Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATJ9_LEIMU

TriTrypDb:

LmxM.36.4150

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	5
GO:0031514	motile cilium	5	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

E9ATJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	575	579	PF00656	0.602
CLV_C14_Caspase3-7	77	81	PF00656	0.641
CLV_NRD_NRD_1	172	174	PF00675	0.530
CLV_NRD_NRD_1	292	294	PF00675	0.636
CLV_NRD_NRD_1	324	326	PF00675	0.663
CLV_NRD_NRD_1	438	440	PF00675	0.539
CLV_NRD_NRD_1	474	476	PF00675	0.596
CLV_NRD_NRD_1	571	573	PF00675	0.624
CLV_PCSK_KEX2_1	172	174	PF00082	0.530
CLV_PCSK_KEX2_1	292	294	PF00082	0.681
CLV_PCSK_KEX2_1	324	326	PF00082	0.603
CLV_PCSK_KEX2_1	570	572	PF00082	0.640
CLV_PCSK_PC7_1	168	174	PF00082	0.603
CLV_PCSK_SKI1_1	207	211	PF00082	0.592
CLV_PCSK_SKI1_1	261	265	PF00082	0.433
CLV_PCSK_SKI1_1	268	272	PF00082	0.403
CLV_PCSK_SKI1_1	3	7	PF00082	0.758
CLV_PCSK_SKI1_1	417	421	PF00082	0.503
CLV_PCSK_SKI1_1	439	443	PF00082	0.481
CLV_PCSK_SKI1_1	99	103	PF00082	0.526
DEG_APCC_DBOX_1	248	256	PF00400	0.474
DEG_APCC_DBOX_1	71	79	PF00400	0.500
DEG_SPOP_SBC_1	370	374	PF00917	0.662
DOC_MAPK_gen_1	427	436	PF00069	0.449
DOC_MAPK_gen_1	500	508	PF00069	0.306
DOC_MAPK_MEF2A_6	430	438	PF00069	0.448
DOC_MAPK_RevD_3	158	173	PF00069	0.601
DOC_USP7_MATH_1	108	112	PF00917	0.711
DOC_USP7_MATH_1	117	121	PF00917	0.684
DOC_USP7_MATH_1	203	207	PF00917	0.608
DOC_USP7_MATH_1	215	219	PF00917	0.552
DOC_USP7_MATH_1	314	318	PF00917	0.752
DOC_USP7_MATH_1	357	361	PF00917	0.705
DOC_USP7_MATH_1	370	374	PF00917	0.471
DOC_USP7_MATH_1	531	535	PF00917	0.613
DOC_USP7_MATH_1	582	586	PF00917	0.621
DOC_USP7_MATH_1	62	66	PF00917	0.617
DOC_USP7_UBL2_3	524	528	PF12436	0.588
DOC_USP7_UBL2_3	605	609	PF12436	0.627
DOC_WW_Pin1_4	10	15	PF00397	0.628
LIG_14-3-3_CanoR_1	157	161	PF00244	0.619
LIG_14-3-3_CanoR_1	226	236	PF00244	0.609
LIG_14-3-3_CanoR_1	292	300	PF00244	0.687
LIG_14-3-3_CanoR_1	324	330	PF00244	0.762
LIG_14-3-3_CanoR_1	368	378	PF00244	0.560
LIG_14-3-3_CanoR_1	430	438	PF00244	0.502
LIG_14-3-3_CanoR_1	61	67	PF00244	0.498
LIG_14-3-3_CanoR_1	99	107	PF00244	0.681
LIG_Actin_WH2_2	207	224	PF00022	0.578
LIG_BIR_III_4	530	534	PF00653	0.611
LIG_BIR_III_4	80	84	PF00653	0.659
LIG_CaM_IQ_9	600	615	PF13499	0.698
LIG_FHA_1	182	188	PF00498	0.697
LIG_FHA_1	222	228	PF00498	0.608
LIG_FHA_1	251	257	PF00498	0.538
