NTP_transf_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9ATI2_LEIMU

TriTrypDb:

LmxM.36.3991

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0031499	TRAMP complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0110165	cellular anatomical entity	1	5
GO:0140513	nuclear protein-containing complex	2	5

Expansion

Sequence features

E9ATI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATI2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006396	RNA processing	6	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0031123	RNA 3'-end processing	7	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043631	RNA polyadenylation	6	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071076	RNA 3' uridylation	8	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016779	nucleotidyltransferase activity	4	5
GO:0050265	RNA uridylyltransferase activity	4	5
GO:0070566	adenylyltransferase activity	5	5
GO:0070569	uridylyltransferase activity	5	5
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	535	539	PF00656	0.793
CLV_C14_Caspase3-7	657	661	PF00656	0.753
CLV_NRD_NRD_1	487	489	PF00675	0.739
CLV_PCSK_KEX2_1	278	280	PF00082	0.534
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.534
CLV_PCSK_SKI1_1	279	283	PF00082	0.503
CLV_PCSK_SKI1_1	622	626	PF00082	0.432
CLV_PCSK_SKI1_1	734	738	PF00082	0.408
CLV_PCSK_SKI1_1	80	84	PF00082	0.566
DOC_CKS1_1	145	150	PF01111	0.722
DOC_CYCLIN_RxL_1	663	673	PF00134	0.633
DOC_CYCLIN_yClb3_PxF_3	144	150	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.748
DOC_MAPK_DCC_7	503	512	PF00069	0.744
DOC_MAPK_gen_1	278	284	PF00069	0.513
DOC_PP2B_LxvP_1	235	238	PF13499	0.535
DOC_PP2B_LxvP_1	409	412	PF13499	0.689
DOC_PP2B_LxvP_1	440	443	PF13499	0.763
DOC_PP2B_LxvP_1	586	589	PF13499	0.759
DOC_PP4_FxxP_1	450	453	PF00568	0.550
DOC_PP4_FxxP_1	692	695	PF00568	0.494
DOC_PP4_FxxP_1	730	733	PF00568	0.462
DOC_USP7_MATH_1	128	132	PF00917	0.652
DOC_USP7_MATH_1	20	24	PF00917	0.802
DOC_USP7_MATH_1	475	479	PF00917	0.677
DOC_USP7_MATH_1	484	488	PF00917	0.449
DOC_USP7_MATH_1	569	573	PF00917	0.795
DOC_USP7_MATH_1	580	584	PF00917	0.610
DOC_USP7_MATH_1	635	639	PF00917	0.392
DOC_USP7_UBL2_3	364	368	PF12436	0.514
DOC_WW_Pin1_4	144	149	PF00397	0.737
DOC_WW_Pin1_4	18	23	PF00397	0.705
DOC_WW_Pin1_4	350	355	PF00397	0.452
DOC_WW_Pin1_4	407	412	PF00397	0.539
DOC_WW_Pin1_4	430	435	PF00397	0.657
DOC_WW_Pin1_4	451	456	PF00397	0.664
DOC_WW_Pin1_4	554	559	PF00397	0.709
DOC_WW_Pin1_4	563	568	PF00397	0.710
DOC_WW_Pin1_4	616	621	PF00397	0.442
DOC_WW_Pin1_4	88	93	PF00397	0.776
LIG_14-3-3_CanoR_1	160	169	PF00244	0.560
LIG_14-3-3_CanoR_1	295	301	PF00244	0.481
LIG_14-3-3_CanoR_1	469	477	PF00244	0.747
LIG_14-3-3_CanoR_1	561	567	PF00244	0.793
LIG_14-3-3_CanoR_1	629	637	PF00244	0.374
LIG_14-3-3_CanoR_1	702	712	PF00244	0.456
LIG_14-3-3_CanoR_1	84	93	PF00244	0.586
LIG_14-3-3_CterR_2	734	739	PF00244	0.427
LIG_Actin_WH2_2	280	297	PF00022	0.485
LIG_APCC_ABBAyCdc20_2	279	285	PF00400	0.594
LIG_BRCT_BRCA1_1	296	300	PF00533	0.607
