Tetratricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATI7_LEIMU

TriTrypDb:

LmxM.36.4040

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATI7

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006335	DNA replication-dependent chromatin assembly	5	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031055	chromatin remodeling at centromere	6	1
GO:0034080	CENP-A containing chromatin assembly	7	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	401	403	PF00675	0.603
CLV_PCSK_KEX2_1	406	408	PF00082	0.630
CLV_PCSK_KEX2_1	421	423	PF00082	0.638
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.693
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.638
CLV_PCSK_PC7_1	402	408	PF00082	0.692
CLV_PCSK_SKI1_1	127	131	PF00082	0.450
DEG_APCC_DBOX_1	266	274	PF00400	0.445
DEG_SPOP_SBC_1	50	54	PF00917	0.761
DOC_CKS1_1	322	327	PF01111	0.627
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.634
DOC_PP1_RVXF_1	167	173	PF00149	0.310
DOC_PP2B_LxvP_1	357	360	PF13499	0.546
DOC_PP2B_LxvP_1	381	384	PF13499	0.611
DOC_USP7_MATH_1	352	356	PF00917	0.651
DOC_USP7_MATH_1	384	388	PF00917	0.672
DOC_USP7_MATH_1	5	9	PF00917	0.678
DOC_USP7_MATH_2	325	331	PF00917	0.593
DOC_WW_Pin1_4	1	6	PF00397	0.515
DOC_WW_Pin1_4	321	326	PF00397	0.631
DOC_WW_Pin1_4	388	393	PF00397	0.706
LIG_14-3-3_CanoR_1	265	271	PF00244	0.464
LIG_Actin_WH2_2	239	257	PF00022	0.359
LIG_BIR_II_1	1	5	PF00653	0.747
LIG_BIR_III_2	226	230	PF00653	0.484
LIG_FHA_1	158	164	PF00498	0.403
LIG_FHA_1	391	397	PF00498	0.723
LIG_FHA_2	1	7	PF00498	0.619
LIG_FHA_2	142	148	PF00498	0.615
LIG_FHA_2	267	273	PF00498	0.483
LIG_FHA_2	322	328	PF00498	0.497
LIG_FHA_2	406	412	PF00498	0.705
LIG_FHA_2	51	57	PF00498	0.816
LIG_FHA_2	78	84	PF00498	0.493
LIG_GBD_Chelix_1	281	289	PF00786	0.516
LIG_LIR_Gen_1	160	170	PF02991	0.325
LIG_LIR_Gen_1	353	363	PF02991	0.595
LIG_LIR_Nem_3	105	111	PF02991	0.358
LIG_LIR_Nem_3	160	165	PF02991	0.334
LIG_LIR_Nem_3	327	331	PF02991	0.602
LIG_NRBOX	288	294	PF00104	0.447
LIG_PCNA_PIPBox_1	107	116	PF02747	0.355
LIG_SH2_CRK	108	112	PF00017	0.362
LIG_SH2_CRK	221	225	PF00017	0.385
LIG_SH2_GRB2like	162	165	PF00017	0.470
LIG_SH2_PTP2	162	165	PF00017	0.470
LIG_SH2_SRC	100	103	PF00017	0.414
LIG_SH2_STAP1	100	104	PF00017	0.430
LIG_SH2_STAP1	207	211	PF00017	0.366
LIG_SH2_STAP1	214	218	PF00017	0.305
LIG_SH2_STAT5	128	131	PF00017	0.339
LIG_SH2_STAT5	162	165	PF00017	0.470
LIG_SH2_STAT5	356	359	PF00017	0.649
LIG_SH3_3	389	395	PF00018	0.707
LIG_SUMO_SIM_anti_2	230	238	PF11976	0.597
LIG_TRAF2_1	228	231	PF00917	0.629
LIG_TRAF2_1	27	30	PF00917	0.611
