Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen), N-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATK4_LEIMU

TriTrypDb:

LmxM.36.4200

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATK4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.569
CLV_C14_Caspase3-7	426	430	PF00656	0.758
CLV_C14_Caspase3-7	546	550	PF00656	0.593
CLV_C14_Caspase3-7	89	93	PF00656	0.596
CLV_NRD_NRD_1	101	103	PF00675	0.619
CLV_NRD_NRD_1	270	272	PF00675	0.655
CLV_NRD_NRD_1	299	301	PF00675	0.597
CLV_NRD_NRD_1	303	305	PF00675	0.561
CLV_NRD_NRD_1	407	409	PF00675	0.731
CLV_NRD_NRD_1	460	462	PF00675	0.539
CLV_NRD_NRD_1	5	7	PF00675	0.687
CLV_NRD_NRD_1	657	659	PF00675	0.620
CLV_NRD_NRD_1	668	670	PF00675	0.595
CLV_NRD_NRD_1	71	73	PF00675	0.545
CLV_NRD_NRD_1	738	740	PF00675	0.614
CLV_PCSK_FUR_1	300	304	PF00082	0.611
CLV_PCSK_KEX2_1	101	103	PF00082	0.587
CLV_PCSK_KEX2_1	270	272	PF00082	0.655
CLV_PCSK_KEX2_1	296	298	PF00082	0.595
CLV_PCSK_KEX2_1	302	304	PF00082	0.583
CLV_PCSK_KEX2_1	344	346	PF00082	0.665
CLV_PCSK_KEX2_1	4	6	PF00082	0.714
CLV_PCSK_KEX2_1	407	409	PF00082	0.732
CLV_PCSK_KEX2_1	460	462	PF00082	0.539
CLV_PCSK_KEX2_1	657	659	PF00082	0.620
CLV_PCSK_KEX2_1	667	669	PF00082	0.597
CLV_PCSK_KEX2_1	738	740	PF00082	0.614
CLV_PCSK_KEX2_1	94	96	PF00082	0.541
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.593
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.678
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.556
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.807
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.643
CLV_PCSK_SKI1_1	176	180	PF00082	0.491
CLV_PCSK_SKI1_1	407	411	PF00082	0.842
CLV_PCSK_SKI1_1	522	526	PF00082	0.569
CLV_PCSK_SKI1_1	56	60	PF00082	0.548
CLV_PCSK_SKI1_1	593	597	PF00082	0.534
CLV_PCSK_SKI1_1	657	661	PF00082	0.614
CLV_PCSK_SKI1_1	675	679	PF00082	0.676
CLV_PCSK_SKI1_1	9	13	PF00082	0.415
DEG_APCC_DBOX_1	109	117	PF00400	0.459
DEG_APCC_DBOX_1	527	535	PF00400	0.494
DEG_APCC_DBOX_1	55	63	PF00400	0.573
DEG_COP1_1	121	131	PF00400	0.541
DEG_SPOP_SBC_1	581	585	PF00917	0.540
DOC_CYCLIN_RxL_1	115	126	PF00134	0.469
DOC_CYCLIN_RxL_1	517	529	PF00134	0.513
DOC_CYCLIN_RxL_1	654	663	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.737
DOC_MAPK_DCC_7	202	210	PF00069	0.555
DOC_MAPK_DCC_7	593	602	PF00069	0.532
DOC_MAPK_gen_1	308	318	PF00069	0.625
DOC_MAPK_gen_1	517	527	PF00069	0.484
DOC_MAPK_gen_1	593	602	PF00069	0.532
DOC_MAPK_gen_1	738	749	PF00069	0.721
DOC_MAPK_gen_1	9	19	PF00069	0.360
DOC_MAPK_MEF2A_6	202	210	PF00069	0.560
DOC_MAPK_MEF2A_6	517	525	PF00069	0.490
DOC_MAPK_MEF2A_6	528	536	PF00069	0.507
DOC_MAPK_MEF2A_6	593	602	PF00069	0.532
DOC_MAPK_MEF2A_6	701	708	PF00069	0.500
DOC_MAPK_MEF2A_6	742	751	PF00069	0.686
DOC_MAPK_MEF2A_6	9	17	PF00069	0.533
