Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/Utp21 specific WD40 associated putative domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATK5_LEIMU

TriTrypDb:

LmxM.36.4210

Length:

984

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0030684	preribosome	3	11
GO:0032040	small-subunit processome	4	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9ATK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATK5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.451
CLV_C14_Caspase3-7	328	332	PF00656	0.379
CLV_C14_Caspase3-7	54	58	PF00656	0.359
CLV_C14_Caspase3-7	611	615	PF00656	0.453
CLV_MEL_PAP_1	939	945	PF00089	0.387
CLV_NRD_NRD_1	340	342	PF00675	0.303
CLV_NRD_NRD_1	756	758	PF00675	0.532
CLV_NRD_NRD_1	829	831	PF00675	0.387
CLV_NRD_NRD_1	917	919	PF00675	0.279
CLV_PCSK_FUR_1	338	342	PF00082	0.321
CLV_PCSK_KEX2_1	116	118	PF00082	0.257
CLV_PCSK_KEX2_1	340	342	PF00082	0.303
CLV_PCSK_KEX2_1	388	390	PF00082	0.375
CLV_PCSK_KEX2_1	755	757	PF00082	0.537
CLV_PCSK_KEX2_1	882	884	PF00082	0.276
CLV_PCSK_KEX2_1	917	919	PF00082	0.301
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.257
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.520
CLV_PCSK_PC1ET2_1	882	884	PF00082	0.276
CLV_PCSK_SKI1_1	152	156	PF00082	0.336
CLV_PCSK_SKI1_1	487	491	PF00082	0.343
CLV_PCSK_SKI1_1	906	910	PF00082	0.336
DEG_Nend_UBRbox_2	1	3	PF02207	0.404
DEG_SCF_FBW7_2	581	587	PF00400	0.331
DEG_SCF_FBW7_2	849	854	PF00400	0.263
DEG_SPOP_SBC_1	608	612	PF00917	0.453
DOC_ANK_TNKS_1	68	75	PF00023	0.285
DOC_CKS1_1	25	30	PF01111	0.459
DOC_CKS1_1	581	586	PF01111	0.253
DOC_CYCLIN_RxL_1	149	159	PF00134	0.387
DOC_CYCLIN_RxL_1	453	462	PF00134	0.441
DOC_CYCLIN_RxL_1	900	913	PF00134	0.340
DOC_CYCLIN_yClb1_LxF_4	780	785	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	800	803	PF00134	0.257
DOC_MAPK_DCC_7	667	676	PF00069	0.468
DOC_MAPK_DCC_7	681	691	PF00069	0.307
DOC_MAPK_gen_1	247	255	PF00069	0.458
DOC_MAPK_gen_1	804	810	PF00069	0.257
DOC_MAPK_gen_1	917	924	PF00069	0.276
DOC_MAPK_HePTP_8	869	881	PF00069	0.336
DOC_MAPK_JIP1_4	819	825	PF00069	0.301
DOC_MAPK_MEF2A_6	632	640	PF00069	0.331
DOC_MAPK_MEF2A_6	667	676	PF00069	0.555
DOC_MAPK_MEF2A_6	872	881	PF00069	0.336
DOC_MAPK_MEF2A_6	96	103	PF00069	0.307
DOC_PP1_RVXF_1	115	122	PF00149	0.387
DOC_PP1_RVXF_1	780	786	PF00149	0.340
DOC_PP1_RVXF_1	918	925	PF00149	0.427
DOC_PP2B_LxvP_1	800	803	PF13499	0.257
