Alternative oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alternative oxidase

Gene product:

alternative oxidase, putative

Species:

Leishmania mexicana

UniProt:

E9ATM2_LEIMU

TriTrypDb:

LmxM.36.4380

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0070469	respirasome	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9ATM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATM2

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0010230	alternative respiration	7	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	9
GO:0009916	alternative oxidase activity	5	9
GO:0016491	oxidoreductase activity	2	9
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	3	9
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	4	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	428	432	PF00656	0.411
CLV_NRD_NRD_1	160	162	PF00675	0.563
CLV_NRD_NRD_1	203	205	PF00675	0.480
CLV_NRD_NRD_1	210	212	PF00675	0.425
CLV_NRD_NRD_1	31	33	PF00675	0.524
CLV_NRD_NRD_1	416	418	PF00675	0.259
CLV_PCSK_KEX2_1	160	162	PF00082	0.598
CLV_PCSK_KEX2_1	203	205	PF00082	0.480
CLV_PCSK_KEX2_1	210	212	PF00082	0.425
CLV_PCSK_KEX2_1	31	33	PF00082	0.593
CLV_PCSK_PC7_1	156	162	PF00082	0.598
CLV_PCSK_SKI1_1	156	160	PF00082	0.492
CLV_PCSK_SKI1_1	238	242	PF00082	0.506
CLV_PCSK_SKI1_1	388	392	PF00082	0.396
CLV_PCSK_SKI1_1	423	427	PF00082	0.349
CLV_PCSK_SKI1_1	8	12	PF00082	0.529
DOC_CKS1_1	344	349	PF01111	0.390
DOC_CKS1_1	424	429	PF01111	0.390
DOC_CYCLIN_RxL_1	472	483	PF00134	0.499
DOC_MAPK_MEF2A_6	106	115	PF00069	0.560
DOC_MAPK_MEF2A_6	134	141	PF00069	0.560
DOC_MAPK_MEF2A_6	395	404	PF00069	0.542
DOC_MAPK_MEF2A_6	4	11	PF00069	0.725
DOC_MAPK_RevD_3	404	419	PF00069	0.390
DOC_PP1_RVXF_1	115	122	PF00149	0.501
DOC_PP1_RVXF_1	473	480	PF00149	0.552
DOC_PP1_RVXF_1	6	12	PF00149	0.574
DOC_PP4_MxPP_1	82	85	PF00568	0.642
DOC_USP7_MATH_1	10	14	PF00917	0.775
DOC_USP7_MATH_1	147	151	PF00917	0.438
DOC_USP7_MATH_1	178	182	PF00917	0.391
DOC_USP7_MATH_1	202	206	PF00917	0.339
DOC_USP7_MATH_1	209	213	PF00917	0.350
DOC_USP7_MATH_1	298	302	PF00917	0.560
DOC_USP7_MATH_1	380	384	PF00917	0.561
DOC_USP7_MATH_1	434	438	PF00917	0.390
DOC_USP7_MATH_1	45	49	PF00917	0.731
DOC_WW_Pin1_4	100	105	PF00397	0.609
DOC_WW_Pin1_4	179	184	PF00397	0.360
DOC_WW_Pin1_4	187	192	PF00397	0.360
DOC_WW_Pin1_4	343	348	PF00397	0.390
DOC_WW_Pin1_4	365	370	PF00397	0.484
DOC_WW_Pin1_4	376	381	PF00397	0.583
DOC_WW_Pin1_4	388	393	PF00397	0.409
DOC_WW_Pin1_4	423	428	PF00397	0.390
LIG_14-3-3_CanoR_1	134	138	PF00244	0.501
LIG_14-3-3_CanoR_1	18	28	PF00244	0.704
LIG_14-3-3_CanoR_1	203	207	PF00244	0.320
LIG_14-3-3_CanoR_1	210	214	PF00244	0.295
LIG_14-3-3_CanoR_1	399	403	PF00244	0.390
LIG_14-3-3_CanoR_1	417	425	PF00244	0.390
