SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATL5_LEIMU

TriTrypDb:

LmxM.36.4310

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATL5

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	268	270	PF00675	0.281
CLV_NRD_NRD_1	389	391	PF00675	0.597
CLV_NRD_NRD_1	395	397	PF00675	0.211
CLV_NRD_NRD_1	448	450	PF00675	0.529
CLV_NRD_NRD_1	519	521	PF00675	0.359
CLV_PCSK_KEX2_1	395	397	PF00082	0.333
CLV_PCSK_KEX2_1	448	450	PF00082	0.529
CLV_PCSK_KEX2_1	519	521	PF00082	0.365
CLV_PCSK_PC7_1	515	521	PF00082	0.407
CLV_PCSK_SKI1_1	27	31	PF00082	0.443
CLV_PCSK_SKI1_1	270	274	PF00082	0.356
CLV_PCSK_SKI1_1	310	314	PF00082	0.456
CLV_PCSK_SKI1_1	374	378	PF00082	0.637
CLV_PCSK_SKI1_1	448	452	PF00082	0.515
CLV_PCSK_SKI1_1	489	493	PF00082	0.436
DOC_CKS1_1	434	439	PF01111	0.590
DOC_MAPK_gen_1	27	36	PF00069	0.399
DOC_MAPK_gen_1	395	405	PF00069	0.417
DOC_MAPK_MEF2A_6	489	496	PF00069	0.401
DOC_PP1_RVXF_1	212	218	PF00149	0.464
DOC_PP4_FxxP_1	35	38	PF00568	0.370
DOC_PP4_FxxP_1	42	45	PF00568	0.362
DOC_SPAK_OSR1_1	300	304	PF12202	0.358
DOC_USP7_MATH_1	460	464	PF00917	0.542
DOC_USP7_MATH_1	69	73	PF00917	0.494
DOC_USP7_UBL2_3	27	31	PF12436	0.490
DOC_WW_Pin1_4	18	23	PF00397	0.424
DOC_WW_Pin1_4	338	343	PF00397	0.649
DOC_WW_Pin1_4	433	438	PF00397	0.581
DOC_WW_Pin1_4	72	77	PF00397	0.470
DOC_WW_Pin1_4	81	86	PF00397	0.470
DOC_WW_Pin1_4	90	95	PF00397	0.339
LIG_14-3-3_CanoR_1	195	203	PF00244	0.549
LIG_14-3-3_CanoR_1	269	278	PF00244	0.531
LIG_14-3-3_CanoR_1	319	325	PF00244	0.365
LIG_14-3-3_CanoR_1	357	364	PF00244	0.568
LIG_14-3-3_CanoR_1	415	421	PF00244	0.466
LIG_14-3-3_CanoR_1	433	437	PF00244	0.559
LIG_14-3-3_CanoR_1	471	479	PF00244	0.539
LIG_APCC_ABBA_1	217	222	PF00400	0.494
LIG_APCC_ABBA_1	34	39	PF00400	0.390
LIG_BIR_II_1	1	5	PF00653	0.750
LIG_BRCT_BRCA1_1	228	232	PF00533	0.472
LIG_deltaCOP1_diTrp_1	208	217	PF00928	0.511
LIG_FHA_1	165	171	PF00498	0.517
LIG_FHA_1	172	178	PF00498	0.481
LIG_FHA_1	278	284	PF00498	0.499
LIG_FHA_1	307	313	PF00498	0.408
LIG_FHA_1	350	356	PF00498	0.623
LIG_FHA_1	366	372	PF00498	0.439
LIG_FHA_1	452	458	PF00498	0.450
LIG_FHA_1	459	465	PF00498	0.459
LIG_FHA_1	61	67	PF00498	0.504
LIG_FHA_1	69	75	PF00498	0.572
LIG_FHA_2	258	264	PF00498	0.532
LIG_FHA_2	364	370	PF00498	0.431