DOC_PP4_FxxP_1	304	307	PF00568	0.471
DOC_PP4_FxxP_1	633	636	PF00568	0.404
DOC_PP4_FxxP_1	810	813	PF00568	0.257
DOC_USP7_MATH_1	240	244	PF00917	0.373
DOC_USP7_MATH_1	499	503	PF00917	0.431
DOC_USP7_MATH_1	609	613	PF00917	0.422
DOC_USP7_MATH_1	706	710	PF00917	0.544
DOC_USP7_MATH_1	711	715	PF00917	0.614
DOC_USP7_MATH_1	888	892	PF00917	0.142
DOC_USP7_MATH_1	946	950	PF00917	0.142
DOC_WW_Pin1_4	24	29	PF00397	0.454
DOC_WW_Pin1_4	580	585	PF00397	0.394
DOC_WW_Pin1_4	590	595	PF00397	0.420
DOC_WW_Pin1_4	632	637	PF00397	0.302
DOC_WW_Pin1_4	674	679	PF00397	0.387
DOC_WW_Pin1_4	847	852	PF00397	0.278
LIG_14-3-3_CanoR_1	376	380	PF00244	0.337
LIG_14-3-3_CanoR_1	712	719	PF00244	0.609
LIG_14-3-3_CanoR_1	962	966	PF00244	0.301
LIG_Actin_WH2_2	520	538	PF00022	0.424
LIG_Actin_WH2_2	805	821	PF00022	0.257
LIG_Actin_WH2_2	947	964	PF00022	0.263
LIG_AP2alpha_2	5	7	PF02296	0.391
LIG_BRCT_BRCA1_1	242	246	PF00533	0.381
LIG_BRCT_BRCA1_1	553	557	PF00533	0.309
LIG_BRCT_BRCA1_1	638	642	PF00533	0.286
LIG_CaM_NSCaTE_8	531	538	PF13499	0.402
LIG_EH1_1	962	970	PF00400	0.253
LIG_eIF4E_1	149	155	PF01652	0.242
LIG_eIF4E_1	25	31	PF01652	0.306
LIG_eIF4E_1	353	359	PF01652	0.296
LIG_eIF4E_1	416	422	PF01652	0.391
LIG_eIF4E_1	963	969	PF01652	0.216
LIG_FHA_1	123	129	PF00498	0.278
LIG_FHA_1	159	165	PF00498	0.324
LIG_FHA_1	224	230	PF00498	0.476
LIG_FHA_1	25	31	PF00498	0.364
LIG_FHA_1	308	314	PF00498	0.415
LIG_FHA_1	346	352	PF00498	0.333
LIG_FHA_1	35	41	PF00498	0.300
LIG_FHA_1	353	359	PF00498	0.311
LIG_FHA_1	512	518	PF00498	0.457
LIG_FHA_1	530	536	PF00498	0.338
LIG_FHA_1	562	568	PF00498	0.339
LIG_FHA_1	813	819	PF00498	0.257
LIG_FHA_1	911	917	PF00498	0.387
LIG_FHA_1	98	104	PF00498	0.387
LIG_FHA_2	229	235	PF00498	0.341
LIG_FHA_2	246	252	PF00498	0.254
LIG_FHA_2	52	58	PF00498	0.491
LIG_FHA_2	575	581	PF00498	0.511
LIG_FHA_2	609	615	PF00498	0.453
LIG_FHA_2	718	724	PF00498	0.651
LIG_FHA_2	786	792	PF00498	0.257
LIG_FHA_2	812	818	PF00498	0.257
LIG_FHA_2	892	898	PF00498	0.289
LIG_LIR_Apic_2	22	28	PF02991	0.323
LIG_LIR_Apic_2	807	813	PF02991	0.257
LIG_LIR_Gen_1	308	314	PF02991	0.476
LIG_LIR_Gen_1	554	565	PF02991	0.184
LIG_LIR_Gen_1	685	694	PF02991	0.442
LIG_LIR_Gen_1	821	826	PF02991	0.301
LIG_LIR_Nem_3	2	7	PF02991	0.319
LIG_LIR_Nem_3	204	209	PF02991	0.258
LIG_LIR_Nem_3	308	312	PF02991	0.497
LIG_LIR_Nem_3	37	41	PF02991	0.282
LIG_LIR_Nem_3	554	560	PF02991	0.178
