Rieske domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATI3_LEIMU

TriTrypDb:

LmxM.36.4000

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.336
CLV_PCSK_FUR_1	13	17	PF00082	0.278
CLV_PCSK_KEX2_1	15	17	PF00082	0.378
CLV_PCSK_SKI1_1	30	34	PF00082	0.357
DEG_Kelch_Keap1_1	84	89	PF01344	0.423
DOC_CYCLIN_yCln2_LP_2	25	31	PF00134	0.437
DOC_MAPK_gen_1	134	143	PF00069	0.365
DOC_USP7_MATH_1	120	124	PF00917	0.443
DOC_USP7_MATH_1	164	168	PF00917	0.426
DOC_WW_Pin1_4	39	44	PF00397	0.326
DOC_WW_Pin1_4	48	53	PF00397	0.369
LIG_14-3-3_CanoR_1	30	35	PF00244	0.360
LIG_Clathr_ClatBox_1	82	86	PF01394	0.366
LIG_Clathr_ClatBox_1	92	96	PF01394	0.474
LIG_eIF4E_1	31	37	PF01652	0.476
LIG_FHA_1	145	151	PF00498	0.474
LIG_FHA_1	31	37	PF00498	0.375
LIG_IRF3_LxIS_1	32	38	PF10401	0.522
LIG_LIR_Nem_3	10	14	PF02991	0.431
LIG_LIR_Nem_3	26	32	PF02991	0.328
LIG_LYPXL_SIV_4	28	36	PF13949	0.439
LIG_PDZ_Class_3	189	194	PF00595	0.611
LIG_SH2_CRK	29	33	PF00017	0.409
LIG_SH2_PTP2	31	34	PF00017	0.432
LIG_SH2_STAT5	31	34	PF00017	0.432
LIG_SH2_STAT5	81	84	PF00017	0.439
LIG_SH3_3	110	116	PF00018	0.512
LIG_SH3_3	37	43	PF00018	0.574
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.567
LIG_SUMO_SIM_anti_2	33	38	PF11976	0.468
LIG_SUMO_SIM_par_1	147	153	PF11976	0.403
LIG_SUMO_SIM_par_1	32	38	PF11976	0.466
LIG_SUMO_SIM_par_1	64	70	PF11976	0.459
LIG_UBA3_1	183	187	PF00899	0.569
MOD_CK2_1	39	45	PF00069	0.419
MOD_GlcNHglycan	121	125	PF01048	0.517
MOD_GSK3_1	144	151	PF00069	0.446
MOD_GSK3_1	35	42	PF00069	0.443
MOD_NEK2_1	35	40	PF00069	0.534
MOD_Plk_2-3	7	13	PF00069	0.446
MOD_Plk_4	125	131	PF00069	0.567
MOD_Plk_4	30	36	PF00069	0.381
MOD_ProDKin_1	39	45	PF00069	0.322
MOD_ProDKin_1	48	54	PF00069	0.370
MOD_SUMO_rev_2	42	49	PF00179	0.462
TRG_DiLeu_BaEn_1	67	72	PF01217	0.551
TRG_DiLeu_BaEn_3	144	150	PF01217	0.523
TRG_ENDOCYTIC_2	11	14	PF00928	0.434
TRG_ENDOCYTIC_2	29	32	PF00928	0.254
TRG_ER_diArg_1	13	16	PF00400	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H7	Leptomonas seymouri	75%	100%
A0A0S4IXL7	Bodo saltans	44%	97%
A0A1X0P3Z4	Trypanosomatidae	48%	90%
A0A3Q8IJQ0	Leishmania donovani	95%	100%
A0A422NVN8	Trypanosoma rangeli	54%	100%
A4HPR8	Leishmania braziliensis	88%	100%
A4ICZ5	Leishmania infantum	94%	100%
D0A8N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	93%
Q4Q115	Leishmania major	92%	100%