Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATH2_LEIMU

TriTrypDb:

LmxM.36.3900

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.562
CLV_PCSK_SKI1_1	223	227	PF00082	0.577
CLV_PCSK_SKI1_1	37	41	PF00082	0.515
DEG_Nend_Nbox_1	1	3	PF02207	0.562
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.527
DOC_MAPK_gen_1	166	175	PF00069	0.519
DOC_MAPK_gen_1	264	272	PF00069	0.520
DOC_MAPK_gen_1	34	43	PF00069	0.585
DOC_MAPK_MEF2A_6	37	45	PF00069	0.487
DOC_PP4_FxxP_1	45	48	PF00568	0.468
DOC_SPAK_OSR1_1	166	170	PF12202	0.569
DOC_USP7_MATH_1	137	141	PF00917	0.694
DOC_USP7_MATH_1	187	191	PF00917	0.580
DOC_USP7_MATH_2	253	259	PF00917	0.578
DOC_WW_Pin1_4	139	144	PF00397	0.709
DOC_WW_Pin1_4	192	197	PF00397	0.654
LIG_14-3-3_CanoR_1	37	42	PF00244	0.522
LIG_CaM_NSCaTE_8	95	102	PF13499	0.607
LIG_FHA_1	38	44	PF00498	0.485
LIG_FHA_1	85	91	PF00498	0.522
LIG_FHA_2	118	124	PF00498	0.534
LIG_FHA_2	150	156	PF00498	0.692
LIG_LIR_Apic_2	42	48	PF02991	0.463
LIG_LIR_Gen_1	174	184	PF02991	0.400
LIG_LIR_Gen_1	268	274	PF02991	0.549
LIG_LIR_Gen_1	46	55	PF02991	0.503
LIG_LIR_Nem_3	13	19	PF02991	0.492
LIG_LIR_Nem_3	165	170	PF02991	0.551
LIG_LIR_Nem_3	174	179	PF02991	0.409
LIG_LIR_Nem_3	268	272	PF02991	0.550
LIG_LIR_Nem_3	46	52	PF02991	0.582
LIG_MYND_1	160	164	PF01753	0.574
LIG_Pex14_2	45	49	PF04695	0.468
LIG_PTB_Apo_2	169	176	PF02174	0.443
LIG_SH2_CRK	67	71	PF00017	0.442
LIG_SH2_SRC	55	58	PF00017	0.589
LIG_SH2_STAP1	11	15	PF00017	0.527
LIG_SH2_STAP1	16	20	PF00017	0.472
LIG_SH2_STAP1	55	59	PF00017	0.532
LIG_SH2_STAT5	19	22	PF00017	0.471
LIG_SH2_STAT5	269	272	PF00017	0.540
LIG_SH3_2	161	166	PF14604	0.488
LIG_SH3_3	107	113	PF00018	0.725
LIG_SH3_3	158	164	PF00018	0.532
LIG_SH3_3	190	196	PF00018	0.645
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.464
LIG_SUMO_SIM_par_1	86	91	PF11976	0.569
LIG_TRAF2_1	54	57	PF00917	0.522
LIG_TYR_ITIM	65	70	PF00017	0.635
MOD_CDK_SPxxK_3	139	146	PF00069	0.505
MOD_CK1_1	149	155	PF00069	0.662
MOD_CK1_1	84	90	PF00069	0.580
MOD_CK2_1	117	123	PF00069	0.580
MOD_CK2_1	149	155	PF00069	0.714
MOD_CK2_1	182	188	PF00069	0.524
MOD_CK2_1	194	200	PF00069	0.511
MOD_CK2_1	50	56	PF00069	0.544
MOD_CK2_1	70	76	PF00069	0.461
MOD_GlcNHglycan	132	135	PF01048	0.733
MOD_GlcNHglycan	139	142	PF01048	0.593
MOD_GlcNHglycan	148	151	PF01048	0.696
MOD_GlcNHglycan	196	199	PF01048	0.811
MOD_GlcNHglycan	272	275	PF01048	0.590
MOD_GlcNHglycan	51	55	PF01048	0.645
MOD_GlcNHglycan	83	86	PF01048	0.649
MOD_GSK3_1	117	124	PF00069	0.618
MOD_GSK3_1	178	185	PF00069	0.425
MOD_GSK3_1	18	25	PF00069	0.536
MOD_GSK3_1	84	91	PF00069	0.605
MOD_N-GLC_1	155	160	PF02516	0.657
MOD_NEK2_1	117	122	PF00069	0.725
MOD_NEK2_1	177	182	PF00069	0.507
MOD_NEK2_1	23	28	PF00069	0.527
MOD_NEK2_1	50	55	PF00069	0.446
MOD_NEK2_1	88	93	PF00069	0.551
MOD_OFUCOSY	118	125	PF10250	0.442
MOD_Plk_1	187	193	PF00069	0.737
MOD_Plk_1	230	236	PF00069	0.506
MOD_Plk_1	50	56	PF00069	0.619
MOD_Plk_4	238	244	PF00069	0.685
MOD_Plk_4	255	261	PF00069	0.453
MOD_ProDKin_1	139	145	PF00069	0.711
MOD_ProDKin_1	192	198	PF00069	0.655
TRG_ENDOCYTIC_2	269	272	PF00928	0.537
TRG_ENDOCYTIC_2	67	70	PF00928	0.642
TRG_ER_diArg_1	31	34	PF00400	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L2	Leptomonas seymouri	41%	100%
A0A3Q8IL86	Leishmania donovani	84%	100%
A4HPQ7	Leishmania braziliensis	69%	99%
A4ID06	Leishmania infantum	84%	100%
Q4Q125	Leishmania major	84%	100%