LIG_14-3-3_CanoR_1	88	98	PF00244	0.541
LIG_BIR_III_2	431	435	PF00653	0.390
LIG_BRCT_BRCA1_1	180	184	PF00533	0.398
LIG_BRCT_BRCA1_1	39	43	PF00533	0.713
LIG_BRCT_BRCA1_1	400	404	PF00533	0.539
LIG_BRCT_BRCA1_1	75	79	PF00533	0.569
LIG_eIF4E_1	279	285	PF01652	0.397
LIG_FHA_1	134	140	PF00498	0.560
LIG_FHA_1	275	281	PF00498	0.438
LIG_FHA_1	304	310	PF00498	0.501
LIG_FHA_1	471	477	PF00498	0.643
LIG_FHA_2	174	180	PF00498	0.408
LIG_FHA_2	259	265	PF00498	0.301
LIG_FHA_2	295	301	PF00498	0.544
LIG_FHA_2	424	430	PF00498	0.533
LIG_FHA_2	438	444	PF00498	0.500
LIG_FHA_2	90	96	PF00498	0.533
LIG_HCF-1_HBM_1	230	233	PF13415	0.398
LIG_LIR_Gen_1	277	287	PF02991	0.361
LIG_LIR_Gen_1	302	312	PF02991	0.560
LIG_LIR_Gen_1	76	87	PF02991	0.634
LIG_LIR_Nem_3	277	282	PF02991	0.344
LIG_LIR_Nem_3	452	458	PF02991	0.560
LIG_LIR_Nem_3	66	72	PF02991	0.702
LIG_LYPXL_S_1	285	289	PF13949	0.391
LIG_LYPXL_yS_3	286	289	PF13949	0.525
LIG_NRBOX	236	242	PF00104	0.348
LIG_NRBOX	266	272	PF00104	0.492
LIG_REV1ctd_RIR_1	156	165	PF16727	0.314
LIG_SH2_CRK	251	255	PF00017	0.398
LIG_SH2_STAT5	131	134	PF00017	0.498
LIG_SH2_STAT5	154	157	PF00017	0.393
LIG_SH2_STAT5	20	23	PF00017	0.747
LIG_SH2_STAT5	233	236	PF00017	0.348
LIG_SH2_STAT5	279	282	PF00017	0.391
LIG_SH2_STAT5	296	299	PF00017	0.462
LIG_SH2_STAT5	67	70	PF00017	0.733
LIG_SH3_3	194	200	PF00018	0.402
LIG_SH3_3	317	323	PF00018	0.569
LIG_SH3_3	341	347	PF00018	0.445
LIG_SH3_3	397	403	PF00018	0.598
LIG_SH3_3	421	427	PF00018	0.442
LIG_SUMO_SIM_anti_2	259	264	PF11976	0.348
LIG_SUMO_SIM_anti_2	443	448	PF11976	0.525
LIG_SUMO_SIM_par_1	437	443	PF11976	0.519
LIG_TRAF2_1	297	300	PF00917	0.560
LIG_TRAF2_1	348	351	PF00917	0.598
LIG_TYR_ITIM	249	254	PF00017	0.438
LIG_TYR_ITIM	327	332	PF00017	0.357
LIG_UBA3_1	476	484	PF00899	0.586
LIG_WRC_WIRS_1	69	74	PF05994	0.488
LIG_WW_1	64	67	PF00397	0.516
MOD_CDK_SPxK_1	100	106	PF00069	0.438
MOD_CDK_SPxxK_3	388	395	PF00069	0.415
MOD_CK1_1	13	19	PF00069	0.706
MOD_CK1_1	164	170	PF00069	0.457
MOD_CK1_1	172	178	PF00069	0.346
MOD_CK1_1	216	222	PF00069	0.430
MOD_CK1_1	35	41	PF00069	0.746
MOD_CK1_1	376	382	PF00069	0.457
MOD_CK1_1	437	443	PF00069	0.364
MOD_CK1_1	55	61	PF00069	0.575
MOD_CK2_1	173	179	PF00069	0.422
MOD_CK2_1	224	230	PF00069	0.442
MOD_CK2_1	258	264	PF00069	0.372
MOD_CK2_1	294	300	PF00069	0.394
MOD_CK2_1	89	95	PF00069	0.438
MOD_DYRK1A_RPxSP_1	388	392	PF00069	0.415
MOD_DYRK1A_RPxSP_1	423	427	PF00069	0.201
MOD_GlcNHglycan	218	221	PF01048	0.457
MOD_GlcNHglycan	375	378	PF01048	0.486
MOD_GlcNHglycan	412	415	PF01048	0.394
MOD_GlcNHglycan	43	46	PF01048	0.702
MOD_GlcNHglycan	47	50	PF01048	0.702
MOD_GlcNHglycan	480	483	PF01048	0.373
MOD_GlcNHglycan	54	57	PF01048	0.719
