Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ATK9_LEIMU

TriTrypDb:

LmxM.36.4250

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATK9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	363	367	PF00656	0.291
CLV_C14_Caspase3-7	494	498	PF00656	0.312
CLV_NRD_NRD_1	146	148	PF00675	0.340
CLV_NRD_NRD_1	251	253	PF00675	0.576
CLV_NRD_NRD_1	335	337	PF00675	0.355
CLV_NRD_NRD_1	429	431	PF00675	0.312
CLV_NRD_NRD_1	448	450	PF00675	0.312
CLV_NRD_NRD_1	54	56	PF00675	0.324
CLV_PCSK_KEX2_1	146	148	PF00082	0.340
CLV_PCSK_KEX2_1	251	253	PF00082	0.576
CLV_PCSK_KEX2_1	335	337	PF00082	0.355
CLV_PCSK_KEX2_1	429	431	PF00082	0.312
CLV_PCSK_KEX2_1	538	540	PF00082	0.453
CLV_PCSK_KEX2_1	54	56	PF00082	0.324
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.453
CLV_PCSK_SKI1_1	300	304	PF00082	0.599
CLV_PCSK_SKI1_1	381	385	PF00082	0.312
CLV_PCSK_SKI1_1	55	59	PF00082	0.312
CLV_PCSK_SKI1_1	95	99	PF00082	0.312
CLV_Separin_Metazoa	99	103	PF03568	0.312
DEG_APCC_DBOX_1	54	62	PF00400	0.312
DEG_APCC_KENBOX_2	67	71	PF00400	0.388
DEG_COP1_1	469	478	PF00400	0.207
DEG_SCF_FBW7_2	486	493	PF00400	0.340
DEG_SIAH_1	751	759	PF03145	0.618
DEG_SPOP_SBC_1	570	574	PF00917	0.715
DEG_SPOP_SBC_1	647	651	PF00917	0.476
DOC_CYCLIN_RxL_1	378	388	PF00134	0.327
DOC_CYCLIN_yClb5_NLxxxL_5	92	101	PF00134	0.312
DOC_MAPK_gen_1	102	111	PF00069	0.312
DOC_MAPK_gen_1	112	121	PF00069	0.312
DOC_MAPK_HePTP_8	109	121	PF00069	0.340
DOC_MAPK_MEF2A_6	112	121	PF00069	0.340
DOC_PP2B_LxvP_1	585	588	PF13499	0.662
DOC_PP4_FxxP_1	417	420	PF00568	0.388
DOC_USP7_MATH_1	124	128	PF00917	0.388
DOC_USP7_MATH_1	150	154	PF00917	0.662
DOC_USP7_MATH_1	364	368	PF00917	0.312
DOC_USP7_MATH_1	385	389	PF00917	0.350
DOC_USP7_MATH_1	516	520	PF00917	0.418
DOC_USP7_MATH_1	556	560	PF00917	0.599
DOC_USP7_MATH_1	601	605	PF00917	0.609
DOC_USP7_MATH_1	616	620	PF00917	0.633
DOC_USP7_MATH_1	752	756	PF00917	0.622
DOC_WW_Pin1_4	146	151	PF00397	0.550
DOC_WW_Pin1_4	154	159	PF00397	0.572
DOC_WW_Pin1_4	231	236	PF00397	0.633
DOC_WW_Pin1_4	486	491	PF00397	0.388
DOC_WW_Pin1_4	547	552	PF00397	0.605
DOC_WW_Pin1_4	580	585	PF00397	0.599
DOC_WW_Pin1_4	589	594	PF00397	0.583
DOC_WW_Pin1_4	699	704	PF00397	0.597
DOC_WW_Pin1_4	717	722	PF00397	0.622
DOC_WW_Pin1_4	736	741	PF00397	0.599
DOC_WW_Pin1_4	785	790	PF00397	0.542
LIG_14-3-3_CanoR_1	123	129	PF00244	0.320
LIG_14-3-3_CanoR_1	146	150	PF00244	0.575
LIG_14-3-3_CanoR_1	521	528	PF00244	0.388
LIG_14-3-3_CanoR_1	539	547	PF00244	0.458
