Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATG1_LEIMU

TriTrypDb:

LmxM.36.3790

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ATG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.440
CLV_C14_Caspase3-7	445	449	PF00656	0.714
CLV_C14_Caspase3-7	573	577	PF00656	0.657
CLV_C14_Caspase3-7	853	857	PF00656	0.660
CLV_NRD_NRD_1	144	146	PF00675	0.588
CLV_NRD_NRD_1	248	250	PF00675	0.542
CLV_NRD_NRD_1	562	564	PF00675	0.347
CLV_NRD_NRD_1	58	60	PF00675	0.530
CLV_NRD_NRD_1	590	592	PF00675	0.614
CLV_NRD_NRD_1	721	723	PF00675	0.640
CLV_NRD_NRD_1	735	737	PF00675	0.517
CLV_NRD_NRD_1	76	78	PF00675	0.473
CLV_NRD_NRD_1	772	774	PF00675	0.426
CLV_NRD_NRD_1	860	862	PF00675	0.735
CLV_NRD_NRD_1	952	954	PF00675	0.550
CLV_NRD_NRD_1	958	960	PF00675	0.585
CLV_PCSK_FUR_1	588	592	PF00082	0.704
CLV_PCSK_KEX2_1	144	146	PF00082	0.588
CLV_PCSK_KEX2_1	248	250	PF00082	0.542
CLV_PCSK_KEX2_1	562	564	PF00082	0.347
CLV_PCSK_KEX2_1	58	60	PF00082	0.478
CLV_PCSK_KEX2_1	590	592	PF00082	0.619
CLV_PCSK_KEX2_1	723	725	PF00082	0.625
CLV_PCSK_KEX2_1	734	736	PF00082	0.530
CLV_PCSK_KEX2_1	76	78	PF00082	0.367
CLV_PCSK_KEX2_1	772	774	PF00082	0.426
CLV_PCSK_KEX2_1	860	862	PF00082	0.735
CLV_PCSK_KEX2_1	952	954	PF00082	0.550
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.408
CLV_PCSK_PC7_1	719	725	PF00082	0.480
CLV_PCSK_SKI1_1	178	182	PF00082	0.753
CLV_PCSK_SKI1_1	263	267	PF00082	0.626
CLV_PCSK_SKI1_1	42	46	PF00082	0.438
CLV_PCSK_SKI1_1	426	430	PF00082	0.664
CLV_PCSK_SKI1_1	475	479	PF00082	0.579
CLV_PCSK_SKI1_1	483	487	PF00082	0.512
CLV_PCSK_SKI1_1	562	566	PF00082	0.343
CLV_PCSK_SKI1_1	736	740	PF00082	0.657
CLV_PCSK_SKI1_1	751	755	PF00082	0.415
CLV_PCSK_SKI1_1	772	776	PF00082	0.629
CLV_PCSK_SKI1_1	904	908	PF00082	0.620
DEG_APCC_DBOX_1	316	324	PF00400	0.560
DEG_APCC_DBOX_1	482	490	PF00400	0.539
DEG_APCC_DBOX_1	535	543	PF00400	0.363
DEG_SCF_TRCP1_1	173	179	PF00400	0.827
DEG_SPOP_SBC_1	213	217	PF00917	0.721
DEG_SPOP_SBC_1	400	404	PF00917	0.359
DEG_SPOP_SBC_1	623	627	PF00917	0.576
DOC_CYCLIN_RxL_1	39	48	PF00134	0.451
DOC_CYCLIN_RxL_1	480	491	PF00134	0.546
DOC_CYCLIN_RxL_1	767	780	PF00134	0.642
DOC_CYCLIN_yCln2_LP_2	290	293	PF00134	0.498
DOC_MAPK_gen_1	144	150	PF00069	0.617
DOC_MAPK_HePTP_8	341	353	PF00069	0.374
DOC_MAPK_MEF2A_6	32	40	PF00069	0.426
DOC_MAPK_MEF2A_6	344	353	PF00069	0.369
