Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent DEAD/H RNA helicase, putative

Species:

Leishmania mexicana

UniProt:

E9ATM4_LEIMU

TriTrypDb:

LmxM.36.4400

Length:

963

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATM4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003676	nucleic acid binding	3	8
GO:0003724	RNA helicase activity	3	8
GO:0003743	translation initiation factor activity	4	8
GO:0003824	catalytic activity	1	8
GO:0004386	helicase activity	2	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0008186	ATP-dependent activity, acting on RNA	2	8
GO:0016787	hydrolase activity	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	588	592	PF00656	0.663
CLV_C14_Caspase3-7	886	890	PF00656	0.600
CLV_NRD_NRD_1	11	13	PF00675	0.650
CLV_NRD_NRD_1	118	120	PF00675	0.726
CLV_NRD_NRD_1	26	28	PF00675	0.714
CLV_NRD_NRD_1	34	36	PF00675	0.702
CLV_NRD_NRD_1	411	413	PF00675	0.356
CLV_NRD_NRD_1	548	550	PF00675	0.761
CLV_NRD_NRD_1	631	633	PF00675	0.686
CLV_NRD_NRD_1	636	638	PF00675	0.690
CLV_NRD_NRD_1	717	719	PF00675	0.317
CLV_NRD_NRD_1	815	817	PF00675	0.545
CLV_NRD_NRD_1	823	825	PF00675	0.598
CLV_NRD_NRD_1	910	912	PF00675	0.653
CLV_PCSK_FUR_1	246	250	PF00082	0.540
CLV_PCSK_FUR_1	327	331	PF00082	0.342
CLV_PCSK_KEX2_1	118	120	PF00082	0.803
CLV_PCSK_KEX2_1	245	247	PF00082	0.762
CLV_PCSK_KEX2_1	248	250	PF00082	0.793
CLV_PCSK_KEX2_1	28	30	PF00082	0.680
CLV_PCSK_KEX2_1	326	328	PF00082	0.320
CLV_PCSK_KEX2_1	329	331	PF00082	0.315
CLV_PCSK_KEX2_1	34	36	PF00082	0.698
CLV_PCSK_KEX2_1	411	413	PF00082	0.356
CLV_PCSK_KEX2_1	514	516	PF00082	0.756
CLV_PCSK_KEX2_1	631	633	PF00082	0.686
CLV_PCSK_KEX2_1	717	719	PF00082	0.317
CLV_PCSK_KEX2_1	870	872	PF00082	0.441
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.762
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.793
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.662
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.323
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.311
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.756
CLV_PCSK_PC1ET2_1	870	872	PF00082	0.441
CLV_PCSK_SKI1_1	137	141	PF00082	0.608
CLV_PCSK_SKI1_1	352	356	PF00082	0.334
CLV_PCSK_SKI1_1	5	9	PF00082	0.737
CLV_PCSK_SKI1_1	534	538	PF00082	0.755
CLV_PCSK_SKI1_1	550	554	PF00082	0.528
CLV_PCSK_SKI1_1	613	617	PF00082	0.544
CLV_PCSK_SKI1_1	718	722	PF00082	0.327
CLV_PCSK_SKI1_1	73	77	PF00082	0.678
CLV_PCSK_SKI1_1	870	874	PF00082	0.365
CLV_PCSK_SKI1_1	911	915	PF00082	0.618
CLV_PCSK_SKI1_1	920	924	PF00082	0.664
