IQ calmodulin-binding motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATJ1_LEIMU

TriTrypDb:

LmxM.36.4080

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATJ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.504
CLV_NRD_NRD_1	134	136	PF00675	0.346
CLV_NRD_NRD_1	187	189	PF00675	0.516
CLV_NRD_NRD_1	412	414	PF00675	0.791
CLV_NRD_NRD_1	458	460	PF00675	0.689
CLV_NRD_NRD_1	74	76	PF00675	0.349
CLV_NRD_NRD_1	97	99	PF00675	0.349
CLV_PCSK_KEX2_1	109	111	PF00082	0.501
CLV_PCSK_KEX2_1	178	180	PF00082	0.642
CLV_PCSK_KEX2_1	187	189	PF00082	0.419
CLV_PCSK_KEX2_1	21	23	PF00082	0.421
CLV_PCSK_KEX2_1	458	460	PF00082	0.787
CLV_PCSK_KEX2_1	463	465	PF00082	0.701
CLV_PCSK_KEX2_1	99	101	PF00082	0.334
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.656
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.421
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.784
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.363
CLV_PCSK_PC7_1	105	111	PF00082	0.326
CLV_PCSK_PC7_1	459	465	PF00082	0.784
CLV_PCSK_SKI1_1	261	265	PF00082	0.439
CLV_PCSK_SKI1_1	379	383	PF00082	0.706
CLV_PCSK_SKI1_1	75	79	PF00082	0.348
DEG_COP1_1	197	204	PF00400	0.717
DEG_COP1_1	427	435	PF00400	0.526
DEG_Nend_UBRbox_2	1	3	PF02207	0.444
DEG_SCF_FBW7_1	342	349	PF00400	0.534
DEG_SPOP_SBC_1	209	213	PF00917	0.586
DEG_SPOP_SBC_1	399	403	PF00917	0.656
DOC_CKS1_1	31	36	PF01111	0.619
DOC_CKS1_1	380	385	PF01111	0.707
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.740
DOC_MAPK_gen_1	75	81	PF00069	0.549
DOC_PP2B_LxvP_1	304	307	PF13499	0.738
DOC_SPAK_OSR1_1	459	463	PF12202	0.782
DOC_USP7_MATH_1	153	157	PF00917	0.606
DOC_USP7_MATH_1	209	213	PF00917	0.724
DOC_USP7_MATH_1	214	218	PF00917	0.770
DOC_USP7_MATH_1	227	231	PF00917	0.487
DOC_USP7_MATH_1	244	248	PF00917	0.692
DOC_USP7_MATH_1	295	299	PF00917	0.627
DOC_USP7_MATH_1	308	312	PF00917	0.590
DOC_USP7_MATH_1	346	350	PF00917	0.588
DOC_USP7_MATH_1	355	359	PF00917	0.793
DOC_USP7_MATH_1	399	403	PF00917	0.664
DOC_USP7_MATH_1	437	441	PF00917	0.805
DOC_USP7_MATH_1	446	450	PF00917	0.642
DOC_USP7_MATH_1	451	455	PF00917	0.779
DOC_USP7_MATH_1	487	491	PF00917	0.766
DOC_USP7_MATH_2	368	374	PF00917	0.813
DOC_WW_Pin1_4	205	210	PF00397	0.570
DOC_WW_Pin1_4	236	241	PF00397	0.798
DOC_WW_Pin1_4	297	302	PF00397	0.618
DOC_WW_Pin1_4	30	35	PF00397	0.695
DOC_WW_Pin1_4	309	314	PF00397	0.728
DOC_WW_Pin1_4	342	347	PF00397	0.742
DOC_WW_Pin1_4	379	384	PF00397	0.704
DOC_WW_Pin1_4	408	413	PF00397	0.575
LIG_14-3-3_CanoR_1	105	109	PF00244	0.501
