Paraflagellar rod component

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania mexicana

UniProt:

E9ATK7_LEIMU

TriTrypDb:

LmxM.36.4230

Length:

1079

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0031514	motile cilium	5	3

Expansion

Sequence features

E9ATK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	745	749	PF00656	0.366
CLV_C14_Caspase3-7	843	847	PF00656	0.332
CLV_NRD_NRD_1	1071	1073	PF00675	0.515
CLV_NRD_NRD_1	242	244	PF00675	0.524
CLV_NRD_NRD_1	491	493	PF00675	0.278
CLV_NRD_NRD_1	680	682	PF00675	0.373
CLV_PCSK_KEX2_1	1071	1073	PF00082	0.555
CLV_PCSK_KEX2_1	491	493	PF00082	0.278
CLV_PCSK_KEX2_1	606	608	PF00082	0.570
CLV_PCSK_KEX2_1	768	770	PF00082	0.415
CLV_PCSK_KEX2_1	899	901	PF00082	0.313
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.439
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.415
CLV_PCSK_PC1ET2_1	899	901	PF00082	0.346
CLV_PCSK_SKI1_1	1012	1016	PF00082	0.490
CLV_PCSK_SKI1_1	1036	1040	PF00082	0.674
CLV_PCSK_SKI1_1	134	138	PF00082	0.362
CLV_PCSK_SKI1_1	157	161	PF00082	0.409
CLV_PCSK_SKI1_1	447	451	PF00082	0.475
CLV_PCSK_SKI1_1	468	472	PF00082	0.528
CLV_PCSK_SKI1_1	575	579	PF00082	0.454
CLV_PCSK_SKI1_1	606	610	PF00082	0.259
CLV_PCSK_SKI1_1	682	686	PF00082	0.524
CLV_PCSK_SKI1_1	7	11	PF00082	0.527
CLV_PCSK_SKI1_1	812	816	PF00082	0.217
CLV_Separin_Metazoa	158	162	PF03568	0.365
CLV_Separin_Metazoa	964	968	PF03568	0.503
DEG_APCC_DBOX_1	1011	1019	PF00400	0.482
DEG_APCC_DBOX_1	446	454	PF00400	0.519
DOC_CYCLIN_RxL_1	157	167	PF00134	0.369
DOC_CYCLIN_RxL_1	485	499	PF00134	0.427
DOC_CYCLIN_RxL_1	753	762	PF00134	0.409
DOC_CYCLIN_RxL_1	807	820	PF00134	0.339
DOC_CYCLIN_RxL_1	896	906	PF00134	0.438
DOC_MAPK_gen_1	1071	1077	PF00069	0.500
DOC_MAPK_gen_1	413	421	PF00069	0.502
DOC_MAPK_gen_1	445	452	PF00069	0.371
DOC_MAPK_gen_1	768	774	PF00069	0.392
DOC_MAPK_gen_1	98	104	PF00069	0.502
DOC_MAPK_MEF2A_6	409	416	PF00069	0.519
DOC_MAPK_MEF2A_6	458	465	PF00069	0.549
DOC_MAPK_MEF2A_6	516	523	PF00069	0.302
DOC_PP1_RVXF_1	866	873	PF00149	0.382
DOC_USP7_MATH_1	115	119	PF00917	0.446
DOC_USP7_MATH_1	197	201	PF00917	0.481
DOC_USP7_MATH_1	70	74	PF00917	0.505
DOC_USP7_MATH_1	759	763	PF00917	0.258
DOC_USP7_MATH_1	9	13	PF00917	0.405
DOC_USP7_MATH_1	981	985	PF00917	0.302
DOC_USP7_UBL2_3	99	103	PF12436	0.463
DOC_WW_Pin1_4	1024	1029	PF00397	0.530
DOC_WW_Pin1_4	264	269	PF00397	0.493
DOC_WW_Pin1_4	40	45	PF00397	0.424
LIG_14-3-3_CanoR_1	1050	1056	PF00244	0.635
LIG_14-3-3_CanoR_1	224	230	PF00244	0.452