MOD_GlcNHglycan	58	61	PF01048	0.699
MOD_GSK3_1	133	140	PF00069	0.438
MOD_GSK3_1	159	166	PF00069	0.423
MOD_GSK3_1	169	176	PF00069	0.336
MOD_GSK3_1	209	216	PF00069	0.502
MOD_GSK3_1	225	232	PF00069	0.350
MOD_GSK3_1	294	301	PF00069	0.416
MOD_GSK3_1	32	39	PF00069	0.706
MOD_GSK3_1	376	383	PF00069	0.407
MOD_GSK3_1	41	48	PF00069	0.777
MOD_GSK3_1	52	59	PF00069	0.556
MOD_GSK3_1	9	16	PF00069	0.643
MOD_N-GLC_1	164	169	PF02516	0.419
MOD_N-GLC_1	52	57	PF02516	0.488
MOD_NEK2_1	115	120	PF00069	0.228
MOD_NEK2_1	137	142	PF00069	0.408
MOD_NEK2_1	14	19	PF00069	0.715
MOD_NEK2_1	159	164	PF00069	0.479
MOD_NEK2_1	213	218	PF00069	0.444
MOD_NEK2_1	229	234	PF00069	0.412
MOD_NEK2_1	404	409	PF00069	0.346
MOD_NEK2_1	43	48	PF00069	0.669
MOD_NEK2_1	52	57	PF00069	0.735
MOD_NEK2_1	68	73	PF00069	0.494
MOD_NEK2_1	99	104	PF00069	0.492
MOD_NEK2_2	209	214	PF00069	0.201
MOD_PIKK_1	303	309	PF00454	0.438
MOD_PIKK_1	32	38	PF00454	0.708
MOD_PIKK_1	470	476	PF00454	0.616
MOD_PIKK_1	89	95	PF00454	0.492
MOD_PKA_1	417	423	PF00069	0.298
MOD_PKA_2	133	139	PF00069	0.357
MOD_PKA_2	159	165	PF00069	0.445
MOD_PKA_2	202	208	PF00069	0.390
MOD_PKA_2	209	215	PF00069	0.479
MOD_PKA_2	398	404	PF00069	0.201
MOD_Plk_1	170	176	PF00069	0.257
MOD_Plk_1	229	235	PF00069	0.442
MOD_Plk_1	258	264	PF00069	0.357
MOD_Plk_1	298	304	PF00069	0.354
MOD_Plk_1	434	440	PF00069	0.282
MOD_Plk_4	133	139	PF00069	0.357
MOD_Plk_4	229	235	PF00069	0.257
MOD_Plk_4	299	305	PF00069	0.358
MOD_Plk_4	434	440	PF00069	0.492
MOD_Plk_4	63	69	PF00069	0.592
MOD_ProDKin_1	100	106	PF00069	0.507
MOD_ProDKin_1	179	185	PF00069	0.438
MOD_ProDKin_1	187	193	PF00069	0.438
MOD_ProDKin_1	343	349	PF00069	0.201
MOD_ProDKin_1	365	371	PF00069	0.332
MOD_ProDKin_1	376	382	PF00069	0.471
MOD_ProDKin_1	388	394	PF00069	0.228
MOD_ProDKin_1	423	429	PF00069	0.201
TRG_DiLeu_BaEn_1	236	241	PF01217	0.333
TRG_DiLeu_BaEn_1	351	356	PF01217	0.201
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.483
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.555
TRG_ENDOCYTIC_2	154	157	PF00928	0.438
TRG_ENDOCYTIC_2	251	254	PF00928	0.430
TRG_ENDOCYTIC_2	279	282	PF00928	0.397
TRG_ENDOCYTIC_2	286	289	PF00928	0.400
TRG_ENDOCYTIC_2	329	332	PF00928	0.357
TRG_ENDOCYTIC_2	69	72	PF00928	0.629
TRG_ER_diArg_1	159	161	PF00400	0.415
TRG_NES_CRM1_1	259	272	PF08389	0.422
TRG_NES_CRM1_1	457	469	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	456	461	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P770	Leptomonas seymouri	56%	100%
A0A3Q8IWB1	Leishmania donovani	87%	100%
A4HPV5	Leishmania braziliensis	69%	100%
A4IDL7	Leishmania infantum	87%	100%
D0A4A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q0X6	Leishmania major	85%	100%
V5BQ82	Trypanosoma cruzi	32%	100%