Regulator_of_chromosome_condensation_(RCC1)_repea t

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulator of chromosome condensation 1-like protein

Species:

Leishmania mexicana

UniProt:

E9ATI9_LEIMU

TriTrypDb:

LmxM.36.4060

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0031010	ISWI-type complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1

Expansion

Sequence features

E9ATI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	591	595	PF00656	0.477
CLV_NRD_NRD_1	217	219	PF00675	0.397
CLV_NRD_NRD_1	316	318	PF00675	0.368
CLV_NRD_NRD_1	37	39	PF00675	0.527
CLV_PCSK_KEX2_1	217	219	PF00082	0.555
CLV_PCSK_KEX2_1	37	39	PF00082	0.527
CLV_PCSK_KEX2_1	638	640	PF00082	0.593
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.593
CLV_PCSK_SKI1_1	510	514	PF00082	0.403
CLV_PCSK_SKI1_1	638	642	PF00082	0.596
CLV_PCSK_SKI1_1	65	69	PF00082	0.583
DEG_APCC_KENBOX_2	336	340	PF00400	0.479
DEG_Nend_Nbox_1	1	3	PF02207	0.320
DEG_SPOP_SBC_1	155	159	PF00917	0.370
DEG_SPOP_SBC_1	48	52	PF00917	0.669
DEG_SPOP_SBC_1	589	593	PF00917	0.613
DOC_CKS1_1	253	258	PF01111	0.417
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.464
DOC_MAPK_gen_1	264	272	PF00069	0.310
DOC_MAPK_MEF2A_6	266	274	PF00069	0.292
DOC_MAPK_MEF2A_6	553	561	PF00069	0.507
DOC_PP1_RVXF_1	309	315	PF00149	0.275
DOC_PP1_RVXF_1	639	645	PF00149	0.494
DOC_PP2B_LxvP_1	173	176	PF13499	0.493
DOC_PP4_FxxP_1	445	448	PF00568	0.406
DOC_PP4_FxxP_1	9	12	PF00568	0.449
DOC_USP7_MATH_1	370	374	PF00917	0.448
DOC_USP7_MATH_1	408	412	PF00917	0.517
DOC_USP7_MATH_1	454	458	PF00917	0.538
DOC_USP7_MATH_1	479	483	PF00917	0.701
DOC_USP7_MATH_1	48	52	PF00917	0.698
DOC_USP7_MATH_1	579	583	PF00917	0.761
DOC_USP7_MATH_1	589	593	PF00917	0.715
DOC_USP7_MATH_1	616	620	PF00917	0.753
DOC_USP7_MATH_1	63	67	PF00917	0.485
DOC_USP7_MATH_1	86	90	PF00917	0.412
DOC_USP7_MATH_1	99	103	PF00917	0.542
DOC_USP7_UBL2_3	459	463	PF12436	0.737
DOC_WW_Pin1_4	252	257	PF00397	0.369
DOC_WW_Pin1_4	628	633	PF00397	0.749
LIG_14-3-3_CanoR_1	37	41	PF00244	0.603
LIG_14-3-3_CanoR_1	447	452	PF00244	0.682
LIG_14-3-3_CanoR_1	65	74	PF00244	0.393
LIG_APCC_ABBA_1	654	659	PF00400	0.516
LIG_BRCT_BRCA1_1	5	9	PF00533	0.393
LIG_BRCT_BRCA1_1	601	605	PF00533	0.600
LIG_CaM_IQ_9	57	73	PF13499	0.468
LIG_CtBP_PxDLS_1	30	34	PF00389	0.368
LIG_deltaCOP1_diTrp_1	643	649	PF00928	0.506
LIG_FHA_1	157	163	PF00498	0.420
LIG_FHA_1	241	247	PF00498	0.400
LIG_FHA_1	253	259	PF00498	0.315
LIG_FHA_1	331	337	PF00498	0.284
LIG_FHA_1	366	372	PF00498	0.459
LIG_FHA_1	432	438	PF00498	0.346
LIG_FHA_2	287	293	PF00498	0.274
LIG_FHA_2	567	573	PF00498	0.525
LIG_FHA_2	589	595	PF00498	0.517
LIG_FHA_2	660	666	PF00498	0.560
LIG_LIR_Apic_2	444	448	PF02991	0.394
LIG_LIR_Apic_2	6	12	PF02991	0.419
