Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ATL8_LEIMU

TriTrypDb:

LmxM.36.4340

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.565
CLV_C14_Caspase3-7	2	6	PF00656	0.533
CLV_C14_Caspase3-7	53	57	PF00656	0.640
CLV_NRD_NRD_1	110	112	PF00675	0.745
CLV_NRD_NRD_1	233	235	PF00675	0.739
CLV_NRD_NRD_1	336	338	PF00675	0.666
CLV_NRD_NRD_1	352	354	PF00675	0.430
CLV_NRD_NRD_1	437	439	PF00675	0.625
CLV_NRD_NRD_1	476	478	PF00675	0.747
CLV_NRD_NRD_1	490	492	PF00675	0.653
CLV_NRD_NRD_1	510	512	PF00675	0.504
CLV_PCSK_KEX2_1	110	112	PF00082	0.798
CLV_PCSK_KEX2_1	233	235	PF00082	0.739
CLV_PCSK_KEX2_1	320	322	PF00082	0.608
CLV_PCSK_KEX2_1	336	338	PF00082	0.494
CLV_PCSK_KEX2_1	351	353	PF00082	0.584
CLV_PCSK_KEX2_1	431	433	PF00082	0.654
CLV_PCSK_KEX2_1	468	470	PF00082	0.773
CLV_PCSK_KEX2_1	476	478	PF00082	0.747
CLV_PCSK_KEX2_1	510	512	PF00082	0.502
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.691
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.654
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.773
CLV_PCSK_SKI1_1	16	20	PF00082	0.738
CLV_PCSK_SKI1_1	274	278	PF00082	0.625
CLV_PCSK_SKI1_1	340	344	PF00082	0.676
CLV_PCSK_SKI1_1	432	436	PF00082	0.623
CLV_PCSK_SKI1_1	511	515	PF00082	0.667
CLV_PCSK_SKI1_1	90	94	PF00082	0.738
CLV_Separin_Metazoa	100	104	PF03568	0.529
DEG_APCC_DBOX_1	510	518	PF00400	0.482
DEG_COP1_1	308	318	PF00400	0.700
DEG_SPOP_SBC_1	302	306	PF00917	0.523
DOC_CYCLIN_RxL_1	508	516	PF00134	0.669
DOC_CYCLIN_yClb5_NLxxxL_5	8	17	PF00134	0.751
DOC_PP1_RVXF_1	509	516	PF00149	0.669
DOC_PP2B_LxvP_1	277	280	PF13499	0.621
DOC_PP4_FxxP_1	104	107	PF00568	0.722
DOC_USP7_MATH_1	129	133	PF00917	0.810
DOC_USP7_MATH_1	139	143	PF00917	0.734
DOC_USP7_MATH_1	145	149	PF00917	0.706
DOC_USP7_MATH_1	154	158	PF00917	0.730
DOC_USP7_MATH_1	302	306	PF00917	0.735
DOC_USP7_MATH_1	494	498	PF00917	0.790
DOC_USP7_MATH_1	505	509	PF00917	0.537
DOC_USP7_MATH_1	520	524	PF00917	0.664
DOC_USP7_MATH_1	94	98	PF00917	0.636
DOC_USP7_UBL2_3	431	435	PF12436	0.658
DOC_WW_Pin1_4	113	118	PF00397	0.725
DOC_WW_Pin1_4	159	164	PF00397	0.728
DOC_WW_Pin1_4	216	221	PF00397	0.800
DOC_WW_Pin1_4	254	259	PF00397	0.657
DOC_WW_Pin1_4	414	419	PF00397	0.781
DOC_WW_Pin1_4	424	429	PF00397	0.752
DOC_WW_Pin1_4	469	474	PF00397	0.676
DOC_WW_Pin1_4	490	495	PF00397	0.686
LIG_14-3-3_CanoR_1	103	107	PF00244	0.572
LIG_14-3-3_CanoR_1	131	138	PF00244	0.767
LIG_14-3-3_CanoR_1	153	163	PF00244	0.822
LIG_14-3-3_CanoR_1	187	192	PF00244	0.685
LIG_14-3-3_CanoR_1	196	206	PF00244	0.655
LIG_14-3-3_CanoR_1	213	220	PF00244	0.718
LIG_14-3-3_CanoR_1	233	239	PF00244	0.574
LIG_14-3-3_CanoR_1	245	250	PF00244	0.710
LIG_14-3-3_CanoR_1	461	466	PF00244	0.755
LIG_14-3-3_CanoR_1	90	98	PF00244	0.694
LIG_Actin_WH2_2	256	271	PF00022	0.707
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_deltaCOP1_diTrp_1	348	355	PF00928	0.505
LIG_deltaCOP1_diTrp_1	458	465	PF00928	0.612
LIG_FHA_1	160	166	PF00498	0.707
