TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATM8_LEIMU

TriTrypDb:

LmxM.36.4440

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.343
CLV_NRD_NRD_1	151	153	PF00675	0.427
CLV_NRD_NRD_1	199	201	PF00675	0.436
CLV_NRD_NRD_1	240	242	PF00675	0.367
CLV_PCSK_KEX2_1	199	201	PF00082	0.520
CLV_PCSK_KEX2_1	240	242	PF00082	0.370
CLV_PCSK_SKI1_1	136	140	PF00082	0.474
DOC_MAPK_gen_1	152	160	PF00069	0.359
DOC_MAPK_gen_1	199	208	PF00069	0.472
DOC_MAPK_gen_1	240	246	PF00069	0.502
DOC_MAPK_gen_1	274	281	PF00069	0.623
DOC_MAPK_MEF2A_6	199	208	PF00069	0.468
DOC_PP4_FxxP_1	272	275	PF00568	0.564
DOC_USP7_MATH_1	12	16	PF00917	0.626
DOC_USP7_UBL2_3	80	84	PF12436	0.386
DOC_WW_Pin1_4	6	11	PF00397	0.736
DOC_WW_Pin1_4	61	66	PF00397	0.392
LIG_BRCT_BRCA1_1	204	208	PF00533	0.406
LIG_BRCT_BRCA1_1	268	272	PF00533	0.374
LIG_BRCT_BRCA1_2	204	210	PF00533	0.409
LIG_BRCT_BRCA1_2	268	274	PF00533	0.412
LIG_FHA_1	196	202	PF00498	0.457
LIG_FHA_1	268	274	PF00498	0.527
LIG_FHA_1	52	58	PF00498	0.422
LIG_FHA_1	72	78	PF00498	0.242
LIG_FHA_2	161	167	PF00498	0.420
LIG_LIR_Apic_2	269	275	PF02991	0.438
LIG_LIR_Gen_1	145	155	PF02991	0.345
LIG_LIR_Gen_1	186	196	PF02991	0.379
LIG_LIR_Gen_1	33	42	PF02991	0.381
LIG_LIR_Nem_3	137	141	PF02991	0.406
LIG_LIR_Nem_3	145	150	PF02991	0.335
LIG_LIR_Nem_3	186	192	PF02991	0.551
LIG_LIR_Nem_3	257	263	PF02991	0.418
LIG_LIR_Nem_3	28	34	PF02991	0.425
LIG_PALB2_WD40_1	187	195	PF16756	0.377
LIG_Pex14_1	277	281	PF04695	0.475
LIG_SH2_CRK	147	151	PF00017	0.322
LIG_SH2_CRK	193	197	PF00017	0.480
LIG_SH2_PTP2	243	246	PF00017	0.474
LIG_SH2_SRC	183	186	PF00017	0.482
LIG_SH2_STAP1	189	193	PF00017	0.491
LIG_SH2_STAP1	222	226	PF00017	0.316
LIG_SH2_STAP1	53	57	PF00017	0.361
LIG_SH2_STAT5	121	124	PF00017	0.291
LIG_SH2_STAT5	230	233	PF00017	0.404
LIG_SH2_STAT5	243	246	PF00017	0.420
LIG_SH2_STAT5	34	37	PF00017	0.419
LIG_SH2_STAT5	53	56	PF00017	0.253
LIG_SH3_3	59	65	PF00018	0.426
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.339
LIG_TRAF2_1	251	254	PF00917	0.512
LIG_WRC_WIRS_1	135	140	PF05994	0.426
LIG_WRC_WIRS_1	41	46	PF05994	0.287
MOD_CK1_1	15	21	PF00069	0.625
MOD_CK1_1	3	9	PF00069	0.599
MOD_CK2_1	160	166	PF00069	0.481
MOD_GlcNHglycan	14	17	PF01048	0.696
MOD_GlcNHglycan	48	51	PF01048	0.345
MOD_GSK3_1	2	9	PF00069	0.720
MOD_GSK3_1	263	270	PF00069	0.380
MOD_N-GLC_1	26	31	PF02516	0.503
MOD_NEK2_1	1	6	PF00069	0.679
MOD_NEK2_1	46	51	PF00069	0.371
MOD_NEK2_1	71	76	PF00069	0.318
MOD_NMyristoyl	1	7	PF02799	0.580
MOD_PIKK_1	263	269	PF00454	0.524
MOD_PK_1	202	208	PF00069	0.445
MOD_PKB_1	200	208	PF00069	0.351
MOD_Plk_1	202	208	PF00069	0.465
MOD_Plk_1	72	78	PF00069	0.273
MOD_Plk_4	72	78	PF00069	0.285
MOD_ProDKin_1	6	12	PF00069	0.734
MOD_ProDKin_1	61	67	PF00069	0.385
MOD_SUMO_for_1	255	258	PF00179	0.446
MOD_SUMO_rev_2	214	220	PF00179	0.375
TRG_DiLeu_BaEn_1	66	71	PF01217	0.327
TRG_ENDOCYTIC_2	147	150	PF00928	0.348
TRG_ENDOCYTIC_2	189	192	PF00928	0.501
TRG_ENDOCYTIC_2	230	233	PF00928	0.434
TRG_ENDOCYTIC_2	243	246	PF00928	0.376
TRG_ENDOCYTIC_2	34	37	PF00928	0.355
TRG_ER_diArg_1	199	202	PF00400	0.421
TRG_ER_diArg_1	240	242	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P695	Leptomonas seymouri	80%	96%
A0A1X0P0E3	Trypanosomatidae	71%	97%
A0A3R7MCL3	Trypanosoma rangeli	65%	97%
A0A3S7XBK2	Leishmania donovani	95%	100%
A4HPW1	Leishmania braziliensis	87%	100%
A4IDM3	Leishmania infantum	96%	100%
D0A4A9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	94%
Q4Q0X0	Leishmania major	94%	100%
V5DLL6	Trypanosoma cruzi	67%	97%