Peroxisomal biogenesis factor 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATI4_LEIMU

TriTrypDb:

LmxM.36.4010

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.678
CLV_NRD_NRD_1	146	148	PF00675	0.529
CLV_NRD_NRD_1	171	173	PF00675	0.744
CLV_NRD_NRD_1	318	320	PF00675	0.582
CLV_NRD_NRD_1	395	397	PF00675	0.738
CLV_NRD_NRD_1	412	414	PF00675	0.591
CLV_NRD_NRD_1	427	429	PF00675	0.532
CLV_PCSK_KEX2_1	146	148	PF00082	0.527
CLV_PCSK_KEX2_1	171	173	PF00082	0.757
CLV_PCSK_KEX2_1	318	320	PF00082	0.618
CLV_PCSK_KEX2_1	394	396	PF00082	0.684
CLV_PCSK_KEX2_1	412	414	PF00082	0.560
CLV_PCSK_KEX2_1	427	429	PF00082	0.532
CLV_PCSK_KEX2_1	433	435	PF00082	0.534
CLV_PCSK_KEX2_1	472	474	PF00082	0.594
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.541
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.528
CLV_PCSK_PC7_1	391	397	PF00082	0.745
CLV_PCSK_SKI1_1	224	228	PF00082	0.704
CLV_PCSK_SKI1_1	255	259	PF00082	0.590
CLV_PCSK_SKI1_1	27	31	PF00082	0.303
CLV_PCSK_SKI1_1	412	416	PF00082	0.689
CLV_PCSK_SKI1_1	472	476	PF00082	0.531
CLV_PCSK_SKI1_1	77	81	PF00082	0.340
CLV_PCSK_SKI1_1	99	103	PF00082	0.341
DEG_APCC_DBOX_1	110	118	PF00400	0.531
DEG_APCC_DBOX_1	171	179	PF00400	0.452
DEG_APCC_DBOX_1	76	84	PF00400	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.711
DOC_CYCLIN_RxL_1	134	145	PF00134	0.368
DOC_CYCLIN_RxL_1	74	84	PF00134	0.552
DOC_MAPK_gen_1	108	117	PF00069	0.542
DOC_MAPK_HePTP_8	131	143	PF00069	0.443
DOC_MAPK_MEF2A_6	134	143	PF00069	0.268
DOC_MAPK_MEF2A_6	255	262	PF00069	0.365
DOC_MAPK_RevD_3	131	147	PF00069	0.390
DOC_PP1_RVXF_1	136	143	PF00149	0.366
DOC_PP2B_LxvP_1	215	218	PF13499	0.477
DOC_USP7_MATH_1	272	276	PF00917	0.332
DOC_USP7_MATH_1	311	315	PF00917	0.419
DOC_USP7_MATH_1	320	324	PF00917	0.479
DOC_USP7_MATH_1	338	342	PF00917	0.564
DOC_USP7_MATH_1	365	369	PF00917	0.496
DOC_USP7_MATH_1	379	383	PF00917	0.400
DOC_USP7_MATH_1	492	496	PF00917	0.352
DOC_WW_Pin1_4	193	198	PF00397	0.369
DOC_WW_Pin1_4	334	339	PF00397	0.498
LIG_14-3-3_CanoR_1	111	115	PF00244	0.524
LIG_14-3-3_CanoR_1	27	36	PF00244	0.507
LIG_14-3-3_CanoR_1	310	320	PF00244	0.360
LIG_14-3-3_CanoR_1	333	338	PF00244	0.600
LIG_14-3-3_CanoR_1	412	421	PF00244	0.430
LIG_14-3-3_CanoR_1	473	478	PF00244	0.392
LIG_Actin_WH2_2	287	303	PF00022	0.246
LIG_APCC_ABBA_1	511	516	PF00400	0.318
LIG_BRCT_BRCA1_1	445	449	PF00533	0.336
LIG_EH1_1	284	292	PF00400	0.343
LIG_EVH1_1	215	219	PF00568	0.521
LIG_FHA_1	121	127	PF00498	0.307
LIG_FHA_1	207	213	PF00498	0.509
LIG_FHA_1	66	72	PF00498	0.579
LIG_FHA_1	74	80	PF00498	0.511
LIG_FHA_2	368	374	PF00498	0.493
LIG_FHA_2	413	419	PF00498	0.454
LIG_FHA_2	67	73	PF00498	0.609
LIG_FHA_2	95	101	PF00498	0.554
LIG_LIR_Gen_1	336	346	PF02991	0.371
LIG_LIR_Gen_1	509	514	PF02991	0.379
LIG_LIR_Nem_3	336	342	PF02991	0.371
LIG_LIR_Nem_3	446	452	PF02991	0.339
LIG_LIR_Nem_3	509	513	PF02991	0.377
LIG_MYND_1	322	326	PF01753	0.514
LIG_NRBOX	139	145	PF00104	0.339
LIG_NRBOX	295	301	PF00104	0.326
LIG_Pex14_1	106	110	PF04695	0.571
LIG_Rb_LxCxE_1	509	525	PF01857	0.381
LIG_SH2_CRK	510	514	PF00017	0.374
LIG_SH2_NCK_1	477	481	PF00017	0.370
LIG_SH2_STAP1	122	126	PF00017	0.335
LIG_SH2_STAP1	456	460	PF00017	0.296
LIG_SH2_STAT5	122	125	PF00017	0.328
LIG_SH2_STAT5	37	40	PF00017	0.596
LIG_SH3_1	213	219	PF00018	0.477
LIG_SH3_3	213	219	PF00018	0.526
LIG_SH3_3	257	263	PF00018	0.383
