LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

HEAT repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
HEAT repeat-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ATJ4_LEIMU
TriTrypDb:
LmxM.36.4110
Length:
1022

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATJ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATJ4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 464 468 PF00656 0.524
CLV_C14_Caspase3-7 839 843 PF00656 0.534
CLV_MEL_PAP_1 858 864 PF00089 0.406
CLV_NRD_NRD_1 1016 1018 PF00675 0.437
CLV_NRD_NRD_1 251 253 PF00675 0.485
CLV_NRD_NRD_1 695 697 PF00675 0.429
CLV_NRD_NRD_1 760 762 PF00675 0.437
CLV_NRD_NRD_1 805 807 PF00675 0.532
CLV_NRD_NRD_1 85 87 PF00675 0.558
CLV_NRD_NRD_1 950 952 PF00675 0.388
CLV_PCSK_FUR_1 1014 1018 PF00082 0.432
CLV_PCSK_KEX2_1 1016 1018 PF00082 0.430
CLV_PCSK_KEX2_1 185 187 PF00082 0.523
CLV_PCSK_KEX2_1 251 253 PF00082 0.485
CLV_PCSK_KEX2_1 565 567 PF00082 0.651
CLV_PCSK_KEX2_1 695 697 PF00082 0.429
CLV_PCSK_KEX2_1 760 762 PF00082 0.437
CLV_PCSK_KEX2_1 805 807 PF00082 0.532
CLV_PCSK_KEX2_1 85 87 PF00082 0.558
CLV_PCSK_KEX2_1 950 952 PF00082 0.388
CLV_PCSK_PC1ET2_1 185 187 PF00082 0.513
CLV_PCSK_PC1ET2_1 565 567 PF00082 0.646
CLV_PCSK_SKI1_1 252 256 PF00082 0.456
CLV_PCSK_SKI1_1 356 360 PF00082 0.419
CLV_PCSK_SKI1_1 389 393 PF00082 0.594
CLV_PCSK_SKI1_1 4 8 PF00082 0.580
CLV_PCSK_SKI1_1 421 425 PF00082 0.371
CLV_PCSK_SKI1_1 444 448 PF00082 0.524
CLV_PCSK_SKI1_1 600 604 PF00082 0.411
CLV_PCSK_SKI1_1 696 700 PF00082 0.511
DEG_APCC_DBOX_1 3 11 PF00400 0.490
DEG_APCC_DBOX_1 355 363 PF00400 0.406
DEG_SCF_FBW7_1 360 367 PF00400 0.449
DEG_SPOP_SBC_1 23 27 PF00917 0.627
DEG_SPOP_SBC_1 877 881 PF00917 0.637
DEG_SPOP_SBC_1 977 981 PF00917 0.594
DOC_CKS1_1 124 129 PF01111 0.483
DOC_CYCLIN_RxL_1 418 426 PF00134 0.370
DOC_CYCLIN_RxL_1 438 449 PF00134 0.445
DOC_CYCLIN_yCln2_LP_2 586 592 PF00134 0.495
DOC_CYCLIN_yCln2_LP_2 884 890 PF00134 0.578
DOC_MAPK_DCC_7 185 194 PF00069 0.411
DOC_MAPK_gen_1 1014 1022 PF00069 0.467
DOC_MAPK_gen_1 577 586 PF00069 0.586
DOC_MAPK_gen_1 803 811 PF00069 0.636
DOC_MAPK_gen_1 907 916 PF00069 0.454
DOC_PP1_RVXF_1 808 814 PF00149 0.315
DOC_PP2B_LxvP_1 601 604 PF13499 0.409
DOC_PP4_FxxP_1 1012 1015 PF00568 0.401
DOC_PP4_FxxP_1 368 371 PF00568 0.657
DOC_USP7_MATH_1 23 27 PF00917 0.629
DOC_USP7_MATH_1 358 362 PF00917 0.389
DOC_USP7_MATH_1 459 463 PF00917 0.460