LIG_FHA_1	175	181	PF00498	0.568
LIG_FHA_1	310	316	PF00498	0.671
LIG_FHA_2	114	120	PF00498	0.849
LIG_FHA_2	141	147	PF00498	0.562
LIG_FHA_2	330	336	PF00498	0.704
LIG_FHA_2	41	47	PF00498	0.643
LIG_FHA_2	51	57	PF00498	0.642
LIG_LIR_Apic_2	458	462	PF02991	0.706
LIG_LIR_Gen_1	171	180	PF02991	0.758
LIG_LIR_Nem_3	171	176	PF02991	0.665
LIG_LIR_Nem_3	286	292	PF02991	0.513
LIG_LIR_Nem_3	324	329	PF02991	0.644
LIG_LIR_Nem_3	46	52	PF02991	0.672
LIG_PDZ_Class_1	520	525	PF00595	0.697
LIG_SH2_CRK	195	199	PF00017	0.716
LIG_SH2_CRK	49	53	PF00017	0.679
LIG_SH2_NCK_1	173	177	PF00017	0.742
LIG_SH2_NCK_1	227	231	PF00017	0.550
LIG_SH2_PTP2	328	331	PF00017	0.620
LIG_SH2_SRC	173	176	PF00017	0.768
LIG_SH2_SRC	284	287	PF00017	0.606
LIG_SH2_SRC	328	331	PF00017	0.620
LIG_SH2_STAP1	27	31	PF00017	0.665
LIG_SH2_STAP1	284	288	PF00017	0.599
LIG_SH2_STAP1	294	298	PF00017	0.657
LIG_SH2_STAT5	267	270	PF00017	0.643
LIG_SH2_STAT5	27	30	PF00017	0.764
LIG_SH2_STAT5	314	317	PF00017	0.669
LIG_SH2_STAT5	328	331	PF00017	0.504
LIG_SH3_2	151	156	PF14604	0.744
LIG_SH3_2	163	168	PF14604	0.726
LIG_SH3_3	148	154	PF00018	0.711
LIG_SH3_3	160	166	PF00018	0.641
LIG_SH3_3	514	520	PF00018	0.553
LIG_TRAF2_1	262	265	PF00917	0.703
LIG_TRAF2_1	331	334	PF00917	0.643
LIG_TRAF2_1	346	349	PF00917	0.465
LIG_TYR_ITIM	47	52	PF00017	0.672
LIG_WRC_WIRS_1	294	299	PF05994	0.474
LIG_WRC_WIRS_1	506	511	PF05994	0.697
MOD_CDK_SPK_2	113	118	PF00069	0.725
MOD_CDK_SPK_2	159	164	PF00069	0.769
MOD_CDK_SPK_2	216	221	PF00069	0.842
MOD_CDK_SPxK_1	424	430	PF00069	0.760
MOD_CDK_SPxxK_3	254	261	PF00069	0.688
MOD_CDK_SPxxK_3	424	431	PF00069	0.830
MOD_CDK_SPxxK_3	469	476	PF00069	0.669
MOD_CK1_1	127	133	PF00069	0.812
MOD_CK1_1	157	163	PF00069	0.847
MOD_CK1_1	186	192	PF00069	0.563
MOD_CK1_1	202	208	PF00069	0.809
MOD_CK1_1	219	225	PF00069	0.559
MOD_CK1_1	247	253	PF00069	0.709
MOD_CK1_1	26	32	PF00069	0.674
MOD_CK1_1	305	311	PF00069	0.723
MOD_CK1_1	35	41	PF00069	0.670
MOD_CK1_1	419	425	PF00069	0.745
MOD_CK1_1	483	489	PF00069	0.678
MOD_CK1_1	63	69	PF00069	0.753
MOD_CK1_1	79	85	PF00069	0.541
MOD_CK2_1	113	119	PF00069	0.849
MOD_CK2_1	144	150	PF00069	0.778
MOD_CK2_1	329	335	PF00069	0.606
MOD_CK2_1	40	46	PF00069	0.657
MOD_CK2_1	448	454	PF00069	0.704
MOD_CK2_1	490	496	PF00069	0.765
MOD_CK2_1	94	100	PF00069	0.618
MOD_Cter_Amidation	466	469	PF01082	0.767
MOD_Cter_Amidation	489	492	PF01082	0.799
MOD_DYRK1A_RPxSP_1	159	163	PF00069	0.670
MOD_DYRK1A_RPxSP_1	469	473	PF00069	0.665
MOD_GlcNHglycan	135	138	PF01048	0.668
MOD_GlcNHglycan	216	219	PF01048	0.796
MOD_GlcNHglycan	221	224	PF01048	0.714
MOD_GlcNHglycan	235	238	PF01048	0.693
MOD_GlcNHglycan	29	32	PF01048	0.751
MOD_GlcNHglycan	418	421	PF01048	0.836
MOD_GlcNHglycan	432	435	PF01048	0.600
MOD_GlcNHglycan	469	472	PF01048	0.805
MOD_GlcNHglycan	496	499	PF01048	0.806
MOD_GlcNHglycan	62	65	PF01048	0.603
MOD_GlcNHglycan	77	81	PF01048	0.774
MOD_GSK3_1	127	134	PF00069	0.707
MOD_GSK3_1	140	147	PF00069	0.652