DOC_MAPK_MEF2A_6	96	105	PF00069	0.513
DOC_PP2B_LxvP_1	202	205	PF13499	0.716
DOC_PP2B_LxvP_1	220	223	PF13499	0.594
DOC_PP2B_LxvP_1	290	293	PF13499	0.688
DOC_PP2B_LxvP_1	618	621	PF13499	0.480
DOC_PP2B_LxvP_1	917	920	PF13499	0.818
DOC_PP4_FxxP_1	121	124	PF00568	0.503
DOC_USP7_MATH_1	205	209	PF00917	0.798
DOC_USP7_MATH_1	213	217	PF00917	0.755
DOC_USP7_MATH_1	265	269	PF00917	0.810
DOC_USP7_MATH_1	278	282	PF00917	0.568
DOC_USP7_MATH_1	299	303	PF00917	0.687
DOC_USP7_MATH_1	439	443	PF00917	0.632
DOC_USP7_MATH_1	444	448	PF00917	0.716
DOC_USP7_MATH_1	507	511	PF00917	0.530
DOC_USP7_MATH_1	528	532	PF00917	0.690
DOC_USP7_MATH_1	786	790	PF00917	0.737
DOC_USP7_MATH_1	793	797	PF00917	0.764
DOC_USP7_MATH_1	826	830	PF00917	0.716
DOC_USP7_MATH_1	847	851	PF00917	0.830
DOC_USP7_MATH_1	882	886	PF00917	0.731
DOC_USP7_MATH_1	913	917	PF00917	0.681
DOC_USP7_MATH_1	924	928	PF00917	0.802
DOC_USP7_MATH_1	936	940	PF00917	0.602
DOC_USP7_MATH_2	533	539	PF00917	0.603
DOC_WW_Pin1_4	132	137	PF00397	0.457
DOC_WW_Pin1_4	182	187	PF00397	0.681
DOC_WW_Pin1_4	20	25	PF00397	0.466
DOC_WW_Pin1_4	258	263	PF00397	0.780
DOC_WW_Pin1_4	297	302	PF00397	0.646
DOC_WW_Pin1_4	383	388	PF00397	0.661
DOC_WW_Pin1_4	633	638	PF00397	0.436
DOC_WW_Pin1_4	778	783	PF00397	0.636
DOC_WW_Pin1_4	787	792	PF00397	0.722
DOC_WW_Pin1_4	822	827	PF00397	0.736
DOC_WW_Pin1_4	834	839	PF00397	0.677
DOC_WW_Pin1_4	843	848	PF00397	0.811
DOC_WW_Pin1_4	876	881	PF00397	0.737
DOC_WW_Pin1_4	920	925	PF00397	0.717
LIG_14-3-3_CanoR_1	182	186	PF00244	0.727
LIG_14-3-3_CanoR_1	276	286	PF00244	0.710
LIG_14-3-3_CanoR_1	344	351	PF00244	0.542
LIG_14-3-3_CanoR_1	562	568	PF00244	0.409
LIG_14-3-3_CanoR_1	652	661	PF00244	0.414
LIG_14-3-3_CanoR_1	820	826	PF00244	0.794
LIG_14-3-3_CanoR_1	828	835	PF00244	0.775
LIG_14-3-3_CanoR_1	894	903	PF00244	0.755
LIG_14-3-3_CanoR_1	914	918	PF00244	0.749
LIG_14-3-3_CanoR_1	926	935	PF00244	0.803
LIG_Actin_WH2_2	460	477	PF00022	0.654
LIG_Actin_WH2_2	478	495	PF00022	0.532
LIG_APCC_ABBA_1	405	410	PF00400	0.590
LIG_BIR_II_1	1	5	PF00653	0.457
LIG_BIR_III_4	240	244	PF00653	0.520
LIG_BRCT_BRCA1_1	530	534	PF00533	0.630
LIG_CaM_IQ_9	743	758	PF13499	0.370
LIG_eIF4E_1	310	316	PF01652	0.653
LIG_eIF4E_1	97	103	PF01652	0.430
LIG_FHA_1	207	213	PF00498	0.667
LIG_FHA_1	285	291	PF00498	0.687
LIG_FHA_1	39	45	PF00498	0.441