DOC_MAPK_RevD_3	81	95	PF00069	0.500
DOC_PP1_RVXF_1	441	447	PF00149	0.752
DOC_PP1_RVXF_1	656	663	PF00149	0.606
DOC_PP2B_LxvP_1	120	123	PF13499	0.539
DOC_PP2B_LxvP_1	157	160	PF13499	0.474
DOC_PP2B_LxvP_1	36	39	PF13499	0.342
DOC_PP2B_LxvP_1	453	456	PF13499	0.724
DOC_PP2B_LxvP_1	602	605	PF13499	0.570
DOC_PP2B_LxvP_1	679	682	PF13499	0.707
DOC_PP2B_LxvP_1	762	765	PF13499	0.712
DOC_PP4_FxxP_1	446	449	PF00568	0.686
DOC_PP4_FxxP_1	498	501	PF00568	0.731
DOC_PP4_FxxP_1	787	790	PF00568	0.659
DOC_USP7_MATH_1	227	231	PF00917	0.491
DOC_USP7_MATH_1	373	377	PF00917	0.531
DOC_USP7_MATH_1	380	384	PF00917	0.708
DOC_USP7_MATH_1	39	43	PF00917	0.579
DOC_USP7_MATH_1	427	431	PF00917	0.542
DOC_USP7_MATH_1	473	477	PF00917	0.711
DOC_USP7_MATH_1	717	721	PF00917	0.644
DOC_WW_Pin1_4	374	379	PF00397	0.692
DOC_WW_Pin1_4	444	449	PF00397	0.600
DOC_WW_Pin1_4	526	531	PF00397	0.492
DOC_WW_Pin1_4	605	610	PF00397	0.509
LIG_14-3-3_CanoR_1	118	123	PF00244	0.710
LIG_14-3-3_CanoR_1	5	13	PF00244	0.488
LIG_14-3-3_CanoR_1	556	562	PF00244	0.523
LIG_14-3-3_CanoR_1	568	576	PF00244	0.489
LIG_14-3-3_CanoR_1	638	647	PF00244	0.516
LIG_14-3-3_CanoR_1	72	77	PF00244	0.511
LIG_14-3-3_CanoR_1	738	746	PF00244	0.671
LIG_Actin_RPEL_3	17	36	PF02755	0.286
LIG_Actin_WH2_2	504	519	PF00022	0.539
LIG_APCC_ABBA_1	625	630	PF00400	0.262
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BRCT_BRCA1_1	151	155	PF00533	0.463
LIG_EH_1	784	788	PF12763	0.656
LIG_EH1_1	181	189	PF00400	0.374
LIG_FHA_1	320	326	PF00498	0.646
LIG_FHA_1	432	438	PF00498	0.822
LIG_FHA_1	516	522	PF00498	0.620
LIG_FHA_1	531	537	PF00498	0.355
LIG_FHA_1	540	546	PF00498	0.427
LIG_FHA_1	640	646	PF00498	0.461
LIG_FHA_1	681	687	PF00498	0.699
LIG_FHA_2	252	258	PF00498	0.491
LIG_FHA_2	567	573	PF00498	0.612
LIG_FHA_2	581	587	PF00498	0.443
LIG_FHA_2	73	79	PF00498	0.545
LIG_LIR_Apic_2	150	154	PF02991	0.473
LIG_LIR_Apic_2	445	449	PF02991	0.659
LIG_LIR_Apic_2	482	486	PF02991	0.756
LIG_LIR_Apic_2	496	501	PF02991	0.619
LIG_LIR_Gen_1	152	163	PF02991	0.483
LIG_LIR_Gen_1	621	629	PF02991	0.441
LIG_LIR_Gen_1	74	83	PF02991	0.500
LIG_LIR_Nem_3	152	158	PF02991	0.488
LIG_LIR_Nem_3	621	625	PF02991	0.435
LIG_LIR_Nem_3	74	80	PF02991	0.513
LIG_LIR_Nem_3	802	807	PF02991	0.694
LIG_MAD2	522	530	PF02301	0.583
LIG_Pex14_1	503	507	PF04695	0.521
LIG_Pex14_1	662	666	PF04695	0.601
LIG_PTB_Apo_2	389	396	PF02174	0.741
LIG_REV1ctd_RIR_1	663	673	PF16727	0.705
LIG_SH2_CRK	151	155	PF00017	0.481
LIG_SH2_CRK	181	185	PF00017	0.419
LIG_SH2_CRK	559	563	PF00017	0.452
LIG_SH2_GRB2like	234	237	PF00017	0.560
LIG_SH2_GRB2like	396	399	PF00017	0.557
LIG_SH2_NCK_1	559	563	PF00017	0.452
LIG_SH2_SRC	758	761	PF00017	0.760
LIG_SH2_STAP1	195	199	PF00017	0.308
LIG_SH2_STAP1	290	294	PF00017	0.592