DEG_APCC_DBOX_1	739	747	PF00400	0.556
DEG_APCC_KENBOX_2	175	179	PF00400	0.542
DEG_SCF_FBW7_1	543	548	PF00400	0.739
DEG_SCF_FBW7_2	213	218	PF00400	0.551
DEG_SCF_SKP2-CKS1_1	540	547	PF00560	0.741
DEG_SPOP_SBC_1	296	300	PF00917	0.399
DEG_SPOP_SBC_1	527	531	PF00917	0.731
DEG_SPOP_SBC_1	99	103	PF00917	0.755
DOC_CKS1_1	387	392	PF01111	0.517
DOC_CYCLIN_RxL_1	134	141	PF00134	0.474
DOC_CYCLIN_RxL_1	203	214	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.470
DOC_MAPK_DCC_7	595	604	PF00069	0.755
DOC_MAPK_gen_1	326	337	PF00069	0.520
DOC_MAPK_gen_1	411	418	PF00069	0.556
DOC_MAPK_gen_1	717	728	PF00069	0.509
DOC_MAPK_gen_1	748	756	PF00069	0.556
DOC_MAPK_gen_1	893	901	PF00069	0.562
DOC_MAPK_gen_1	942	950	PF00069	0.637
DOC_MAPK_HePTP_8	648	660	PF00069	0.558
DOC_MAPK_MEF2A_6	137	144	PF00069	0.770
DOC_MAPK_MEF2A_6	651	660	PF00069	0.559
DOC_MAPK_MEF2A_6	721	730	PF00069	0.556
DOC_MAPK_MEF2A_6	750	758	PF00069	0.556
DOC_MAPK_NFAT4_5	137	145	PF00069	0.474
DOC_PP1_RVXF_1	204	211	PF00149	0.557
DOC_PP1_RVXF_1	269	276	PF00149	0.556
DOC_PP1_RVXF_1	703	710	PF00149	0.556
DOC_PP1_RVXF_1	740	746	PF00149	0.556
DOC_PP1_RVXF_1	845	851	PF00149	0.577
DOC_PP2B_LxvP_1	140	143	PF13499	0.686
DOC_PP2B_LxvP_1	150	153	PF13499	0.766
DOC_PP2B_PxIxI_1	382	388	PF00149	0.556
DOC_PP4_FxxP_1	210	213	PF00568	0.484
DOC_PP4_FxxP_1	275	278	PF00568	0.517
DOC_USP7_MATH_1	104	108	PF00917	0.744
DOC_USP7_MATH_1	114	118	PF00917	0.738
DOC_USP7_MATH_1	253	257	PF00917	0.670
DOC_USP7_MATH_1	297	301	PF00917	0.505
DOC_USP7_MATH_1	463	467	PF00917	0.582
DOC_USP7_MATH_1	491	495	PF00917	0.570
DOC_USP7_MATH_1	545	549	PF00917	0.736
DOC_USP7_MATH_1	552	556	PF00917	0.752
DOC_USP7_MATH_1	62	66	PF00917	0.783
DOC_USP7_MATH_1	636	640	PF00917	0.634
DOC_USP7_MATH_1	686	690	PF00917	0.515
DOC_USP7_MATH_1	92	96	PF00917	0.729
DOC_USP7_MATH_1	99	103	PF00917	0.724
DOC_USP7_UBL2_3	13	17	PF12436	0.661
DOC_USP7_UBL2_3	4	8	PF12436	0.668
DOC_USP7_UBL2_3	488	492	PF12436	0.743
DOC_USP7_UBL2_3	510	514	PF12436	0.697
DOC_USP7_UBL2_3	534	538	PF12436	0.800
DOC_USP7_UBL2_3	553	557	PF12436	0.720
DOC_USP7_UBL2_3	744	748	PF12436	0.556
DOC_USP7_UBL2_3	857	861	PF12436	0.546
DOC_USP7_UBL2_3	870	874	PF12436	0.421
DOC_WW_Pin1_4	211	216	PF00397	0.515
DOC_WW_Pin1_4	335	340	PF00397	0.556
DOC_WW_Pin1_4	386	391	PF00397	0.529
DOC_WW_Pin1_4	541	546	PF00397	0.738
DOC_WW_Pin1_4	82	87	PF00397	0.686
LIG_14-3-3_CanoR_1	291	297	PF00244	0.550
LIG_14-3-3_CanoR_1	330	336	PF00244	0.556
LIG_14-3-3_CanoR_1	352	358	PF00244	0.454