LIG_14-3-3_CanoR_1	154	160	PF00244	0.424
LIG_14-3-3_CanoR_1	187	195	PF00244	0.551
LIG_14-3-3_CanoR_1	265	270	PF00244	0.435
LIG_14-3-3_CanoR_1	27	32	PF00244	0.563
LIG_14-3-3_CanoR_1	404	412	PF00244	0.707
LIG_14-3-3_CanoR_1	450	460	PF00244	0.713
LIG_CaM_IQ_9	122	138	PF13499	0.546
LIG_CaM_IQ_9	62	78	PF13499	0.546
LIG_CaM_IQ_9	85	101	PF13499	0.546
LIG_FHA_1	196	202	PF00498	0.563
LIG_FHA_1	3	9	PF00498	0.631
LIG_FHA_1	331	337	PF00498	0.556
LIG_FHA_1	362	368	PF00498	0.633
LIG_FHA_1	427	433	PF00498	0.643
LIG_FHA_1	60	66	PF00498	0.549
LIG_FHA_2	114	120	PF00498	0.508
LIG_FHA_2	163	169	PF00498	0.532
LIG_IRF3_LxIS_1	468	475	PF10401	0.500
LIG_LIR_Gen_1	116	125	PF02991	0.511
LIG_LIR_Gen_1	26	36	PF02991	0.676
LIG_LIR_Nem_3	116	121	PF02991	0.507
LIG_LIR_Nem_3	26	32	PF02991	0.677
LIG_MYND_1	342	346	PF01753	0.739
LIG_Pex14_2	456	460	PF04695	0.688
LIG_PTB_Apo_2	179	186	PF02174	0.355
LIG_PTB_Phospho_1	179	185	PF10480	0.356
LIG_SH2_CRK	29	33	PF00017	0.594
LIG_SH2_GRB2like	147	150	PF00017	0.491
LIG_SH2_NCK_1	29	33	PF00017	0.594
LIG_SH2_SRC	147	150	PF00017	0.537
LIG_SH2_STAP1	142	146	PF00017	0.532
LIG_SH2_STAT3	141	144	PF00017	0.546
LIG_SH2_STAT5	113	116	PF00017	0.449
LIG_SH2_STAT5	147	150	PF00017	0.495
LIG_SH2_STAT5	269	272	PF00017	0.507
LIG_SH3_3	234	240	PF00018	0.754
LIG_SH3_3	317	323	PF00018	0.816
LIG_SH3_3	333	339	PF00018	0.657
LIG_SH3_3	362	368	PF00018	0.729
LIG_SH3_3	374	380	PF00018	0.679
LIG_SUMO_SIM_par_1	55	60	PF11976	0.534
LIG_TRFH_1	205	209	PF08558	0.457
LIG_WRC_WIRS_1	453	458	PF05994	0.688
MOD_CDC14_SPxK_1	314	317	PF00782	0.737
MOD_CDK_SPK_2	379	384	PF00069	0.633
MOD_CDK_SPK_2	408	413	PF00069	0.548
MOD_CDK_SPxK_1	311	317	PF00069	0.732
MOD_CDK_SPxK_1	408	414	PF00069	0.550
MOD_CK1_1	134	140	PF00069	0.634
MOD_CK1_1	197	203	PF00069	0.560
MOD_CK1_1	208	214	PF00069	0.605
MOD_CK1_1	30	36	PF00069	0.689
MOD_CK1_1	311	317	PF00069	0.730
MOD_CK1_1	331	337	PF00069	0.498
MOD_CK1_1	402	408	PF00069	0.725
MOD_CK1_1	440	446	PF00069	0.770
MOD_CK2_1	162	168	PF00069	0.530
MOD_CK2_1	244	250	PF00069	0.774
MOD_CK2_1	43	49	PF00069	0.602
MOD_CK2_1	491	497	PF00069	0.653
MOD_CK2_1	9	15	PF00069	0.647
MOD_GlcNHglycan	246	249	PF01048	0.671
MOD_GlcNHglycan	270	273	PF01048	0.656
MOD_GlcNHglycan	330	333	PF01048	0.801
MOD_GlcNHglycan	336	339	PF01048	0.710
MOD_GlcNHglycan	348	351	PF01048	0.562
MOD_GlcNHglycan	372	375	PF01048	0.695
MOD_GlcNHglycan	439	442	PF01048	0.760
MOD_GlcNHglycan	45	48	PF01048	0.545
MOD_GlcNHglycan	489	492	PF01048	0.767