LIG_14-3-3_CanoR_1	295	304	PF00244	0.524
LIG_14-3-3_CanoR_1	445	450	PF00244	0.465
LIG_14-3-3_CanoR_1	485	491	PF00244	0.390
LIG_14-3-3_CanoR_1	492	500	PF00244	0.381
LIG_14-3-3_CanoR_1	646	652	PF00244	0.440
LIG_14-3-3_CanoR_1	663	673	PF00244	0.421
LIG_14-3-3_CanoR_1	769	773	PF00244	0.403
LIG_14-3-3_CanoR_1	863	870	PF00244	0.420
LIG_Actin_WH2_2	177	194	PF00022	0.230
LIG_Actin_WH2_2	854	870	PF00022	0.467
LIG_APCC_ABBA_1	162	167	PF00400	0.365
LIG_APCC_ABBAyCdc20_2	161	167	PF00400	0.369
LIG_BIR_II_1	1	5	PF00653	0.439
LIG_BRCT_BRCA1_1	170	174	PF00533	0.449
LIG_BRCT_BRCA1_1	227	231	PF00533	0.388
LIG_BRCT_BRCA1_1	399	403	PF00533	0.354
LIG_BRCT_BRCA1_1	868	872	PF00533	0.385
LIG_BRCT_BRCA1_1	950	954	PF00533	0.350
LIG_Clathr_ClatBox_1	163	167	PF01394	0.415
LIG_eIF4E_1	322	328	PF01652	0.223
LIG_FHA_1	1057	1063	PF00498	0.679
LIG_FHA_1	128	134	PF00498	0.532
LIG_FHA_1	236	242	PF00498	0.437
LIG_FHA_1	255	261	PF00498	0.370
LIG_FHA_1	403	409	PF00498	0.383
LIG_FHA_1	556	562	PF00498	0.471
LIG_FHA_1	593	599	PF00498	0.346
LIG_FHA_1	675	681	PF00498	0.593
LIG_FHA_1	69	75	PF00498	0.497
LIG_FHA_1	732	738	PF00498	0.411
LIG_FHA_1	749	755	PF00498	0.406
LIG_FHA_1	871	877	PF00498	0.376
LIG_FHA_2	1059	1065	PF00498	0.720
LIG_FHA_2	149	155	PF00498	0.535
LIG_FHA_2	246	252	PF00498	0.420
LIG_FHA_2	36	42	PF00498	0.489
LIG_FHA_2	469	475	PF00498	0.429
LIG_FHA_2	515	521	PF00498	0.411
LIG_FHA_2	618	624	PF00498	0.505
LIG_FHA_2	647	653	PF00498	0.463
LIG_FHA_2	670	676	PF00498	0.381
LIG_FHA_2	740	746	PF00498	0.591
LIG_FHA_2	904	910	PF00498	0.449
LIG_FHA_2	925	931	PF00498	0.473
LIG_GBD_Chelix_1	319	327	PF00786	0.222
LIG_IRF3_LxIS_1	328	335	PF10401	0.454
LIG_LIR_Gen_1	151	160	PF02991	0.334
LIG_LIR_Gen_1	267	274	PF02991	0.533
LIG_LIR_Nem_3	1027	1032	PF02991	0.643
LIG_LIR_Nem_3	151	155	PF02991	0.460
LIG_LIR_Nem_3	267	273	PF02991	0.509
LIG_LIR_Nem_3	700	705	PF02991	0.455
LIG_LIR_Nem_3	735	741	PF02991	0.504
LIG_LIR_Nem_3	91	96	PF02991	0.372
LIG_MAD2	415	423	PF02301	0.257
LIG_NRBOX	159	165	PF00104	0.469
LIG_NRBOX	933	939	PF00104	0.486
LIG_PCNA_PIPBox_1	184	193	PF02747	0.275
LIG_PCNA_yPIPBox_3	205	215	PF02747	0.469
LIG_Pex14_2	92	96	PF04695	0.370
LIG_PTB_Apo_2	219	226	PF02174	0.488
LIG_PTB_Phospho_1	219	225	PF10480	0.495
LIG_SH2_CRK	1029	1033	PF00017	0.575
LIG_SH2_PTP2	270	273	PF00017	0.332
LIG_SH2_STAP1	714	718	PF00017	0.257
LIG_SH2_STAT3	1055	1058	PF00017	0.601
LIG_SH2_STAT5	1055	1058	PF00017	0.652
LIG_SH2_STAT5	122	125	PF00017	0.394
LIG_SH2_STAT5	152	155	PF00017	0.393