LIG_LIR_Nem_3	603	608	PF02991	0.431
LIG_LIR_Nem_3	685	691	PF02991	0.541
LIG_LRP6_Inhibitor_1	661	667	PF00058	0.362
LIG_MAD2	8	16	PF02301	0.422
LIG_MYND_1	799	803	PF01753	0.257
LIG_PCNA_yPIPBox_3	900	909	PF02747	0.381
LIG_PCNA_yPIPBox_3	920	933	PF02747	0.121
LIG_PDZ_Class_1	979	984	PF00595	0.413
LIG_Pex14_2	911	915	PF04695	0.276
LIG_PTB_Apo_2	662	669	PF02174	0.464
LIG_PTB_Phospho_1	662	668	PF10480	0.456
LIG_Rb_pABgroove_1	484	492	PF01858	0.382
LIG_SH2_CRK	25	29	PF00017	0.339
LIG_SH2_CRK	309	313	PF00017	0.470
LIG_SH2_CRK	466	470	PF00017	0.409
LIG_SH2_CRK	605	609	PF00017	0.431
LIG_SH2_CRK	668	672	PF00017	0.366
LIG_SH2_CRK	68	72	PF00017	0.293
LIG_SH2_GRB2like	149	152	PF00017	0.276
LIG_SH2_GRB2like	887	890	PF00017	0.252
LIG_SH2_NCK_1	466	470	PF00017	0.409
LIG_SH2_NCK_1	893	897	PF00017	0.369
LIG_SH2_SRC	80	83	PF00017	0.394
LIG_SH2_SRC	887	890	PF00017	0.306
LIG_SH2_STAP1	149	153	PF00017	0.276
LIG_SH2_STAP1	309	313	PF00017	0.470
LIG_SH2_STAT5	149	152	PF00017	0.276
LIG_SH2_STAT5	309	312	PF00017	0.482
LIG_SH2_STAT5	607	610	PF00017	0.418
LIG_SH2_STAT5	660	663	PF00017	0.383
LIG_SH2_STAT5	670	673	PF00017	0.534
LIG_SH2_STAT5	80	83	PF00017	0.394
LIG_SH2_STAT5	867	870	PF00017	0.276
LIG_SH2_STAT5	893	896	PF00017	0.254
LIG_SH3_1	796	802	PF00018	0.257
LIG_SH3_2	799	804	PF14604	0.257
LIG_SH3_3	15	21	PF00018	0.432
LIG_SH3_3	397	403	PF00018	0.498
LIG_SH3_3	672	678	PF00018	0.379
LIG_SH3_3	796	802	PF00018	0.257
LIG_SH3_3	966	972	PF00018	0.301
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.263
LIG_SUMO_SIM_par_1	27	34	PF11976	0.297
LIG_SUMO_SIM_par_1	513	518	PF11976	0.482
LIG_SUMO_SIM_par_1	821	828	PF11976	0.307
LIG_SUMO_SIM_par_1	866	873	PF11976	0.177
LIG_TRAF2_1	577	580	PF00917	0.483
LIG_TRAF2_1	722	725	PF00917	0.636
LIG_TRAF2_1	814	817	PF00917	0.276
LIG_TRAF2_1	851	854	PF00917	0.263
LIG_TRAF2_1	950	953	PF00917	0.387
LIG_TYR_ITIM	666	671	PF00017	0.362
LIG_UBA3_1	864	872	PF00899	0.216
LIG_WRC_WIRS_1	1	6	PF05994	0.374
LIG_WRC_WIRS_1	230	235	PF05994	0.352
LIG_WRC_WIRS_1	908	913	PF05994	0.301
MOD_CDK_SPK_2	674	679	PF00069	0.387
MOD_CDK_SPxK_1	580	586	PF00069	0.253
MOD_CDK_SPxxK_3	674	681	PF00069	0.274
MOD_CK1_1	176	182	PF00069	0.364
MOD_CK1_1	188	194	PF00069	0.310
MOD_CK1_1	256	262	PF00069	0.307
MOD_CK1_1	420	426	PF00069	0.297
MOD_CK1_1	451	457	PF00069	0.390
MOD_CK1_1	593	599	PF00069	0.525
MOD_CK1_1	870	876	PF00069	0.301
MOD_CK1_1	891	897	PF00069	0.385