LIG_LIR_Apic_2	681	687	PF02991	0.638
LIG_LIR_Gen_1	167	176	PF02991	0.398
LIG_LIR_Gen_1	192	200	PF02991	0.450
LIG_LIR_Gen_1	482	491	PF02991	0.514
LIG_LIR_Nem_3	115	119	PF02991	0.420
LIG_LIR_Nem_3	167	173	PF02991	0.368
LIG_LIR_Nem_3	192	196	PF02991	0.362
LIG_LIR_Nem_3	226	232	PF02991	0.289
LIG_LIR_Nem_3	292	298	PF02991	0.274
LIG_LIR_Nem_3	482	486	PF02991	0.542
LIG_MYND_1	305	309	PF01753	0.417
LIG_NRBOX	508	514	PF00104	0.455
LIG_PCNA_yPIPBox_3	337	346	PF02747	0.416
LIG_PTAP_UEV_1	600	605	PF05743	0.468
LIG_PTB_Apo_2	110	117	PF02174	0.483
LIG_PTB_Phospho_1	110	116	PF10480	0.417
LIG_REV1ctd_RIR_1	292	301	PF16727	0.400
LIG_REV1ctd_RIR_1	346	355	PF16727	0.489
LIG_SH2_CRK	116	120	PF00017	0.457
LIG_SH2_CRK	399	403	PF00017	0.459
LIG_SH2_NCK_1	399	403	PF00017	0.513
LIG_SH2_NCK_1	439	443	PF00017	0.367
LIG_SH2_PTP2	684	687	PF00017	0.652
LIG_SH2_SRC	189	192	PF00017	0.508
LIG_SH2_SRC	28	31	PF00017	0.368
LIG_SH2_SRC	505	508	PF00017	0.556
LIG_SH2_STAP1	126	130	PF00017	0.362
LIG_SH2_STAP1	399	403	PF00017	0.403
LIG_SH2_STAT3	525	528	PF00017	0.551
LIG_SH2_STAT3	7	10	PF00017	0.431
LIG_SH2_STAT5	163	166	PF00017	0.351
LIG_SH2_STAT5	28	31	PF00017	0.368
LIG_SH2_STAT5	288	291	PF00017	0.274
LIG_SH2_STAT5	347	350	PF00017	0.402
LIG_SH2_STAT5	392	395	PF00017	0.349
LIG_SH2_STAT5	399	402	PF00017	0.435
LIG_SH2_STAT5	516	519	PF00017	0.378
LIG_SH2_STAT5	525	528	PF00017	0.401
LIG_SH2_STAT5	684	687	PF00017	0.612
LIG_SH3_2	530	535	PF14604	0.589
LIG_SH3_3	15	21	PF00018	0.528
LIG_SH3_3	250	256	PF00018	0.271
LIG_SH3_3	309	315	PF00018	0.278
LIG_SH3_3	361	367	PF00018	0.484
LIG_SH3_3	446	452	PF00018	0.577
LIG_SH3_3	482	488	PF00018	0.530
LIG_SH3_3	527	533	PF00018	0.479
LIG_SH3_3	598	604	PF00018	0.581
LIG_SH3_5	501	505	PF00018	0.440
LIG_SH3_CIN85_PxpxPR_1	530	535	PF14604	0.572
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.448
LIG_SUMO_SIM_par_1	247	252	PF11976	0.464
LIG_SUMO_SIM_par_1	330	338	PF11976	0.308
LIG_SUMO_SIM_par_1	650	662	PF11976	0.573
LIG_TRAF2_1	59	62	PF00917	0.539
LIG_TRAF2_1	622	625	PF00917	0.699
LIG_WW_3	314	318	PF00397	0.368
LIG_WW_3	532	536	PF00397	0.646
MOD_CK1_1	431	437	PF00069	0.410
MOD_CK1_1	52	58	PF00069	0.535
MOD_CK1_1	590	596	PF00069	0.688
MOD_CK1_1	631	637	PF00069	0.692
MOD_CK2_1	220	226	PF00069	0.287
MOD_CK2_1	265	271	PF00069	0.454
MOD_CK2_1	286	292	PF00069	0.340
MOD_CK2_1	56	62	PF00069	0.503
MOD_CK2_1	655	661	PF00069	0.510
MOD_Cter_Amidation	636	639	PF01082	0.644
MOD_GlcNHglycan	207	210	PF01048	0.453
MOD_GlcNHglycan	38	41	PF01048	0.580
MOD_GlcNHglycan	406	409	PF01048	0.490
MOD_GlcNHglycan	430	433	PF01048	0.428
MOD_GlcNHglycan	456	459	PF01048	0.735
MOD_GlcNHglycan	464	468	PF01048	0.764
MOD_GlcNHglycan	469	472	PF01048	0.448
MOD_GlcNHglycan	601	604	PF01048	0.765