LIG_SH2_STAT5	270	273	PF00017	0.522
LIG_SH2_STAT5	318	321	PF00017	0.365
LIG_SH2_STAT5	322	325	PF00017	0.368
LIG_SH2_STAT5	511	514	PF00017	0.396
LIG_SH2_STAT5	64	67	PF00017	0.439
LIG_SH2_STAT5	68	71	PF00017	0.407
LIG_SH2_STAT5	828	831	PF00017	0.487
LIG_SH2_STAT5	902	905	PF00017	0.565
LIG_SH3_3	41	47	PF00018	0.423
LIG_SUMO_SIM_anti_2	459	464	PF11976	0.406
LIG_SUMO_SIM_anti_2	649	655	PF11976	0.417
LIG_SUMO_SIM_anti_2	927	935	PF11976	0.482
LIG_SUMO_SIM_par_1	1057	1065	PF11976	0.744
LIG_SUMO_SIM_par_1	183	189	PF11976	0.348
LIG_SUMO_SIM_par_1	459	464	PF11976	0.556
LIG_SUMO_SIM_par_1	48	53	PF11976	0.442
LIG_SUMO_SIM_par_1	564	570	PF11976	0.380
LIG_SUMO_SIM_par_1	652	657	PF11976	0.350
LIG_TRAF2_1	300	303	PF00917	0.320
LIG_TRAF2_1	429	432	PF00917	0.441
LIG_TRAF2_1	627	630	PF00917	0.526
LIG_TRAF2_1	927	930	PF00917	0.500
LIG_TYR_ITSM	1025	1032	PF00017	0.560
LIG_UBA3_1	375	381	PF00899	0.401
LIG_WRC_WIRS_1	187	192	PF05994	0.340
LIG_WRC_WIRS_1	211	216	PF05994	0.278
LIG_WW_3	442	446	PF00397	0.370
MOD_CDC14_SPxK_1	43	46	PF00782	0.375
MOD_CDK_SPxK_1	1024	1030	PF00069	0.537
MOD_CDK_SPxK_1	40	46	PF00069	0.367
MOD_CK1_1	1017	1023	PF00069	0.430
MOD_CK1_1	113	119	PF00069	0.461
MOD_CK1_1	148	154	PF00069	0.521
MOD_CK1_1	210	216	PF00069	0.506
MOD_CK1_1	426	432	PF00069	0.491
MOD_CK1_1	496	502	PF00069	0.417
MOD_CK1_1	674	680	PF00069	0.521
MOD_CK1_1	817	823	PF00069	0.285
MOD_CK1_1	878	884	PF00069	0.521
MOD_CK1_1	943	949	PF00069	0.169
MOD_CK2_1	121	127	PF00069	0.466
MOD_CK2_1	148	154	PF00069	0.524
MOD_CK2_1	35	41	PF00069	0.410
MOD_CK2_1	381	387	PF00069	0.254
MOD_CK2_1	42	48	PF00069	0.440
MOD_CK2_1	426	432	PF00069	0.464
MOD_CK2_1	514	520	PF00069	0.390
MOD_CK2_1	617	623	PF00069	0.535
MOD_CK2_1	646	652	PF00069	0.463
MOD_CK2_1	669	675	PF00069	0.363
MOD_CK2_1	903	909	PF00069	0.363
MOD_CK2_1	924	930	PF00069	0.460
MOD_GlcNHglycan	112	115	PF01048	0.465
MOD_GlcNHglycan	134	137	PF01048	0.455
MOD_GlcNHglycan	140	143	PF01048	0.423
MOD_GlcNHglycan	147	150	PF01048	0.390
MOD_GlcNHglycan	173	177	PF01048	0.356
MOD_GlcNHglycan	298	301	PF01048	0.467
MOD_GlcNHglycan	425	428	PF01048	0.395
MOD_GlcNHglycan	464	468	PF01048	0.411
MOD_GlcNHglycan	561	564	PF01048	0.525
MOD_GlcNHglycan	655	659	PF01048	0.372
MOD_GlcNHglycan	666	669	PF01048	0.359
MOD_GlcNHglycan	761	764	PF01048	0.362
MOD_GlcNHglycan	822	825	PF01048	0.414
MOD_GlcNHglycan	985	988	PF01048	0.169
MOD_GSK3_1	1044	1051	PF00069	0.540
MOD_GSK3_1	1054	1061	PF00069	0.566
MOD_GSK3_1	123	130	PF00069	0.473