MOD_CK1_1	910	916	PF00069	0.455
MOD_CK2_1	256	262	PF00069	0.299
MOD_CK2_1	282	288	PF00069	0.467
MOD_CK2_1	499	505	PF00069	0.425
MOD_CK2_1	574	580	PF00069	0.476
MOD_CK2_1	717	723	PF00069	0.629
MOD_CK2_1	811	817	PF00069	0.257
MOD_CK2_1	86	92	PF00069	0.415
MOD_CK2_1	891	897	PF00069	0.280
MOD_CK2_1	946	952	PF00069	0.142
MOD_CMANNOS	528	531	PF00535	0.348
MOD_Cter_Amidation	386	389	PF01082	0.371
MOD_GlcNHglycan	168	171	PF01048	0.302
MOD_GlcNHglycan	179	182	PF01048	0.336
MOD_GlcNHglycan	183	186	PF01048	0.338
MOD_GlcNHglycan	255	258	PF01048	0.288
MOD_GlcNHglycan	427	430	PF01048	0.347
MOD_GlcNHglycan	445	448	PF01048	0.294
MOD_GlcNHglycan	450	453	PF01048	0.404
MOD_GlcNHglycan	472	475	PF01048	0.323
MOD_GlcNHglycan	611	614	PF01048	0.213
MOD_GlcNHglycan	703	707	PF01048	0.686
MOD_GlcNHglycan	713	716	PF01048	0.651
MOD_GlcNHglycan	948	951	PF01048	0.142
MOD_GlcNHglycan	979	982	PF01048	0.390
MOD_GSK3_1	134	141	PF00069	0.296
MOD_GSK3_1	154	161	PF00069	0.232
MOD_GSK3_1	173	180	PF00069	0.154
MOD_GSK3_1	181	188	PF00069	0.275
MOD_GSK3_1	229	236	PF00069	0.463
MOD_GSK3_1	273	280	PF00069	0.499
MOD_GSK3_1	308	315	PF00069	0.376
MOD_GSK3_1	367	374	PF00069	0.313
MOD_GSK3_1	375	382	PF00069	0.342
MOD_GSK3_1	416	423	PF00069	0.304
MOD_GSK3_1	443	450	PF00069	0.357
MOD_GSK3_1	51	58	PF00069	0.484
MOD_GSK3_1	511	518	PF00069	0.418
MOD_GSK3_1	632	639	PF00069	0.325
MOD_GSK3_1	698	705	PF00069	0.699
MOD_GSK3_1	706	713	PF00069	0.710
MOD_GSK3_1	907	914	PF00069	0.147
MOD_GSK3_1	957	964	PF00069	0.277
MOD_GSK3_1	975	982	PF00069	0.366
MOD_N-GLC_1	482	487	PF02516	0.363
MOD_N-GLC_1	706	711	PF02516	0.567
MOD_N-GLC_1	785	790	PF02516	0.301
MOD_N-GLC_1	888	893	PF02516	0.252
MOD_N-GLC_2	270	272	PF02516	0.360
MOD_NEK2_1	108	113	PF00069	0.387
MOD_NEK2_1	173	178	PF00069	0.377
MOD_NEK2_1	201	206	PF00069	0.301
MOD_NEK2_1	253	258	PF00069	0.374
MOD_NEK2_1	273	278	PF00069	0.221
MOD_NEK2_1	31	36	PF00069	0.311
MOD_NEK2_1	312	317	PF00069	0.373
MOD_NEK2_1	357	362	PF00069	0.272
MOD_NEK2_1	367	372	PF00069	0.292
MOD_NEK2_1	443	448	PF00069	0.471
MOD_NEK2_1	545	550	PF00069	0.363
MOD_NEK2_1	55	60	PF00069	0.414
MOD_NEK2_1	638	643	PF00069	0.348
MOD_NEK2_1	648	653	PF00069	0.328
MOD_NEK2_1	785	790	PF00069	0.276
MOD_NEK2_1	86	91	PF00069	0.307
MOD_NEK2_1	911	916	PF00069	0.397
MOD_NEK2_1	975	980	PF00069	0.413
MOD_NEK2_2	867	872	PF00069	0.387
MOD_PIKK_1	379	385	PF00454	0.342
