Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATH1_LEIMU

TriTrypDb:

LmxM.36.3890

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9ATH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.530
CLV_C14_Caspase3-7	190	194	PF00656	0.592
CLV_NRD_NRD_1	25	27	PF00675	0.590
CLV_NRD_NRD_1	299	301	PF00675	0.378
CLV_NRD_NRD_1	46	48	PF00675	0.663
CLV_NRD_NRD_1	89	91	PF00675	0.472
CLV_PCSK_KEX2_1	25	27	PF00082	0.590
CLV_PCSK_KEX2_1	46	48	PF00082	0.663
CLV_PCSK_KEX2_1	89	91	PF00082	0.472
CLV_PCSK_SKI1_1	218	222	PF00082	0.285
CLV_PCSK_SKI1_1	286	290	PF00082	0.479
CLV_PCSK_SKI1_1	379	383	PF00082	0.440
DEG_APCC_DBOX_1	351	359	PF00400	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DEG_SPOP_SBC_1	148	152	PF00917	0.593
DOC_CYCLIN_RxL_1	376	384	PF00134	0.445
DOC_MAPK_MEF2A_6	254	261	PF00069	0.376
DOC_PP4_FxxP_1	373	376	PF00568	0.510
DOC_USP7_MATH_1	108	112	PF00917	0.795
DOC_USP7_MATH_1	148	152	PF00917	0.689
DOC_USP7_MATH_1	159	163	PF00917	0.578
DOC_USP7_MATH_1	35	39	PF00917	0.703
DOC_USP7_MATH_1	8	12	PF00917	0.615
DOC_WW_Pin1_4	106	111	PF00397	0.669
DOC_WW_Pin1_4	14	19	PF00397	0.591
DOC_WW_Pin1_4	178	183	PF00397	0.624
LIG_14-3-3_CanoR_1	218	223	PF00244	0.364
LIG_14-3-3_CanoR_1	336	342	PF00244	0.429
LIG_14-3-3_CanoR_1	46	55	PF00244	0.571
LIG_14-3-3_CanoR_1	9	14	PF00244	0.497
LIG_14-3-3_CterR_2	391	395	PF00244	0.529
LIG_BRCT_BRCA1_1	339	343	PF00533	0.364
LIG_deltaCOP1_diTrp_1	333	341	PF00928	0.430
LIG_FHA_1	49	55	PF00498	0.611
LIG_FHA_2	188	194	PF00498	0.573
LIG_FHA_2	239	245	PF00498	0.473
LIG_LIR_Apic_2	370	376	PF02991	0.524
LIG_LIR_Apic_2	91	96	PF02991	0.523
LIG_LIR_Gen_1	320	330	PF02991	0.363
LIG_LIR_Gen_1	71	81	PF02991	0.387
LIG_LIR_Nem_3	244	248	PF02991	0.389
LIG_LIR_Nem_3	340	344	PF02991	0.369
LIG_LIR_Nem_3	346	350	PF02991	0.386
LIG_LIR_Nem_3	71	77	PF02991	0.395
LIG_PTB_Apo_2	316	323	PF02174	0.379
LIG_PTB_Phospho_1	316	322	PF10480	0.377
LIG_Rb_pABgroove_1	316	324	PF01858	0.455
LIG_SH2_CRK	305	309	PF00017	0.383
LIG_SH2_CRK	93	97	PF00017	0.539
LIG_SH2_GRB2like	347	350	PF00017	0.329
LIG_SH2_NCK_1	93	97	PF00017	0.530
LIG_SH2_STAT5	344	347	PF00017	0.373
LIG_SH2_STAT5	350	353	PF00017	0.398
LIG_SH2_STAT5	93	96	PF00017	0.578
LIG_SH3_1	93	99	PF00018	0.533
LIG_SH3_3	181	187	PF00018	0.600
LIG_SH3_3	274	280	PF00018	0.395