LIG_FHA_1	400	406	PF00498	0.366
LIG_FHA_1	563	569	PF00498	0.625
LIG_FHA_1	668	674	PF00498	0.593
LIG_FHA_1	70	76	PF00498	0.449
LIG_FHA_1	752	758	PF00498	0.674
LIG_FHA_1	906	912	PF00498	0.778
LIG_FHA_2	625	631	PF00498	0.580
LIG_FHA_2	847	853	PF00498	0.840
LIG_FHA_2	894	900	PF00498	0.712
LIG_LIR_Apic_2	120	124	PF02991	0.490
LIG_LIR_Apic_2	833	838	PF02991	0.642
LIG_LIR_Gen_1	521	528	PF02991	0.679
LIG_LIR_Nem_3	26	31	PF02991	0.461
LIG_LIR_Nem_3	521	526	PF02991	0.679
LIG_NRBOX	679	685	PF00104	0.526
LIG_PDZ_Class_3	959	964	PF00595	0.639
LIG_Pex14_2	117	121	PF04695	0.494
LIG_RPA_C_Plants	724	735	PF08784	0.395
LIG_SH2_CRK	835	839	PF00017	0.820
LIG_SH2_STAP1	418	422	PF00017	0.552
LIG_SH2_STAP1	455	459	PF00017	0.665
LIG_SH2_STAT5	106	109	PF00017	0.359
LIG_SH2_STAT5	310	313	PF00017	0.612
LIG_SH2_STAT5	37	40	PF00017	0.353
LIG_SH2_STAT5	687	690	PF00017	0.556
LIG_SH2_STAT5	97	100	PF00017	0.390
LIG_SH3_1	835	841	PF00018	0.604
LIG_SH3_3	121	127	PF00018	0.493
LIG_SH3_3	835	841	PF00018	0.679
LIG_SUMO_SIM_anti_2	677	685	PF11976	0.623
LIG_SUMO_SIM_par_1	137	143	PF11976	0.573
LIG_SUMO_SIM_par_1	485	491	PF11976	0.572
LIG_TRAF2_1	454	457	PF00917	0.570
LIG_TYR_ITIM	104	109	PF00017	0.419
LIG_TYR_ITIM	35	40	PF00017	0.417
LIG_WW_3	222	226	PF00397	0.595
MOD_CDC14_SPxK_1	636	639	PF00782	0.397
MOD_CDC14_SPxK_1	923	926	PF00782	0.756
MOD_CDK_SPK_2	258	263	PF00069	0.742
MOD_CDK_SPxK_1	633	639	PF00069	0.411
MOD_CDK_SPxK_1	822	828	PF00069	0.798
MOD_CDK_SPxK_1	920	926	PF00069	0.749
MOD_CDK_SPxxK_3	20	27	PF00069	0.450
MOD_CDK_SPxxK_3	787	794	PF00069	0.660
MOD_CK1_1	135	141	PF00069	0.459
MOD_CK1_1	151	157	PF00069	0.694
MOD_CK1_1	185	191	PF00069	0.711
MOD_CK1_1	258	264	PF00069	0.748
MOD_CK1_1	297	303	PF00069	0.491
MOD_CK1_1	442	448	PF00069	0.644
MOD_CK1_1	491	497	PF00069	0.694
MOD_CK1_1	521	527	PF00069	0.638
MOD_CK1_1	538	544	PF00069	0.596
MOD_CK1_1	633	639	PF00069	0.605
MOD_CK1_1	69	75	PF00069	0.427
MOD_CK1_1	833	839	PF00069	0.792
MOD_CK1_1	846	852	PF00069	0.689
MOD_CK1_1	889	895	PF00069	0.769
MOD_CK1_1	927	933	PF00069	0.728
MOD_CK1_1	939	945	PF00069	0.715
MOD_CK2_1	278	284	PF00069	0.709
MOD_CK2_1	727	733	PF00069	0.685
MOD_CK2_1	749	755	PF00069	0.662
MOD_CK2_1	893	899	PF00069	0.718
MOD_CK2_1	943	949	PF00069	0.629
MOD_GlcNHglycan	160	163	PF01048	0.692
MOD_GlcNHglycan	173	176	PF01048	0.808
