TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATL2_LEIMU

TriTrypDb:

LmxM.36.4280

Length:

821

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000974	Prp19 complex	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0071007	U2-type catalytic step 2 spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0071014	post-mRNA release spliceosomal complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ATL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATL2

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000245	spliceosomal complex assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.674
CLV_NRD_NRD_1	20	22	PF00675	0.544
CLV_NRD_NRD_1	207	209	PF00675	0.522
CLV_NRD_NRD_1	217	219	PF00675	0.385
CLV_NRD_NRD_1	341	343	PF00675	0.404
CLV_NRD_NRD_1	442	444	PF00675	0.540
CLV_NRD_NRD_1	480	482	PF00675	0.392
CLV_NRD_NRD_1	618	620	PF00675	0.448
CLV_NRD_NRD_1	629	631	PF00675	0.547
CLV_NRD_NRD_1	755	757	PF00675	0.507
CLV_NRD_NRD_1	76	78	PF00675	0.453
CLV_NRD_NRD_1	812	814	PF00675	0.539
CLV_NRD_NRD_1	85	87	PF00675	0.474
CLV_PCSK_FUR_1	73	77	PF00082	0.427
CLV_PCSK_KEX2_1	19	21	PF00082	0.529
CLV_PCSK_KEX2_1	2	4	PF00082	0.570
CLV_PCSK_KEX2_1	207	209	PF00082	0.522
CLV_PCSK_KEX2_1	217	219	PF00082	0.385
CLV_PCSK_KEX2_1	442	444	PF00082	0.540
CLV_PCSK_KEX2_1	480	482	PF00082	0.484
CLV_PCSK_KEX2_1	618	620	PF00082	0.431
CLV_PCSK_KEX2_1	629	631	PF00082	0.540
CLV_PCSK_KEX2_1	75	77	PF00082	0.424
CLV_PCSK_KEX2_1	755	757	PF00082	0.554
CLV_PCSK_KEX2_1	811	813	PF00082	0.540
CLV_PCSK_KEX2_1	85	87	PF00082	0.350
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.570
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.424
CLV_PCSK_PC1ET2_1	811	813	PF00082	0.558
CLV_PCSK_PC7_1	213	219	PF00082	0.374
CLV_PCSK_PC7_1	625	631	PF00082	0.471
CLV_PCSK_PC7_1	751	757	PF00082	0.453
CLV_PCSK_SKI1_1	150	154	PF00082	0.357
CLV_PCSK_SKI1_1	179	183	PF00082	0.335
CLV_PCSK_SKI1_1	213	217	PF00082	0.376
CLV_PCSK_SKI1_1	401	405	PF00082	0.522
CLV_PCSK_SKI1_1	421	425	PF00082	0.421
CLV_PCSK_SKI1_1	480	484	PF00082	0.379
CLV_PCSK_SKI1_1	560	564	PF00082	0.470
CLV_PCSK_SKI1_1	740	744	PF00082	0.378
CLV_PCSK_SKI1_1	808	812	PF00082	0.580
CLV_PCSK_SKI1_1	815	819	PF00082	0.561
CLV_PCSK_SKI1_1	86	90	PF00082	0.513
CLV_Separin_Metazoa	570	574	PF03568	0.419
DEG_APCC_DBOX_1	640	648	PF00400	0.502
DEG_APCC_DBOX_1	739	747	PF00400	0.505
DEG_Nend_UBRbox_1	1	4	PF02207	0.575
DOC_ANK_TNKS_1	316	323	PF00023	0.494
DOC_CKS1_1	223	228	PF01111	0.390
DOC_CYCLIN_RxL_1	477	487	PF00134	0.491