DOC_USP7_MATH_1 606 610 PF00917 0.525
DOC_USP7_MATH_1 837 841 PF00917 0.587
DOC_USP7_MATH_1 843 847 PF00917 0.498
DOC_USP7_MATH_1 875 879 PF00917 0.592
DOC_USP7_MATH_1 90 94 PF00917 0.505
DOC_USP7_MATH_1 931 935 PF00917 0.555
DOC_USP7_MATH_1 977 981 PF00917 0.594
DOC_WW_Pin1_4 108 113 PF00397 0.647
DOC_WW_Pin1_4 114 119 PF00397 0.653
DOC_WW_Pin1_4 123 128 PF00397 0.457
DOC_WW_Pin1_4 24 29 PF00397 0.640
DOC_WW_Pin1_4 360 365 PF00397 0.422
DOC_WW_Pin1_4 475 480 PF00397 0.435
DOC_WW_Pin1_4 846 851 PF00397 0.416
DOC_WW_Pin1_4 888 893 PF00397 0.548
DOC_WW_Pin1_4 920 925 PF00397 0.560
LIG_14-3-3_CanoR_1 203 207 PF00244 0.497
LIG_14-3-3_CanoR_1 580 586 PF00244 0.538
LIG_14-3-3_CanoR_1 917 927 PF00244 0.602
LIG_14-3-3_CanoR_1 950 960 PF00244 0.502
LIG_Actin_WH2_2 187 205 PF00022 0.468
LIG_Actin_WH2_2 901 919 PF00022 0.469
LIG_APCC_ABBA_1 862 867 PF00400 0.380
LIG_APCC_ABBAyCdc20_2 861 867 PF00400 0.380
LIG_BIR_II_1 1 5 PF00653 0.662
LIG_BRCT_BRCA1_1 235 239 PF00533 0.593
LIG_Clathr_ClatBox_1 192 196 PF01394 0.383
LIG_CSL_BTD_1 343 346 PF09270 0.508
LIG_CtBP_PxDLS_1 850 854 PF00389 0.424
LIG_deltaCOP1_diTrp_1 153 160 PF00928 0.275
LIG_deltaCOP1_diTrp_1 283 289 PF00928 0.429
LIG_deltaCOP1_diTrp_1 714 721 PF00928 0.600
LIG_FHA_1 135 141 PF00498 0.480
LIG_FHA_1 150 156 PF00498 0.325
LIG_FHA_1 264 270 PF00498 0.587
LIG_FHA_1 275 281 PF00498 0.430
LIG_FHA_1 348 354 PF00498 0.423
LIG_FHA_1 411 417 PF00498 0.470
LIG_FHA_1 424 430 PF00498 0.432
LIG_FHA_1 447 453 PF00498 0.345
LIG_FHA_1 543 549 PF00498 0.389
LIG_FHA_1 665 671 PF00498 0.446
LIG_FHA_1 680 686 PF00498 0.437
LIG_FHA_1 720 726 PF00498 0.681
LIG_FHA_1 753 759 PF00498 0.461
LIG_FHA_1 853 859 PF00498 0.432
LIG_FHA_1 896 902 PF00498 0.467
LIG_FHA_1 930 936 PF00498 0.505
LIG_FHA_1 95 101 PF00498 0.646
LIG_FHA_1 952 958 PF00498 0.380
LIG_FHA_2 296 302 PF00498 0.458
LIG_FHA_2 459 465 PF00498 0.767
LIG_FHA_2 570 576 PF00498 0.527
LIG_FHA_2 658 664 PF00498 0.516
LIG_FHA_2 701 707 PF00498 0.513
LIG_FHA_2 786 792 PF00498 0.615
LIG_FHA_2 877 883 PF00498 0.634
LIG_FHA_2 985 991 PF00498 0.485
LIG_GBD_Chelix_1 198 206 PF00786 0.394
LIG_Integrin_RGD_1 69 71 PF01839 0.428
LIG_IRF3_LxIS_1 894 900 PF10401 0.488
LIG_LIR_Apic_2 367 372 PF02991 0.655
LIG_LIR_Gen_1 298 307 PF02991 0.518
LIG_LIR_Gen_1 425 435 PF02991 0.367
LIG_LIR_Gen_1 52 62 PF02991 0.520
LIG_LIR_Gen_1 544 554 PF02991 0.411