LIG_14-3-3_CanoR_1	54	61	PF00244	0.326
LIG_Actin_WH2_2	131	148	PF00022	0.312
LIG_BIR_III_2	319	323	PF00653	0.478
LIG_BRCT_BRCA1_1	220	224	PF00533	0.620
LIG_BRCT_BRCA1_1	268	272	PF00533	0.481
LIG_BRCT_BRCA1_1	719	723	PF00533	0.594
LIG_CtBP_PxDLS_1	108	112	PF00389	0.312
LIG_deltaCOP1_diTrp_1	366	375	PF00928	0.312
LIG_eIF4E_1	323	329	PF01652	0.361
LIG_EVH1_2	7	11	PF00568	0.446
LIG_FHA_1	207	213	PF00498	0.641
LIG_FHA_1	256	262	PF00498	0.704
LIG_FHA_1	324	330	PF00498	0.397
LIG_FHA_1	360	366	PF00498	0.312
LIG_FHA_1	470	476	PF00498	0.340
LIG_FHA_1	523	529	PF00498	0.319
LIG_FHA_1	627	633	PF00498	0.627
LIG_FHA_1	648	654	PF00498	0.580
LIG_FHA_1	657	663	PF00498	0.651
LIG_FHA_2	290	296	PF00498	0.609
LIG_FHA_2	339	345	PF00498	0.312
LIG_FHA_2	36	42	PF00498	0.276
LIG_FHA_2	361	367	PF00498	0.291
LIG_FHA_2	497	503	PF00498	0.255
LIG_GBD_Chelix_1	506	514	PF00786	0.255
LIG_IBAR_NPY_1	321	323	PF08397	0.478
LIG_LIR_Apic_2	347	353	PF02991	0.312
LIG_LIR_Apic_2	4	8	PF02991	0.456
LIG_LIR_Apic_2	415	420	PF02991	0.340
LIG_LIR_Apic_2	697	703	PF02991	0.577
LIG_LIR_Gen_1	269	280	PF02991	0.478
LIG_LIR_Nem_3	24	30	PF02991	0.312
LIG_LIR_Nem_3	269	275	PF02991	0.476
LIG_LIR_Nem_3	330	334	PF02991	0.312
LIG_LIR_Nem_3	339	345	PF02991	0.312
LIG_LIR_Nem_3	643	648	PF02991	0.653
LIG_LYPXL_yS_3	645	648	PF13949	0.655
LIG_Pex14_2	272	276	PF04695	0.477
LIG_PTB_Apo_2	127	134	PF02174	0.388
LIG_PTB_Phospho_1	127	133	PF10480	0.388
LIG_SH2_CRK	27	31	PF00017	0.312
LIG_SH2_CRK	5	9	PF00017	0.446
LIG_SH2_CRK	700	704	PF00017	0.605
LIG_SH2_STAP1	361	365	PF00017	0.312
LIG_SH2_STAT3	244	247	PF00017	0.719
LIG_SH2_STAT3	343	346	PF00017	0.312
LIG_SH2_STAT5	133	136	PF00017	0.340
LIG_SH2_STAT5	16	19	PF00017	0.395
LIG_SH2_STAT5	323	326	PF00017	0.347
LIG_SH2_STAT5	361	364	PF00017	0.348
LIG_SH2_STAT5	547	550	PF00017	0.503
LIG_SH2_STAT5	654	657	PF00017	0.721
LIG_SH2_STAT5	700	703	PF00017	0.682
LIG_SH2_STAT5	764	767	PF00017	0.661
LIG_SH2_STAT5	790	793	PF00017	0.563
LIG_SH3_3	379	385	PF00018	0.312
LIG_SH3_3	397	403	PF00018	0.312
LIG_SH3_3	590	596	PF00018	0.580
LIG_SH3_3	746	752	PF00018	0.642
LIG_SH3_3	801	807	PF00018	0.572
LIG_SUMO_SIM_par_1	107	113	PF11976	0.312
LIG_TRAF2_1	188	191	PF00917	0.570
LIG_TRAF2_1	499	502	PF00917	0.352
LIG_UBA3_1	374	381	PF00899	0.312
LIG_UBA3_1	64	68	PF00899	0.312
LIG_WRC_WIRS_1	160	165	PF05994	0.522
LIG_WRC_WIRS_1	77	82	PF05994	0.312
MOD_CDK_SPK_2	231	236	PF00069	0.599