LIG_14-3-3_CanoR_1	613	618	PF00244	0.538
LIG_14-3-3_CanoR_1	73	82	PF00244	0.696
LIG_14-3-3_CanoR_1	782	788	PF00244	0.556
LIG_14-3-3_CanoR_1	924	930	PF00244	0.653
LIG_Actin_WH2_2	730	746	PF00022	0.556
LIG_Actin_WH2_2	831	849	PF00022	0.613
LIG_AP2alpha_1	745	749	PF02296	0.556
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BRCT_BRCA1_1	426	430	PF00533	0.556
LIG_FHA_1	338	344	PF00498	0.551
LIG_FHA_1	620	626	PF00498	0.579
LIG_FHA_1	669	675	PF00498	0.483
LIG_FHA_1	74	80	PF00498	0.686
LIG_FHA_1	945	951	PF00498	0.637
LIG_FHA_2	283	289	PF00498	0.535
LIG_FHA_2	301	307	PF00498	0.371
LIG_FHA_2	317	323	PF00498	0.399
LIG_FHA_2	433	439	PF00498	0.513
LIG_FHA_2	496	502	PF00498	0.740
LIG_FHA_2	569	575	PF00498	0.627
LIG_FHA_2	581	587	PF00498	0.725
LIG_FHA_2	625	631	PF00498	0.663
LIG_FHA_2	698	704	PF00498	0.542
LIG_FHA_2	83	89	PF00498	0.515
LIG_GBD_Chelix_1	838	846	PF00786	0.494
LIG_IRF3_LxIS_1	331	338	PF10401	0.607
LIG_LIR_Apic_2	207	213	PF02991	0.500
LIG_LIR_Apic_2	272	278	PF02991	0.517
LIG_LIR_Gen_1	427	437	PF02991	0.556
LIG_LIR_Nem_3	427	433	PF02991	0.556
LIG_LIR_Nem_3	473	479	PF02991	0.689
LIG_LIR_Nem_3	691	696	PF02991	0.556
LIG_LIR_Nem_3	814	818	PF02991	0.493
LIG_NRBOX	279	285	PF00104	0.556
LIG_NRBOX	432	438	PF00104	0.517
LIG_NRBOX	718	724	PF00104	0.556
LIG_NRBOX	74	80	PF00104	0.686
LIG_NRBOX	801	807	PF00104	0.485
LIG_PCNA_yPIPBox_3	360	374	PF02747	0.560
LIG_Pex14_2	745	749	PF04695	0.517
LIG_SH2_CRK	778	782	PF00017	0.607
LIG_SH2_NCK_1	40	44	PF00017	0.801
LIG_SH2_PTP2	415	418	PF00017	0.542
LIG_SH2_STAP1	884	888	PF00017	0.477
LIG_SH2_STAT5	189	192	PF00017	0.586
LIG_SH2_STAT5	404	407	PF00017	0.556
LIG_SH2_STAT5	415	418	PF00017	0.556
LIG_SH2_STAT5	617	620	PF00017	0.488
LIG_SH2_STAT5	682	685	PF00017	0.468
LIG_SH2_STAT5	693	696	PF00017	0.451
LIG_SH2_STAT5	774	777	PF00017	0.551
LIG_SH2_STAT5	787	790	PF00017	0.477
LIG_SH3_3	140	146	PF00018	0.691
LIG_SH3_3	600	606	PF00018	0.735
LIG_SH3_3	66	72	PF00018	0.753
LIG_SH3_4	488	495	PF00018	0.746
LIG_SUMO_SIM_anti_2	800	806	PF11976	0.501
LIG_SUMO_SIM_par_1	147	155	PF11976	0.687
LIG_SUMO_SIM_par_1	619	627	PF11976	0.579
LIG_TRAF2_1	215	218	PF00917	0.557
LIG_TRAF2_1	571	574	PF00917	0.818
LIG_TRAF2_1	64	67	PF00917	0.720
LIG_TYR_ITIM	413	418	PF00017	0.542
LIG_UBA3_1	715	721	PF00899	0.534
LIG_UBA3_1	818	825	PF00899	0.640
LIG_WRC_WIRS_1	354	359	PF05994	0.433
LIG_WRC_WIRS_1	829	834	PF05994	0.576
MOD_CDC14_SPxK_1	338	341	PF00782	0.556
MOD_CDK_SPxK_1	335	341	PF00069	0.556
MOD_CDK_SPxK_1	386	392	PF00069	0.517
MOD_CDK_SPxK_1	541	547	PF00069	0.741