DOC_MAPK_gen_1	772	781	PF00069	0.494
DOC_PP1_RVXF_1	754	761	PF00149	0.616
DOC_PP2B_LxvP_1	408	411	PF13499	0.549
DOC_PP4_FxxP_1	223	226	PF00568	0.393
DOC_PP4_FxxP_1	49	52	PF00568	0.631
DOC_USP7_MATH_1	154	158	PF00917	0.377
DOC_USP7_MATH_1	397	401	PF00917	0.479
DOC_USP7_MATH_1	52	56	PF00917	0.647
DOC_WW_Pin1_4	222	227	PF00397	0.483
DOC_WW_Pin1_4	389	394	PF00397	0.712
DOC_WW_Pin1_4	395	400	PF00397	0.563
DOC_WW_Pin1_4	48	53	PF00397	0.586
DOC_WW_Pin1_4	519	524	PF00397	0.499
DOC_WW_Pin1_4	699	704	PF00397	0.463
DOC_WW_Pin1_4	779	784	PF00397	0.327
LIG_14-3-3_CanoR_1	150	159	PF00244	0.431
LIG_14-3-3_CanoR_1	288	292	PF00244	0.411
LIG_14-3-3_CanoR_1	342	352	PF00244	0.439
LIG_14-3-3_CanoR_1	366	374	PF00244	0.430
LIG_14-3-3_CanoR_1	442	446	PF00244	0.448
LIG_14-3-3_CanoR_1	591	596	PF00244	0.419
LIG_14-3-3_CanoR_1	707	715	PF00244	0.495
LIG_14-3-3_CanoR_1	755	759	PF00244	0.602
LIG_APCC_ABBA_1	118	123	PF00400	0.507
LIG_APCC_ABBA_1	334	339	PF00400	0.525
LIG_APCC_ABBA_1	493	498	PF00400	0.433
LIG_APCC_ABBAyCdc20_2	20	26	PF00400	0.521
LIG_BIR_III_2	189	193	PF00653	0.514
LIG_BRCT_BRCA1_1	136	140	PF00533	0.443
LIG_BRCT_BRCA1_1	674	678	PF00533	0.434
LIG_deltaCOP1_diTrp_1	786	791	PF00928	0.365
LIG_FHA_1	331	337	PF00498	0.465
LIG_FHA_1	385	391	PF00498	0.758
LIG_FHA_1	488	494	PF00498	0.410
LIG_FHA_1	734	740	PF00498	0.407
LIG_FHA_2	432	438	PF00498	0.279
LIG_FHA_2	582	588	PF00498	0.340
LIG_FHA_2	644	650	PF00498	0.434
LIG_FHA_2	763	769	PF00498	0.588
LIG_LIR_Apic_2	221	226	PF02991	0.482
LIG_LIR_Gen_1	106	114	PF02991	0.378
LIG_LIR_Gen_1	130	136	PF02991	0.342
LIG_LIR_Gen_1	311	319	PF02991	0.389
LIG_LIR_Gen_1	349	358	PF02991	0.383
LIG_LIR_Gen_1	764	773	PF02991	0.448
LIG_LIR_Gen_1	786	793	PF02991	0.458
LIG_LIR_Nem_3	130	134	PF02991	0.327
LIG_LIR_Nem_3	160	165	PF02991	0.317
LIG_LIR_Nem_3	228	232	PF02991	0.323
LIG_LIR_Nem_3	311	315	PF02991	0.365
LIG_LIR_Nem_3	345	351	PF02991	0.379
LIG_LIR_Nem_3	661	666	PF02991	0.322
LIG_LIR_Nem_3	764	770	PF02991	0.460
LIG_LIR_Nem_3	775	779	PF02991	0.354
LIG_LIR_Nem_3	786	791	PF02991	0.383
LIG_LRP6_Inhibitor_1	90	96	PF00058	0.472
LIG_MLH1_MIPbox_1	674	678	PF16413	0.434
LIG_PCNA_PIPBox_1	33	42	PF02747	0.488
LIG_PCNA_PIPBox_1	648	657	PF02747	0.461
LIG_PCNA_yPIPBox_3	28	40	PF02747	0.510
LIG_PCNA_yPIPBox_3	641	655	PF02747	0.466
LIG_Pex14_1	557	561	PF04695	0.410
LIG_Pex14_1	673	677	PF04695	0.490
LIG_Pex14_2	553	557	PF04695	0.371
LIG_Pex14_2	674	678	PF04695	0.434
LIG_PTB_Apo_2	448	455	PF02174	0.490
LIG_RPA_C_Fungi	614	626	PF08784	0.427
LIG_SH2_CRK	599	603	PF00017	0.467