MOD_CK1_1	152	158	PF00069	0.617
MOD_CK1_1	162	168	PF00069	0.671
MOD_CK1_1	169	175	PF00069	0.522
MOD_CK1_1	211	217	PF00069	0.686
MOD_CK1_1	234	240	PF00069	0.724
MOD_CK1_1	254	260	PF00069	0.518
MOD_CK1_1	469	475	PF00069	0.285
MOD_CK1_1	477	483	PF00069	0.285
MOD_CK1_1	583	589	PF00069	0.619
MOD_CK1_1	592	598	PF00069	0.605
MOD_CK1_1	702	708	PF00069	0.645
MOD_CK1_1	715	721	PF00069	0.582
MOD_CK1_1	744	750	PF00069	0.601
MOD_CK1_1	768	774	PF00069	0.697
MOD_CK2_1	107	113	PF00069	0.312
MOD_CK2_1	436	442	PF00069	0.402
MOD_CK2_1	496	502	PF00069	0.243
MOD_Cter_Amidation	249	252	PF01082	0.532
MOD_GlcNHglycan	130	133	PF01048	0.330
MOD_GlcNHglycan	169	172	PF01048	0.652
MOD_GlcNHglycan	175	178	PF01048	0.615
MOD_GlcNHglycan	220	223	PF01048	0.590
MOD_GlcNHglycan	253	256	PF01048	0.739
MOD_GlcNHglycan	261	264	PF01048	0.698
MOD_GlcNHglycan	268	271	PF01048	0.724
MOD_GlcNHglycan	278	281	PF01048	0.557
MOD_GlcNHglycan	285	288	PF01048	0.576
MOD_GlcNHglycan	476	479	PF01048	0.262
MOD_GlcNHglycan	540	543	PF01048	0.605
MOD_GlcNHglycan	55	58	PF01048	0.352
MOD_GlcNHglycan	558	561	PF01048	0.527
MOD_GlcNHglycan	60	64	PF01048	0.352
MOD_GlcNHglycan	603	606	PF01048	0.608
MOD_GlcNHglycan	696	699	PF01048	0.566
MOD_GlcNHglycan	714	717	PF01048	0.723
MOD_GlcNHglycan	746	749	PF01048	0.494
MOD_GlcNHglycan	761	764	PF01048	0.549
MOD_GlcNHglycan	767	770	PF01048	0.594
MOD_GlcNHglycan	783	786	PF01048	0.445
MOD_GSK3_1	124	131	PF00069	0.361
MOD_GSK3_1	145	152	PF00069	0.506
MOD_GSK3_1	162	169	PF00069	0.627
MOD_GSK3_1	251	258	PF00069	0.723
MOD_GSK3_1	285	292	PF00069	0.658
MOD_GSK3_1	307	314	PF00069	0.683
MOD_GSK3_1	360	367	PF00069	0.312
MOD_GSK3_1	516	523	PF00069	0.352
MOD_GSK3_1	534	541	PF00069	0.563
MOD_GSK3_1	570	577	PF00069	0.627
MOD_GSK3_1	606	613	PF00069	0.592
MOD_GSK3_1	626	633	PF00069	0.627
MOD_GSK3_1	648	655	PF00069	0.659
MOD_GSK3_1	699	706	PF00069	0.720
MOD_GSK3_1	711	718	PF00069	0.611
MOD_GSK3_1	777	784	PF00069	0.648
MOD_LATS_1	249	255	PF00433	0.528
MOD_N-GLC_1	153	158	PF02516	0.646
MOD_N-GLC_1	166	171	PF02516	0.629
MOD_N-GLC_1	173	178	PF02516	0.619
MOD_N-GLC_1	289	294	PF02516	0.639
MOD_N-GLC_1	534	539	PF02516	0.517
MOD_N-GLC_1	656	661	PF02516	0.662
MOD_NEK2_1	1	6	PF00069	0.574
MOD_NEK2_1	128	133	PF00069	0.388
MOD_NEK2_1	145	150	PF00069	0.381
MOD_NEK2_1	159	164	PF00069	0.583
MOD_NEK2_1	224	229	PF00069	0.633
MOD_NEK2_1	266	271	PF00069	0.584
MOD_NEK2_1	276	281	PF00069	0.597
MOD_NEK2_1	522	527	PF00069	0.291