LIG_SH3_3	93	99	PF00018	0.569
LIG_SUMO_SIM_anti_2	38	43	PF11976	0.653
LIG_TRAF2_1	282	285	PF00917	0.412
LIG_TRAF2_1	29	32	PF00917	0.604
LIG_TRAF2_1	50	53	PF00917	0.564
LIG_UBA3_1	76	82	PF00899	0.417
LIG_WRC_WIRS_1	239	244	PF05994	0.483
LIG_WW_3	232	236	PF00397	0.575
MOD_CDC14_SPxK_1	17	20	PF00782	0.483
MOD_CDK_SPxK_1	14	20	PF00069	0.489
MOD_CK1_1	134	140	PF00069	0.640
MOD_CK1_1	150	156	PF00069	0.777
MOD_CK1_1	262	268	PF00069	0.359
MOD_CK1_1	48	54	PF00069	0.602
MOD_CK2_1	159	165	PF00069	0.761
MOD_CK2_1	182	188	PF00069	0.604
MOD_CK2_1	279	285	PF00069	0.426
MOD_CK2_1	47	53	PF00069	0.563
MOD_CMANNOS	334	337	PF00535	0.346
MOD_Cter_Amidation	44	47	PF01082	0.664
MOD_GlcNHglycan	126	129	PF01048	0.672
MOD_GlcNHglycan	133	136	PF01048	0.623
MOD_GlcNHglycan	281	284	PF01048	0.548
MOD_GlcNHglycan	32	36	PF01048	0.608
MOD_GlcNHglycan	70	73	PF01048	0.478
MOD_GSK3_1	102	109	PF00069	0.702
MOD_GSK3_1	130	137	PF00069	0.632
MOD_GSK3_1	146	153	PF00069	0.786
MOD_GSK3_1	178	185	PF00069	0.570
MOD_GSK3_1	31	38	PF00069	0.613
MOD_GSK3_1	59	66	PF00069	0.436
MOD_GSK3_1	9	16	PF00069	0.541
MOD_NEK2_1	13	18	PF00069	0.553
MOD_PIKK_1	150	156	PF00454	0.655
MOD_PIKK_1	182	188	PF00454	0.658
MOD_PIKK_1	56	62	PF00454	0.474
MOD_PK_1	138	144	PF00069	0.602
MOD_PKA_2	103	109	PF00069	0.613
MOD_PKA_2	175	181	PF00069	0.726
MOD_PKA_2	45	51	PF00069	0.621
MOD_PKA_2	8	14	PF00069	0.567
MOD_Plk_1	187	193	PF00069	0.625
MOD_Plk_1	56	62	PF00069	0.459
MOD_Plk_4	108	114	PF00069	0.571
MOD_Plk_4	337	343	PF00069	0.356
MOD_Plk_4	37	43	PF00069	0.562
MOD_Plk_4	9	15	PF00069	0.555
MOD_ProDKin_1	106	112	PF00069	0.666
MOD_ProDKin_1	14	20	PF00069	0.590
MOD_ProDKin_1	178	184	PF00069	0.623
TRG_DiLeu_BaEn_1	285	290	PF01217	0.392
TRG_DiLeu_BaEn_1	370	375	PF01217	0.520
TRG_DiLeu_BaEn_4	370	376	PF01217	0.524
TRG_ENDOCYTIC_2	322	325	PF00928	0.363
TRG_ENDOCYTIC_2	74	77	PF00928	0.458
TRG_ENDOCYTIC_2	81	84	PF00928	0.379
TRG_ER_diArg_1	24	26	PF00400	0.593
TRG_ER_diArg_1	88	90	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	47	52	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ8	Leptomonas seymouri	60%	100%
A0A3Q8IGD8	Leishmania donovani	90%	100%
A4HPQ6	Leishmania braziliensis	79%	98%
A4ID07	Leishmania infantum	89%	100%
Q4Q126	Leishmania major	87%	100%