Spindle pole body component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

gamma-tubulin complex component 2

Species:

Leishmania mexicana

UniProt:

E9ATM3_LEIMU

TriTrypDb:

LmxM.36.4390

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	12
GO:0005737	cytoplasm	2	12
GO:0005815	microtubule organizing center	2	12
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0000923	equatorial microtubule organizing center	3	1
GO:0000930	gamma-tubulin complex	2	1
GO:0005813	centrosome	3	1
GO:0008275	gamma-tubulin small complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9ATM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATM3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0007020	microtubule nucleation	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0000278	mitotic cell cycle	3	1
GO:0007049	cell cycle	2	1
GO:0007051	spindle organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0022607	cellular component assembly	4	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0051225	spindle assembly	4	1
GO:0051321	meiotic cell cycle	2	1
GO:0070925	organelle assembly	5	1
GO:0097435	supramolecular fiber organization	4	1
GO:0140694	non-membrane-bounded organelle assembly	6	1
GO:1904158	axonemal central apparatus assembly	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0043015	gamma-tubulin binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.668
CLV_C14_Caspase3-7	548	552	PF00656	0.465
CLV_NRD_NRD_1	323	325	PF00675	0.254
CLV_NRD_NRD_1	411	413	PF00675	0.293
CLV_NRD_NRD_1	424	426	PF00675	0.190
CLV_NRD_NRD_1	632	634	PF00675	0.292
CLV_NRD_NRD_1	688	690	PF00675	0.276
CLV_PCSK_KEX2_1	16	18	PF00082	0.553
CLV_PCSK_KEX2_1	323	325	PF00082	0.254
CLV_PCSK_KEX2_1	411	413	PF00082	0.291
CLV_PCSK_KEX2_1	424	426	PF00082	0.185
CLV_PCSK_KEX2_1	632	634	PF00082	0.314
CLV_PCSK_KEX2_1	688	690	PF00082	0.276
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.594
CLV_PCSK_SKI1_1	260	264	PF00082	0.265
CLV_PCSK_SKI1_1	442	446	PF00082	0.254
CLV_PCSK_SKI1_1	468	472	PF00082	0.153
CLV_PCSK_SKI1_1	532	536	PF00082	0.332
CLV_Separin_Metazoa	248	252	PF03568	0.465
DEG_APCC_DBOX_1	644	652	PF00400	0.559
DEG_SCF_TRCP1_1	611	617	PF00400	0.559
DEG_SPOP_SBC_1	156	160	PF00917	0.544
DEG_SPOP_SBC_1	279	283	PF00917	0.543
DEG_SPOP_SBC_1	765	769	PF00917	0.536
DOC_ANK_TNKS_1	483	490	PF00023	0.537
DOC_CDC14_PxL_1	109	117	PF14671	0.527
DOC_CKS1_1	150	155	PF01111	0.536
DOC_CKS1_1	437	442	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	657	663	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	818	824	PF00134	0.471
DOC_MAPK_DCC_7	323	332	PF00069	0.495
DOC_MAPK_gen_1	258	267	PF00069	0.540
DOC_MAPK_gen_1	563	571	PF00069	0.540
DOC_MAPK_gen_1	688	695	PF00069	0.535
DOC_MAPK_HePTP_8	320	332	PF00069	0.454
DOC_MAPK_HePTP_8	665	677	PF00069	0.540
DOC_MAPK_MEF2A_6	323	332	PF00069	0.474
DOC_MAPK_MEF2A_6	430	437	PF00069	0.533
DOC_MAPK_MEF2A_6	565	573	PF00069	0.461