MOD_CK1_1	121	127	PF00069	0.666
MOD_CK1_1	264	270	PF00069	0.511
MOD_CK1_1	300	306	PF00069	0.557
MOD_CK1_1	528	534	PF00069	0.802
MOD_CK1_1	548	554	PF00069	0.752
MOD_CK1_1	624	630	PF00069	0.649
MOD_CK1_1	862	868	PF00069	0.465
MOD_CK1_1	95	101	PF00069	0.654
MOD_CK2_1	224	230	PF00069	0.624
MOD_CK2_1	296	302	PF00069	0.605
MOD_CK2_1	316	322	PF00069	0.399
MOD_CK2_1	432	438	PF00069	0.542
MOD_CK2_1	491	497	PF00069	0.837
MOD_CK2_1	558	564	PF00069	0.563
MOD_CK2_1	568	574	PF00069	0.783
MOD_CK2_1	580	586	PF00069	0.750
MOD_CK2_1	624	630	PF00069	0.649
MOD_CK2_1	664	670	PF00069	0.565
MOD_CK2_1	824	830	PF00069	0.587
MOD_Cter_Amidation	511	514	PF01082	0.829
MOD_Cter_Amidation	822	825	PF01082	0.584
MOD_Cter_Amidation	909	912	PF01082	0.651
MOD_GlcNHglycan	102	105	PF01048	0.723
MOD_GlcNHglycan	112	115	PF01048	0.683
MOD_GlcNHglycan	124	127	PF01048	0.642
MOD_GlcNHglycan	184	187	PF01048	0.670
MOD_GlcNHglycan	226	229	PF01048	0.679
MOD_GlcNHglycan	23	26	PF01048	0.557
MOD_GlcNHglycan	255	258	PF01048	0.662
MOD_GlcNHglycan	263	266	PF01048	0.281
MOD_GlcNHglycan	268	271	PF01048	0.240
MOD_GlcNHglycan	292	295	PF01048	0.410
MOD_GlcNHglycan	299	302	PF01048	0.334
MOD_GlcNHglycan	426	429	PF01048	0.320
MOD_GlcNHglycan	465	468	PF01048	0.666
MOD_GlcNHglycan	501	505	PF01048	0.591
MOD_GlcNHglycan	554	557	PF01048	0.756
MOD_GlcNHglycan	619	622	PF01048	0.486
MOD_GlcNHglycan	633	637	PF01048	0.685
MOD_GlcNHglycan	90	93	PF01048	0.754
MOD_GlcNHglycan	925	928	PF01048	0.653
MOD_GlcNHglycan	94	97	PF01048	0.744
MOD_GSK3_1	100	107	PF00069	0.755
MOD_GSK3_1	110	117	PF00069	0.707
MOD_GSK3_1	118	125	PF00069	0.721
MOD_GSK3_1	296	303	PF00069	0.565
MOD_GSK3_1	331	338	PF00069	0.524
MOD_GSK3_1	491	498	PF00069	0.551
MOD_GSK3_1	541	548	PF00069	0.707
MOD_GSK3_1	58	65	PF00069	0.763
MOD_GSK3_1	580	587	PF00069	0.714
MOD_GSK3_1	613	620	PF00069	0.519
MOD_GSK3_1	632	639	PF00069	0.657
MOD_GSK3_1	664	671	PF00069	0.578
MOD_GSK3_1	757	764	PF00069	0.532
MOD_GSK3_1	824	831	PF00069	0.558
MOD_GSK3_1	88	95	PF00069	0.668
MOD_LATS_1	37	43	PF00433	0.505
MOD_N-GLC_1	678	683	PF02516	0.522
MOD_N-GLC_1	88	93	PF02516	0.623
MOD_N-GLC_2	110	112	PF02516	0.734
MOD_NEK2_1	127	132	PF00069	0.684
MOD_NEK2_1	208	213	PF00069	0.575
MOD_NEK2_1	3	8	PF00069	0.451
MOD_NEK2_1	405	410	PF00069	0.556
MOD_NEK2_1	424	429	PF00069	0.519
MOD_NEK2_1	668	673	PF00069	0.617
MOD_NEK2_1	697	702	PF00069	0.556
MOD_NEK2_1	733	738	PF00069	0.556
MOD_NEK2_1	818	823	PF00069	0.562
MOD_NEK2_1	834	839	PF00069	0.352
MOD_NEK2_1	923	928	PF00069	0.660
