Sld5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GINS complex protein, putative

Species:

Leishmania mexicana

UniProt:

E9ATK3_LEIMU

TriTrypDb:

LmxM.36.4190

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000228	nuclear chromosome	6	9
GO:0005694	chromosome	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0000811	GINS complex	4	1
GO:0031261	DNA replication preinitiation complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ATK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATK3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006260	DNA replication	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.673
CLV_NRD_NRD_1	337	339	PF00675	0.575
CLV_PCSK_KEX2_1	336	338	PF00082	0.585
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.585
CLV_PCSK_SKI1_1	131	135	PF00082	0.325
DEG_APCC_DBOX_1	223	231	PF00400	0.539
DEG_SPOP_SBC_1	257	261	PF00917	0.594
DOC_MAPK_gen_1	170	180	PF00069	0.442
DOC_MAPK_gen_1	222	230	PF00069	0.582
DOC_MAPK_RevD_3	324	338	PF00069	0.678
DOC_USP7_MATH_1	24	28	PF00917	0.594
DOC_USP7_MATH_1	302	306	PF00917	0.685
DOC_USP7_MATH_1	311	315	PF00917	0.669
DOC_WW_Pin1_4	183	188	PF00397	0.442
DOC_WW_Pin1_4	234	239	PF00397	0.537
DOC_WW_Pin1_4	265	270	PF00397	0.746
DOC_WW_Pin1_4	324	329	PF00397	0.622
LIG_14-3-3_CanoR_1	207	211	PF00244	0.373
LIG_14-3-3_CanoR_1	240	246	PF00244	0.674
LIG_14-3-3_CanoR_1	247	251	PF00244	0.689
LIG_14-3-3_CanoR_1	258	264	PF00244	0.691
LIG_14-3-3_CanoR_1	337	341	PF00244	0.578
LIG_14-3-3_CanoR_1	87	97	PF00244	0.442
LIG_14-3-3_CterR_2	341	343	PF00244	0.593
LIG_Actin_WH2_2	191	209	PF00022	0.442
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	120	124	PF00533	0.525
LIG_BRCT_BRCA1_1	185	189	PF00533	0.484
LIG_BRCT_BRCA1_1	283	287	PF00533	0.585
LIG_deltaCOP1_diTrp_1	30	34	PF00928	0.530
LIG_FHA_1	194	200	PF00498	0.481
LIG_FHA_1	258	264	PF00498	0.767
LIG_FHA_1	266	272	PF00498	0.629
LIG_FHA_1	321	327	PF00498	0.607
LIG_FHA_1	89	95	PF00498	0.442
LIG_FHA_2	272	278	PF00498	0.721
LIG_LIR_Gen_1	116	127	PF02991	0.382
LIG_LIR_Gen_1	40	49	PF02991	0.358
LIG_LIR_Gen_1	98	105	PF02991	0.541
LIG_LIR_Nem_3	116	122	PF02991	0.382
LIG_LIR_Nem_3	209	213	PF02991	0.409
LIG_LIR_Nem_3	31	37	PF02991	0.453
LIG_LIR_Nem_3	66	70	PF02991	0.428
LIG_LIR_Nem_3	98	102	PF02991	0.541
LIG_PCNA_yPIPBox_3	170	178	PF02747	0.525
LIG_Pex14_1	81	85	PF04695	0.525
LIG_Rb_LxCxE_1	196	209	PF01857	0.571
LIG_SH2_SRC	127	130	PF00017	0.472
LIG_SH2_STAT3	85	88	PF00017	0.525
LIG_SH2_STAT5	104	107	PF00017	0.464
LIG_SH2_STAT5	125	128	PF00017	0.442
LIG_SH2_STAT5	85	88	PF00017	0.523
LIG_SH2_STAT5	99	102	PF00017	0.457
LIG_SH3_3	66	72	PF00018	0.344
LIG_WRC_WIRS_1	39	44	PF05994	0.302
LIG_WW_1	96	99	PF00397	0.484
MOD_CDK_SPxK_1	234	240	PF00069	0.543
MOD_CK1_1	15	21	PF00069	0.672
MOD_CK1_1	2	8	PF00069	0.620
MOD_CK1_1	234	240	PF00069	0.652
MOD_CK1_1	252	258	PF00069	0.556
MOD_CK1_1	265	271	PF00069	0.648
MOD_CK1_1	295	301	PF00069	0.616
MOD_CK1_1	305	311	PF00069	0.555
MOD_CK1_1	318	324	PF00069	0.667
MOD_GlcNHglycan	140	143	PF01048	0.238
MOD_GlcNHglycan	17	20	PF01048	0.573
MOD_GlcNHglycan	233	236	PF01048	0.664
MOD_GlcNHglycan	251	254	PF01048	0.550
MOD_GlcNHglycan	283	286	PF01048	0.535
MOD_GlcNHglycan	297	300	PF01048	0.661
MOD_GSK3_1	241	248	PF00069	0.635
MOD_GSK3_1	249	256	PF00069	0.600
MOD_GSK3_1	257	264	PF00069	0.520
MOD_GSK3_1	277	284	PF00069	0.649
MOD_GSK3_1	298	305	PF00069	0.618
MOD_GSK3_1	311	318	PF00069	0.607
MOD_GSK3_1	320	327	PF00069	0.562
MOD_GSK3_1	336	343	PF00069	0.710
MOD_N-GLC_2	90	92	PF02516	0.257
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	206	211	PF00069	0.371
MOD_NEK2_1	241	246	PF00069	0.597
MOD_NEK2_1	263	268	PF00069	0.734
MOD_NEK2_1	63	68	PF00069	0.424
MOD_NEK2_1	86	91	PF00069	0.584
MOD_PIKK_1	292	298	PF00454	0.671
MOD_PIKK_1	315	321	PF00454	0.775
MOD_PIKK_1	327	333	PF00454	0.504
MOD_PKA_1	131	137	PF00069	0.525
MOD_PKA_1	336	342	PF00069	0.576
MOD_PKA_2	206	212	PF00069	0.372
MOD_PKA_2	239	245	PF00069	0.526
MOD_PKA_2	246	252	PF00069	0.593
MOD_PKA_2	257	263	PF00069	0.783
MOD_PKA_2	336	342	PF00069	0.576
MOD_PKA_2	86	92	PF00069	0.442
MOD_Plk_4	283	289	PF00069	0.678
MOD_Plk_4	38	44	PF00069	0.417
MOD_Plk_4	47	53	PF00069	0.350
MOD_ProDKin_1	183	189	PF00069	0.442
MOD_ProDKin_1	234	240	PF00069	0.543
MOD_ProDKin_1	265	271	PF00069	0.747
MOD_ProDKin_1	324	330	PF00069	0.620
TRG_DiLeu_BaEn_1	158	163	PF01217	0.442
TRG_ENDOCYTIC_2	67	70	PF00928	0.381
TRG_ENDOCYTIC_2	99	102	PF00928	0.518
TRG_NES_CRM1_1	202	216	PF08389	0.427
TRG_NLS_MonoCore_2	334	339	PF00514	0.576
TRG_NLS_MonoExtN_4	332	339	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.171
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H9	Leptomonas seymouri	67%	100%
A0A3Q8IPD7	Leishmania donovani	94%	100%
A0A3R7KS72	Trypanosoma rangeli	46%	100%
A4HPT8	Leishmania braziliensis	82%	100%
A4IE54	Leishmania infantum	94%	100%
D0A8Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q0Z5	Leishmania major	91%	100%
V5BMD4	Trypanosoma cruzi	47%	83%