LIG_BRCT_BRCA1_1	330	334	PF00533	0.312
LIG_BRCT_BRCA1_1	446	450	PF00533	0.574
LIG_BRCT_BRCA1_1	726	730	PF00533	0.474
LIG_FHA_1	173	179	PF00498	0.450
LIG_FHA_1	220	226	PF00498	0.399
LIG_FHA_1	256	262	PF00498	0.550
LIG_FHA_1	726	732	PF00498	0.565
LIG_FHA_2	186	192	PF00498	0.488
LIG_FHA_2	213	219	PF00498	0.552
LIG_FHA_2	27	33	PF00498	0.572
LIG_FHA_2	297	303	PF00498	0.602
LIG_FHA_2	670	676	PF00498	0.540
LIG_FHA_2	704	710	PF00498	0.448
LIG_FHA_2	99	105	PF00498	0.726
LIG_LIR_Apic_2	447	453	PF02991	0.732
LIG_LIR_Apic_2	691	695	PF02991	0.492
LIG_LIR_Apic_2	727	733	PF02991	0.477
LIG_LIR_Gen_1	131	141	PF02991	0.531
LIG_LIR_Gen_1	180	187	PF02991	0.312
LIG_LIR_Gen_1	383	394	PF02991	0.429
LIG_LIR_Nem_3	131	136	PF02991	0.765
LIG_LIR_Nem_3	147	153	PF02991	0.597
LIG_LIR_Nem_3	180	185	PF02991	0.453
LIG_LIR_Nem_3	297	303	PF02991	0.602
LIG_LIR_Nem_3	374	380	PF02991	0.483
LIG_LIR_Nem_3	383	389	PF02991	0.341
LIG_PCNA_PIPBox_1	203	212	PF02747	0.564
LIG_PCNA_yPIPBox_3	197	210	PF02747	0.550
LIG_PCNA_yPIPBox_3	364	376	PF02747	0.457
LIG_RPA_C_Fungi	336	348	PF08784	0.551
LIG_SH2_CRK	386	390	PF00017	0.421
LIG_SH2_NCK_1	414	418	PF00017	0.622
LIG_SH2_NCK_1	540	544	PF00017	0.796
LIG_SH2_SRC	414	417	PF00017	0.625
LIG_SH2_SRC	479	482	PF00017	0.641
LIG_SH2_STAP1	133	137	PF00017	0.533
LIG_SH2_STAP1	414	418	PF00017	0.709
LIG_SH2_STAT5	184	187	PF00017	0.461
LIG_SH2_STAT5	201	204	PF00017	0.460
LIG_SH2_STAT5	386	389	PF00017	0.422
LIG_SH2_STAT5	479	482	PF00017	0.641
LIG_SH2_STAT5	540	543	PF00017	0.800
LIG_SH3_1	143	149	PF00018	0.728
LIG_SH3_3	142	148	PF00018	0.701
LIG_SH3_3	150	156	PF00018	0.595
LIG_SH3_3	19	25	PF00018	0.588
LIG_SUMO_SIM_par_1	257	262	PF11976	0.485
LIG_SUMO_SIM_par_1	93	99	PF11976	0.579
LIG_SxIP_EBH_1	469	482	PF03271	0.508
LIG_TRAF2_1	188	191	PF00917	0.598
LIG_TRAF2_1	249	252	PF00917	0.399
LIG_TRAF2_1	655	658	PF00917	0.507
LIG_WRC_WIRS_1	133	138	PF05994	0.765
LIG_WRC_WIRS_1	676	681	PF05994	0.364
LIG_WW_1	411	414	PF00397	0.624
MOD_CDC14_SPxK_1	619	622	PF00782	0.428
MOD_CDK_SPxK_1	616	622	PF00069	0.443
MOD_CDK_SPxxK_3	554	561	PF00069	0.708
MOD_CK1_1	236	242	PF00069	0.399
MOD_CK1_1	273	279	PF00069	0.406
MOD_CK1_1	30	36	PF00069	0.571
MOD_CK1_1	333	339	PF00069	0.488
MOD_CK1_1	433	439	PF00069	0.666
MOD_CK1_1	471	477	PF00069	0.524
MOD_CK1_1	688	694	PF00069	0.479
MOD_CK1_1	704	710	PF00069	0.433
MOD_CK1_1	87	93	PF00069	0.787
MOD_CK2_1	128	134	PF00069	0.526
MOD_CK2_1	185	191	PF00069	0.485
MOD_CK2_1	212	218	PF00069	0.649
MOD_CK2_1	296	302	PF00069	0.612
MOD_CK2_1	30	36	PF00069	0.571
MOD_CK2_1	652	658	PF00069	0.460
MOD_CK2_1	669	675	PF00069	0.327
MOD_CK2_1	703	709	PF00069	0.454
MOD_CK2_1	98	104	PF00069	0.768
MOD_GlcNHglycan	130	133	PF01048	0.685
MOD_GlcNHglycan	162	165	PF01048	0.581
MOD_GlcNHglycan	264	267	PF01048	0.642
MOD_GlcNHglycan	272	275	PF01048	0.505
MOD_GlcNHglycan	296	299	PF01048	0.620
MOD_GlcNHglycan	335	338	PF01048	0.504
MOD_GlcNHglycan	470	473	PF01048	0.689
MOD_GlcNHglycan	548	551	PF01048	0.768
MOD_GlcNHglycan	582	585	PF01048	0.698
