CLP1_P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ATF3_LEIMU

TriTrypDb:

LmxM.36.3710

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ATF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ATF3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	1
GO:0006397	mRNA processing	7	1
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0008380	RNA splicing	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0019205	nucleobase-containing compound kinase activity	5	12
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	421	423	PF00675	0.399
CLV_NRD_NRD_1	9	11	PF00675	0.409
CLV_NRD_NRD_1	95	97	PF00675	0.401
CLV_PCSK_KEX2_1	102	104	PF00082	0.366
CLV_PCSK_KEX2_1	421	423	PF00082	0.399
CLV_PCSK_KEX2_1	5	7	PF00082	0.623
CLV_PCSK_KEX2_1	9	11	PF00082	0.521
CLV_PCSK_KEX2_1	95	97	PF00082	0.424
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.422
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.529
CLV_PCSK_SKI1_1	135	139	PF00082	0.411
CLV_PCSK_SKI1_1	315	319	PF00082	0.551
CLV_PCSK_SKI1_1	340	344	PF00082	0.385
CLV_PCSK_SKI1_1	9	13	PF00082	0.397
CLV_PCSK_SKI1_1	96	100	PF00082	0.435
CLV_Separin_Metazoa	316	320	PF03568	0.404
DEG_ODPH_VHL_1	352	364	PF01847	0.409
DEG_ODPH_VHL_1	389	401	PF01847	0.346
DOC_CYCLIN_RxL_1	334	347	PF00134	0.473
DOC_MAPK_gen_1	102	109	PF00069	0.339
DOC_MAPK_gen_1	134	142	PF00069	0.411
DOC_MAPK_gen_1	4	13	PF00069	0.567
DOC_PP1_RVXF_1	338	345	PF00149	0.429
DOC_PP2B_LxvP_1	149	152	PF13499	0.360
DOC_PP4_FxxP_1	301	304	PF00568	0.411
DOC_USP7_MATH_1	188	192	PF00917	0.411
DOC_USP7_MATH_1	338	342	PF00917	0.462
DOC_USP7_MATH_1	367	371	PF00917	0.405
DOC_WW_Pin1_4	169	174	PF00397	0.284
DOC_WW_Pin1_4	222	227	PF00397	0.287
DOC_WW_Pin1_4	322	327	PF00397	0.384
LIG_14-3-3_CanoR_1	113	119	PF00244	0.327
LIG_14-3-3_CanoR_1	281	286	PF00244	0.447
LIG_14-3-3_CanoR_1	311	318	PF00244	0.435
LIG_14-3-3_CanoR_1	47	52	PF00244	0.406
LIG_14-3-3_CanoR_1	57	63	PF00244	0.356
LIG_14-3-3_CanoR_1	9	14	PF00244	0.444
LIG_APCC_ABBA_1	51	56	PF00400	0.478
LIG_BRCT_BRCA1_1	340	344	PF00533	0.487
LIG_Clathr_ClatBox_1	62	66	PF01394	0.466
LIG_deltaCOP1_diTrp_1	279	285	PF00928	0.301
LIG_FHA_1	102	108	PF00498	0.411
LIG_FHA_1	300	306	PF00498	0.322
LIG_FHA_1	48	54	PF00498	0.401
LIG_FHA_1	57	63	PF00498	0.350
LIG_FHA_2	341	347	PF00498	0.342
LIG_FHA_2	441	447	PF00498	0.507
LIG_LIR_Apic_2	298	304	PF02991	0.325
LIG_LIR_Gen_1	17	27	PF02991	0.385
LIG_LIR_Gen_1	279	290	PF02991	0.300
LIG_LIR_Gen_1	368	378	PF02991	0.446
LIG_LIR_Gen_1	446	451	PF02991	0.447
LIG_LIR_Nem_3	17	22	PF02991	0.375
LIG_LIR_Nem_3	279	285	PF02991	0.300
LIG_LIR_Nem_3	325	330	PF02991	0.496
LIG_LIR_Nem_3	368	374	PF02991	0.457
LIG_LIR_Nem_3	446	451	PF02991	0.447
LIG_MYND_1	173	177	PF01753	0.281
LIG_NRBOX	122	128	PF00104	0.411
LIG_PCNA_yPIPBox_3	281	294	PF02747	0.331
LIG_PDZ_Class_2	446	451	PF00595	0.426
LIG_SH2_CRK	19	23	PF00017	0.374
LIG_SH2_CRK	200	204	PF00017	0.331
LIG_SH2_CRK	257	261	PF00017	0.479
LIG_SH2_NCK_1	19	23	PF00017	0.374
LIG_SH2_PTP2	448	451	PF00017	0.462
LIG_SH2_SRC	229	232	PF00017	0.287
LIG_SH2_STAP1	49	53	PF00017	0.436
LIG_SH2_STAT3	199	202	PF00017	0.411
LIG_SH2_STAT5	181	184	PF00017	0.380
LIG_SH2_STAT5	19	22	PF00017	0.454
LIG_SH2_STAT5	210	213	PF00017	0.388
LIG_SH2_STAT5	321	324	PF00017	0.317