LIG_FHA_2	436	442	PF00498	0.399
LIG_LIR_Apic_2	241	247	PF02991	0.470
LIG_LIR_Apic_2	39	45	PF02991	0.382
LIG_LIR_Apic_2	431	437	PF02991	0.592
LIG_LIR_Apic_2	473	479	PF02991	0.559
LIG_LIR_Gen_1	273	283	PF02991	0.483
LIG_LIR_Gen_1	304	313	PF02991	0.367
LIG_LIR_Gen_1	463	472	PF02991	0.460
LIG_LIR_Gen_1	490	499	PF02991	0.466
LIG_LIR_Nem_3	216	220	PF02991	0.478
LIG_LIR_Nem_3	273	278	PF02991	0.488
LIG_LIR_Nem_3	287	293	PF02991	0.433
LIG_LIR_Nem_3	304	308	PF02991	0.357
LIG_LIR_Nem_3	463	468	PF02991	0.456
LIG_LIR_Nem_3	490	494	PF02991	0.443
LIG_MYND_1	243	247	PF01753	0.470
LIG_Pex14_1	373	377	PF04695	0.671
LIG_Pex14_2	206	210	PF04695	0.464
LIG_Pex14_2	301	305	PF04695	0.339
LIG_PTB_Apo_2	250	257	PF02174	0.494
LIG_Rb_LxCxE_1	63	83	PF01857	0.556
LIG_Rb_pABgroove_1	401	409	PF01858	0.392
LIG_SH2_CRK	293	297	PF00017	0.509
LIG_SH2_CRK	469	473	PF00017	0.554
LIG_SH2_CRK	537	541	PF00017	0.233
LIG_SH2_GRB2like	537	540	PF00017	0.511
LIG_SH2_NCK_1	465	469	PF00017	0.528
LIG_SH2_SRC	407	410	PF00017	0.520
LIG_SH2_SRC	465	468	PF00017	0.399
LIG_SH2_STAP1	465	469	PF00017	0.484
LIG_SH2_STAP1	537	541	PF00017	0.508
LIG_SH2_STAT5	15	18	PF00017	0.446
LIG_SH2_STAT5	244	247	PF00017	0.460
LIG_SH2_STAT5	354	357	PF00017	0.578
LIG_SH2_STAT5	412	415	PF00017	0.360
LIG_SH2_STAT5	456	459	PF00017	0.374
LIG_Sin3_3	103	110	PF02671	0.482
LIG_SUMO_SIM_anti_2	104	111	PF11976	0.556
LIG_SUMO_SIM_par_1	62	67	PF11976	0.531
LIG_TRAF2_1	439	442	PF00917	0.529
LIG_WRPW_2	119	122	PF00400	0.556
MOD_CDK_SPxxK_3	72	79	PF00069	0.494
MOD_CK1_1	321	327	PF00069	0.426
MOD_CK1_1	349	355	PF00069	0.626
MOD_CK1_1	435	441	PF00069	0.371
MOD_CK1_1	72	78	PF00069	0.477
MOD_CK2_1	145	151	PF00069	0.501
MOD_CK2_1	257	263	PF00069	0.528
MOD_CK2_1	363	369	PF00069	0.702
MOD_CK2_1	435	441	PF00069	0.375
MOD_CK2_1	526	532	PF00069	0.394
MOD_CK2_1	64	70	PF00069	0.556
MOD_CMANNOS	119	122	PF00535	0.281
MOD_Cter_Amidation	267	270	PF01082	0.281
MOD_GlcNHglycan	1	4	PF01048	0.778
MOD_GlcNHglycan	137	140	PF01048	0.368
MOD_GlcNHglycan	171	174	PF01048	0.350
MOD_GlcNHglycan	320	323	PF01048	0.486
MOD_GlcNHglycan	347	351	PF01048	0.629
MOD_GlcNHglycan	381	384	PF01048	0.595
MOD_GlcNHglycan	480	483	PF01048	0.580
MOD_GlcNHglycan	484	487	PF01048	0.509
MOD_GlcNHglycan	70	74	PF01048	0.332