MOD_GlcNHglycan	187	190	PF01048	0.565
MOD_GlcNHglycan	233	236	PF01048	0.674
MOD_GlcNHglycan	280	283	PF01048	0.676
MOD_GlcNHglycan	345	348	PF01048	0.662
MOD_GlcNHglycan	448	451	PF01048	0.629
MOD_GlcNHglycan	509	512	PF01048	0.778
MOD_GlcNHglycan	523	526	PF01048	0.553
MOD_GlcNHglycan	547	550	PF01048	0.611
MOD_GlcNHglycan	572	575	PF01048	0.568
MOD_GlcNHglycan	605	609	PF01048	0.485
MOD_GlcNHglycan	751	754	PF01048	0.657
MOD_GlcNHglycan	783	786	PF01048	0.678
MOD_GlcNHglycan	809	812	PF01048	0.799
MOD_GlcNHglycan	884	887	PF01048	0.687
MOD_GlcNHglycan	938	941	PF01048	0.738
MOD_GlcNHglycan	945	948	PF01048	0.574
MOD_GSK3_1	148	155	PF00069	0.684
MOD_GSK3_1	178	185	PF00069	0.725
MOD_GSK3_1	188	195	PF00069	0.721
MOD_GSK3_1	438	445	PF00069	0.600
MOD_GSK3_1	487	494	PF00069	0.584
MOD_GSK3_1	600	607	PF00069	0.480
MOD_GSK3_1	619	626	PF00069	0.613
MOD_GSK3_1	66	73	PF00069	0.461
MOD_GSK3_1	663	670	PF00069	0.561
MOD_GSK3_1	745	752	PF00069	0.378
MOD_GSK3_1	777	784	PF00069	0.738
MOD_GSK3_1	79	86	PF00069	0.470
MOD_GSK3_1	793	800	PF00069	0.558
MOD_GSK3_1	822	829	PF00069	0.819
MOD_GSK3_1	830	837	PF00069	0.750
MOD_GSK3_1	843	850	PF00069	0.679
MOD_GSK3_1	876	883	PF00069	0.820
MOD_GSK3_1	886	893	PF00069	0.682
MOD_GSK3_1	920	927	PF00069	0.755
MOD_GSK3_1	939	946	PF00069	0.482
MOD_LATS_1	322	328	PF00433	0.604
MOD_LATS_1	866	872	PF00433	0.745
MOD_N-GLC_1	66	71	PF02516	0.462
MOD_N-GLC_1	761	766	PF02516	0.679
MOD_NEK2_1	1	6	PF00069	0.543
MOD_NEK2_1	206	211	PF00069	0.719
MOD_NEK2_1	212	217	PF00069	0.646
MOD_NEK2_1	266	271	PF00069	0.610
MOD_NEK2_1	329	334	PF00069	0.636
MOD_NEK2_1	343	348	PF00069	0.495
MOD_NEK2_1	367	372	PF00069	0.564
MOD_NEK2_1	38	43	PF00069	0.445
MOD_NEK2_1	485	490	PF00069	0.563
MOD_NEK2_1	492	497	PF00069	0.604
MOD_NEK2_1	526	531	PF00069	0.761
MOD_NEK2_1	570	575	PF00069	0.355
MOD_NEK2_1	663	668	PF00069	0.552
MOD_NEK2_1	70	75	PF00069	0.452
MOD_NEK2_1	776	781	PF00069	0.642
MOD_NEK2_1	943	948	PF00069	0.745
MOD_PIKK_1	324	330	PF00454	0.524
MOD_PIKK_1	411	417	PF00454	0.656
MOD_PIKK_1	600	606	PF00454	0.698
MOD_PIKK_1	647	653	PF00454	0.594
MOD_PIKK_1	745	751	PF00454	0.514
MOD_PIKK_1	756	762	PF00454	0.621
MOD_PIKK_1	800	806	PF00454	0.749
MOD_PIKK_1	83	89	PF00454	0.501
MOD_PKA_1	562	568	PF00069	0.335
MOD_PKA_2	181	187	PF00069	0.723
MOD_PKA_2	206	212	PF00069	0.719
MOD_PKA_2	252	258	PF00069	0.812
