	98	103	PF05994	0.336
MOD_CK1_1	168	174	PF00069	0.568
MOD_CK1_1	199	205	PF00069	0.479
MOD_CK1_1	225	231	PF00069	0.551
MOD_CK2_1	105	111	PF00069	0.361
MOD_CK2_1	15	21	PF00069	0.372
MOD_CK2_1	150	156	PF00069	0.463
MOD_CK2_1	167	173	PF00069	0.474
MOD_CK2_1	221	227	PF00069	0.543
MOD_CK2_1	240	246	PF00069	0.436
MOD_CK2_1	254	260	PF00069	0.456
MOD_CK2_1	54	60	PF00069	0.389
MOD_GlcNHglycan	107	110	PF01048	0.490
MOD_GlcNHglycan	198	201	PF01048	0.621
MOD_GlcNHglycan	241	245	PF01048	0.515
MOD_GlcNHglycan	90	93	PF01048	0.329
MOD_GSK3_1	17	24	PF00069	0.270
MOD_GSK3_1	199	206	PF00069	0.527
MOD_GSK3_1	221	228	PF00069	0.516
MOD_GSK3_1	232	239	PF00069	0.489
MOD_GSK3_1	240	247	PF00069	0.442
MOD_GSK3_1	65	72	PF00069	0.483
MOD_GSK3_1	75	82	PF00069	0.538
MOD_GSK3_1	97	104	PF00069	0.424
MOD_N-GLC_1	158	163	PF02516	0.496
MOD_NEK2_1	101	106	PF00069	0.405
MOD_NEK2_1	150	155	PF00069	0.399
MOD_NEK2_1	196	201	PF00069	0.571
MOD_NEK2_1	74	79	PF00069	0.631
MOD_PK_1	45	51	PF00069	0.276
MOD_PKA_1	269	275	PF00069	0.624
MOD_PKA_2	244	250	PF00069	0.581
MOD_PKA_2	262	268	PF00069	0.565
MOD_PKB_1	219	227	PF00069	0.589
MOD_Plk_1	209	215	PF00069	0.555
MOD_Plk_1	75	81	PF00069	0.444
MOD_Plk_2-3	17	23	PF00069	0.143
MOD_Plk_4	150	156	PF00069	0.474
MOD_Plk_4	225	231	PF00069	0.552
MOD_ProDKin_1	160	166	PF00069	0.565
MOD_ProDKin_1	168	174	PF00069	0.514
MOD_SUMO_rev_2	120	129	PF00179	0.558
MOD_SUMO_rev_2	228	238	PF00179	0.485
TRG_ENDOCYTIC_2	133	136	PF00928	0.530
TRG_ENDOCYTIC_2	226	229	PF00928	0.542
TRG_ENDOCYTIC_2	27	30	PF00928	0.185
TRG_ENDOCYTIC_2	53	56	PF00928	0.248
TRG_ENDOCYTIC_2	9	12	PF00928	0.262
TRG_ER_diArg_1	218	221	PF00400	0.590
TRG_ER_diArg_1	27	29	PF00400	0.235
TRG_NLS_Bipartite_1	249	270	PF00514	0.574
TRG_NLS_MonoExtC_3	265	270	PF00514	0.597
TRG_NLS_MonoExtN_4	263	270	PF00514	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P699	Leptomonas seymouri	66%	100%
A0A0S4J0E0	Bodo saltans	41%	100%
A0A1X0P0E8	Trypanosomatidae	42%	97%
A0A3Q8IIZ8	Leishmania donovani	88%	100%
A0A3S5ISR2	Trypanosoma rangeli	43%	100%
A4HPW4	Leishmania braziliensis	76%	100%
A4IDM6	Leishmania infantum	88%	100%
D0A4B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q0W7	Leishmania major	88%	100%
Q8WXX5	Homo sapiens	30%	100%
Q91WN1	Mus musculus	28%	100%
Q9VGR7	Drosophila melanogaster	26%	92%
V5BUT9	Trypanosoma cruzi	44%	100%