MOD_GlcNHglycan	493	496	PF01048	0.652
MOD_GlcNHglycan	521	524	PF01048	0.764
MOD_GSK3_1	149	156	PF00069	0.488
MOD_GSK3_1	205	212	PF00069	0.704
MOD_GSK3_1	214	221	PF00069	0.696
MOD_GSK3_1	23	30	PF00069	0.629
MOD_GSK3_1	261	268	PF00069	0.421
MOD_GSK3_1	302	309	PF00069	0.709
MOD_GSK3_1	311	318	PF00069	0.708
MOD_GSK3_1	330	337	PF00069	0.634
MOD_GSK3_1	342	349	PF00069	0.670
MOD_GSK3_1	389	396	PF00069	0.742
MOD_GSK3_1	398	405	PF00069	0.751
MOD_GSK3_1	440	447	PF00069	0.714
MOD_GSK3_1	477	484	PF00069	0.699
MOD_GSK3_1	487	494	PF00069	0.698
MOD_N-GLC_1	181	186	PF02516	0.352
MOD_N-GLC_1	219	224	PF02516	0.685
MOD_N-GLC_1	27	32	PF02516	0.482
MOD_N-GLC_1	356	361	PF02516	0.738
MOD_N-GLC_1	482	487	PF02516	0.716
MOD_NEK2_1	120	125	PF00069	0.411
MOD_NEK2_1	195	200	PF00069	0.560
MOD_NEK2_1	330	335	PF00069	0.691
MOD_NEK2_1	393	398	PF00069	0.807
MOD_NEK2_1	424	429	PF00069	0.613
MOD_NEK2_1	472	477	PF00069	0.683
MOD_NEK2_1	519	524	PF00069	0.767
MOD_NEK2_1	9	14	PF00069	0.654
MOD_NEK2_2	113	118	PF00069	0.470
MOD_NEK2_2	452	457	PF00069	0.791
MOD_PIKK_1	162	168	PF00454	0.587
MOD_PIKK_1	215	221	PF00454	0.500
MOD_PIKK_1	331	337	PF00454	0.700
MOD_PIKK_1	344	350	PF00454	0.760
MOD_PIKK_1	391	397	PF00454	0.784
MOD_PKA_2	104	110	PF00069	0.494
MOD_PKA_2	134	140	PF00069	0.634
MOD_PKA_2	153	159	PF00069	0.510
MOD_PKA_2	186	192	PF00069	0.486
MOD_PKA_2	403	409	PF00069	0.849
MOD_Plk_1	181	187	PF00069	0.647
MOD_Plk_1	27	33	PF00069	0.481
MOD_Plk_1	315	321	PF00069	0.667
MOD_Plk_1	59	65	PF00069	0.416
MOD_Plk_4	113	119	PF00069	0.488
MOD_Plk_4	15	21	PF00069	0.453
MOD_Plk_4	200	206	PF00069	0.564
MOD_Plk_4	265	271	PF00069	0.483
MOD_Plk_4	27	33	PF00069	0.689
MOD_Plk_4	315	321	PF00069	0.558
MOD_ProDKin_1	205	211	PF00069	0.574
MOD_ProDKin_1	236	242	PF00069	0.795
MOD_ProDKin_1	297	303	PF00069	0.623
MOD_ProDKin_1	30	36	PF00069	0.695
MOD_ProDKin_1	309	315	PF00069	0.723
MOD_ProDKin_1	342	348	PF00069	0.746
MOD_ProDKin_1	379	385	PF00069	0.704
MOD_ProDKin_1	408	414	PF00069	0.577
MOD_SUMO_rev_2	170	180	PF00179	0.570
MOD_SUMO_rev_2	253	263	PF00179	0.452
TRG_ENDOCYTIC_2	147	150	PF00928	0.615
TRG_ENDOCYTIC_2	29	32	PF00928	0.595
TRG_ER_diArg_1	108	110	PF00400	0.417
TRG_ER_diArg_1	352	355	PF00400	0.632
TRG_ER_diArg_1	458	460	PF00400	0.787
TRG_ER_diArg_1	98	101	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I2	Leptomonas seymouri	41%	100%
A0A3S7XBK4	Leishmania donovani	85%	99%
A4HPS6	Leishmania braziliensis	69%	100%
A4IE66	Leishmania infantum	84%	99%
Q4Q107	Leishmania major	86%	100%