LIG_TRAF2_1	324	327	PF00917	0.508
LIG_TRAF2_1	44	47	PF00917	0.703
LIG_TRAF2_1	80	83	PF00917	0.488
LIG_TYR_ITIM	106	111	PF00017	0.351
LIG_TYR_ITIM	219	224	PF00017	0.389
MOD_CK1_1	355	361	PF00069	0.560
MOD_CK1_1	41	47	PF00069	0.739
MOD_CK1_1	51	57	PF00069	0.690
MOD_CK2_1	254	260	PF00069	0.557
MOD_CK2_1	266	272	PF00069	0.423
MOD_CK2_1	321	327	PF00069	0.501
MOD_CK2_1	41	47	PF00069	0.689
MOD_CK2_1	51	57	PF00069	0.602
MOD_CK2_1	77	83	PF00069	0.530
MOD_DYRK1A_RPxSP_1	388	392	PF00069	0.732
MOD_GlcNHglycan	121	124	PF01048	0.508
MOD_GlcNHglycan	340	343	PF01048	0.563
MOD_GlcNHglycan	361	364	PF01048	0.621
MOD_GlcNHglycan	388	391	PF01048	0.703
MOD_GlcNHglycan	426	429	PF01048	0.789
MOD_GSK3_1	1	8	PF00069	0.693
MOD_GSK3_1	277	284	PF00069	0.547
MOD_GSK3_1	355	362	PF00069	0.550
MOD_GSK3_1	367	374	PF00069	0.593
MOD_GSK3_1	38	45	PF00069	0.726
MOD_GSK3_1	384	391	PF00069	0.561
MOD_GSK3_1	405	412	PF00069	0.748
MOD_GSK3_1	48	55	PF00069	0.665
MOD_NEK2_1	377	382	PF00069	0.587
MOD_NEK2_2	157	162	PF00069	0.385
MOD_PIKK_1	132	138	PF00454	0.321
MOD_PIKK_1	42	48	PF00454	0.688
MOD_PKA_2	266	272	PF00069	0.469
MOD_PKB_1	422	430	PF00069	0.740
MOD_Plk_1	352	358	PF00069	0.594
MOD_Plk_1	409	415	PF00069	0.749
MOD_Plk_1	72	78	PF00069	0.692
MOD_Plk_2-3	327	333	PF00069	0.591
MOD_Plk_4	232	238	PF00069	0.470
MOD_Plk_4	281	287	PF00069	0.496
MOD_Plk_4	352	358	PF00069	0.689
MOD_Plk_4	377	383	PF00069	0.605
MOD_ProDKin_1	1	7	PF00069	0.510
MOD_ProDKin_1	321	327	PF00069	0.631
MOD_ProDKin_1	388	394	PF00069	0.704
MOD_SUMO_rev_2	226	235	PF00179	0.493
MOD_SUMO_rev_2	271	275	PF00179	0.503
MOD_SUMO_rev_2	330	338	PF00179	0.639
MOD_SUMO_rev_2	414	423	PF00179	0.636
TRG_DiLeu_BaEn_1	21	26	PF01217	0.771
TRG_DiLeu_BaEn_1	288	293	PF01217	0.444
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.430
TRG_ENDOCYTIC_2	108	111	PF00928	0.382
TRG_ENDOCYTIC_2	162	165	PF00928	0.470
TRG_ENDOCYTIC_2	221	224	PF00928	0.393
TRG_ENDOCYTIC_2	356	359	PF00928	0.571
TRG_NLS_Bipartite_1	403	425	PF00514	0.697
TRG_NLS_MonoExtC_3	401	406	PF00514	0.616
TRG_NLS_MonoExtC_3	420	426	PF00514	0.599
TRG_NLS_MonoExtN_4	402	407	PF00514	0.599
TRG_NLS_MonoExtN_4	418	425	PF00514	0.656
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXN4	Leptomonas seymouri	84%	100%
A0A0S4IPT5	Bodo saltans	46%	100%
A0A1X0P488	Trypanosomatidae	49%	89%
A0A3R7NPK3	Trypanosoma rangeli	50%	95%
A0A3S7XBE8	Leishmania donovani	97%	100%
A4HPS2	Leishmania braziliensis	87%	100%
A4ICZ1	Leishmania infantum	96%	100%
D0A8N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4Q111	Leishmania major	96%	100%
V5BS19	Trypanosoma cruzi	52%	94%