LIG_LIR_Gen_1 63 73 PF02991 0.444
LIG_LIR_Gen_1 992 1002 PF02991 0.478
LIG_LIR_Nem_3 154 160 PF02991 0.375
LIG_LIR_Nem_3 2 6 PF02991 0.602
LIG_LIR_Nem_3 298 302 PF02991 0.480
LIG_LIR_Nem_3 363 369 PF02991 0.515
LIG_LIR_Nem_3 425 430 PF02991 0.401
LIG_LIR_Nem_3 484 490 PF02991 0.416
LIG_LIR_Nem_3 52 57 PF02991 0.541
LIG_LIR_Nem_3 544 549 PF02991 0.402
LIG_LIR_Nem_3 63 68 PF02991 0.459
LIG_LIR_Nem_3 992 997 PF02991 0.478
LIG_LYPXL_SIV_4 693 701 PF13949 0.464
LIG_NRBOX 442 448 PF00104 0.431
LIG_OCRL_FandH_1 248 260 PF00620 0.439
LIG_PCNA_yPIPBox_3 170 179 PF02747 0.404
LIG_PCNA_yPIPBox_3 941 951 PF02747 0.374
LIG_PDZ_Class_2 1017 1022 PF00595 0.491
LIG_Pex14_1 813 817 PF04695 0.469
LIG_Pex14_2 235 239 PF04695 0.418
LIG_RPA_C_Fungi 575 587 PF08784 0.650
LIG_RPA_C_Fungi 755 767 PF08784 0.457
LIG_SH2_CRK 369 373 PF00017 0.490
LIG_SH2_CRK 528 532 PF00017 0.391
LIG_SH2_CRK 631 635 PF00017 0.299
LIG_SH2_CRK 65 69 PF00017 0.446
LIG_SH2_CRK 655 659 PF00017 0.325
LIG_SH2_NCK_1 369 373 PF00017 0.490
LIG_SH2_NCK_1 490 494 PF00017 0.504
LIG_SH2_NCK_1 649 653 PF00017 0.521
LIG_SH2_SRC 369 372 PF00017 0.490
LIG_SH2_SRC 649 652 PF00017 0.526
LIG_SH2_STAP1 276 280 PF00017 0.411
LIG_SH2_STAP1 366 370 PF00017 0.633
LIG_SH2_STAP1 655 659 PF00017 0.325
LIG_SH2_STAP1 998 1002 PF00017 0.478
LIG_SH2_STAT5 276 279 PF00017 0.480
LIG_SH2_STAT5 65 68 PF00017 0.450
LIG_SH2_STAT5 769 772 PF00017 0.399
LIG_SH2_STAT5 865 868 PF00017 0.333
LIG_SH3_1 185 191 PF00018 0.493
LIG_SH3_3 115 121 PF00018 0.688
LIG_SH3_3 185 191 PF00018 0.430
LIG_SH3_3 205 211 PF00018 0.325
LIG_SH3_3 404 410 PF00018 0.589
LIG_SH3_3 97 103 PF00018 0.578
LIG_SUMO_SIM_anti_2 131 137 PF11976 0.463
LIG_SUMO_SIM_anti_2 522 527 PF11976 0.363
LIG_SUMO_SIM_anti_2 748 755 PF11976 0.466
LIG_SUMO_SIM_anti_2 854 860 PF11976 0.365
LIG_SUMO_SIM_anti_2 954 961 PF11976 0.490
LIG_SUMO_SIM_par_1 131 137 PF11976 0.423
LIG_SUMO_SIM_par_1 350 357 PF11976 0.425
LIG_SUMO_SIM_par_1 849 855 PF11976 0.453
LIG_SUMO_SIM_par_1 895 900 PF11976 0.523
LIG_TRAF2_1 533 536 PF00917 0.378
LIG_TRAF2_1 591 594 PF00917 0.668
LIG_TYR_ITIM 526 531 PF00017 0.386
LIG_UBA3_1 133 139 PF00899 0.418
LIG_WRC_WIRS_1 365 370 PF05994 0.545
LIG_WRC_WIRS_1 608 613 PF05994 0.379
MOD_CDC14_SPxK_1 27 30 PF00782 0.667
MOD_CDK_SPK_2 24 29 PF00069 0.594
MOD_CDK_SPxK_1 24 30 PF00069 0.628
MOD_CK1_1 227 233 PF00069 0.544
MOD_CK1_1 331 337 PF00069 0.535