MOD_GSK3_1	154	161	PF00069	0.699
MOD_GSK3_1	183	190	PF00069	0.507
MOD_GSK3_1	197	204	PF00069	0.774
MOD_GSK3_1	21	28	PF00069	0.720
MOD_GSK3_1	212	219	PF00069	0.576
MOD_GSK3_1	240	247	PF00069	0.738
MOD_GSK3_1	250	257	PF00069	0.615
MOD_GSK3_1	301	308	PF00069	0.730
MOD_GSK3_1	31	38	PF00069	0.735
MOD_GSK3_1	358	365	PF00069	0.517
MOD_GSK3_1	380	387	PF00069	0.699
MOD_GSK3_1	412	419	PF00069	0.784
MOD_GSK3_1	422	429	PF00069	0.702
MOD_GSK3_1	467	474	PF00069	0.611
MOD_GSK3_1	480	487	PF00069	0.710
MOD_GSK3_1	490	497	PF00069	0.659
MOD_GSK3_1	501	508	PF00069	0.630
MOD_GSK3_1	90	97	PF00069	0.691
MOD_LATS_1	14	20	PF00433	0.737
MOD_N-GLC_1	140	145	PF02516	0.623
MOD_N-GLC_1	202	207	PF02516	0.804
MOD_N-GLC_1	292	297	PF02516	0.718
MOD_N-GLC_1	309	314	PF02516	0.794
MOD_N-GLC_1	358	363	PF02516	0.593
MOD_N-GLC_1	384	389	PF02516	0.653
MOD_N-GLC_1	412	417	PF02516	0.753
MOD_N-GLC_1	82	87	PF02516	0.580
MOD_NEK2_2	505	510	PF00069	0.485
MOD_PIKK_1	124	130	PF00454	0.773
MOD_PIKK_1	204	210	PF00454	0.760
MOD_PIKK_1	212	218	PF00454	0.658
MOD_PIKK_1	240	246	PF00454	0.551
MOD_PIKK_1	388	394	PF00454	0.748
MOD_PK_1	245	251	PF00069	0.648
MOD_PKA_1	233	239	PF00069	0.670
MOD_PKA_1	430	436	PF00069	0.756
MOD_PKA_2	102	108	PF00069	0.628
MOD_PKA_2	130	136	PF00069	0.601
MOD_PKA_2	139	145	PF00069	0.598
MOD_PKA_2	158	164	PF00069	0.855
MOD_PKA_2	183	189	PF00069	0.712
MOD_PKA_2	212	218	PF00069	0.786
MOD_PKA_2	232	238	PF00069	0.550
MOD_PKA_2	244	250	PF00069	0.750
MOD_PKA_2	306	312	PF00069	0.527
MOD_PKA_2	31	37	PF00069	0.817
MOD_PKA_2	483	489	PF00069	0.692
MOD_PKA_2	68	74	PF00069	0.804
MOD_PKB_1	238	246	PF00069	0.841
MOD_PKB_1	378	386	PF00069	0.546
MOD_Plk_1	202	208	PF00069	0.754
MOD_Plk_1	292	298	PF00069	0.587
MOD_Plk_1	340	346	PF00069	0.572
MOD_Plk_1	362	368	PF00069	0.506
MOD_Plk_4	175	181	PF00069	0.600
MOD_Plk_4	461	467	PF00069	0.599
MOD_ProDKin_1	113	119	PF00069	0.725
MOD_ProDKin_1	159	165	PF00069	0.725
MOD_ProDKin_1	216	222	PF00069	0.800
MOD_ProDKin_1	254	260	PF00069	0.652
MOD_ProDKin_1	414	420	PF00069	0.782
MOD_ProDKin_1	424	430	PF00069	0.751
MOD_ProDKin_1	469	475	PF00069	0.677
MOD_ProDKin_1	490	496	PF00069	0.687
TRG_DiLeu_BaEn_4	333	339	PF01217	0.507
TRG_DiLeu_BaEn_4	67	73	PF01217	0.736
TRG_ENDOCYTIC_2	173	176	PF00928	0.666
TRG_ENDOCYTIC_2	195	198	PF00928	0.593
TRG_ENDOCYTIC_2	294	297	PF00928	0.466
TRG_ENDOCYTIC_2	49	52	PF00928	0.684
TRG_ER_diArg_1	110	112	PF00400	0.551
TRG_ER_diArg_1	336	338	PF00400	0.666
TRG_ER_diArg_1	350	353	PF00400	0.532
TRG_ER_diArg_1	509	511	PF00400	0.499
TRG_NLS_MonoExtC_3	434	439	PF00514	0.637
TRG_NLS_MonoExtN_4	428	434	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.729
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	511	516	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U4	Leptomonas seymouri	39%	100%
A0A3Q8IPF2	Leishmania donovani	80%	95%
A4HPV1	Leishmania braziliensis	55%	100%
A4IE40	Leishmania infantum	79%	95%
Q4Q0Y0	Leishmania major	80%	100%