Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9ATJ7_LEIMU

TriTrypDb:

LmxM.36.4140

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ATJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	5	9	PF00082	0.419
DEG_APCC_DBOX_1	4	12	PF00400	0.619
DEG_Nend_Nbox_1	1	3	PF02207	0.642
DOC_CKS1_1	186	191	PF01111	0.513
DOC_MAPK_gen_1	112	121	PF00069	0.546
DOC_MAPK_HePTP_8	113	125	PF00069	0.546
DOC_MAPK_HePTP_8	2	14	PF00069	0.530
DOC_MAPK_MEF2A_6	112	121	PF00069	0.506
DOC_MAPK_MEF2A_6	151	160	PF00069	0.232
DOC_MAPK_MEF2A_6	5	14	PF00069	0.529
DOC_MAPK_NFAT4_5	114	122	PF00069	0.546
DOC_USP7_UBL2_3	143	147	PF12436	0.363
DOC_WW_Pin1_4	185	190	PF00397	0.513
LIG_14-3-3_CanoR_1	81	85	PF00244	0.330
LIG_BRCT_BRCA1_1	141	145	PF00533	0.396
LIG_BRCT_BRCA1_2	141	147	PF00533	0.363
LIG_DCNL_PONY_1	1	4	PF03556	0.637
LIG_EH1_1	14	22	PF00400	0.436
LIG_EH1_1	180	188	PF00400	0.513
LIG_FHA_1	167	173	PF00498	0.357
LIG_FHA_1	189	195	PF00498	0.586
LIG_FHA_1	21	27	PF00498	0.411
LIG_LIR_Gen_1	45	54	PF02991	0.326
LIG_LIR_Nem_3	45	50	PF02991	0.346
LIG_LIR_Nem_3	95	100	PF02991	0.342
LIG_Pex14_2	120	124	PF04695	0.513
LIG_Pex14_2	167	171	PF04695	0.252
LIG_Pex14_2	80	84	PF04695	0.346
LIG_SH2_CRK	100	104	PF00017	0.411
LIG_SH2_GRB2like	29	32	PF00017	0.419
LIG_SH2_STAP1	100	104	PF00017	0.513
LIG_SH2_STAP1	141	145	PF00017	0.330
LIG_SH2_STAP1	29	33	PF00017	0.346
LIG_SH3_3	112	118	PF00018	0.591
LIG_SH3_3	21	27	PF00018	0.436
LIG_SUMO_SIM_anti_2	153	160	PF11976	0.211
LIG_SUMO_SIM_par_1	174	179	PF11976	0.222
MOD_CK1_1	154	160	PF00069	0.249
MOD_GSK3_1	150	157	PF00069	0.240
MOD_GSK3_1	16	23	PF00069	0.355
MOD_GSK3_1	27	34	PF00069	0.461
MOD_GSK3_1	54	61	PF00069	0.359
MOD_N-GLC_1	151	156	PF02516	0.547
MOD_N-GLC_1	59	64	PF02516	0.504
MOD_NEK2_1	102	107	PF00069	0.360
MOD_NEK2_1	16	21	PF00069	0.384
MOD_NEK2_1	80	85	PF00069	0.330
MOD_PIKK_1	188	194	PF00454	0.501
MOD_PKA_2	80	86	PF00069	0.330
MOD_Plk_1	151	157	PF00069	0.347
MOD_Plk_1	42	48	PF00069	0.398
MOD_Plk_4	182	188	PF00069	0.436
MOD_Plk_4	42	48	PF00069	0.318
MOD_Plk_4	92	98	PF00069	0.411
MOD_ProDKin_1	185	191	PF00069	0.513
TRG_ENDOCYTIC_2	100	103	PF00928	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C3	Leptomonas seymouri	62%	100%
A0A3S7XBF7	Leishmania donovani	91%	100%
A4HPT2	Leishmania braziliensis	78%	100%
A4IE60	Leishmania infantum	91%	100%
Q4Q101	Leishmania major	90%	100%