MOD_GSK3_1	132	139	PF00069	0.434
MOD_GSK3_1	168	175	PF00069	0.371
MOD_GSK3_1	225	232	PF00069	0.417
MOD_GSK3_1	246	253	PF00069	0.447
MOD_GSK3_1	262	269	PF00069	0.318
MOD_GSK3_1	496	503	PF00069	0.315
MOD_GSK3_1	545	552	PF00069	0.372
MOD_GSK3_1	555	562	PF00069	0.322
MOD_GSK3_1	739	746	PF00069	0.579
MOD_GSK3_1	789	796	PF00069	0.553
MOD_GSK3_1	810	817	PF00069	0.273
MOD_GSK3_1	838	845	PF00069	0.438
MOD_GSK3_1	862	869	PF00069	0.502
MOD_GSK3_1	920	927	PF00069	0.606
MOD_GSK3_1	939	946	PF00069	0.145
MOD_N-GLC_1	1024	1029	PF02516	0.486
MOD_N-GLC_1	108	113	PF02516	0.335
MOD_N-GLC_1	207	212	PF02516	0.512
MOD_N-GLC_1	283	288	PF02516	0.306
MOD_N-GLC_1	295	300	PF02516	0.437
MOD_N-GLC_1	332	337	PF02516	0.368
MOD_N-GLC_1	353	358	PF02516	0.325
MOD_N-GLC_1	454	459	PF02516	0.487
MOD_N-GLC_1	486	491	PF02516	0.358
MOD_N-GLC_1	493	498	PF02516	0.319
MOD_N-GLC_1	514	519	PF02516	0.284
MOD_N-GLC_1	521	526	PF02516	0.261
MOD_N-GLC_1	55	60	PF02516	0.415
MOD_N-GLC_1	646	651	PF02516	0.433
MOD_N-GLC_1	716	721	PF02516	0.442
MOD_N-GLC_1	732	737	PF02516	0.287
MOD_N-GLC_1	749	754	PF02516	0.421
MOD_N-GLC_1	870	875	PF02516	0.313
MOD_N-GLC_1	917	922	PF02516	0.443
MOD_N-GLC_1	939	944	PF02516	0.386
MOD_N-GLC_1	968	973	PF02516	0.342
MOD_N-GLC_2	110	112	PF02516	0.315
MOD_N-GLC_2	364	366	PF02516	0.169
MOD_N-GLC_2	535	537	PF02516	0.241
MOD_NEK2_1	1	6	PF00069	0.491
MOD_NEK2_1	1005	1010	PF00069	0.423
MOD_NEK2_1	138	143	PF00069	0.282
MOD_NEK2_1	191	196	PF00069	0.440
MOD_NEK2_1	229	234	PF00069	0.380
MOD_NEK2_1	250	255	PF00069	0.420
MOD_NEK2_1	259	264	PF00069	0.319
MOD_NEK2_1	332	337	PF00069	0.437
MOD_NEK2_1	35	40	PF00069	0.455
MOD_NEK2_1	463	468	PF00069	0.502
MOD_NEK2_1	486	491	PF00069	0.310
MOD_NEK2_1	493	498	PF00069	0.264
MOD_NEK2_1	500	505	PF00069	0.236
MOD_NEK2_1	521	526	PF00069	0.311
MOD_NEK2_1	549	554	PF00069	0.362
MOD_NEK2_1	579	584	PF00069	0.390
MOD_NEK2_1	594	599	PF00069	0.350
MOD_NEK2_1	664	669	PF00069	0.399
MOD_NEK2_1	713	718	PF00069	0.398
MOD_NEK2_1	801	806	PF00069	0.373
MOD_NEK2_1	814	819	PF00069	0.264
MOD_NEK2_1	901	906	PF00069	0.513
MOD_NEK2_1	917	922	PF00069	0.512
MOD_NEK2_1	938	943	PF00069	0.433
MOD_NEK2_2	88	93	PF00069	0.300
MOD_PIKK_1	1044	1050	PF00454	0.519
MOD_PIKK_1	1054	1060	PF00454	0.546
MOD_PIKK_1	191	197	PF00454	0.435
MOD_PK_1	353	359	PF00069	0.169
MOD_PK_1	445	451	PF00069	0.544
MOD_PK_1	98	104	PF00069	0.452
MOD_PKA_1	768	774	PF00069	0.392
MOD_PKA_1	98	104	PF00069	0.404
MOD_PKA_2	1049	1055	PF00069	0.566
MOD_PKA_2	204	210	PF00069	0.265
MOD_PKA_2	768	774	PF00069	0.573