MOD_PIKK_1	745	751	PF00454	0.593
MOD_PIKK_1	794	800	PF00454	0.338
MOD_PIKK_1	812	818	PF00454	0.266
MOD_PKA_1	756	762	PF00069	0.586
MOD_PKA_2	177	183	PF00069	0.303
MOD_PKA_2	367	373	PF00069	0.303
MOD_PKA_2	375	381	PF00069	0.330
MOD_PKA_2	711	717	PF00069	0.614
MOD_PKA_2	756	762	PF00069	0.447
MOD_PKA_2	818	824	PF00069	0.257
MOD_PKA_2	829	835	PF00069	0.257
MOD_PKA_2	961	967	PF00069	0.276
MOD_Plk_1	307	313	PF00069	0.497
MOD_Plk_1	482	488	PF00069	0.350
MOD_Plk_1	500	506	PF00069	0.367
MOD_Plk_1	551	557	PF00069	0.430
MOD_Plk_1	785	791	PF00069	0.257
MOD_Plk_2-3	375	381	PF00069	0.330
MOD_Plk_4	124	130	PF00069	0.307
MOD_Plk_4	141	147	PF00069	0.148
MOD_Plk_4	19	25	PF00069	0.347
MOD_Plk_4	240	246	PF00069	0.326
MOD_Plk_4	297	303	PF00069	0.292
MOD_Plk_4	308	314	PF00069	0.331
MOD_Plk_4	417	423	PF00069	0.293
MOD_Plk_4	511	517	PF00069	0.433
MOD_Plk_4	552	558	PF00069	0.322
MOD_Plk_4	785	791	PF00069	0.262
MOD_Plk_4	818	824	PF00069	0.257
MOD_Plk_4	907	913	PF00069	0.336
MOD_ProDKin_1	24	30	PF00069	0.446
MOD_ProDKin_1	580	586	PF00069	0.255
MOD_ProDKin_1	590	596	PF00069	0.420
MOD_ProDKin_1	632	638	PF00069	0.304
MOD_ProDKin_1	674	680	PF00069	0.392
MOD_ProDKin_1	847	853	PF00069	0.278
MOD_SUMO_rev_2	111	118	PF00179	0.363
MOD_SUMO_rev_2	437	446	PF00179	0.325
MOD_SUMO_rev_2	878	884	PF00179	0.276
TRG_DiLeu_BaEn_1	308	313	PF01217	0.485
TRG_DiLeu_BaLyEn_6	796	801	PF01217	0.257
TRG_DiLeu_BaLyEn_6	837	842	PF01217	0.142
TRG_ENDOCYTIC_2	206	209	PF00928	0.257
TRG_ENDOCYTIC_2	309	312	PF00928	0.482
TRG_ENDOCYTIC_2	466	469	PF00928	0.411
TRG_ENDOCYTIC_2	605	608	PF00928	0.431
TRG_ENDOCYTIC_2	660	663	PF00928	0.365
TRG_ENDOCYTIC_2	668	671	PF00928	0.289
TRG_ENDOCYTIC_2	68	71	PF00928	0.295
TRG_ER_diArg_1	755	757	PF00400	0.591
TRG_ER_diArg_1	916	918	PF00400	0.336
TRG_NES_CRM1_1	847	859	PF08389	0.305
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H8	Leptomonas seymouri	83%	100%
A0A0S4IK94	Bodo saltans	50%	100%
A0A1X0P3D2	Trypanosomatidae	63%	100%
A0A3R7KJ70	Trypanosoma rangeli	64%	100%
A0A3S7XBK1	Leishmania donovani	97%	100%
A4HPU0	Leishmania braziliensis	90%	100%
A4IE52	Leishmania infantum	97%	100%
D0A8Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	89%
O14053	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q06078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4Q0Z3	Leishmania major	94%	99%
Q8NI36	Homo sapiens	24%	100%
V5BS01	Trypanosoma cruzi	63%	100%