Serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATL0_LEIMU

TriTrypDb:

LmxM.36.4260

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATL0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.475
CLV_NRD_NRD_1	197	199	PF00675	0.513
CLV_NRD_NRD_1	309	311	PF00675	0.455
CLV_NRD_NRD_1	332	334	PF00675	0.444
CLV_NRD_NRD_1	339	341	PF00675	0.424
CLV_NRD_NRD_1	355	357	PF00675	0.447
CLV_NRD_NRD_1	405	407	PF00675	0.553
CLV_NRD_NRD_1	90	92	PF00675	0.785
CLV_PCSK_KEX2_1	124	126	PF00082	0.496
CLV_PCSK_KEX2_1	197	199	PF00082	0.513
CLV_PCSK_KEX2_1	309	311	PF00082	0.472
CLV_PCSK_KEX2_1	332	334	PF00082	0.444
CLV_PCSK_KEX2_1	35	37	PF00082	0.732
CLV_PCSK_KEX2_1	355	357	PF00082	0.447
CLV_PCSK_KEX2_1	405	407	PF00082	0.537
CLV_PCSK_KEX2_1	90	92	PF00082	0.712
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.732
CLV_PCSK_SKI1_1	127	131	PF00082	0.485
CLV_PCSK_SKI1_1	187	191	PF00082	0.467
CLV_PCSK_SKI1_1	197	201	PF00082	0.452
CLV_PCSK_SKI1_1	260	264	PF00082	0.446
DEG_APCC_DBOX_1	126	134	PF00400	0.474
DEG_MDM2_SWIB_1	211	219	PF02201	0.419
DOC_CKS1_1	22	27	PF01111	0.672
DOC_CYCLIN_RxL_1	172	183	PF00134	0.440
DOC_CYCLIN_RxL_1	254	265	PF00134	0.473
DOC_MAPK_gen_1	124	130	PF00069	0.539
DOC_MAPK_gen_1	338	348	PF00069	0.436
DOC_MAPK_gen_1	366	374	PF00069	0.478
DOC_MAPK_MEF2A_6	340	348	PF00069	0.455
DOC_USP7_MATH_1	11	15	PF00917	0.692
DOC_USP7_MATH_1	129	133	PF00917	0.510
DOC_USP7_MATH_1	302	306	PF00917	0.583
DOC_USP7_MATH_1	324	328	PF00917	0.286
DOC_USP7_MATH_1	354	358	PF00917	0.502
DOC_USP7_MATH_1	38	42	PF00917	0.654
DOC_USP7_MATH_1	99	103	PF00917	0.574
DOC_WW_Pin1_4	21	26	PF00397	0.731
DOC_WW_Pin1_4	73	78	PF00397	0.591
LIG_14-3-3_CanoR_1	187	194	PF00244	0.537
LIG_14-3-3_CanoR_1	257	263	PF00244	0.504
LIG_14-3-3_CanoR_1	303	307	PF00244	0.572
LIG_14-3-3_CanoR_1	355	359	PF00244	0.547
LIG_14-3-3_CanoR_1	412	418	PF00244	0.635
LIG_Actin_WH2_2	241	259	PF00022	0.523
LIG_Actin_WH2_2	396	414	PF00022	0.503
LIG_AP_GAE_1	116	122	PF02883	0.605
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BRCT_BRCA1_1	395	399	PF00533	0.557
LIG_eIF4E_1	164	170	PF01652	0.436
LIG_FHA_1	2	8	PF00498	0.690
LIG_FHA_1	25	31	PF00498	0.686
LIG_FHA_1	367	373	PF00498	0.455
LIG_FHA_1	385	391	PF00498	0.630
LIG_FHA_2	133	139	PF00498	0.663
LIG_FHA_2	154	160	PF00498	0.481
LIG_Integrin_RGD_1	85	87	PF01839	0.807
LIG_Integrin_RGD_1	91	93	PF01839	0.694
LIG_LIR_Gen_1	116	126	PF02991	0.501
LIG_LIR_Nem_3	116	122	PF02991	0.500
LIG_LIR_Nem_3	207	211	PF02991	0.432
LIG_LIR_Nem_3	396	402	PF02991	0.531
LIG_NRBOX	343	349	PF00104	0.456
LIG_Pex14_2	211	215	PF04695	0.414
LIG_SH2_CRK	34	38	PF00017	0.596
LIG_SH2_GRB2like	351	354	PF00017	0.443
LIG_SH2_SRC	351	354	PF00017	0.467
LIG_SH2_STAP1	258	262	PF00017	0.495
LIG_SH2_STAP1	409	413	PF00017	0.567
LIG_SH2_STAT3	103	106	PF00017	0.475
LIG_SH2_STAT3	168	171	PF00017	0.535