LIG_SH2_STAT5	400	403	PF00017	0.475
LIG_SH2_STAT5	448	451	PF00017	0.462
LIG_SH2_STAT5	49	52	PF00017	0.393
LIG_SH3_3	161	167	PF00018	0.447
LIG_SH3_3	225	231	PF00018	0.459
LIG_SH3_3	239	245	PF00018	0.354
LIG_SH3_3	260	266	PF00018	0.387
LIG_SH3_3	332	338	PF00018	0.406
LIG_SH3_3	361	367	PF00018	0.494
LIG_SH3_3	385	391	PF00018	0.349
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.302
LIG_SUMO_SIM_anti_2	267	274	PF11976	0.360
LIG_SUMO_SIM_par_1	176	182	PF11976	0.276
LIG_SUMO_SIM_par_1	267	274	PF11976	0.282
LIG_SUMO_SIM_par_1	58	64	PF11976	0.391
LIG_TRAF2_1	15	18	PF00917	0.358
LIG_TRAF2_1	414	417	PF00917	0.575
LIG_TRAF2_1	444	447	PF00917	0.432
LIG_TYR_ITIM	255	260	PF00017	0.424
MOD_CDK_SPK_2	169	174	PF00069	0.331
MOD_CK1_1	114	120	PF00069	0.300
MOD_CK1_1	179	185	PF00069	0.334
MOD_CK2_1	229	235	PF00069	0.465
MOD_CK2_1	270	276	PF00069	0.413
MOD_CK2_1	310	316	PF00069	0.395
MOD_CK2_1	340	346	PF00069	0.516
MOD_CK2_1	376	382	PF00069	0.331
MOD_CK2_1	440	446	PF00069	0.454
MOD_GlcNHglycan	113	116	PF01048	0.283
MOD_GlcNHglycan	188	191	PF01048	0.322
MOD_GlcNHglycan	213	217	PF01048	0.346
MOD_GlcNHglycan	32	35	PF01048	0.506
MOD_GlcNHglycan	355	358	PF01048	0.610
MOD_GSK3_1	188	195	PF00069	0.411
MOD_GSK3_1	229	236	PF00069	0.483
MOD_GSK3_1	322	329	PF00069	0.548
MOD_GSK3_1	431	438	PF00069	0.394
MOD_GSK3_1	5	12	PF00069	0.509
MOD_GSK3_1	52	59	PF00069	0.324
MOD_N-GLC_1	233	238	PF02516	0.357
MOD_NEK2_1	203	208	PF00069	0.383
MOD_NEK2_1	233	238	PF00069	0.320
MOD_NEK2_1	330	335	PF00069	0.489
MOD_NEK2_1	435	440	PF00069	0.449
MOD_NEK2_2	431	436	PF00069	0.504
MOD_PIKK_1	233	239	PF00454	0.180
MOD_PIKK_1	77	83	PF00454	0.276
MOD_PKA_1	4	10	PF00069	0.486
MOD_PKA_2	186	192	PF00069	0.411
MOD_PKA_2	280	286	PF00069	0.298
MOD_PKA_2	310	316	PF00069	0.491
MOD_PKA_2	431	437	PF00069	0.489
MOD_PKA_2	5	11	PF00069	0.492
MOD_PKA_2	56	62	PF00069	0.314
MOD_PKA_2	94	100	PF00069	0.385
MOD_Plk_1	17	23	PF00069	0.326
MOD_Plk_1	367	373	PF00069	0.497
MOD_Plk_4	133	139	PF00069	0.360
MOD_Plk_4	17	23	PF00069	0.375
MOD_Plk_4	176	182	PF00069	0.292
MOD_Plk_4	192	198	PF00069	0.227
MOD_Plk_4	203	209	PF00069	0.278
MOD_Plk_4	281	287	PF00069	0.307
MOD_Plk_4	340	346	PF00069	0.501
MOD_Plk_4	394	400	PF00069	0.496
MOD_Plk_4	47	53	PF00069	0.392
MOD_ProDKin_1	169	175	PF00069	0.284
MOD_ProDKin_1	222	228	PF00069	0.287
MOD_ProDKin_1	322	328	PF00069	0.383
TRG_DiLeu_BaEn_1	17	22	PF01217	0.375
TRG_DiLeu_BaEn_1	407	412	PF01217	0.345
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.480
TRG_ENDOCYTIC_2	19	22	PF00928	0.374
TRG_ENDOCYTIC_2	200	203	PF00928	0.411
TRG_ENDOCYTIC_2	257	260	PF00928	0.424
TRG_ENDOCYTIC_2	448	451	PF00928	0.462
TRG_ER_diArg_1	420	422	PF00400	0.445
TRG_ER_diArg_1	9	11	PF00400	0.536
TRG_NLS_MonoExtN_4	2	8	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.272
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ5	Leptomonas seymouri	76%	100%
A0A0S4JES6	Bodo saltans	30%	100%
A0A1X0P3J8	Trypanosomatidae	45%	100%
A0A3Q8IL58	Leishmania donovani	96%	100%
A0A422N1N1	Trypanosoma rangeli	46%	100%
A4HPN9	Leishmania braziliensis	93%	100%
A4ID25	Leishmania infantum	96%	100%
D0A8H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q144	Leishmania major	96%	100%
V5AU86	Trypanosoma cruzi	46%	100%