MOD_NEK2_1	528	533	PF00069	0.291
MOD_NEK2_1	569	574	PF00069	0.586
MOD_NEK2_1	625	630	PF00069	0.645
MOD_NEK2_1	688	693	PF00069	0.663
MOD_NEK2_1	759	764	PF00069	0.601
MOD_NEK2_2	124	129	PF00069	0.388
MOD_PIKK_1	242	248	PF00454	0.584
MOD_PIKK_1	307	313	PF00454	0.664
MOD_PIKK_1	401	407	PF00454	0.291
MOD_PIKK_1	412	418	PF00454	0.291
MOD_PIKK_1	516	522	PF00454	0.312
MOD_PIKK_1	668	674	PF00454	0.654
MOD_PIKK_1	705	711	PF00454	0.638
MOD_PKA_1	251	257	PF00069	0.526
MOD_PKA_1	538	544	PF00069	0.459
MOD_PKA_2	145	151	PF00069	0.495
MOD_PKA_2	206	212	PF00069	0.587
MOD_PKA_2	251	257	PF00069	0.702
MOD_PKA_2	266	272	PF00069	0.590
MOD_PKA_2	520	526	PF00069	0.352
MOD_PKA_2	53	59	PF00069	0.388
MOD_PKA_2	538	544	PF00069	0.604
MOD_Plk_1	311	317	PF00069	0.649
MOD_Plk_1	338	344	PF00069	0.312
MOD_Plk_1	59	65	PF00069	0.312
MOD_Plk_1	625	631	PF00069	0.626
MOD_Plk_1	70	76	PF00069	0.312
MOD_Plk_2-3	497	503	PF00069	0.312
MOD_Plk_4	211	217	PF00069	0.638
MOD_Plk_4	338	344	PF00069	0.312
MOD_Plk_4	391	397	PF00069	0.312
MOD_Plk_4	528	534	PF00069	0.207
MOD_Plk_4	574	580	PF00069	0.531
MOD_Plk_4	616	622	PF00069	0.663
MOD_Plk_4	649	655	PF00069	0.662
MOD_Plk_4	800	806	PF00069	0.562
MOD_ProDKin_1	146	152	PF00069	0.560
MOD_ProDKin_1	154	160	PF00069	0.575
MOD_ProDKin_1	231	237	PF00069	0.635
MOD_ProDKin_1	486	492	PF00069	0.388
MOD_ProDKin_1	547	553	PF00069	0.606
MOD_ProDKin_1	580	586	PF00069	0.596
MOD_ProDKin_1	589	595	PF00069	0.583
MOD_ProDKin_1	699	705	PF00069	0.595
MOD_ProDKin_1	717	723	PF00069	0.623
MOD_ProDKin_1	736	742	PF00069	0.599
MOD_ProDKin_1	785	791	PF00069	0.540
MOD_SUMO_for_1	138	141	PF00179	0.312
MOD_SUMO_for_1	478	481	PF00179	0.255
MOD_SUMO_rev_2	131	140	PF00179	0.388
MOD_SUMO_rev_2	497	506	PF00179	0.207
TRG_DiLeu_BaEn_1	481	486	PF01217	0.388
TRG_DiLeu_BaEn_1	501	506	PF01217	0.183
TRG_DiLeu_BaEn_1	60	65	PF01217	0.312
TRG_DiLeu_BaEn_4	481	487	PF01217	0.388
TRG_ENDOCYTIC_2	27	30	PF00928	0.381
TRG_ENDOCYTIC_2	342	345	PF00928	0.312
TRG_ENDOCYTIC_2	645	648	PF00928	0.655
TRG_ER_diArg_1	101	104	PF00400	0.312
TRG_ER_diArg_1	145	147	PF00400	0.340
TRG_ER_diArg_1	334	336	PF00400	0.298
TRG_ER_diArg_1	53	55	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	441	446	PF00026	0.234
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR0	Leptomonas seymouri	57%	100%
A0A3S7XBF4	Leishmania donovani	92%	100%
A4HPU4	Leishmania braziliensis	79%	100%
A4IE49	Leishmania infantum	92%	99%
Q4Q0Y9	Leishmania major	92%	100%