LIG_SH2_STAT3	339	342	PF00017	0.529
LIG_SH2_STAT5	168	171	PF00017	0.456
LIG_SH2_STAT5	278	281	PF00017	0.596
LIG_SH2_STAT5	335	338	PF00017	0.518
LIG_SH2_STAT5	351	354	PF00017	0.338
LIG_SH3_3	104	110	PF00018	0.763
LIG_SH3_3	19	25	PF00018	0.689
LIG_SH3_3	27	33	PF00018	0.703
LIG_SUMO_SIM_anti_2	146	153	PF11976	0.547
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.542
LIG_SUMO_SIM_anti_2	343	348	PF11976	0.428
LIG_TRAF2_1	221	224	PF00917	0.465
LIG_TRAF2_1	37	40	PF00917	0.491
LIG_TRFH_1	103	107	PF08558	0.475
MOD_CK1_1	101	107	PF00069	0.620
MOD_CK1_1	132	138	PF00069	0.598
MOD_CK1_1	153	159	PF00069	0.525
MOD_CK1_1	16	22	PF00069	0.445
MOD_CK1_1	3	9	PF00069	0.759
MOD_CK1_1	357	363	PF00069	0.540
MOD_CK1_1	393	399	PF00069	0.583
MOD_CK1_1	42	48	PF00069	0.716
MOD_CK1_1	67	73	PF00069	0.785
MOD_CK2_1	132	138	PF00069	0.608
MOD_CK2_1	153	159	PF00069	0.505
MOD_CK2_1	258	264	PF00069	0.510
MOD_CK2_1	302	308	PF00069	0.561
MOD_CK2_1	324	330	PF00069	0.502
MOD_GlcNHglycan	383	387	PF01048	0.544
MOD_GlcNHglycan	392	395	PF01048	0.526
MOD_GlcNHglycan	421	424	PF01048	0.712
MOD_GlcNHglycan	66	69	PF01048	0.721
MOD_GlcNHglycan	7	10	PF01048	0.708
MOD_GSK3_1	1	8	PF00069	0.762
MOD_GSK3_1	12	19	PF00069	0.642
MOD_GSK3_1	20	27	PF00069	0.693
MOD_GSK3_1	258	265	PF00069	0.442
MOD_GSK3_1	324	331	PF00069	0.509
MOD_GSK3_1	38	45	PF00069	0.664
MOD_GSK3_1	63	70	PF00069	0.747
MOD_LATS_1	185	191	PF00433	0.470
MOD_N-GLC_1	366	371	PF02516	0.525
MOD_NEK2_1	1	6	PF00069	0.696
MOD_NEK2_1	211	216	PF00069	0.526
MOD_NEK2_1	256	261	PF00069	0.518
MOD_NEK2_1	262	267	PF00069	0.462
MOD_NEK2_1	390	395	PF00069	0.568
MOD_NEK2_1	411	416	PF00069	0.576
MOD_NEK2_1	71	76	PF00069	0.782
MOD_NEK2_2	302	307	PF00069	0.575
MOD_PIKK_1	132	138	PF00454	0.599
MOD_PIKK_1	357	363	PF00454	0.588
MOD_PIKK_1	411	417	PF00454	0.681
MOD_PKA_2	256	262	PF00069	0.503
MOD_PKA_2	302	308	PF00069	0.580
MOD_PKA_2	354	360	PF00069	0.551
MOD_PKA_2	411	417	PF00069	0.629
MOD_PKA_2	64	70	PF00069	0.757
MOD_Plk_1	39	45	PF00069	0.638
MOD_Plk_4	26	32	PF00069	0.765
MOD_Plk_4	302	308	PF00069	0.580
MOD_Plk_4	368	374	PF00069	0.477
MOD_Plk_4	398	404	PF00069	0.673
MOD_ProDKin_1	21	27	PF00069	0.729
MOD_ProDKin_1	73	79	PF00069	0.592
TRG_DiLeu_BaEn_1	343	348	PF01217	0.452
TRG_DiLeu_BaEn_4	195	201	PF01217	0.537
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.600
TRG_ER_diArg_1	124	127	PF00400	0.531
TRG_ER_diArg_1	197	199	PF00400	0.572
TRG_ER_diArg_1	332	334	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J8	Leptomonas seymouri	66%	100%
A0A0S4JG62	Bodo saltans	50%	100%
A0A1X0P1T1	Trypanosomatidae	52%	100%
A0A3Q8ILB9	Leishmania donovani	90%	100%
A0A422P583	Trypanosoma rangeli	55%	100%
A4HPU5	Leishmania braziliensis	78%	100%
A4IE48	Leishmania infantum	90%	100%
Q4Q0Y8	Leishmania major	88%	100%
V5BQ98	Trypanosoma cruzi	57%	100%