Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATG9_LEIMU

TriTrypDb:

LmxM.36.3870

Length:

842

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9ATG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	528	532	PF00656	0.783
CLV_C14_Caspase3-7	78	82	PF00656	0.740
CLV_NRD_NRD_1	141	143	PF00675	0.587
CLV_NRD_NRD_1	681	683	PF00675	0.686
CLV_NRD_NRD_1	732	734	PF00675	0.560
CLV_NRD_NRD_1	79	81	PF00675	0.756
CLV_NRD_NRD_1	803	805	PF00675	0.511
CLV_PCSK_KEX2_1	141	143	PF00082	0.587
CLV_PCSK_KEX2_1	79	81	PF00082	0.762
CLV_PCSK_SKI1_1	307	311	PF00082	0.626
CLV_PCSK_SKI1_1	357	361	PF00082	0.542
CLV_PCSK_SKI1_1	389	393	PF00082	0.357
CLV_PCSK_SKI1_1	682	686	PF00082	0.675
CLV_PCSK_SKI1_1	80	84	PF00082	0.540
DEG_APCC_DBOX_1	681	689	PF00400	0.671
DEG_APCC_DBOX_1	721	729	PF00400	0.551
DEG_APCC_KENBOX_2	151	155	PF00400	0.316
DEG_SCF_FBW7_1	127	134	PF00400	0.616
DEG_SCF_FBW7_1	474	480	PF00400	0.624
DEG_SPOP_SBC_1	341	345	PF00917	0.457
DOC_CKS1_1	471	476	PF01111	0.622
DOC_CKS1_1	606	611	PF01111	0.830
DOC_MAPK_DCC_7	544	553	PF00069	0.789
DOC_MAPK_gen_1	682	688	PF00069	0.672
DOC_MAPK_MEF2A_6	30	38	PF00069	0.574
DOC_MAPK_MEF2A_6	544	553	PF00069	0.789
DOC_PP1_RVXF_1	103	109	PF00149	0.520
DOC_PP2B_LxvP_1	220	223	PF13499	0.344
DOC_USP7_MATH_1	225	229	PF00917	0.738
DOC_USP7_MATH_1	268	272	PF00917	0.651
DOC_USP7_MATH_1	420	424	PF00917	0.798
DOC_USP7_MATH_1	456	460	PF00917	0.513
DOC_USP7_MATH_1	477	481	PF00917	0.760
DOC_USP7_MATH_1	489	493	PF00917	0.560
DOC_USP7_MATH_1	526	530	PF00917	0.774
DOC_USP7_MATH_1	535	539	PF00917	0.655
DOC_USP7_MATH_1	588	592	PF00917	0.674
DOC_USP7_MATH_1	595	599	PF00917	0.780
DOC_USP7_MATH_1	619	623	PF00917	0.775
DOC_USP7_MATH_1	63	67	PF00917	0.697
DOC_USP7_MATH_1	657	661	PF00917	0.713
DOC_USP7_MATH_1	665	669	PF00917	0.623
DOC_USP7_MATH_1	694	698	PF00917	0.649
DOC_USP7_MATH_1	758	762	PF00917	0.590
DOC_USP7_MATH_1	95	99	PF00917	0.635
DOC_WW_Pin1_4	122	127	PF00397	0.790
DOC_WW_Pin1_4	17	22	PF00397	0.621
DOC_WW_Pin1_4	221	226	PF00397	0.674
DOC_WW_Pin1_4	282	287	PF00397	0.577
DOC_WW_Pin1_4	416	421	PF00397	0.766
DOC_WW_Pin1_4	434	439	PF00397	0.562
DOC_WW_Pin1_4	441	446	PF00397	0.728
DOC_WW_Pin1_4	470	475	PF00397	0.629
DOC_WW_Pin1_4	502	507	PF00397	0.705
DOC_WW_Pin1_4	54	59	PF00397	0.583
DOC_WW_Pin1_4	584	589	PF00397	0.777
DOC_WW_Pin1_4	596	601	PF00397	0.590
DOC_WW_Pin1_4	605	610	PF00397	0.726
DOC_WW_Pin1_4	624	629	PF00397	0.798
DOC_WW_Pin1_4	647	652	PF00397	0.574
DOC_WW_Pin1_4	804	809	PF00397	0.705
DOC_WW_Pin1_4	814	819	PF00397	0.695
DOC_WW_Pin1_4	84	89	PF00397	0.758
