WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATK8_LEIMU

TriTrypDb:

LmxM.36.4240

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	566	570	PF00656	0.593
CLV_NRD_NRD_1	182	184	PF00675	0.830
CLV_NRD_NRD_1	359	361	PF00675	0.486
CLV_NRD_NRD_1	417	419	PF00675	0.633
CLV_NRD_NRD_1	505	507	PF00675	0.586
CLV_NRD_NRD_1	539	541	PF00675	0.618
CLV_NRD_NRD_1	58	60	PF00675	0.620
CLV_PCSK_KEX2_1	182	184	PF00082	0.830
CLV_PCSK_KEX2_1	359	361	PF00082	0.486
CLV_PCSK_KEX2_1	417	419	PF00082	0.633
CLV_PCSK_KEX2_1	505	507	PF00082	0.586
CLV_PCSK_KEX2_1	58	60	PF00082	0.620
CLV_PCSK_SKI1_1	360	364	PF00082	0.532
CLV_PCSK_SKI1_1	487	491	PF00082	0.588
CLV_PCSK_SKI1_1	505	509	PF00082	0.271
CLV_PCSK_SKI1_1	595	599	PF00082	0.377
DEG_APCC_DBOX_1	684	692	PF00400	0.616
DEG_SPOP_SBC_1	322	326	PF00917	0.769
DEG_SPOP_SBC_1	406	410	PF00917	0.661
DOC_MAPK_gen_1	540	548	PF00069	0.583
DOC_MAPK_gen_1	58	64	PF00069	0.605
DOC_MAPK_MEF2A_6	249	257	PF00069	0.629
DOC_MAPK_MEF2A_6	429	438	PF00069	0.595
DOC_MAPK_MEF2A_6	685	692	PF00069	0.624
DOC_MAPK_NFAT4_5	685	693	PF00069	0.629
DOC_PP1_RVXF_1	58	65	PF00149	0.605
DOC_PP2B_LxvP_1	257	260	PF13499	0.450
DOC_PP2B_LxvP_1	282	285	PF13499	0.598
DOC_PP4_FxxP_1	377	380	PF00568	0.633
DOC_USP7_MATH_1	148	152	PF00917	0.708
DOC_USP7_MATH_1	185	189	PF00917	0.799
DOC_USP7_MATH_1	266	270	PF00917	0.600
DOC_USP7_MATH_1	285	289	PF00917	0.330
DOC_USP7_MATH_1	322	326	PF00917	0.686
DOC_USP7_MATH_1	380	384	PF00917	0.725
DOC_USP7_MATH_1	448	452	PF00917	0.573
DOC_USP7_MATH_1	471	475	PF00917	0.626
DOC_USP7_MATH_1	477	481	PF00917	0.604
DOC_USP7_MATH_1	509	513	PF00917	0.540
DOC_USP7_MATH_1	625	629	PF00917	0.765
DOC_USP7_MATH_1	655	659	PF00917	0.794
DOC_USP7_MATH_1	673	677	PF00917	0.242
DOC_USP7_MATH_2	266	272	PF00917	0.609
DOC_USP7_UBL2_3	363	367	PF12436	0.658
DOC_WW_Pin1_4	123	128	PF00397	0.702
DOC_WW_Pin1_4	210	215	PF00397	0.700
DOC_WW_Pin1_4	242	247	PF00397	0.638
DOC_WW_Pin1_4	378	383	PF00397	0.610
DOC_WW_Pin1_4	639	644	PF00397	0.771
DOC_WW_Pin1_4	649	654	PF00397	0.623
DOC_WW_Pin1_4	83	88	PF00397	0.681
LIG_14-3-3_CanoR_1	306	313	PF00244	0.688
LIG_14-3-3_CanoR_1	321	331	PF00244	0.606
LIG_14-3-3_CanoR_1	417	423	PF00244	0.500
LIG_14-3-3_CanoR_1	435	439	PF00244	0.296
LIG_14-3-3_CanoR_1	59	65	PF00244	0.604
LIG_14-3-3_CanoR_1	595	600	PF00244	0.382
LIG_Actin_WH2_2	526	542	PF00022	0.518
LIG_BIR_III_4	45	49	PF00653	0.567
LIG_BRCT_BRCA1_1	115	119	PF00533	0.571
LIG_BRCT_BRCA1_1	23	27	PF00533	0.500
LIG_BRCT_BRCA1_1	37	41	PF00533	0.600
LIG_BRCT_BRCA1_1	382	386	PF00533	0.736
LIG_BRCT_BRCA1_1	410	414	PF00533	0.681
LIG_CtBP_PxDLS_1	121	125	PF00389	0.635
LIG_FHA_1	184	190	PF00498	0.813
LIG_FHA_1	308	314	PF00498	0.623
LIG_FHA_1	559	565	PF00498	0.569
LIG_FHA_1	619	625	PF00498	0.559
LIG_FHA_1	678	684	PF00498	0.554
LIG_FHA_1	86	92	PF00498	0.580
LIG_FHA_2	291	297	PF00498	0.607
LIG_FHA_2	580	586	PF00498	0.453