MOD_GlcNHglycan	593	596	PF01048	0.718
MOD_GlcNHglycan	603	606	PF01048	0.444
MOD_GlcNHglycan	631	634	PF01048	0.449
MOD_GlcNHglycan	637	640	PF01048	0.414
MOD_GlcNHglycan	654	657	PF01048	0.682
MOD_GlcNHglycan	660	663	PF01048	0.667
MOD_GlcNHglycan	686	690	PF01048	0.540
MOD_GlcNHglycan	86	89	PF01048	0.784
MOD_GSK3_1	128	135	PF00069	0.659
MOD_GSK3_1	158	165	PF00069	0.635
MOD_GSK3_1	20	27	PF00069	0.606
MOD_GSK3_1	233	240	PF00069	0.474
MOD_GSK3_1	270	277	PF00069	0.588
MOD_GSK3_1	324	331	PF00069	0.387
MOD_GSK3_1	421	428	PF00069	0.645
MOD_GSK3_1	430	437	PF00069	0.671
MOD_GSK3_1	471	478	PF00069	0.653
MOD_GSK3_1	515	522	PF00069	0.672
MOD_GSK3_1	546	553	PF00069	0.715
MOD_GSK3_1	559	566	PF00069	0.686
MOD_GSK3_1	681	688	PF00069	0.498
MOD_GSK3_1	721	728	PF00069	0.612
MOD_GSK3_1	80	87	PF00069	0.759
MOD_GSK3_1	9	16	PF00069	0.784
MOD_LATS_1	317	323	PF00433	0.574
MOD_N-GLC_1	407	412	PF02516	0.579
MOD_N-GLC_1	658	663	PF02516	0.563
MOD_N-GLC_2	125	127	PF02516	0.763
MOD_N-GLC_2	525	527	PF02516	0.564
MOD_NEK2_1	185	190	PF00069	0.500
MOD_NEK2_1	227	232	PF00069	0.399
MOD_NEK2_1	233	238	PF00069	0.399
MOD_NEK2_1	244	249	PF00069	0.175
MOD_NEK2_1	270	275	PF00069	0.431
MOD_NEK2_1	294	299	PF00069	0.463
MOD_NEK2_1	318	323	PF00069	0.376
MOD_NEK2_1	515	520	PF00069	0.521
MOD_NEK2_1	545	550	PF00069	0.650
MOD_NEK2_1	701	706	PF00069	0.439
MOD_NEK2_1	725	730	PF00069	0.567
MOD_NEK2_1	82	87	PF00069	0.618
MOD_PIKK_1	186	192	PF00454	0.341
MOD_PIKK_1	421	427	PF00454	0.585
MOD_PIKK_1	538	544	PF00454	0.708
MOD_PIKK_1	82	88	PF00454	0.612
MOD_PKA_2	114	120	PF00069	0.831
MOD_PKA_2	294	300	PF00069	0.485
MOD_PKA_2	318	324	PF00069	0.382
MOD_PKA_2	360	366	PF00069	0.420
MOD_PKA_2	468	474	PF00069	0.749
MOD_PKA_2	519	525	PF00069	0.539
MOD_PKA_2	546	552	PF00069	0.699
MOD_PKA_2	701	707	PF00069	0.453
MOD_Plk_1	4	10	PF00069	0.771
MOD_Plk_2-3	255	261	PF00069	0.252
MOD_Plk_4	132	138	PF00069	0.762
MOD_Plk_4	330	336	PF00069	0.317
MOD_Plk_4	475	481	PF00069	0.647
MOD_Plk_4	492	498	PF00069	0.525
MOD_Plk_4	721	727	PF00069	0.516
MOD_ProDKin_1	144	150	PF00069	0.730
MOD_ProDKin_1	18	24	PF00069	0.707
MOD_ProDKin_1	350	356	PF00069	0.447
MOD_ProDKin_1	407	413	PF00069	0.544
MOD_ProDKin_1	430	436	PF00069	0.659
MOD_ProDKin_1	451	457	PF00069	0.661
MOD_ProDKin_1	554	560	PF00069	0.708
MOD_ProDKin_1	563	569	PF00069	0.710
MOD_ProDKin_1	616	622	PF00069	0.443
MOD_ProDKin_1	88	94	PF00069	0.775
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.555
TRG_DiLeu_BaLyEn_6	619	624	PF01217	0.423
TRG_DiLeu_BaLyEn_6	731	736	PF01217	0.430
TRG_ENDOCYTIC_2	133	136	PF00928	0.682
TRG_ENDOCYTIC_2	184	187	PF00928	0.461
TRG_ENDOCYTIC_2	386	389	PF00928	0.422
TRG_ER_diArg_1	345	348	PF00400	0.409
TRG_ER_diArg_1	53	56	PF00400	0.771
TRG_ER_diArg_1	613	616	PF00400	0.580
TRG_NES_CRM1_1	177	191	PF08389	0.552
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	629	634	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P668	Leptomonas seymouri	51%	96%
A0A3Q8IPC3	Leishmania donovani	84%	100%
A4ICZ6	Leishmania infantum	84%	100%