DOC_MAPK_MEF2A_6	668	677	PF00069	0.527
DOC_PP1_RVXF_1	15	22	PF00149	0.460
DOC_PP1_RVXF_1	443	450	PF00149	0.497
DOC_PP1_RVXF_1	533	539	PF00149	0.559
DOC_PP1_RVXF_1	676	683	PF00149	0.515
DOC_USP7_MATH_1	156	160	PF00917	0.542
DOC_USP7_MATH_1	280	284	PF00917	0.546
DOC_USP7_MATH_1	480	484	PF00917	0.754
DOC_USP7_MATH_1	644	648	PF00917	0.535
DOC_USP7_MATH_1	854	858	PF00917	0.622
DOC_USP7_MATH_1	859	863	PF00917	0.631
DOC_USP7_MATH_1	98	102	PF00917	0.675
DOC_WW_Pin1_4	149	154	PF00397	0.537
DOC_WW_Pin1_4	160	165	PF00397	0.548
DOC_WW_Pin1_4	168	173	PF00397	0.527
DOC_WW_Pin1_4	284	289	PF00397	0.559
DOC_WW_Pin1_4	358	363	PF00397	0.441
DOC_WW_Pin1_4	436	441	PF00397	0.559
DOC_WW_Pin1_4	519	524	PF00397	0.431
DOC_WW_Pin1_4	817	822	PF00397	0.446
LIG_14-3-3_CanoR_1	323	327	PF00244	0.472
LIG_14-3-3_CanoR_1	424	429	PF00244	0.440
LIG_14-3-3_CanoR_1	468	473	PF00244	0.559
LIG_14-3-3_CanoR_1	579	585	PF00244	0.517
LIG_14-3-3_CanoR_1	632	636	PF00244	0.500
LIG_14-3-3_CanoR_1	771	776	PF00244	0.440
LIG_14-3-3_CanoR_1	784	789	PF00244	0.446
LIG_14-3-3_CanoR_1	813	822	PF00244	0.532
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BIR_III_4	643	647	PF00653	0.458
LIG_Clathr_ClatBox_1	650	654	PF01394	0.454
LIG_deltaCOP1_diTrp_1	544	549	PF00928	0.454
LIG_deltaCOP1_diTrp_1	6	10	PF00928	0.539
LIG_DLG_GKlike_1	424	432	PF00625	0.540
LIG_EH1_1	566	574	PF00400	0.465
LIG_eIF4E_1	203	209	PF01652	0.465
LIG_eIF4E_1	567	573	PF01652	0.397
LIG_FHA_1	133	139	PF00498	0.368
LIG_FHA_1	317	323	PF00498	0.571
LIG_FHA_1	38	44	PF00498	0.491
LIG_FHA_1	6	12	PF00498	0.499
LIG_FHA_1	616	622	PF00498	0.548
LIG_FHA_1	624	630	PF00498	0.558
LIG_FHA_1	660	666	PF00498	0.454
LIG_FHA_1	668	674	PF00498	0.454
LIG_FHA_1	694	700	PF00498	0.566
LIG_FHA_1	760	766	PF00498	0.557
LIG_FHA_1	79	85	PF00498	0.755
LIG_FHA_1	794	800	PF00498	0.488
LIG_FHA_2	596	602	PF00498	0.522
LIG_FHA_2	832	838	PF00498	0.446
LIG_Integrin_RGD_1	542	544	PF01839	0.265
LIG_Integrin_RGDW_4	542	545	PF00362	0.265
LIG_LIR_Gen_1	190	198	PF02991	0.465
LIG_LIR_Gen_1	4	14	PF02991	0.458
LIG_LIR_Gen_1	583	594	PF02991	0.480
LIG_LIR_Gen_1	730	740	PF02991	0.500
LIG_LIR_Gen_1	782	790	PF02991	0.472
LIG_LIR_Gen_1	834	842	PF02991	0.446
LIG_LIR_Nem_3	190	195	PF02991	0.511
LIG_LIR_Nem_3	343	349	PF02991	0.488
LIG_LIR_Nem_3	4	10	PF02991	0.447
LIG_LIR_Nem_3	583	589	PF02991	0.480
LIG_LIR_Nem_3	730	736	PF02991	0.500
LIG_LIR_Nem_3	754	760	PF02991	0.415
LIG_LIR_Nem_3	769	775	PF02991	0.500
LIG_LIR_Nem_3	782	788	PF02991	0.436
LIG_LIR_Nem_3	825	829	PF02991	0.455
LIG_LIR_Nem_3	834	838	PF02991	0.448
LIG_LYPXL_yS_3	826	829	PF13949	0.446
LIG_MYND_1	827	831	PF01753	0.446
LIG_NRBOX	316	322	PF00104	0.455
LIG_NRBOX	598	604	PF00104	0.540
LIG_PCNA_yPIPBox_3	596	610	PF02747	0.559
LIG_Pex14_1	545	549	PF04695	0.454
LIG_Pex14_2	422	426	PF04695	0.465
LIG_Pex14_2	716	720	PF04695	0.450
LIG_Rb_LxCxE_1	190	207	PF01857	0.540
LIG_REV1ctd_RIR_1	446	456	PF16727	0.515