LIG_SH2_STAP1	758	762	PF00017	0.769
LIG_SH2_STAP1	77	81	PF00017	0.495
LIG_SH2_STAT3	574	577	PF00017	0.451
LIG_SH2_STAT3	76	79	PF00017	0.513
LIG_SH2_STAT5	195	198	PF00017	0.338
LIG_SH2_STAT5	566	569	PF00017	0.530
LIG_SH2_STAT5	628	631	PF00017	0.463
LIG_SH3_3	372	378	PF00018	0.692
LIG_SH3_3	592	598	PF00018	0.536
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.597
LIG_SUMO_SIM_anti_2	31	37	PF11976	0.341
LIG_SUMO_SIM_anti_2	607	615	PF11976	0.444
LIG_SUMO_SIM_anti_2	642	648	PF11976	0.475
LIG_SUMO_SIM_par_1	31	37	PF11976	0.492
LIG_SUMO_SIM_par_1	42	48	PF11976	0.397
LIG_SUMO_SIM_par_1	523	529	PF11976	0.577
LIG_SUMO_SIM_par_1	541	546	PF11976	0.280
LIG_SUMO_SIM_par_1	607	615	PF11976	0.444
LIG_SUMO_SIM_par_1	642	648	PF11976	0.569
LIG_TRAF2_1	476	479	PF00917	0.747
LIG_TRFH_1	677	681	PF08558	0.704
LIG_TYR_ITIM	179	184	PF00017	0.432
LIG_TYR_ITIM	557	562	PF00017	0.456
LIG_UBA3_1	58	67	PF00899	0.710
LIG_WRC_WIRS_1	633	638	PF05994	0.514
MOD_CDK_SPK_2	374	379	PF00069	0.513
MOD_CK1_1	251	257	PF00069	0.730
MOD_CK1_1	346	352	PF00069	0.698
MOD_CK1_1	431	437	PF00069	0.532
MOD_CK1_1	469	475	PF00069	0.706
MOD_CK1_1	526	532	PF00069	0.419
MOD_CK1_1	548	554	PF00069	0.552
MOD_CK1_1	560	566	PF00069	0.389
MOD_CK1_1	639	645	PF00069	0.466
MOD_CK1_1	711	717	PF00069	0.689
MOD_CK1_1	725	731	PF00069	0.740
MOD_CK1_1	737	743	PF00069	0.736
MOD_CK1_1	93	99	PF00069	0.621
MOD_CK2_1	118	124	PF00069	0.555
MOD_CK2_1	135	141	PF00069	0.490
MOD_CK2_1	251	257	PF00069	0.570
MOD_CK2_1	4	10	PF00069	0.678
MOD_CK2_1	473	479	PF00069	0.821
MOD_CK2_1	566	572	PF00069	0.556
MOD_CK2_1	72	78	PF00069	0.555
MOD_Cter_Amidation	294	297	PF01082	0.467
MOD_Cter_Amidation	413	416	PF01082	0.651
MOD_GlcNHglycan	130	134	PF01048	0.535
MOD_GlcNHglycan	137	140	PF01048	0.590
MOD_GlcNHglycan	190	193	PF01048	0.531
MOD_GlcNHglycan	229	232	PF01048	0.442
MOD_GlcNHglycan	250	253	PF01048	0.783
MOD_GlcNHglycan	328	331	PF01048	0.541
MOD_GlcNHglycan	398	401	PF01048	0.790
MOD_GlcNHglycan	429	433	PF01048	0.569
MOD_GlcNHglycan	512	515	PF01048	0.596
MOD_GlcNHglycan	549	553	PF01048	0.473
MOD_GlcNHglycan	647	650	PF01048	0.612
MOD_GlcNHglycan	724	727	PF01048	0.663
MOD_GSK3_1	108	115	PF00069	0.635
MOD_GSK3_1	131	138	PF00069	0.611
MOD_GSK3_1	149	156	PF00069	0.451
MOD_GSK3_1	183	190	PF00069	0.478
MOD_GSK3_1	243	250	PF00069	0.711
MOD_GSK3_1	319	326	PF00069	0.549
MOD_GSK3_1	427	434	PF00069	0.831
MOD_GSK3_1	469	476	PF00069	0.719
MOD_GSK3_1	526	533	PF00069	0.489
MOD_GSK3_1	548	555	PF00069	0.490
MOD_GSK3_1	577	584	PF00069	0.568
MOD_GSK3_1	604	611	PF00069	0.507
MOD_GSK3_1	628	635	PF00069	0.501
MOD_GSK3_1	680	687	PF00069	0.705
MOD_GSK3_1	733	740	PF00069	0.742
MOD_GSK3_1	789	796	PF00069	0.677
MOD_LATS_1	3	9	PF00433	0.492
MOD_N-GLC_1	235	240	PF02516	0.668
MOD_N-GLC_1	326	331	PF02516	0.604