MOD_CK1_1 387 393 PF00069 0.737
MOD_CK1_1 56 62 PF00069 0.697
MOD_CK1_1 582 588 PF00069 0.693
MOD_CK1_1 679 685 PF00069 0.459
MOD_CK1_1 730 736 PF00069 0.607
MOD_CK1_1 846 852 PF00069 0.438
MOD_CK1_1 876 882 PF00069 0.715
MOD_CK1_1 920 926 PF00069 0.639
MOD_CK2_1 227 233 PF00069 0.521
MOD_CK2_1 331 337 PF00069 0.549
MOD_CK2_1 376 382 PF00069 0.699
MOD_CK2_1 459 465 PF00069 0.695
MOD_CK2_1 657 663 PF00069 0.538
MOD_CK2_1 700 706 PF00069 0.564
MOD_CK2_1 777 783 PF00069 0.561
MOD_CK2_1 876 882 PF00069 0.597
MOD_CK2_1 90 96 PF00069 0.475
MOD_CMANNOS 286 289 PF00535 0.362
MOD_CMANNOS 718 721 PF00535 0.569
MOD_CMANNOS 939 942 PF00535 0.379
MOD_GlcNHglycan 106 111 PF01048 0.635
MOD_GlcNHglycan 212 215 PF01048 0.454
MOD_GlcNHglycan 226 229 PF01048 0.489
MOD_GlcNHglycan 270 273 PF01048 0.451
MOD_GlcNHglycan 373 376 PF01048 0.616
MOD_GlcNHglycan 389 392 PF01048 0.747
MOD_GlcNHglycan 461 464 PF01048 0.590
MOD_GlcNHglycan 549 552 PF01048 0.440
MOD_GlcNHglycan 569 572 PF01048 0.599
MOD_GlcNHglycan 581 584 PF01048 0.668
MOD_GlcNHglycan 624 627 PF01048 0.539
MOD_GlcNHglycan 678 681 PF01048 0.492
MOD_GlcNHglycan 733 736 PF01048 0.724
MOD_GlcNHglycan 839 842 PF01048 0.567
MOD_GlcNHglycan 875 878 PF01048 0.611
MOD_GlcNHglycan 92 95 PF01048 0.570
MOD_GlcNHglycan 966 970 PF01048 0.734
MOD_GlcNHglycan 971 974 PF01048 0.665
MOD_GSK3_1 198 205 PF00069 0.509
MOD_GSK3_1 259 266 PF00069 0.657
MOD_GSK3_1 268 275 PF00069 0.472
MOD_GSK3_1 327 334 PF00069 0.684
MOD_GSK3_1 354 361 PF00069 0.498
MOD_GSK3_1 565 572 PF00069 0.509
MOD_GSK3_1 664 671 PF00069 0.368
MOD_GSK3_1 696 703 PF00069 0.573
MOD_GSK3_1 727 734 PF00069 0.563
MOD_GSK3_1 837 844 PF00069 0.564
MOD_GSK3_1 873 880 PF00069 0.567
MOD_GSK3_1 90 97 PF00069 0.641
MOD_GSK3_1 918 925 PF00069 0.593
MOD_GSK3_1 927 934 PF00069 0.560
MOD_GSK3_1 965 972 PF00069 0.486
MOD_GSK3_1 979 986 PF00069 0.549
MOD_LATS_1 915 921 PF00433 0.347
MOD_N-GLC_1 233 238 PF02516 0.579
MOD_N-GLC_1 295 300 PF02516 0.475
MOD_N-GLC_1 410 415 PF02516 0.353
MOD_N-GLC_1 519 524 PF02516 0.452
MOD_N-GLC_1 676 681 PF02516 0.532
MOD_NEK2_1 134 139 PF00069 0.422
MOD_NEK2_1 198 203 PF00069 0.581
MOD_NEK2_1 217 222 PF00069 0.408
MOD_NEK2_1 224 229 PF00069 0.542
MOD_NEK2_1 295 300 PF00069 0.475
MOD_NEK2_1 423 428 PF00069 0.433
MOD_NEK2_1 446 451 PF00069 0.419
MOD_NEK2_1 542 547 PF00069 0.369
MOD_NEK2_1 607 612 PF00069 0.473
MOD_NEK2_1 666 671 PF00069 0.447