MOD_PIKK_1	62	68	PF00454	0.787
MOD_PK_1	39	45	PF00069	0.803
MOD_PKA_1	118	124	PF00069	0.748
MOD_PKA_1	824	830	PF00069	0.587
MOD_PKA_1	870	876	PF00069	0.368
MOD_PKA_1	911	917	PF00069	0.634
MOD_PKA_2	118	124	PF00069	0.798
MOD_PKA_2	182	188	PF00069	0.749
MOD_PKA_2	290	296	PF00069	0.551
MOD_PKA_2	548	554	PF00069	0.807
MOD_PKA_2	636	642	PF00069	0.685
MOD_PKA_2	781	787	PF00069	0.556
MOD_PKA_2	862	868	PF00069	0.525
MOD_PKA_2	870	876	PF00069	0.588
MOD_PKA_2	923	929	PF00069	0.652
MOD_PKA_2	944	950	PF00069	0.636
MOD_Plk_1	678	684	PF00069	0.529
MOD_Plk_2-3	432	438	PF00069	0.542
MOD_Plk_2-3	568	574	PF00069	0.599
MOD_Plk_2-3	71	77	PF00069	0.662
MOD_Plk_2-3	877	883	PF00069	0.649
MOD_Plk_4	269	275	PF00069	0.556
MOD_Plk_4	331	337	PF00069	0.517
MOD_Plk_4	432	438	PF00069	0.607
MOD_Plk_4	472	478	PF00069	0.751
MOD_Plk_4	636	642	PF00069	0.632
MOD_Plk_4	678	684	PF00069	0.525
MOD_Plk_4	800	806	PF00069	0.441
MOD_Plk_4	834	840	PF00069	0.534
MOD_ProDKin_1	211	217	PF00069	0.509
MOD_ProDKin_1	335	341	PF00069	0.556
MOD_ProDKin_1	386	392	PF00069	0.529
MOD_ProDKin_1	541	547	PF00069	0.741
MOD_ProDKin_1	82	88	PF00069	0.686
MOD_SUMO_for_1	959	962	PF00179	0.455
MOD_SUMO_rev_2	237	244	PF00179	0.716
MOD_SUMO_rev_2	561	571	PF00179	0.628
TRG_DiLeu_BaEn_1	432	437	PF01217	0.522
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.399
TRG_ENDOCYTIC_2	40	43	PF00928	0.799
TRG_ENDOCYTIC_2	415	418	PF00928	0.542
TRG_ENDOCYTIC_2	695	698	PF00928	0.556
TRG_ER_diArg_1	26	29	PF00400	0.685
TRG_ER_diArg_1	34	36	PF00400	0.699
TRG_ER_diArg_1	411	413	PF00400	0.519
TRG_ER_diArg_1	716	718	PF00400	0.517
TRG_ER_diArg_1	740	743	PF00400	0.556
TRG_NLS_Bipartite_1	12	31	PF00514	0.651
TRG_NLS_Bipartite_1	492	514	PF00514	0.648
TRG_NLS_MonoExtC_3	244	249	PF00514	0.710
TRG_NLS_MonoExtC_3	325	330	PF00514	0.551
TRG_NLS_MonoExtC_3	509	514	PF00514	0.801
TRG_NLS_MonoExtC_3	533	538	PF00514	0.717
TRG_NLS_MonoExtN_4	242	249	PF00514	0.721
TRG_NLS_MonoExtN_4	324	330	PF00514	0.545
TRG_NLS_MonoExtN_4	508	514	PF00514	0.723
TRG_NLS_MonoExtN_4	532	538	PF00514	0.716
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	765	770	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	816	820	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	900	905	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ87	Leptomonas seymouri	70%	100%
A0A0S4II81	Bodo saltans	26%	100%
A0A3S7XBG9	Leishmania donovani	92%	100%
A4HPV7	Leishmania braziliensis	80%	100%
A4IDL9	Leishmania infantum	92%	100%
Q4Q0X4	Leishmania major	93%	100%