LIG_FHA_1	34	40	PF00498	0.677
LIG_FHA_1	458	464	PF00498	0.591
LIG_FHA_1	466	472	PF00498	0.578
LIG_FHA_2	26	32	PF00498	0.696
LIG_FHA_2	297	303	PF00498	0.623
LIG_FHA_2	488	494	PF00498	0.599
LIG_FHA_2	50	56	PF00498	0.608
LIG_FHA_2	515	521	PF00498	0.558
LIG_FHA_2	541	547	PF00498	0.558
LIG_FHA_2	563	569	PF00498	0.417
LIG_FHA_2	84	90	PF00498	0.480
LIG_Integrin_isoDGR_2	247	249	PF01839	0.552
LIG_LIR_Gen_1	303	314	PF02991	0.556
LIG_LIR_Gen_1	372	383	PF02991	0.492
LIG_LIR_Gen_1	55	64	PF02991	0.638
LIG_LIR_Nem_3	171	177	PF02991	0.495
LIG_LIR_Nem_3	240	245	PF02991	0.526
LIG_LIR_Nem_3	303	309	PF02991	0.612
LIG_LIR_Nem_3	372	378	PF02991	0.515
LIG_LIR_Nem_3	493	498	PF02991	0.563
LIG_LIR_Nem_3	55	59	PF02991	0.648
LIG_MYND_1	192	196	PF01753	0.594
LIG_NRBOX	251	257	PF00104	0.471
LIG_NRBOX	74	80	PF00104	0.510
LIG_Pex14_2	346	350	PF04695	0.718
LIG_SH2_NCK_1	581	585	PF00017	0.511
LIG_SH2_STAT5	498	501	PF00017	0.606
LIG_SH3_3	186	192	PF00018	0.598
LIG_SH3_3	199	205	PF00018	0.582
LIG_SH3_3	364	370	PF00018	0.641
LIG_SUMO_SIM_anti_2	159	166	PF11976	0.591
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.624
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.505
LIG_SUMO_SIM_par_1	144	149	PF11976	0.594
LIG_SUMO_SIM_par_1	74	80	PF11976	0.581
LIG_TRAF2_1	551	554	PF00917	0.648
MOD_CK1_1	10	16	PF00069	0.690
MOD_CK1_1	111	117	PF00069	0.702
MOD_CK1_1	128	134	PF00069	0.466
MOD_CK1_1	135	141	PF00069	0.528
MOD_CK1_1	326	332	PF00069	0.636
MOD_CK1_1	336	342	PF00069	0.621
MOD_CK1_1	49	55	PF00069	0.638
MOD_CK1_1	97	103	PF00069	0.687
MOD_CK2_1	156	162	PF00069	0.577
MOD_CK2_1	18	24	PF00069	0.753
MOD_CK2_1	296	302	PF00069	0.621
MOD_CK2_1	487	493	PF00069	0.522
MOD_CK2_1	514	520	PF00069	0.551
MOD_CK2_1	540	546	PF00069	0.557
MOD_CK2_1	582	588	PF00069	0.576
MOD_CK2_1	83	89	PF00069	0.558
MOD_GlcNHglycan	102	105	PF01048	0.712
MOD_GlcNHglycan	127	130	PF01048	0.507
MOD_GlcNHglycan	20	23	PF01048	0.730
MOD_GlcNHglycan	3	6	PF01048	0.768
MOD_GlcNHglycan	311	314	PF01048	0.655
MOD_GlcNHglycan	316	319	PF01048	0.640
MOD_GlcNHglycan	338	341	PF01048	0.670
MOD_GlcNHglycan	431	434	PF01048	0.545
MOD_GlcNHglycan	495	498	PF01048	0.561
MOD_GlcNHglycan	560	563	PF01048	0.568
MOD_GSK3_1	128	135	PF00069	0.631
MOD_GSK3_1	287	294	PF00069	0.659
MOD_GSK3_1	3	10	PF00069	0.662
MOD_GSK3_1	334	341	PF00069	0.544
MOD_GSK3_1	483	490	PF00069	0.589
MOD_GSK3_1	558	565	PF00069	0.542