LIG_SH2_CRK	655	659	PF00017	0.418
LIG_SH2_GRB2like	544	547	PF00017	0.462
LIG_SH2_NCK_1	196	200	PF00017	0.446
LIG_SH2_SRC	544	547	PF00017	0.462
LIG_SH2_STAP1	196	200	PF00017	0.453
LIG_SH2_STAP1	337	341	PF00017	0.454
LIG_SH2_STAP1	655	659	PF00017	0.355
LIG_SH2_STAT3	202	205	PF00017	0.473
LIG_SH2_STAT3	358	361	PF00017	0.462
LIG_SH2_STAT3	416	419	PF00017	0.509
LIG_SH2_STAT5	165	168	PF00017	0.312
LIG_SH2_STAT5	351	354	PF00017	0.357
LIG_SH2_STAT5	536	539	PF00017	0.485
LIG_SH2_STAT5	677	680	PF00017	0.490
LIG_SH3_2	396	401	PF14604	0.310
LIG_SH3_3	387	393	PF00018	0.527
LIG_SUMO_SIM_par_1	270	276	PF11976	0.413
LIG_TRAF2_1	468	471	PF00917	0.479
LIG_TRAF2_1	646	649	PF00917	0.487
LIG_TRAF2_1	65	68	PF00917	0.406
LIG_TYR_ITIM	559	564	PF00017	0.448
LIG_WRC_WIRS_1	582	587	PF05994	0.372
LIG_WRC_WIRS_1	592	597	PF05994	0.429
MOD_CDC14_SPxK_1	398	401	PF00782	0.532
MOD_CDK_SPxK_1	395	401	PF00069	0.574
MOD_CK1_1	487	493	PF00069	0.519
MOD_CK1_1	699	705	PF00069	0.565
MOD_CK2_1	310	316	PF00069	0.374
MOD_CK2_1	431	437	PF00069	0.278
MOD_CK2_1	522	528	PF00069	0.644
MOD_CK2_1	581	587	PF00069	0.502
MOD_CK2_1	62	68	PF00069	0.401
MOD_CK2_1	643	649	PF00069	0.443
MOD_CK2_1	742	748	PF00069	0.463
MOD_CK2_1	786	792	PF00069	0.455
MOD_GlcNHglycan	416	419	PF01048	0.392
MOD_GlcNHglycan	524	527	PF01048	0.543
MOD_GlcNHglycan	54	57	PF01048	0.620
MOD_GlcNHglycan	682	686	PF01048	0.600
MOD_GlcNHglycan	722	725	PF01048	0.485
MOD_GSK3_1	134	141	PF00069	0.461
MOD_GSK3_1	146	153	PF00069	0.381
MOD_GSK3_1	362	369	PF00069	0.415
MOD_GSK3_1	384	391	PF00069	0.666
MOD_GSK3_1	48	55	PF00069	0.634
MOD_GSK3_1	518	525	PF00069	0.589
MOD_GSK3_1	693	700	PF00069	0.620
MOD_GSK3_1	702	709	PF00069	0.495
MOD_GSK3_1	750	757	PF00069	0.497
MOD_GSK3_1	758	765	PF00069	0.551
MOD_GSK3_1	791	798	PF00069	0.480
MOD_N-GLC_1	343	348	PF02516	0.450
MOD_N-GLC_1	52	57	PF02516	0.521
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	134	139	PF00069	0.524
MOD_NEK2_1	353	358	PF00069	0.425
MOD_NEK2_1	367	372	PF00069	0.652
MOD_NEK2_1	496	501	PF00069	0.295
MOD_NEK2_1	654	659	PF00069	0.298
MOD_NEK2_1	791	796	PF00069	0.421
MOD_NEK2_1	80	85	PF00069	0.492
MOD_NEK2_2	287	292	PF00069	0.255
MOD_PIKK_1	474	480	PF00454	0.471
MOD_PIKK_1	762	768	PF00454	0.533
MOD_PKA_1	342	348	PF00069	0.394
MOD_PKA_1	811	817	PF00069	0.559
MOD_PKA_2	287	293	PF00069	0.409
MOD_PKA_2	362	368	PF00069	0.522
MOD_PKA_2	441	447	PF00069	0.446
MOD_PKA_2	706	712	PF00069	0.492
MOD_PKA_2	720	726	PF00069	0.568
MOD_PKA_2	750	756	PF00069	0.538
MOD_PKA_2	811	817	PF00069	0.540