MOD_PKA_2	862	868	PF00069	0.499
MOD_Plk_1	1005	1011	PF00069	0.518
MOD_Plk_1	1044	1050	PF00069	0.519
MOD_Plk_1	207	213	PF00069	0.445
MOD_Plk_1	283	289	PF00069	0.557
MOD_Plk_1	353	359	PF00069	0.320
MOD_Plk_1	468	474	PF00069	0.411
MOD_Plk_1	486	492	PF00069	0.338
MOD_Plk_1	514	520	PF00069	0.289
MOD_Plk_1	569	575	PF00069	0.462
MOD_Plk_1	579	585	PF00069	0.410
MOD_Plk_1	615	621	PF00069	0.455
MOD_Plk_1	634	640	PF00069	0.266
MOD_Plk_1	646	652	PF00069	0.276
MOD_Plk_1	731	737	PF00069	0.392
MOD_Plk_1	749	755	PF00069	0.410
MOD_Plk_1	789	795	PF00069	0.500
MOD_Plk_1	939	945	PF00069	0.417
MOD_Plk_1	968	974	PF00069	0.310
MOD_Plk_2-3	127	133	PF00069	0.292
MOD_Plk_2-3	514	520	PF00069	0.440
MOD_Plk_2-3	910	916	PF00069	0.309
MOD_Plk_4	1	7	PF00069	0.299
MOD_Plk_4	1017	1023	PF00069	0.481
MOD_Plk_4	186	192	PF00069	0.416
MOD_Plk_4	207	213	PF00069	0.268
MOD_Plk_4	266	272	PF00069	0.478
MOD_Plk_4	323	329	PF00069	0.384
MOD_Plk_4	334	340	PF00069	0.401
MOD_Plk_4	381	387	PF00069	0.517
MOD_Plk_4	473	479	PF00069	0.485
MOD_Plk_4	503	509	PF00069	0.370
MOD_Plk_4	732	738	PF00069	0.448
MOD_Plk_4	749	755	PF00069	0.481
MOD_Plk_4	88	94	PF00069	0.486
MOD_Plk_4	920	926	PF00069	0.496
MOD_ProDKin_1	1024	1030	PF00069	0.537
MOD_ProDKin_1	264	270	PF00069	0.491
MOD_ProDKin_1	40	46	PF00069	0.428
MOD_SUMO_for_1	577	580	PF00179	0.435
MOD_SUMO_rev_2	1068	1078	PF00179	0.652
MOD_SUMO_rev_2	570	579	PF00179	0.439
TRG_DiLeu_BaEn_2	157	163	PF01217	0.365
TRG_DiLeu_BaEn_3	731	737	PF01217	0.392
TRG_DiLeu_BaEn_4	929	935	PF01217	0.484
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.504
TRG_DiLeu_BaLyEn_6	834	839	PF01217	0.248
TRG_ENDOCYTIC_2	1029	1032	PF00928	0.585
TRG_ENDOCYTIC_2	152	155	PF00928	0.433
TRG_ENDOCYTIC_2	270	273	PF00928	0.447
TRG_ER_diArg_1	1071	1073	PF00400	0.511
TRG_ER_diArg_1	444	447	PF00400	0.451
TRG_ER_diArg_1	490	492	PF00400	0.278
TRG_ER_diArg_1	581	584	PF00400	0.460
TRG_NES_CRM1_1	1013	1026	PF08389	0.438
TRG_NES_CRM1_1	154	167	PF08389	0.472
TRG_NES_CRM1_1	834	846	PF08389	0.357
TRG_NES_CRM1_1	883	896	PF08389	0.263
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA2	Leptomonas seymouri	52%	100%
A0A0S4JML5	Bodo saltans	29%	99%
A0A1X0P080	Trypanosomatidae	37%	100%
A0A3Q8IWA4	Leishmania donovani	87%	96%
A0A422MVT9	Trypanosoma rangeli	35%	100%
A4HPU2	Leishmania braziliensis	72%	100%
A4IE50	Leishmania infantum	87%	96%
D0A481	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q0Z1	Leishmania major	87%	100%
V5DLP2	Trypanosoma cruzi	36%	100%