LIG_SH2_CRK	151	155	PF00017	0.353
LIG_SH2_CRK	453	457	PF00017	0.454
LIG_SH2_NCK_1	151	155	PF00017	0.485
LIG_SH2_SRC	355	358	PF00017	0.353
LIG_SH2_STAP1	224	228	PF00017	0.515
LIG_SH2_STAP1	567	571	PF00017	0.397
LIG_SH2_STAP1	723	727	PF00017	0.446
LIG_SH2_STAT3	224	227	PF00017	0.540
LIG_SH2_STAT3	537	540	PF00017	0.515
LIG_SH2_STAT3	567	570	PF00017	0.397
LIG_SH2_STAT3	848	851	PF00017	0.502
LIG_SH2_STAT5	151	154	PF00017	0.528
LIG_SH2_STAT5	329	332	PF00017	0.454
LIG_SH2_STAT5	453	456	PF00017	0.456
LIG_SH2_STAT5	537	540	PF00017	0.454
LIG_SH3_3	150	156	PF00018	0.559
LIG_SH3_3	169	175	PF00018	0.540
LIG_SH3_3	351	357	PF00018	0.522
LIG_SH3_3	725	731	PF00018	0.446
LIG_SH3_3	77	83	PF00018	0.653
LIG_SH3_3	818	824	PF00018	0.509
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.540
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.486
LIG_SUMO_SIM_anti_2	44	51	PF11976	0.430
LIG_SUMO_SIM_anti_2	524	529	PF11976	0.428
LIG_SUMO_SIM_anti_2	647	652	PF11976	0.515
LIG_SUMO_SIM_par_1	661	666	PF11976	0.540
LIG_SUMO_SIM_par_1	777	783	PF11976	0.459
LIG_TRAF2_1	598	601	PF00917	0.540
LIG_TRFH_1	727	731	PF08558	0.383
LIG_UBA3_1	527	535	PF00899	0.306
LIG_UBA3_1	676	684	PF00899	0.321
MOD_CDK_SPK_2	160	165	PF00069	0.391
MOD_CDK_SPxK_1	436	442	PF00069	0.453
MOD_CK1_1	119	125	PF00069	0.568
MOD_CK1_1	160	166	PF00069	0.405
MOD_CK1_1	177	183	PF00069	0.261
MOD_CK1_1	2	8	PF00069	0.551
MOD_CK1_1	204	210	PF00069	0.453
MOD_CK1_1	283	289	PF00069	0.413
MOD_CK1_1	397	403	PF00069	0.426
MOD_CK1_1	552	558	PF00069	0.419
MOD_CK1_1	580	586	PF00069	0.392
MOD_CK1_1	793	799	PF00069	0.356
MOD_CK2_1	160	166	PF00069	0.405
MOD_CK2_1	177	183	PF00069	0.428
MOD_CK2_1	595	601	PF00069	0.348
MOD_CK2_1	635	641	PF00069	0.413
MOD_GlcNHglycan	100	103	PF01048	0.729
MOD_GlcNHglycan	138	141	PF01048	0.281
MOD_GlcNHglycan	159	162	PF01048	0.421
MOD_GlcNHglycan	289	292	PF01048	0.246
MOD_GlcNHglycan	308	311	PF01048	0.325
MOD_GlcNHglycan	338	341	PF01048	0.456
MOD_GlcNHglycan	383	386	PF01048	0.438
MOD_GlcNHglycan	396	399	PF01048	0.380
MOD_GlcNHglycan	472	475	PF01048	0.296
MOD_GlcNHglycan	495	498	PF01048	0.493
MOD_GlcNHglycan	512	515	PF01048	0.251
MOD_GlcNHglycan	551	554	PF01048	0.341
MOD_GlcNHglycan	611	614	PF01048	0.389
MOD_GlcNHglycan	637	640	PF01048	0.287
MOD_GlcNHglycan	702	706	PF01048	0.396
MOD_GlcNHglycan	73	76	PF01048	0.753
MOD_GlcNHglycan	856	859	PF01048	0.679
MOD_GSK3_1	1	8	PF00069	0.452
MOD_GSK3_1	128	135	PF00069	0.536
MOD_GSK3_1	156	163	PF00069	0.430
MOD_GSK3_1	177	184	PF00069	0.355
MOD_GSK3_1	215	222	PF00069	0.322
MOD_GSK3_1	279	286	PF00069	0.431
MOD_GSK3_1	37	44	PF00069	0.481
MOD_GSK3_1	394	401	PF00069	0.407
MOD_GSK3_1	424	431	PF00069	0.405
MOD_GSK3_1	505	512	PF00069	0.484
MOD_GSK3_1	609	616	PF00069	0.462
MOD_GSK3_1	631	638	PF00069	0.347
MOD_GSK3_1	747	754	PF00069	0.411
MOD_GSK3_1	789	796	PF00069	0.349
MOD_GSK3_1	813	820	PF00069	0.318
MOD_GSK3_1	98	105	PF00069	0.762
MOD_N-GLC_1	220	225	PF02516	0.401