MOD_PKB_1	340	348	PF00069	0.454
MOD_PKB_1	366	374	PF00069	0.426
MOD_Plk_1	496	502	PF00069	0.226
MOD_Plk_1	80	86	PF00069	0.498
MOD_Plk_2-3	643	649	PF00069	0.369
MOD_Plk_4	225	231	PF00069	0.389
MOD_Plk_4	353	359	PF00069	0.474
MOD_Plk_4	484	490	PF00069	0.239
MOD_Plk_4	654	660	PF00069	0.336
MOD_Plk_4	742	748	PF00069	0.421
MOD_ProDKin_1	222	228	PF00069	0.476
MOD_ProDKin_1	389	395	PF00069	0.710
MOD_ProDKin_1	48	54	PF00069	0.589
MOD_ProDKin_1	519	525	PF00069	0.491
MOD_ProDKin_1	699	705	PF00069	0.459
MOD_ProDKin_1	779	785	PF00069	0.330
MOD_SUMO_for_1	562	565	PF00179	0.318
TRG_DiLeu_BaEn_1	775	780	PF01217	0.484
TRG_DiLeu_BaEn_4	649	655	PF01217	0.405
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.521
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.494
TRG_DiLeu_BaLyEn_6	780	785	PF01217	0.456
TRG_ENDOCYTIC_2	131	134	PF00928	0.339
TRG_ENDOCYTIC_2	165	168	PF00928	0.312
TRG_ENDOCYTIC_2	312	315	PF00928	0.360
TRG_ENDOCYTIC_2	351	354	PF00928	0.372
TRG_ENDOCYTIC_2	561	564	PF00928	0.319
TRG_ENDOCYTIC_2	599	602	PF00928	0.323
TRG_ENDOCYTIC_2	655	658	PF00928	0.303
TRG_ER_diArg_1	18	21	PF00400	0.545
TRG_ER_diArg_1	216	218	PF00400	0.373
TRG_ER_diArg_1	480	482	PF00400	0.457
TRG_ER_diArg_1	618	621	PF00400	0.424
TRG_ER_diArg_1	754	756	PF00400	0.596
TRG_ER_diArg_1	812	815	PF00400	0.542
TRG_ER_diArg_1	84	86	PF00400	0.513
TRG_NES_CRM1_1	108	123	PF08389	0.430
TRG_NLS_MonoExtC_3	1	7	PF00514	0.611
TRG_NLS_MonoExtC_3	810	815	PF00514	0.534
TRG_NLS_MonoExtN_4	808	815	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	621	626	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P767	Leptomonas seymouri	74%	99%
A0A0S4JKT1	Bodo saltans	29%	94%
A0A1X0P0C5	Trypanosomatidae	43%	100%
A0A3Q8IHN6	Leishmania donovani	93%	100%
A0A3R7P515	Trypanosoma rangeli	42%	100%
A4HPU7	Leishmania braziliensis	87%	100%
A4IE46	Leishmania infantum	93%	100%
D0A493	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
P63154	Mus musculus	25%	100%
P63155	Rattus norvegicus	25%	100%
Q4PB37	Ustilago maydis (strain 521 / FGSC 9021)	28%	100%
Q4Q0Y6	Leishmania major	92%	100%
Q4WT84	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q527H0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	100%
Q5BDX1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q5K654	Paracoccidioides brasiliensis	26%	100%
Q6CJK2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
Q7SGD2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
Q9BZJ0	Homo sapiens	25%	97%
V5B545	Trypanosoma cruzi	43%	100%