MOD_GlcNHglycan	618	621	PF01048	0.772
MOD_GSK3_1	150	157	PF00069	0.310
MOD_GSK3_1	162	169	PF00069	0.274
MOD_GSK3_1	185	192	PF00069	0.514
MOD_GSK3_1	205	212	PF00069	0.189
MOD_GSK3_1	220	227	PF00069	0.318
MOD_GSK3_1	366	373	PF00069	0.428
MOD_GSK3_1	404	411	PF00069	0.375
MOD_GSK3_1	44	51	PF00069	0.687
MOD_GSK3_1	463	470	PF00069	0.677
MOD_GSK3_1	475	482	PF00069	0.673
MOD_GSK3_1	52	59	PF00069	0.629
MOD_GSK3_1	595	602	PF00069	0.663
MOD_GSK3_1	655	662	PF00069	0.508
MOD_N-GLC_1	209	214	PF02516	0.327
MOD_N-GLC_1	403	408	PF02516	0.452
MOD_N-GLC_1	44	49	PF02516	0.634
MOD_N-GLC_1	628	633	PF02516	0.493
MOD_NEK2_1	139	144	PF00069	0.509
MOD_NEK2_1	3	8	PF00069	0.361
MOD_NEK2_1	341	346	PF00069	0.481
MOD_NEK2_1	36	41	PF00069	0.529
MOD_NEK2_1	420	425	PF00069	0.402
MOD_NEK2_1	559	564	PF00069	0.690
MOD_NEK2_2	166	171	PF00069	0.394
MOD_PIKK_1	191	197	PF00454	0.501
MOD_PIKK_1	240	246	PF00454	0.302
MOD_PIKK_1	383	389	PF00454	0.407
MOD_PIKK_1	410	416	PF00454	0.448
MOD_PIKK_1	581	587	PF00454	0.539
MOD_PIKK_1	608	614	PF00454	0.813
MOD_PK_1	247	253	PF00069	0.323
MOD_PKA_2	150	156	PF00069	0.385
MOD_PKA_2	265	271	PF00069	0.445
MOD_PKA_2	36	42	PF00069	0.624
MOD_PKA_2	377	383	PF00069	0.337
MOD_Plk_1	166	172	PF00069	0.289
MOD_Plk_1	209	215	PF00069	0.327
MOD_Plk_1	330	336	PF00069	0.274
MOD_Plk_1	659	665	PF00069	0.553
MOD_Plk_2-3	56	62	PF00069	0.498
MOD_Plk_2-3	659	665	PF00069	0.531
MOD_Plk_4	139	145	PF00069	0.432
MOD_Plk_4	150	156	PF00069	0.210
MOD_Plk_4	330	336	PF00069	0.274
MOD_Plk_4	341	347	PF00069	0.426
MOD_Plk_4	359	365	PF00069	0.484
MOD_Plk_4	431	437	PF00069	0.373
MOD_Plk_4	441	447	PF00069	0.479
MOD_Plk_4	566	572	PF00069	0.467
MOD_Plk_4	652	658	PF00069	0.600
MOD_Plk_4	86	92	PF00069	0.421
MOD_ProDKin_1	252	258	PF00069	0.369
MOD_ProDKin_1	628	634	PF00069	0.745
MOD_SUMO_for_1	462	465	PF00179	0.704
MOD_SUMO_for_1	640	643	PF00179	0.591
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.486
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.319
TRG_ENDOCYTIC_2	116	119	PF00928	0.456
TRG_ENDOCYTIC_2	229	232	PF00928	0.289
TRG_ENDOCYTIC_2	399	402	PF00928	0.442
TRG_ER_diArg_1	264	267	PF00400	0.337
TRG_ER_diArg_1	36	38	PF00400	0.544
TRG_NES_CRM1_1	62	73	PF08389	0.458
TRG_NLS_MonoExtC_3	637	643	PF00514	0.605
TRG_NLS_MonoExtN_4	636	642	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4I0	Leptomonas seymouri	68%	100%
A0A0S4JSE7	Bodo saltans	32%	100%
A0A1X0P381	Trypanosomatidae	42%	100%
A0A3Q8IGE7	Leishmania donovani	92%	100%
A0A3S5IS08	Trypanosoma rangeli	44%	100%
A4HPS4	Leishmania braziliensis	85%	100%
A4ICY9	Leishmania infantum	92%	100%
D0A8N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q109	Leishmania major	91%	100%
V5DNG6	Trypanosoma cruzi	44%	100%