MOD_N-GLC_1	428	433	PF02516	0.427
MOD_N-GLC_1	595	600	PF02516	0.398
MOD_NEK2_1	128	133	PF00069	0.551
MOD_NEK2_1	181	186	PF00069	0.370
MOD_NEK2_1	267	272	PF00069	0.398
MOD_NEK2_1	322	327	PF00069	0.427
MOD_NEK2_1	394	399	PF00069	0.394
MOD_NEK2_1	407	412	PF00069	0.419
MOD_NEK2_1	428	433	PF00069	0.381
MOD_NEK2_1	493	498	PF00069	0.470
MOD_NEK2_1	509	514	PF00069	0.315
MOD_NEK2_1	631	636	PF00069	0.247
MOD_NEK2_1	747	752	PF00069	0.341
MOD_NEK2_1	764	769	PF00069	0.184
MOD_NEK2_1	790	795	PF00069	0.365
MOD_PIKK_1	116	122	PF00454	0.625
MOD_PIKK_1	400	406	PF00454	0.453
MOD_PIKK_1	747	753	PF00454	0.419
MOD_PIKK_1	766	772	PF00454	0.199
MOD_PIKK_1	86	92	PF00454	0.740
MOD_PK_1	784	790	PF00069	0.164
MOD_PKA_1	424	430	PF00069	0.282
MOD_PKA_2	102	108	PF00069	0.771
MOD_PKA_2	322	328	PF00069	0.358
MOD_PKA_2	34	40	PF00069	0.568
MOD_PKA_2	405	411	PF00069	0.438
MOD_PKA_2	424	430	PF00069	0.257
MOD_PKA_2	609	615	PF00069	0.427
MOD_PKA_2	631	637	PF00069	0.289
MOD_PKA_2	644	650	PF00069	0.415
MOD_Plk_1	116	122	PF00069	0.603
MOD_Plk_1	220	226	PF00069	0.427
MOD_Plk_1	428	434	PF00069	0.412
MOD_Plk_1	5	11	PF00069	0.477
MOD_Plk_1	595	601	PF00069	0.341
MOD_Plk_1	800	806	PF00069	0.369
MOD_Plk_1	836	842	PF00069	0.383
MOD_Plk_4	128	134	PF00069	0.505
MOD_Plk_4	181	187	PF00069	0.322
MOD_Plk_4	316	322	PF00069	0.449
MOD_Plk_4	428	434	PF00069	0.381
MOD_Plk_4	552	558	PF00069	0.419
MOD_Plk_4	659	665	PF00069	0.301
MOD_Plk_4	742	748	PF00069	0.307
MOD_Plk_4	831	837	PF00069	0.294
MOD_ProDKin_1	149	155	PF00069	0.423
MOD_ProDKin_1	160	166	PF00069	0.438
MOD_ProDKin_1	168	174	PF00069	0.409
MOD_ProDKin_1	284	290	PF00069	0.453
MOD_ProDKin_1	358	364	PF00069	0.288
MOD_ProDKin_1	436	442	PF00069	0.453
MOD_ProDKin_1	519	525	PF00069	0.426
MOD_ProDKin_1	817	823	PF00069	0.295
TRG_DiLeu_BaEn_1	313	318	PF01217	0.322
TRG_DiLeu_BaLyEn_6	675	680	PF01217	0.378
TRG_DiLeu_BaLyEn_6	795	800	PF01217	0.422
TRG_DiLeu_BaLyEn_6	828	833	PF01217	0.295
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.736
TRG_ENDOCYTIC_2	329	332	PF00928	0.306
TRG_ENDOCYTIC_2	346	349	PF00928	0.306
TRG_ENDOCYTIC_2	453	456	PF00928	0.306
TRG_ENDOCYTIC_2	586	589	PF00928	0.341
TRG_ENDOCYTIC_2	826	829	PF00928	0.295
TRG_ER_diArg_1	257	260	PF00400	0.322
TRG_ER_diArg_1	322	324	PF00400	0.306
TRG_ER_diArg_1	424	426	PF00400	0.316
TRG_ER_diArg_1	631	633	PF00400	0.226
TRG_ER_diArg_1	688	690	PF00400	0.344
TRG_NES_CRM1_1	526	540	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I635	Leptomonas seymouri	73%	98%
A0A0S4J3M1	Bodo saltans	40%	98%
A0A1X0P0Y3	Trypanosomatidae	48%	100%
A0A3R7RTV6	Trypanosoma rangeli	47%	100%
A0A3S7XBK0	Leishmania donovani	94%	100%
A4HPV6	Leishmania braziliensis	82%	100%
A4IDL8	Leishmania infantum	94%	100%
D0A4A5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q0X5	Leishmania major	93%	100%
Q5R5J6	Pongo abelii	22%	96%
Q9BSJ2	Homo sapiens	22%	96%
Q9C5H9	Arabidopsis thaliana	23%	100%
V5DLM1	Trypanosoma cruzi	48%	100%