MOD_N-GLC_1	118	123	PF02516	0.697
MOD_N-GLC_1	95	100	PF02516	0.737
MOD_NEK2_1	102	107	PF00069	0.573
MOD_NEK2_1	146	151	PF00069	0.582
MOD_NEK2_1	221	226	PF00069	0.502
MOD_NEK2_1	227	232	PF00069	0.552
MOD_NEK2_1	287	292	PF00069	0.679
MOD_NEK2_1	32	37	PF00069	0.593
MOD_NEK2_1	350	355	PF00069	0.565
MOD_NEK2_1	371	376	PF00069	0.636
MOD_NEK2_1	603	608	PF00069	0.685
MOD_PIKK_1	146	152	PF00454	0.563
MOD_PIKK_1	176	182	PF00454	0.638
MOD_PIKK_1	227	233	PF00454	0.602
MOD_PIKK_1	385	391	PF00454	0.598
MOD_PIKK_1	49	55	PF00454	0.626
MOD_PKA_1	292	298	PF00069	0.719
MOD_PKA_1	324	330	PF00069	0.654
MOD_PKA_2	156	162	PF00069	0.493
MOD_PKA_2	221	227	PF00069	0.555
MOD_PKA_2	280	286	PF00069	0.598
MOD_PKA_2	291	297	PF00069	0.682
MOD_PKA_2	314	320	PF00069	0.578
MOD_PKA_2	323	329	PF00069	0.743
MOD_PKA_2	341	347	PF00069	0.709
MOD_PKA_2	429	435	PF00069	0.488
MOD_PKA_2	540	546	PF00069	0.579
MOD_PKA_2	558	564	PF00069	0.444
MOD_PKA_2	596	602	PF00069	0.661
MOD_Plk_1	132	138	PF00069	0.619
MOD_Plk_1	250	256	PF00069	0.521
MOD_Plk_1	261	267	PF00069	0.504
MOD_Plk_2-3	514	520	PF00069	0.605
MOD_Plk_2-3	74	80	PF00069	0.552
MOD_Plk_4	111	117	PF00069	0.740
MOD_Plk_4	156	162	PF00069	0.635
MOD_Plk_4	181	187	PF00069	0.711
MOD_Plk_4	341	347	PF00069	0.634
MOD_Plk_4	582	588	PF00069	0.558
MOD_Plk_4	74	80	PF00069	0.561
MOD_ProDKin_1	10	16	PF00069	0.629
MOD_SUMO_for_1	434	437	PF00179	0.578
MOD_SUMO_rev_2	512	518	PF00179	0.458
TRG_DiLeu_BaEn_1	251	256	PF01217	0.475
TRG_DiLeu_BaEn_1	71	76	PF01217	0.488
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.597
TRG_ENDOCYTIC_2	174	177	PF00928	0.498
TRG_ENDOCYTIC_2	375	378	PF00928	0.571
TRG_ER_diArg_1	172	174	PF00400	0.557
TRG_ER_diArg_1	291	293	PF00400	0.702
TRG_ER_diArg_1	570	572	PF00400	0.624
TRG_ER_diLys_1	611	616	PF00400	0.710
TRG_NES_CRM1_1	426	437	PF08389	0.522
TRG_NLS_MonoCore_2	607	612	PF00514	0.646
TRG_NLS_MonoExtC_3	607	612	PF00514	0.660
TRG_NLS_MonoExtN_4	605	612	PF00514	0.646
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM9	Leptomonas seymouri	58%	92%
A0A1X0P338	Trypanosomatidae	37%	100%
A0A3R7NMF4	Trypanosoma rangeli	36%	100%
A0A3S7XBE2	Leishmania donovani	91%	100%
A4HPT4	Leishmania braziliensis	78%	100%
A4IE58	Leishmania infantum	91%	100%
D0A8P9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q0Z9	Leishmania major	90%	100%
V5BS07	Trypanosoma cruzi	39%	100%