LIG_14-3-3_CanoR_1	201	206	PF00244	0.475
LIG_14-3-3_CanoR_1	264	268	PF00244	0.380
LIG_14-3-3_CanoR_1	302	309	PF00244	0.572
LIG_14-3-3_CanoR_1	490	494	PF00244	0.559
LIG_14-3-3_CanoR_1	605	609	PF00244	0.759
LIG_14-3-3_CanoR_1	61	69	PF00244	0.738
LIG_14-3-3_CanoR_1	709	717	PF00244	0.557
LIG_14-3-3_CanoR_1	71	77	PF00244	0.716
LIG_14-3-3_CanoR_1	742	750	PF00244	0.542
LIG_14-3-3_CanoR_1	811	819	PF00244	0.593
LIG_Actin_WH2_2	400	416	PF00022	0.531
LIG_BRCT_BRCA1_1	375	379	PF00533	0.629
LIG_CSL_BTD_1	509	512	PF09270	0.638
LIG_CtBP_PxDLS_1	189	193	PF00389	0.509
LIG_FHA_1	191	197	PF00498	0.504
LIG_FHA_1	296	302	PF00498	0.696
LIG_FHA_1	427	433	PF00498	0.808
LIG_FHA_1	452	458	PF00498	0.515
LIG_FHA_1	473	479	PF00498	0.617
LIG_FHA_1	642	648	PF00498	0.831
LIG_FHA_1	698	704	PF00498	0.633
LIG_FHA_1	709	715	PF00498	0.522
LIG_FHA_1	742	748	PF00498	0.540
LIG_FHA_1	766	772	PF00498	0.524
LIG_FHA_2	132	138	PF00498	0.681
LIG_FHA_2	361	367	PF00498	0.631
LIG_FHA_2	713	719	PF00498	0.552
LIG_FHA_2	821	827	PF00498	0.658
LIG_GBD_Chelix_1	259	267	PF00786	0.340
LIG_LIR_Gen_1	101	110	PF02991	0.639
LIG_LIR_Gen_1	35	46	PF02991	0.527
LIG_LIR_Nem_3	101	106	PF02991	0.649
LIG_LIR_Nem_3	237	241	PF02991	0.502
LIG_LIR_Nem_3	35	41	PF02991	0.532
LIG_MYND_1	554	558	PF01753	0.666
LIG_OCRL_FandH_1	102	114	PF00620	0.561
LIG_Pex14_1	510	514	PF04695	0.658
LIG_SH2_CRK	563	567	PF00017	0.714
LIG_SH2_GRB2like	338	341	PF00017	0.564
LIG_SH2_PTP2	546	549	PF00017	0.793
LIG_SH2_SRC	338	341	PF00017	0.448
LIG_SH2_SRC	546	549	PF00017	0.793
LIG_SH2_STAT3	10	13	PF00017	0.513
LIG_SH2_STAT5	10	13	PF00017	0.513
LIG_SH2_STAT5	338	341	PF00017	0.564
LIG_SH2_STAT5	546	549	PF00017	0.793
LIG_SH2_STAT5	563	566	PF00017	0.474
LIG_SH3_3	121	127	PF00018	0.567
LIG_SH3_3	439	445	PF00018	0.756
LIG_SH3_3	450	456	PF00018	0.646
LIG_SH3_3	465	471	PF00018	0.795
LIG_SH3_3	503	509	PF00018	0.739
LIG_SH3_3	544	550	PF00018	0.687
LIG_SH3_3	603	609	PF00018	0.846
LIG_SH3_3	625	631	PF00018	0.679
LIG_SUMO_SIM_par_1	409	417	PF11976	0.544
LIG_SUMO_SIM_par_1	52	57	PF11976	0.507
LIG_SUMO_SIM_par_1	684	690	PF11976	0.584
LIG_TRAF2_1	240	243	PF00917	0.500
LIG_TYR_ITIM	336	341	PF00017	0.455
LIG_WRC_WIRS_1	158	163	PF05994	0.468
MOD_CDK_SPK_2	416	421	PF00069	0.473
MOD_CDK_SPxxK_3	282	289	PF00069	0.516
MOD_CDK_SPxxK_3	54	61	PF00069	0.602
MOD_CDK_SPxxK_3	598	605	PF00069	0.658
MOD_CDK_SPxxK_3	627	634	PF00069	0.549
MOD_CDK_SPxxK_3	804	811	PF00069	0.783
MOD_CDK_SPxxK_3	84	91	PF00069	0.761
MOD_CK1_1	159	165	PF00069	0.509
MOD_CK1_1	224	230	PF00069	0.625
MOD_CK1_1	342	348	PF00069	0.578
MOD_CK1_1	416	422	PF00069	0.769
MOD_CK1_1	480	486	PF00069	0.766
MOD_CK1_1	598	604	PF00069	0.753
MOD_CK1_1	627	633	PF00069	0.759
MOD_CK1_1	655	661	PF00069	0.726
MOD_CK1_1	697	703	PF00069	0.595
MOD_CK1_1	70	76	PF00069	0.774
MOD_CK1_1	84	90	PF00069	0.686
MOD_CK1_1	98	104	PF00069	0.561
MOD_CK2_1	131	137	PF00069	0.691
MOD_CK2_1	2	8	PF00069	0.530
MOD_CK2_1	360	366	PF00069	0.545
MOD_CK2_1	381	387	PF00069	0.580
MOD_CK2_1	456	462	PF00069	0.733
MOD_CK2_1	627	633	PF00069	0.772
MOD_CK2_1	687	693	PF00069	0.508
MOD_CK2_1	712	718	PF00069	0.553
MOD_Cter_Amidation	802	805	PF01082	0.512
MOD_DYRK1A_RPxSP_1	605	609	PF00069	0.770
MOD_GlcNHglycan	226	230	PF01048	0.670
MOD_GlcNHglycan	270	273	PF01048	0.653
MOD_GlcNHglycan	303	306	PF01048	0.683
MOD_GlcNHglycan	333	336	PF01048	0.466
MOD_GlcNHglycan	383	386	PF01048	0.615
MOD_GlcNHglycan	393	397	PF01048	0.615
MOD_GlcNHglycan	487	490	PF01048	0.801
MOD_GlcNHglycan	495	498	PF01048	0.842
MOD_GlcNHglycan	528	531	PF01048	0.817
MOD_GlcNHglycan	537	540	PF01048	0.658
MOD_GlcNHglycan	590	593	PF01048	0.550
MOD_GlcNHglycan	65	68	PF01048	0.688
MOD_GlcNHglycan	659	662	PF01048	0.764
MOD_GlcNHglycan	665	668	PF01048	0.668
MOD_GlcNHglycan	73	76	PF01048	0.752
MOD_GlcNHglycan	760	763	PF01048	0.646
MOD_GSK3_1	106	113	PF00069	0.653
MOD_GSK3_1	122	129	PF00069	0.741
MOD_GSK3_1	131	138	PF00069	0.501
MOD_GSK3_1	153	160	PF00069	0.593
MOD_GSK3_1	221	228	PF00069	0.588
MOD_GSK3_1	262	269	PF00069	0.631
MOD_GSK3_1	297	304	PF00069	0.656
MOD_GSK3_1	340	347	PF00069	0.513
MOD_GSK3_1	349	356	PF00069	0.581
MOD_GSK3_1	416	423	PF00069	0.771
MOD_GSK3_1	473	480	PF00069	0.751
MOD_GSK3_1	485	492	PF00069	0.769
MOD_GSK3_1	574	581	PF00069	0.747
MOD_GSK3_1	584	591	PF00069	0.679
MOD_GSK3_1	63	70	PF00069	0.730
MOD_GSK3_1	653	660	PF00069	0.716
MOD_GSK3_1	661	668	PF00069	0.786
MOD_GSK3_1	708	715	PF00069	0.560
MOD_GSK3_1	71	78	PF00069	0.794
MOD_GSK3_1	752	759	PF00069	0.433
MOD_GSK3_1	80	87	PF00069	0.706
MOD_GSK3_1	810	817	PF00069	0.614
MOD_GSK3_1	91	98	PF00069	0.686
MOD_N-GLC_1	110	115	PF02516	0.548
MOD_N-GLC_1	135	140	PF02516	0.518
MOD_N-GLC_1	153	158	PF02516	0.408
MOD_N-GLC_1	339	344	PF02516	0.560
MOD_N-GLC_1	596	601	PF02516	0.559
MOD_N-GLC_1	71	76	PF02516	0.746
MOD_N-GLC_1	84	89	PF02516	0.593
MOD_NEK2_1	106	111	PF00069	0.520
MOD_NEK2_1	166	171	PF00069	0.432
MOD_NEK2_1	218	223	PF00069	0.512
MOD_NEK2_1	262	267	PF00069	0.546
MOD_NEK2_1	301	306	PF00069	0.697
MOD_NEK2_1	312	317	PF00069	0.580
MOD_NEK2_1	339	344	PF00069	0.467
MOD_NEK2_1	349	354	PF00069	0.476
MOD_NEK2_1	360	365	PF00069	0.627
MOD_NEK2_1	368	373	PF00069	0.360
MOD_NEK2_1	391	396	PF00069	0.524
MOD_NEK2_1	425	430	PF00069	0.736
MOD_NEK2_1	513	518	PF00069	0.669
MOD_NEK2_1	765	770	PF00069	0.539
MOD_NEK2_1	829	834	PF00069	0.698
MOD_NEK2_2	275	280	PF00069	0.776
MOD_NEK2_2	489	494	PF00069	0.559
MOD_NEK2_2	795	800	PF00069	0.502
MOD_PIKK_1	131	137	PF00454	0.691
MOD_PIKK_1	312	318	PF00454	0.502
MOD_PIKK_1	655	661	PF00454	0.748
MOD_PIKK_1	709	715	PF00454	0.413
MOD_PIKK_1	98	104	PF00454	0.608
MOD_PKA_2	2	8	PF00069	0.632
MOD_PKA_2	200	206	PF00069	0.483
MOD_PKA_2	263	269	PF00069	0.381
MOD_PKA_2	301	307	PF00069	0.494
MOD_PKA_2	413	419	PF00069	0.616
MOD_PKA_2	489	495	PF00069	0.558
MOD_PKA_2	604	610	PF00069	0.770
MOD_PKA_2	63	69	PF00069	0.656
MOD_PKA_2	673	679	PF00069	0.633
MOD_PKA_2	70	76	PF00069	0.733
MOD_PKA_2	708	714	PF00069	0.563
MOD_PKA_2	741	747	PF00069	0.578
MOD_PKA_2	810	816	PF00069	0.595
MOD_Plk_1	110	116	PF00069	0.565
MOD_Plk_1	135	141	PF00069	0.516
MOD_Plk_1	153	159	PF00069	0.408
MOD_Plk_1	242	248	PF00069	0.480
MOD_Plk_1	360	366	PF00069	0.412
MOD_Plk_4	2	8	PF00069	0.530
MOD_Plk_4	242	248	PF00069	0.522
MOD_Plk_4	349	355	PF00069	0.515
MOD_Plk_4	420	426	PF00069	0.800
MOD_Plk_4	456	462	PF00069	0.733
MOD_Plk_4	513	519	PF00069	0.639
MOD_Plk_4	765	771	PF00069	0.628
MOD_ProDKin_1	122	128	PF00069	0.790
MOD_ProDKin_1	17	23	PF00069	0.626
MOD_ProDKin_1	221	227	PF00069	0.682
MOD_ProDKin_1	282	288	PF00069	0.580
MOD_ProDKin_1	416	422	PF00069	0.770
MOD_ProDKin_1	434	440	PF00069	0.563
MOD_ProDKin_1	441	447	PF00069	0.728
MOD_ProDKin_1	470	476	PF00069	0.630
MOD_ProDKin_1	502	508	PF00069	0.698
MOD_ProDKin_1	54	60	PF00069	0.594
MOD_ProDKin_1	584	590	PF00069	0.779
MOD_ProDKin_1	596	602	PF00069	0.588
MOD_ProDKin_1	605	611	PF00069	0.725
MOD_ProDKin_1	624	630	PF00069	0.797
MOD_ProDKin_1	647	653	PF00069	0.575
MOD_ProDKin_1	804	810	PF00069	0.705
MOD_ProDKin_1	814	820	PF00069	0.692
MOD_ProDKin_1	84	90	PF00069	0.759
MOD_SUMO_rev_2	384	391	PF00179	0.538
MOD_SUMO_rev_2	676	685	PF00179	0.696
TRG_DiLeu_BaEn_2	241	247	PF01217	0.475
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.643
TRG_DiLeu_BaLyEn_6	805	810	PF01217	0.702
TRG_ENDOCYTIC_2	338	341	PF00928	0.564
TRG_ENDOCYTIC_2	51	54	PF00928	0.290
TRG_ENDOCYTIC_2	546	549	PF00928	0.793
TRG_ER_diArg_1	140	142	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL79	Leptomonas seymouri	41%	94%
A0A3S7XBE3	Leishmania donovani	85%	100%
A4HPQ4	Leishmania braziliensis	65%	99%
A4ID09	Leishmania infantum	85%	100%
Q4Q128	Leishmania major	85%	100%