LIG_LIR_Apic_2	167	173	PF02991	0.815
LIG_LIR_Apic_2	296	302	PF02991	0.657
LIG_LIR_Apic_2	375	380	PF02991	0.631
LIG_LIR_Gen_1	278	285	PF02991	0.610
LIG_LIR_Gen_1	63	70	PF02991	0.591
LIG_LIR_LC3C_4	687	692	PF02991	0.637
LIG_LIR_Nem_3	116	122	PF02991	0.577
LIG_LIR_Nem_3	278	284	PF02991	0.613
LIG_LIR_Nem_3	63	67	PF02991	0.589
LIG_PDZ_Class_2	697	702	PF00595	0.615
LIG_RPA_C_Fungi	131	143	PF08784	0.540
LIG_RPA_C_Fungi	348	360	PF08784	0.571
LIG_SH2_CRK	609	613	PF00017	0.572
LIG_SH2_PTP2	402	405	PF00017	0.664
LIG_SH2_SRC	402	405	PF00017	0.742
LIG_SH2_STAP1	519	523	PF00017	0.600
LIG_SH2_STAT5	221	224	PF00017	0.461
LIG_SH2_STAT5	230	233	PF00017	0.347
LIG_SH2_STAT5	281	284	PF00017	0.600
LIG_SH2_STAT5	402	405	PF00017	0.664
LIG_SH2_STAT5	648	651	PF00017	0.679
LIG_SH2_STAT5	670	673	PF00017	0.532
LIG_SH3_3	170	176	PF00018	0.747
LIG_SH3_3	600	606	PF00018	0.714
LIG_SUMO_SIM_par_1	120	126	PF11976	0.639
LIG_SUMO_SIM_par_1	128	134	PF11976	0.633
LIG_SUMO_SIM_par_1	252	258	PF11976	0.619
LIG_SUMO_SIM_par_1	571	577	PF11976	0.607
LIG_TRAF2_1	355	358	PF00917	0.673
LIG_TRAF2_1	523	526	PF00917	0.357
LIG_TRAF2_1	663	666	PF00917	0.737
LIG_WRC_WIRS_1	419	424	PF05994	0.591
LIG_WRC_WIRS_1	596	601	PF05994	0.375
LIG_WRC_WIRS_1	61	66	PF05994	0.591
MOD_CDC14_SPxK_1	642	645	PF00782	0.821
MOD_CDK_SPxK_1	639	645	PF00069	0.824
MOD_CDK_SPxxK_3	242	249	PF00069	0.633
MOD_CK1_1	113	119	PF00069	0.571
MOD_CK1_1	123	129	PF00069	0.546
MOD_CK1_1	151	157	PF00069	0.515
MOD_CK1_1	168	174	PF00069	0.573
MOD_CK1_1	195	201	PF00069	0.621
MOD_CK1_1	245	251	PF00069	0.708
MOD_CK1_1	372	378	PF00069	0.673
MOD_CK1_1	389	395	PF00069	0.506
MOD_CK1_1	412	418	PF00069	0.571
MOD_CK1_1	574	580	PF00069	0.478
MOD_CK1_1	626	632	PF00069	0.649
MOD_CK1_1	644	650	PF00069	0.553
MOD_CK1_1	65	71	PF00069	0.572
MOD_CK1_1	658	664	PF00069	0.705
MOD_CK2_1	143	149	PF00069	0.724
MOD_CK2_1	285	291	PF00069	0.615
MOD_CK2_1	306	312	PF00069	0.647
MOD_CK2_1	389	395	PF00069	0.799
MOD_CK2_1	519	525	PF00069	0.385
MOD_CK2_1	579	585	PF00069	0.527
MOD_CK2_1	654	660	PF00069	0.694
MOD_Cter_Amidation	503	506	PF01082	0.611
MOD_GlcNHglycan	151	154	PF01048	0.727
MOD_GlcNHglycan	204	207	PF01048	0.798
MOD_GlcNHglycan	287	290	PF01048	0.575
MOD_GlcNHglycan	325	328	PF01048	0.793
MOD_GlcNHglycan	341	344	PF01048	0.492
MOD_GlcNHglycan	371	374	PF01048	0.645
MOD_GlcNHglycan	382	385	PF01048	0.691
MOD_GlcNHglycan	42	45	PF01048	0.389
MOD_GlcNHglycan	422	425	PF01048	0.575
MOD_GlcNHglycan	450	453	PF01048	0.584
MOD_GlcNHglycan	495	498	PF01048	0.472
MOD_GlcNHglycan	502	505	PF01048	0.428
MOD_GlcNHglycan	520	524	PF01048	0.361
MOD_GlcNHglycan	535	538	PF01048	0.278
MOD_GlcNHglycan	64	67	PF01048	0.505
MOD_GlcNHglycan	673	676	PF01048	0.449
MOD_GSK3_1	1	8	PF00069	0.598
MOD_GSK3_1	164	171	PF00069	0.776
MOD_GSK3_1	183	190	PF00069	0.616
MOD_GSK3_1	210	217	PF00069	0.676