MOD_NEK2_1 746 751 PF00069 0.475
MOD_NEK2_1 776 781 PF00069 0.482
MOD_NEK2_1 835 840 PF00069 0.492
MOD_NEK2_1 851 856 PF00069 0.290
MOD_NEK2_1 983 988 PF00069 0.447
MOD_NEK2_2 364 369 PF00069 0.521
MOD_NEK2_2 721 726 PF00069 0.550
MOD_PIKK_1 347 353 PF00454 0.325
MOD_PIKK_1 664 670 PF00454 0.350
MOD_PIKK_1 727 733 PF00454 0.578
MOD_PIKK_1 785 791 PF00454 0.677
MOD_PK_1 53 59 PF00069 0.528
MOD_PKA_1 565 571 PF00069 0.682
MOD_PKA_2 11 17 PF00069 0.497
MOD_PKA_2 202 208 PF00069 0.494
MOD_PKA_2 319 325 PF00069 0.609
MOD_PKA_2 384 390 PF00069 0.656
MOD_PKA_2 565 571 PF00069 0.602
MOD_PKA_2 579 585 PF00069 0.617
MOD_PKA_2 909 915 PF00069 0.425
MOD_PKA_2 94 100 PF00069 0.639
MOD_Plk_1 233 239 PF00069 0.567
MOD_Plk_1 295 301 PF00069 0.488
MOD_Plk_4 202 208 PF00069 0.445
MOD_Plk_4 218 224 PF00069 0.377
MOD_Plk_4 364 370 PF00069 0.516
MOD_Plk_4 423 429 PF00069 0.432
MOD_Plk_4 521 527 PF00069 0.363
MOD_Plk_4 749 755 PF00069 0.537
MOD_Plk_4 931 937 PF00069 0.479
MOD_Plk_4 943 949 PF00069 0.362
MOD_Plk_4 979 985 PF00069 0.496
MOD_Plk_4 989 995 PF00069 0.434
MOD_ProDKin_1 108 114 PF00069 0.646
MOD_ProDKin_1 123 129 PF00069 0.479
MOD_ProDKin_1 24 30 PF00069 0.641
MOD_ProDKin_1 360 366 PF00069 0.433
MOD_ProDKin_1 475 481 PF00069 0.423
MOD_ProDKin_1 846 852 PF00069 0.409
MOD_ProDKin_1 888 894 PF00069 0.542
MOD_ProDKin_1 920 926 PF00069 0.567
MOD_SUMO_rev_2 318 326 PF00179 0.526
MOD_SUMO_rev_2 706 713 PF00179 0.487
TRG_DiLeu_BaEn_1 131 136 PF01217 0.472
TRG_DiLeu_BaEn_1 594 599 PF01217 0.476
TRG_DiLeu_BaEn_4 131 137 PF01217 0.423
TRG_DiLeu_BaLyEn_6 34 39 PF01217 0.602
TRG_DiLeu_BaLyEn_6 438 443 PF01217 0.444
TRG_ENDOCYTIC_2 146 149 PF00928 0.475
TRG_ENDOCYTIC_2 528 531 PF00928 0.394
TRG_ENDOCYTIC_2 631 634 PF00928 0.296
TRG_ENDOCYTIC_2 65 68 PF00928 0.450
TRG_ENDOCYTIC_2 655 658 PF00928 0.418
TRG_ER_diArg_1 1013 1016 PF00400 0.406
TRG_ER_diArg_1 250 252 PF00400 0.473
TRG_ER_diArg_1 694 696 PF00400 0.422
TRG_NES_CRM1_1 153 165 PF08389 0.382
TRG_NLS_MonoExtN_4 562 568 PF00514 0.632
TRG_Pf-PMV_PEXEL_1 421 425 PF00026 0.371
TRG_Pf-PMV_PEXEL_1 961 966 PF00026 0.455

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHV3 Leptomonas seymouri 43% 99%
A0A3S7XBE1 Leishmania donovani 89% 100%
A4HPS9 Leishmania braziliensis 74% 100%
A4IE63 Leishmania infantum 89% 100%
Q4Q104 Leishmania major 86% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS