RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9ATG5_LEIMU

TriTrypDb:

LmxM.36.3830

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.639
CLV_PCSK_KEX2_1	23	25	PF00082	0.639
CLV_PCSK_KEX2_1	293	295	PF00082	0.403
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.384
CLV_PCSK_SKI1_1	76	80	PF00082	0.577
DEG_APCC_DBOX_1	148	156	PF00400	0.417
DOC_CKS1_1	239	244	PF01111	0.596
DOC_MAPK_gen_1	293	301	PF00069	0.316
DOC_PP2B_LxvP_1	171	174	PF13499	0.461
DOC_PP4_FxxP_1	38	41	PF00568	0.508
DOC_USP7_MATH_1	216	220	PF00917	0.645
DOC_USP7_MATH_1	257	261	PF00917	0.593
DOC_USP7_MATH_1	93	97	PF00917	0.665
DOC_USP7_UBL2_3	42	46	PF12436	0.617
DOC_WW_Pin1_4	153	158	PF00397	0.560
DOC_WW_Pin1_4	16	21	PF00397	0.623
DOC_WW_Pin1_4	230	235	PF00397	0.720
DOC_WW_Pin1_4	238	243	PF00397	0.673
LIG_14-3-3_CanoR_1	117	122	PF00244	0.388
LIG_14-3-3_CanoR_1	15	20	PF00244	0.696
LIG_14-3-3_CanoR_1	23	29	PF00244	0.589
LIG_14-3-3_CanoR_1	259	266	PF00244	0.586
LIG_14-3-3_CanoR_1	294	298	PF00244	0.287
LIG_ActinCP_TwfCPI_2	38	48	PF01115	0.385
LIG_BRCT_BRCA1_1	119	123	PF00533	0.384
LIG_BRCT_BRCA1_1	95	99	PF00533	0.589
LIG_Clathr_ClatBox_1	112	116	PF01394	0.384
LIG_DLG_GKlike_1	117	124	PF00625	0.292
LIG_FHA_1	134	140	PF00498	0.378
LIG_FHA_1	294	300	PF00498	0.289
LIG_FHA_1	45	51	PF00498	0.530
LIG_FHA_1	70	76	PF00498	0.504
LIG_FHA_2	173	179	PF00498	0.451
LIG_FHA_2	189	195	PF00498	0.413
LIG_FHA_2	287	293	PF00498	0.171
LIG_FHA_2	59	65	PF00498	0.561
LIG_LIR_Gen_1	120	129	PF02991	0.405
LIG_LIR_Nem_3	120	124	PF02991	0.405
LIG_SH2_CRK	121	125	PF00017	0.289
LIG_SH2_CRK	272	276	PF00017	0.404
LIG_SH2_NCK_1	288	292	PF00017	0.171
LIG_SH2_STAT5	288	291	PF00017	0.335
LIG_SH2_STAT5	49	52	PF00017	0.541
LIG_SH3_2	41	46	PF14604	0.402
LIG_SH3_3	206	212	PF00018	0.495
LIG_SH3_3	231	237	PF00018	0.606
LIG_SH3_3	239	245	PF00018	0.606
LIG_SH3_3	274	280	PF00018	0.353
LIG_SH3_3	38	44	PF00018	0.516
MOD_CDK_SPxxK_3	16	23	PF00069	0.673
MOD_CK1_1	225	231	PF00069	0.696
MOD_CK2_1	188	194	PF00069	0.505
MOD_CK2_1	23	29	PF00069	0.776
MOD_CK2_1	286	292	PF00069	0.171
MOD_GlcNHglycan	104	107	PF01048	0.577
MOD_GlcNHglycan	217	221	PF01048	0.683
MOD_GlcNHglycan	95	98	PF01048	0.690
MOD_GSK3_1	153	160	PF00069	0.610
MOD_LATS_1	22	28	PF00433	0.457
MOD_N-GLC_1	157	162	PF02516	0.541
MOD_N-GLC_1	223	228	PF02516	0.580
MOD_NEK2_1	286	291	PF00069	0.404
MOD_NMyristoyl	1	7	PF02799	0.535
MOD_OFUCOSY	126	131	PF10250	0.328
MOD_OFUCOSY	290	297	PF10250	0.271
MOD_PIKK_1	188	194	PF00454	0.427
MOD_PK_1	24	30	PF00069	0.616
MOD_PKA_1	23	29	PF00069	0.619
MOD_PKA_1	293	299	PF00069	0.403
MOD_PKA_2	188	194	PF00069	0.427
MOD_PKA_2	22	28	PF00069	0.599
MOD_PKA_2	293	299	PF00069	0.288
MOD_Plk_1	216	222	PF00069	0.434
MOD_Plk_2-3	29	35	PF00069	0.605
MOD_Plk_4	172	178	PF00069	0.483
MOD_Plk_4	58	64	PF00069	0.398
MOD_ProDKin_1	153	159	PF00069	0.562
MOD_ProDKin_1	16	22	PF00069	0.627
MOD_ProDKin_1	230	236	PF00069	0.722
MOD_ProDKin_1	238	244	PF00069	0.670
TRG_ENDOCYTIC_2	121	124	PF00928	0.289
TRG_ENDOCYTIC_2	272	275	PF00928	0.404
TRG_ER_diArg_1	186	189	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK3	Leptomonas seymouri	57%	98%
A0A0S4JLL7	Bodo saltans	33%	100%
A0A1X0P3L1	Trypanosomatidae	42%	100%
A0A3Q8IJF1	Leishmania donovani	93%	100%
A4HPQ0	Leishmania braziliensis	77%	100%
A4ID13	Leishmania infantum	94%	100%
D0A8G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q132	Leishmania major	92%	100%
V5BIP2	Trypanosoma cruzi	34%	100%