LIG_SH3_3	314	320	PF00018	0.380
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.358
LIG_SUMO_SIM_par_1	125	132	PF11976	0.469
LIG_TRAF2_1	415	418	PF00917	0.416
LIG_TRAF2_1	420	423	PF00917	0.414
LIG_TRAF2_1	500	503	PF00917	0.377
LIG_UBA3_1	130	134	PF00899	0.418
LIG_UBA3_1	179	186	PF00899	0.570
MOD_CK1_1	129	135	PF00069	0.475
MOD_CK1_1	332	338	PF00069	0.680
MOD_CK1_1	368	374	PF00069	0.585
MOD_CK1_1	65	71	PF00069	0.515
MOD_CK2_1	142	148	PF00069	0.500
MOD_CK2_1	243	249	PF00069	0.480
MOD_CK2_1	367	373	PF00069	0.652
MOD_CK2_1	412	418	PF00069	0.502
MOD_CK2_1	445	451	PF00069	0.382
MOD_CK2_1	66	72	PF00069	0.512
MOD_CK2_1	94	100	PF00069	0.490
MOD_Cter_Amidation	169	172	PF01082	0.569
MOD_Cter_Amidation	410	413	PF01082	0.418
MOD_GlcNHglycan	148	151	PF01048	0.549
MOD_GlcNHglycan	156	159	PF01048	0.546
MOD_GlcNHglycan	274	277	PF01048	0.439
MOD_GlcNHglycan	287	290	PF01048	0.380
MOD_GlcNHglycan	366	370	PF01048	0.654
MOD_GlcNHglycan	445	448	PF01048	0.471
MOD_GSK3_1	113	120	PF00069	0.308
MOD_GSK3_1	122	129	PF00069	0.249
MOD_GSK3_1	142	149	PF00069	0.249
MOD_GSK3_1	150	157	PF00069	0.471
MOD_GSK3_1	189	196	PF00069	0.555
MOD_GSK3_1	325	332	PF00069	0.680
MOD_GSK3_1	333	340	PF00069	0.599
MOD_GSK3_1	365	372	PF00069	0.623
MOD_GSK3_1	441	448	PF00069	0.463
MOD_GSK3_1	515	522	PF00069	0.348
MOD_GSK3_1	62	69	PF00069	0.467
MOD_N-GLC_1	2	7	PF02516	0.403
MOD_N-GLC_1	285	290	PF02516	0.380
MOD_NEK2_1	110	115	PF00069	0.272
MOD_NEK2_1	126	131	PF00069	0.275
MOD_NEK2_1	142	147	PF00069	0.363
MOD_NEK2_1	152	157	PF00069	0.622
MOD_NEK2_1	179	184	PF00069	0.568
MOD_NEK2_1	285	290	PF00069	0.348
MOD_NEK2_1	443	448	PF00069	0.411
MOD_NEK2_1	452	457	PF00069	0.357
MOD_NEK2_2	159	164	PF00069	0.606
MOD_NEK2_2	492	497	PF00069	0.454
MOD_NEK2_2	515	520	PF00069	0.334
MOD_PIKK_1	189	195	PF00454	0.607
MOD_PIKK_1	243	249	PF00454	0.619
MOD_PKA_1	146	152	PF00069	0.469
MOD_PKA_1	412	418	PF00069	0.436
MOD_PKA_2	110	116	PF00069	0.368
MOD_PKA_2	146	152	PF00069	0.592
MOD_PKA_2	332	338	PF00069	0.746
MOD_PKA_2	412	418	PF00069	0.436
MOD_PKA_2	519	525	PF00069	0.377
MOD_PKA_2	63	69	PF00069	0.476
MOD_PKA_2	73	79	PF00069	0.385
MOD_Plk_1	13	19	PF00069	0.552
MOD_Plk_1	515	521	PF00069	0.355
MOD_Plk_1	62	68	PF00069	0.452
MOD_Plk_2-3	206	212	PF00069	0.557
MOD_Plk_4	110	116	PF00069	0.307
MOD_Plk_4	179	185	PF00069	0.507
MOD_Plk_4	295	301	PF00069	0.339
MOD_Plk_4	320	326	PF00069	0.594
MOD_Plk_4	381	387	PF00069	0.685
MOD_Plk_4	506	512	PF00069	0.466
MOD_ProDKin_1	193	199	PF00069	0.461
MOD_ProDKin_1	334	340	PF00069	0.637
MOD_SUMO_rev_2	399	406	PF00179	0.546
MOD_SUMO_rev_2	467	474	PF00179	0.453
MOD_SUMO_rev_2	502	509	PF00179	0.492
MOD_SUMO_rev_2	95	103	PF00179	0.450
TRG_DiLeu_BaEn_1	357	362	PF01217	0.709
TRG_DiLeu_BaEn_4	210	216	PF01217	0.687
TRG_ENDOCYTIC_2	36	39	PF00928	0.573
TRG_ENDOCYTIC_2	510	513	PF00928	0.353
TRG_ER_diArg_1	317	319	PF00400	0.477
TRG_ER_diArg_1	393	396	PF00400	0.600
TRG_ER_diArg_1	412	414	PF00400	0.614
TRG_ER_diArg_1	426	428	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL78	Leptomonas seymouri	70%	100%
A0A1X0P397	Trypanosomatidae	33%	100%
A0A3Q8IW98	Leishmania donovani	93%	100%
A0A3R7KTQ7	Trypanosoma rangeli	31%	100%
A4HPR9	Leishmania braziliensis	82%	99%
A4ICZ4	Leishmania infantum	94%	100%
D0A8N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q114	Leishmania major	93%	100%
V5B6V7	Trypanosoma cruzi	33%	100%