MOD_GSK3_1	241	248	PF00069	0.554
MOD_GSK3_1	266	273	PF00069	0.499
MOD_GSK3_1	301	308	PF00069	0.714
MOD_GSK3_1	36	43	PF00069	0.460
MOD_GSK3_1	365	372	PF00069	0.701
MOD_GSK3_1	405	412	PF00069	0.644
MOD_GSK3_1	420	427	PF00069	0.534
MOD_GSK3_1	585	592	PF00069	0.438
MOD_GSK3_1	614	621	PF00069	0.655
MOD_GSK3_1	625	632	PF00069	0.580
MOD_GSK3_1	637	644	PF00069	0.611
MOD_GSK3_1	654	661	PF00069	0.725
MOD_GSK3_1	673	680	PF00069	0.402
MOD_N-GLC_1	302	307	PF02516	0.535
MOD_N-GLC_1	339	344	PF02516	0.620
MOD_N-GLC_1	412	417	PF02516	0.629
MOD_N-GLC_1	487	492	PF02516	0.584
MOD_N-GLC_1	53	58	PF02516	0.457
MOD_N-GLC_1	626	631	PF02516	0.565
MOD_N-GLC_1	655	660	PF02516	0.514
MOD_NEK2_1	122	127	PF00069	0.558
MOD_NEK2_1	178	183	PF00069	0.682
MOD_NEK2_1	277	282	PF00069	0.628
MOD_NEK2_1	434	439	PF00069	0.552
MOD_NEK2_1	493	498	PF00069	0.573
MOD_NEK2_1	533	538	PF00069	0.443
MOD_NEK2_1	671	676	PF00069	0.549
MOD_NEK2_2	21	26	PF00069	0.399
MOD_NEK2_2	471	476	PF00069	0.454
MOD_NEK2_2	535	540	PF00069	0.602
MOD_NEK2_2	542	547	PF00069	0.235
MOD_NEK2_2	558	563	PF00069	0.578
MOD_PIKK_1	108	114	PF00454	0.532
MOD_PIKK_1	629	635	PF00454	0.802
MOD_PIKK_1	75	81	PF00454	0.647
MOD_PK_1	571	577	PF00069	0.607
MOD_PKA_2	143	149	PF00069	0.724
MOD_PKA_2	178	184	PF00069	0.688
MOD_PKA_2	305	311	PF00069	0.748
MOD_PKA_2	322	328	PF00069	0.606
MOD_PKA_2	369	375	PF00069	0.740
MOD_PKA_2	395	401	PF00069	0.613
MOD_PKA_2	434	440	PF00069	0.592
MOD_PKA_2	579	585	PF00069	0.605
MOD_PKA_2	644	650	PF00069	0.758
MOD_PKB_1	321	329	PF00069	0.554
MOD_Plk_1	290	296	PF00069	0.604
MOD_Plk_1	302	308	PF00069	0.584
MOD_Plk_1	35	41	PF00069	0.482
MOD_Plk_1	412	418	PF00069	0.478
MOD_Plk_1	5	11	PF00069	0.694
MOD_Plk_1	558	564	PF00069	0.532
MOD_Plk_1	626	632	PF00069	0.554
MOD_Plk_1	655	661	PF00069	0.496
MOD_Plk_1	677	683	PF00069	0.463
MOD_Plk_4	110	116	PF00069	0.535
MOD_Plk_4	138	144	PF00069	0.563
MOD_Plk_4	290	296	PF00069	0.604
MOD_Plk_4	36	42	PF00069	0.608
MOD_Plk_4	386	392	PF00069	0.773
MOD_Plk_4	395	401	PF00069	0.660
MOD_Plk_4	429	435	PF00069	0.493
MOD_Plk_4	542	548	PF00069	0.405
MOD_Plk_4	571	577	PF00069	0.607
MOD_Plk_4	644	650	PF00069	0.779
MOD_ProDKin_1	123	129	PF00069	0.711
MOD_ProDKin_1	210	216	PF00069	0.689
MOD_ProDKin_1	242	248	PF00069	0.641
MOD_ProDKin_1	378	384	PF00069	0.611
MOD_ProDKin_1	639	645	PF00069	0.773
MOD_ProDKin_1	649	655	PF00069	0.649
MOD_ProDKin_1	83	89	PF00069	0.682
MOD_SUMO_rev_2	309	318	PF00179	0.761
TRG_DiLeu_BaEn_1	94	99	PF01217	0.688
TRG_DiLeu_BaEn_2	36	42	PF01217	0.608
TRG_ENDOCYTIC_2	281	284	PF00928	0.600
TRG_ENDOCYTIC_2	609	612	PF00928	0.652
TRG_ER_diArg_1	175	178	PF00400	0.838
TRG_ER_diArg_1	416	418	PF00400	0.633
TRG_ER_diArg_1	505	507	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGF7	Leishmania donovani	88%	100%
A4HPU3	Leishmania braziliensis	75%	100%
E9AHX8	Leishmania infantum	89%	100%
Q4Q0Z0	Leishmania major	89%	100%