MOD_N-GLC_1	605	610	PF02516	0.324
MOD_N-GLC_1	653	658	PF02516	0.576
MOD_N-GLC_1	684	689	PF02516	0.722
MOD_NEK2_1	131	136	PF00069	0.658
MOD_NEK2_1	187	192	PF00069	0.593
MOD_NEK2_1	248	253	PF00069	0.745
MOD_NEK2_1	323	328	PF00069	0.464
MOD_NEK2_1	515	520	PF00069	0.567
MOD_NEK2_1	636	641	PF00069	0.512
MOD_NEK2_1	653	658	PF00069	0.424
MOD_NEK2_1	660	665	PF00069	0.602
MOD_NEK2_1	722	727	PF00069	0.726
MOD_NEK2_1	734	739	PF00069	0.683
MOD_NEK2_1	752	757	PF00069	0.628
MOD_NEK2_1	90	95	PF00069	0.612
MOD_NEK2_2	380	385	PF00069	0.642
MOD_PIKK_1	560	566	PF00454	0.491
MOD_PKA_1	4	10	PF00069	0.763
MOD_PKA_1	72	78	PF00069	0.555
MOD_PKA_1	738	744	PF00069	0.529
MOD_PKA_2	312	318	PF00069	0.669
MOD_PKA_2	4	10	PF00069	0.763
MOD_PKA_2	486	492	PF00069	0.753
MOD_PKA_2	660	666	PF00069	0.602
MOD_PKA_2	71	77	PF00069	0.628
MOD_PKA_2	734	740	PF00069	0.710
MOD_Plk_1	505	511	PF00069	0.438
MOD_Plk_1	54	60	PF00069	0.603
MOD_Plk_1	675	681	PF00069	0.676
MOD_Plk_1	717	723	PF00069	0.690
MOD_Plk_2-3	343	349	PF00069	0.676
MOD_Plk_4	131	137	PF00069	0.657
MOD_Plk_4	183	189	PF00069	0.487
MOD_Plk_4	312	318	PF00069	0.718
MOD_Plk_4	539	545	PF00069	0.576
MOD_Plk_4	557	563	PF00069	0.281
MOD_Plk_4	608	614	PF00069	0.504
MOD_Plk_4	717	723	PF00069	0.578
MOD_Plk_4	72	78	PF00069	0.516
MOD_ProDKin_1	374	380	PF00069	0.695
MOD_ProDKin_1	444	450	PF00069	0.600
MOD_ProDKin_1	526	532	PF00069	0.488
MOD_ProDKin_1	605	611	PF00069	0.507
MOD_SUMO_for_1	11	14	PF00179	0.371
MOD_SUMO_rev_2	251	260	PF00179	0.493
MOD_SUMO_rev_2	359	368	PF00179	0.511
MOD_SUMO_rev_2	476	486	PF00179	0.748
MOD_SUMO_rev_2	7	13	PF00179	0.397
MOD_SUMO_rev_2	87	96	PF00179	0.622
TRG_DiLeu_BaEn_1	14	19	PF01217	0.491
TRG_DiLeu_BaEn_1	312	317	PF01217	0.714
TRG_DiLeu_BaEn_2	758	764	PF01217	0.774
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.593
TRG_DiLeu_BaLyEn_6	747	752	PF01217	0.663
TRG_ENDOCYTIC_2	181	184	PF00928	0.421
TRG_ENDOCYTIC_2	275	278	PF00928	0.733
TRG_ENDOCYTIC_2	559	562	PF00928	0.453
TRG_ENDOCYTIC_2	77	80	PF00928	0.500
TRG_ENDOCYTIC_2	804	807	PF00928	0.697
TRG_ER_diArg_1	101	103	PF00400	0.612
TRG_ER_diArg_1	270	273	PF00400	0.661
TRG_ER_diArg_1	459	461	PF00400	0.543
TRG_ER_diArg_1	494	497	PF00400	0.637
TRG_ER_diArg_1	657	659	PF00400	0.620
TRG_ER_diArg_1	666	669	PF00400	0.598
TRG_NLS_MonoCore_2	300	305	PF00514	0.609
TRG_NLS_MonoExtC_3	301	307	PF00514	0.684
TRG_NLS_MonoExtN_4	300	306	PF00514	0.682
TRG_NLS_MonoExtN_4	413	419	PF00514	0.805
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	345	350	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I967	Leptomonas seymouri	44%	95%
A0A3S7XBE9	Leishmania donovani	86%	100%
A4HPT9	Leishmania braziliensis	66%	100%
A4IE53	Leishmania infantum	86%	100%
Q4Q0Z4	Leishmania major	85%	100%