MOD_GSK3_1	1	8	PF00069	0.710
MOD_GSK3_1	165	172	PF00069	0.480
MOD_GSK3_1	218	225	PF00069	0.562
MOD_GSK3_1	273	280	PF00069	0.541
MOD_GSK3_1	338	345	PF00069	0.545
MOD_GSK3_1	363	370	PF00069	0.605
MOD_GSK3_1	428	435	PF00069	0.537
MOD_GSK3_1	456	463	PF00069	0.433
MOD_GSK3_1	478	485	PF00069	0.514
MOD_GSK3_1	526	533	PF00069	0.442
MOD_GSK3_1	60	67	PF00069	0.478
MOD_GSK3_1	68	75	PF00069	0.481
MOD_N-GLC_1	252	257	PF02516	0.270
MOD_NEK2_1	134	139	PF00069	0.582
MOD_NEK2_1	158	163	PF00069	0.496
MOD_NEK2_1	252	257	PF00069	0.535
MOD_NEK2_1	432	437	PF00069	0.565
MOD_NEK2_1	451	456	PF00069	0.437
MOD_NEK2_1	458	463	PF00069	0.411
MOD_NEK2_1	510	515	PF00069	0.551
MOD_NEK2_2	10	15	PF00069	0.507
MOD_NEK2_2	460	465	PF00069	0.533
MOD_PIKK_1	222	228	PF00454	0.556
MOD_PKA_2	194	200	PF00069	0.436
MOD_PKA_2	318	324	PF00069	0.365
MOD_PKA_2	356	362	PF00069	0.563
MOD_PKA_2	432	438	PF00069	0.588
MOD_PKA_2	470	476	PF00069	0.563
MOD_Plk_1	114	120	PF00069	0.548
MOD_Plk_1	165	171	PF00069	0.586
MOD_Plk_1	252	258	PF00069	0.485
MOD_Plk_1	346	352	PF00069	0.585
MOD_Plk_4	10	16	PF00069	0.584
MOD_Plk_4	114	120	PF00069	0.478
MOD_Plk_4	145	151	PF00069	0.572
MOD_Plk_4	165	171	PF00069	0.339
MOD_Plk_4	451	457	PF00069	0.396
MOD_Plk_4	460	466	PF00069	0.448
MOD_Plk_4	60	66	PF00069	0.470
MOD_ProDKin_1	18	24	PF00069	0.420
MOD_ProDKin_1	338	344	PF00069	0.649
MOD_ProDKin_1	433	439	PF00069	0.575
MOD_ProDKin_1	72	78	PF00069	0.470
MOD_ProDKin_1	81	87	PF00069	0.470
MOD_ProDKin_1	90	96	PF00069	0.339
TRG_DiLeu_BaEn_1	241	246	PF01217	0.475
TRG_DiLeu_BaEn_1	409	414	PF01217	0.472
TRG_ENDOCYTIC_2	293	296	PF00928	0.514
TRG_ENDOCYTIC_2	465	468	PF00928	0.502
TRG_ENDOCYTIC_2	469	472	PF00928	0.549
TRG_ENDOCYTIC_2	537	540	PF00928	0.236
TRG_ER_diArg_1	395	397	PF00400	0.400
TRG_ER_diArg_1	448	450	PF00400	0.529
TRG_ER_diArg_1	518	520	PF00400	0.394
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW4	Leptomonas seymouri	64%	100%
A0A0S4J9V9	Bodo saltans	34%	100%
A0A1X0P0B9	Trypanosomatidae	38%	100%
A0A3R7KPF2	Trypanosoma rangeli	38%	100%
A0A3S7XBL2	Leishmania donovani	92%	100%
A4IE43	Leishmania infantum	91%	100%
D0A495	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q0Y3	Leishmania major	91%	100%
V5DLN2	Trypanosoma cruzi	40%	100%