MOD_PKA_2	334	340	PF00069	0.644
MOD_PKA_2	343	349	PF00069	0.553
MOD_PKA_2	492	498	PF00069	0.596
MOD_PKA_2	535	541	PF00069	0.564
MOD_PKA_2	562	568	PF00069	0.627
MOD_PKA_2	690	696	PF00069	0.634
MOD_PKA_2	718	724	PF00069	0.406
MOD_PKA_2	800	806	PF00069	0.749
MOD_PKA_2	827	833	PF00069	0.804
MOD_PKA_2	893	899	PF00069	0.759
MOD_PKA_2	913	919	PF00069	0.635
MOD_PKA_2	925	931	PF00069	0.809
MOD_Plk_1	266	272	PF00069	0.726
MOD_Plk_1	367	373	PF00069	0.674
MOD_Plk_1	400	406	PF00069	0.654
MOD_Plk_1	418	424	PF00069	0.369
MOD_Plk_1	455	461	PF00069	0.661
MOD_Plk_1	630	636	PF00069	0.624
MOD_Plk_1	66	72	PF00069	0.462
MOD_Plk_4	1	7	PF00069	0.515
MOD_Plk_4	135	141	PF00069	0.486
MOD_Plk_4	266	272	PF00069	0.726
MOD_Plk_4	286	292	PF00069	0.613
MOD_Plk_4	563	569	PF00069	0.333
MOD_Plk_4	830	836	PF00069	0.744
MOD_Plk_4	939	945	PF00069	0.755
MOD_ProDKin_1	132	138	PF00069	0.450
MOD_ProDKin_1	182	188	PF00069	0.682
MOD_ProDKin_1	20	26	PF00069	0.471
MOD_ProDKin_1	258	264	PF00069	0.779
MOD_ProDKin_1	297	303	PF00069	0.641
MOD_ProDKin_1	383	389	PF00069	0.658
MOD_ProDKin_1	633	639	PF00069	0.436
MOD_ProDKin_1	778	784	PF00069	0.640
MOD_ProDKin_1	787	793	PF00069	0.724
MOD_ProDKin_1	822	828	PF00069	0.738
MOD_ProDKin_1	834	840	PF00069	0.677
MOD_ProDKin_1	843	849	PF00069	0.811
MOD_ProDKin_1	876	882	PF00069	0.732
MOD_ProDKin_1	920	926	PF00069	0.721
MOD_SUMO_for_1	354	357	PF00179	0.651
MOD_SUMO_rev_2	256	261	PF00179	0.592
TRG_DiLeu_BaEn_1	679	684	PF01217	0.622
TRG_DiLeu_BaEn_1	858	863	PF01217	0.757
TRG_DiLeu_LyEn_5	858	863	PF01217	0.757
TRG_ENDOCYTIC_2	106	109	PF00928	0.423
TRG_ENDOCYTIC_2	28	31	PF00928	0.444
TRG_ENDOCYTIC_2	37	40	PF00928	0.417
TRG_ER_diArg_1	144	146	PF00400	0.490
TRG_ER_diArg_1	247	249	PF00400	0.535
TRG_ER_diArg_1	561	563	PF00400	0.348
TRG_ER_diArg_1	588	591	PF00400	0.610
TRG_ER_diArg_1	734	736	PF00400	0.650
TRG_ER_diArg_1	75	77	PF00400	0.471
TRG_ER_diArg_1	771	773	PF00400	0.429
TRG_ER_diArg_1	860	862	PF00400	0.837
TRG_NES_CRM1_1	30	43	PF08389	0.432
TRG_Pf-PMV_PEXEL_1	773	777	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	860	864	PF00026	0.756

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T9	Leptomonas seymouri	39%	98%
A0A3S7XBB6	Leishmania donovani	88%	100%
A4HPP7	Leishmania braziliensis	67%	99%
A4ID17	Leishmania infantum	88%	100%
Q4Q136	Leishmania major	85%	98%